LOCUS       NM_031151               1291 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus malate dehydrogenase 2 (Mdh2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_031151
VERSION     NM_031151.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1291)
  AUTHORS   Ait-El-Mkadem,S., Dayem-Quere,M., Gusic,M., Chaussenot,A.,
            Bannwarth,S., Francois,B., Genin,E.C., Fragaki,K.,
            Volker-Touw,C.L.M., Vasnier,C., Serre,V., van Gassen,K.L.I.,
            Lespinasse,F., Richter,S., Eisenhofer,G., Rouzier,C., Mochel,F., De
            Saint-Martin,A., Abi Warde,M.T., de Sain-van der Velde,M.G.M.,
            Jans,J.J.M., Amiel,J., Avsec,Z., Mertes,C., Haack,T.B., Strom,T.,
            Meitinger,T., Bonnen,P.E., Taylor,R.W., Gagneur,J., van
            Hasselt,P.M., Rotig,A., Delahodde,A., Prokisch,H., Fuchs,S.A. and
            Paquis-Flucklinger,V.
  TITLE     Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset
            Severe Encephalopathy
  JOURNAL   Am J Hum Genet 100 (1), 151-159 (2017)
   PUBMED   27989324
REFERENCE   2  (bases 1 to 1291)
  AUTHORS   Ramos,A.C., Ferreira,G.K., Carvalho-Silva,M., Furlanetto,C.B.,
            Goncalves,C.L., Ferreira,G.C., Schuck,P.F. and Streck,E.L.
  TITLE     Acute administration of l-tyrosine alters energetic metabolism of
            hippocampus and striatum of infant rats
  JOURNAL   Int J Dev Neurosci 31 (5), 303-307 (2013)
   PUBMED   23602810
  REMARK    GeneRIF: Our results indicate an alteration in the energy
            metabolism in hippocampus and striatum of infant rats after acute
            administration of l-tyrosine.
REFERENCE   3  (bases 1 to 1291)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1291)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1291)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1291)
  AUTHORS   Wiseman,M.S., McKay,D., Crow,K.E. and Hardman,M.J.
  TITLE     Rat liver mitochondrial malate dehydrogenase: purification, kinetic
            properties, and role in ethanol metabolism
  JOURNAL   Arch Biochem Biophys 290 (1), 191-196 (1991)
   PUBMED   1898089
REFERENCE   7  (bases 1 to 1291)
  AUTHORS   Mavrides,C. and Nadeau,G.
  TITLE     Purification and properties of the cytosolic and mitochondrial
            forms of aspartate aminotransferase and malate dehydrogenase from
            rat heart
  JOURNAL   Biochem Cell Biol 65 (3), 239-244 (1987)
   PUBMED   3580173
REFERENCE   8  (bases 1 to 1291)
  AUTHORS   Grant,P.M., Roderick,S.L., Grant,G.A., Banaszak,L.J. and
            Strauss,A.W.
  TITLE     Comparison of the precursor and mature forms of rat heart
            mitochondrial malate dehydrogenase
  JOURNAL   Biochemistry 26 (1), 128-134 (1987)
   PUBMED   3828294
REFERENCE   9  (bases 1 to 1291)
  AUTHORS   Grant,P.M., Tellam,J., May,V.L. and Strauss,A.W.
  TITLE     Isolation and nucleotide sequence of a cDNA clone encoding rat
            mitochondrial malate dehydrogenase
  JOURNAL   Nucleic Acids Res 14 (15), 6053-6066 (1986)
   PUBMED   3755817
REFERENCE   10 (bases 1 to 1291)
  AUTHORS   Lai,J.C. and Clark,J.B.
  TITLE     Preparation and properties of mitochondria derived from
            synaptosomes
  JOURNAL   Biochem J 154 (2), 423-432 (1976)
   PUBMED   938457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031151.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063165.1, FQ216782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000012.1  26543674-26543841   c
            169-337             JAXUCZ010000012.1  26537973-26538141   c
            338-421             JAXUCZ010000012.1  26537191-26537274   c
            422-531             JAXUCZ010000012.1  26535469-26535578   c
            532-657             JAXUCZ010000012.1  26535161-26535286   c
            658-735             JAXUCZ010000012.1  26533502-26533579   c
            736-835             JAXUCZ010000012.1  26531971-26532070   c
            836-987             JAXUCZ010000012.1  26531518-26531669   c
            988-1291            JAXUCZ010000012.1  26530886-26531189   c
FEATURES             Location/Qualifiers
     source          1..1291
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1291
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /note="malate dehydrogenase 2"
                     /db_xref="GeneID:81829"
                     /db_xref="RGD:619719"
     exon            1..168
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1119
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /EC_number="1.1.1.37"
                     /note="malate dehydrogenase, mitochondrial; malate
                     dehydrogenase 2, NAD (mitochondrial)"
                     /codon_start=1
                     /product="malate dehydrogenase, mitochondrial precursor"
                     /protein_id="NP_112413.2"
                     /db_xref="GeneID:81829"
                     /db_xref="RGD:619719"
                     /translation="MLSALARPVGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLL
                     KNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGV
                     PRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICIISNPVNSTIPITAEVFKKHGV
                     YNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDF
                     PQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVIECS
                     FVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFV
                     KNMK"
     exon            169..337
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..421
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..531
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..657
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..735
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..835
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..987
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1291
                     /gene="Mdh2"
                     /gene_synonym="Mor1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctctggac aggaccggca ctgcgcagag tggaggtcgt tggagtcact tgtctcctct
       61 cagctgctgt gcctgtaggt ccgtgccccg cccgtcccag ccatgctgtc cgctctcgcc
      121 cgtcctgtcg gtgccgctct ccgccgcagc ttcagcactt cagcccagaa caatgctaaa
      181 gtagctgtcc tgggagcttc tgggggcatt gggcaacccc tttcactcct cctgaagaac
      241 agtcccctcg tgagccgcct gaccctctat gacatcgctc acacacctgg tgtggcagca
      301 gatctgagtc acatcgagac cagagcaaat gtgaaaggct acctcgggcc ggagcagctg
      361 ccggactgcc taaaaggttg tgatgttgtg gtcatcccag ctggagtgcc caggaagcca
      421 ggaatgacac gagatgacct gttcaacacc aatgctacca ttgtggccac attgacggct
      481 gcctgtgccc agcactgtcc tgaagccatg atttgcatca tttccaaccc agttaactcc
      541 accatcccca tcacagccga agttttcaag aagcatggcg tatacaaccc caacaagata
      601 ttcggtgtga caacccttga catcgtcaga gcaaacacat ttgtggcaga gctaaagggt
      661 ttggacccag ctcgagtcaa tgtgcctgtc attggtggcc acgccgggaa gacgatcatc
      721 cccctgatct ctcagtgtac ccccaaggtt gactttcccc aagaccagct ggccacactc
      781 accgggagga tccaggaggc tggcactgaa gtcgtgaagg ccaaggctgg agcaggctct
      841 gccactctgt ccatggctta tgctggagcc cgctttgtct tctccctggt ggacgccatg
      901 aatgggaagg aaggagtcat cgagtgctct tttgttcagt ccaaagagac agagtgcact
      961 tatttctcta cacccttgct gttggggaaa aaaggcctgg agaagaacct aggcattggc
     1021 aaaatcactc cttttgagga gaaaatgatt gccgaggcca tccctgagct gaaagcctcc
     1081 atcaagaaag gcgaggactt tgtgaagaac atgaagtgag tgtgagcctc gagcctccag
     1141 cagcagcagc agcagcatcc taacttattc agcatcatgt cattgaacta cttgagagtc
     1201 taatttgctt gttggagggt gttgtgtcag catcagcatc ccttccaaac tacgggctgt
     1261 tgataatgac aataaaacag tctgattttc t
//
