LOCUS       NM_199269               3355 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus MAM domain containing
            glycosylphosphatidylinositol anchor 2 (Mdga2), mRNA.
ACCESSION   NM_199269 XM_234247 XM_234249
VERSION     NM_199269.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Toledo,A., Letellier,M., Bimbi,G., Tessier,B., Daburon,S.,
            Favereaux,A., Chamma,I., Vennekens,K., Vanderlinden,J., Sainlos,M.,
            de Wit,J., Choquet,D. and Thoumine,O.
  TITLE     MDGAs are fast-diffusing molecules that delay excitatory synapse
            development by altering neuroligin behavior
  JOURNAL   Elife 11, e75233 (2022)
   PUBMED   35532105
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Connor,S.A., Ammendrup-Johnsen,I., Chan,A.W., Kishimoto,Y.,
            Murayama,C., Kurihara,N., Tada,A., Ge,Y., Lu,H., Yan,R.,
            LeDue,J.M., Matsumoto,H., Kiyonari,H., Kirino,Y., Matsuzaki,F.,
            Suzuki,T., Murphy,T.H., Wang,Y.T., Yamamoto,T. and Craig,A.M.
  TITLE     Altered Cortical Dynamics and Cognitive Function upon
            Haploinsufficiency of the Autism-Linked Excitatory Synaptic
            Suppressor MDGA2
  JOURNAL   Neuron 91 (5), 1052-1068 (2016)
   PUBMED   27608760
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Moore,J.M., Oliver,P.L., Finelli,M.J., Lee,S., Lickiss,T.,
            Molnar,Z. and Davies,K.E.
  TITLE     Laf4/Aff3, a gene involved in intellectual disability, is required
            for cellular migration in the mouse cerebral cortex
  JOURNAL   PLoS One 9 (8), e105933 (2014)
   PUBMED   25162227
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Lee,K., Kim,Y., Lee,S.J., Qiang,Y., Lee,D., Lee,H.W., Kim,H.,
            Je,H.S., Sudhof,T.C. and Ko,J.
  TITLE     MDGAs interact selectively with neuroligin-2 but not other
            neuroligins to regulate inhibitory synapse development
  JOURNAL   Proc Natl Acad Sci U S A 110 (1), 336-341 (2013)
   PUBMED   23248271
  REMARK    GeneRIF: MDGAs interact selectively with neuroligin-2 but not other
            neuroligins to regulate inhibitory synapse development.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410442121.
            doi: 10.1073/pnas.2410442121.. PMID: 38885391]
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Litwack,E.D., Babey,R., Buser,R., Gesemann,M. and O'Leary,D.D.
  TITLE     Identification and characterization of two novel brain-derived
            immunoglobulin superfamily members with a unique structural
            organization
  JOURNAL   Mol Cell Neurosci 25 (2), 263-274 (2004)
   PUBMED   15019943
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Boulter,C.A., Aguzzi,A., Evans,M.J. and Affara,N.
  TITLE     A chimaeric mouse model for autosomal-dominant polycystic kidney
            disease
  JOURNAL   Contrib Nephrol 97, 60-70 (1992)
   PUBMED   1633717
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY371924.1.
            
            On or before Jan 3, 2004 this sequence version replaced
            XM_234249.2, XM_234247.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY371924.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840130,
                                           SAMN14984033 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3355
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /note="MAM domain containing glycosylphosphatidylinositol
                     anchor 2"
                     /db_xref="GeneID:314180"
                     /db_xref="RGD:735131"
     exon            1..252
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3029
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /note="MAM domain-containing glycosylphosphatidylinositol
                     anchor protein 2; MAM domain-containing protein 1"
                     /codon_start=1
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 precursor"
                     /protein_id="NP_954890.1"
                     /db_xref="GeneID:314180"
                     /db_xref="RGD:735131"
                     /translation="MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEER
                     YSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITSIQR
                     HQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCV
                     ANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIA
                     SVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPMPSLT
                     WVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG
                     RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD
                     PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEK
                     SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSRE
                     MSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRA
                     YPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSF
                     LVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQR
                     WWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTGEFH
                     CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSR
                     PRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLRLKGQTTI
                     ENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAK
                     QDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR"
     exon            253..392
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..567
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..764
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..897
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1167
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1497
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1791
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2061
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2210
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2388
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2544
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2703
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2834
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2940
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3355
                     /gene="Mdga2"
                     /gene_synonym="Mamdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccgctca cggccgctga tagggaagga cagacagaca gcgcttcctc ccattgctag
       61 cagttcccgg gcacctcgac tcggcccggg cacaagtgga gcgcgccttg ctggccgctg
      121 ccctccagaa ggtcccactg cgtccctctt gggctggata tgttcatgtt cacgtgaaga
      181 tggatttagt gtacggtctc gtgtggctgc tgacagtcct cctggaggga atctctggcc
      241 aaggagtgta cgctcccccg acggttcgga ttgtgcactc aggattggcc tgtaatatag
      301 aggaggagcg ctactcggaa agggtctata ccatccggga aggagaaacg ctagagttga
      361 cctgtctggt tactggacat ccacgcccac agatcaggtg gaccaaaaca gcaggaagcg
      421 cctctgacag attccaagac tcaagtgtct tcaatgagac tttgaggatt acaagcattc
      481 agagacacca aggaggccga tattactgta aagcagagaa tggcttgggg tctccagcaa
      541 taaagtcgat ccgagtggat gtgtactact tggatgatcc tgtagtaact gttcatcaaa
      601 gtataggtga agctaaagaa caattttact atgagagaac agtgttcctc cgatgtgtgg
      661 ccaattccaa cccccctgtg cgctacagct ggagacgtgg ccaagaggtg ttgctacaag
      721 gatcagacaa aggagtggag atttacgagc ccttttttac ccagggggaa acaaagatct
      781 taaagctaaa gaatctccga cctcaggact atgctaacta cagctgcatt gcttcagtga
      841 ggaacgtgtg taatattcca gacaagatgg tgtcttttag actttccaat aaaaccgctt
      901 ctccgtcaat taagctcttg gtggatgacc ctatagttgt aaatcctgga gaggccataa
      961 cgttagtgtg tgttacaaca gggggagagc ctatgccctc tctcacctgg gtcaggtcct
     1021 tcgggactct gcctgaaaag attgttttga atggagggac attgaccata cctgccatca
     1081 cctctgatga tgctgggact tacagctgca ttgccaataa taatgtggga aaccctgcaa
     1141 aaaagtccac caacatcatt gtgagagcat taaaaaaagg acgattttgg atcactcctg
     1201 atccttatca caaagatgac aacatccaga ttgggcgtga ggtgaaaata tcttgccaag
     1261 tagaagccgt tccctctgaa gagttaacat tcagttggtt taaaaacggc cgtccattaa
     1321 gaagttctga gcggatggtt attacacaga ctgaccctga tgtgtccccc ggaacaacaa
     1381 atttggatat cattgattta aaattcacgg actttgggac ttacacatgc gtggcctctc
     1441 tgaagggagg aggaatatct gatatcagta ttgacgttaa catttccagc agcacagttc
     1501 cacccaatct gactgttcca caggaaaaat cacctttggt caccagagaa ggggacacaa
     1561 tagaacttca gtgtcaagta actgggaaac caaaaccaat catcctttgg tctagagcag
     1621 ataaagaagt tgcaatgcct gatgggacaa tgcaaatgga gagttatgat gggaccctca
     1681 ggattgtgaa cgtgtcaagg gaaatgtctg ggatgtacag atgccagacc agtcagtaca
     1741 atggattcaa cgtgaagccc agagaagcct tggtgcagct catcgtgcag tatcccccag
     1801 ctgtggaacc agcattcttg gaaatccgtc aaggacaaga cagaagtgtg accatgagct
     1861 gtagggttct aagagcctat ccgatacgtg tgctgactta cgaatggcgt ctgggcaata
     1921 aattattacg gaccggtcag tttgactctc aggagtatac tgagtaccca ctaaagagtc
     1981 tttccaatga aaactatgga gtttataact gcagcatcat taatgaagct ggagcaggga
     2041 gatgcagctt tcttgtgaca ggaaaagcct atgccccaga gttctactat gacacctaca
     2101 accctgtgtg gcagaaccga caccgagtgt attcttacag tctgcagtgg acacaaatga
     2161 atcccgatgc agtggatcgg attgtcgcat accgtttggg tattcggcag gctggacagc
     2221 aacgttggtg ggaacaggag attaaaataa atgggaatat tcaaaaggga gaactaatta
     2281 catataactt gactgaactt ataaaaccag aggcctatga agtccgactg actcctctca
     2341 ctaaatttgg tgaaggagat tcaacaattc gtgtaattaa atatacagga gaatttcact
     2401 gtggatttga agatggtaat atatgcttat tcacccaaga tgatacagat aactttgact
     2461 ggacaaagca aagtactgca acaagaaata caaaatacac ccctaacaca ggtcccaatg
     2521 cagatcggag tggttccaaa gaaggttttt atatgtacat cgagacatcg cgacccagac
     2581 tagaaggaga aaaggctcga cttctcagcc ctgtattcag catagctccc aaaaatccat
     2641 atggacctac caatagtgca tattgtttca gtttcttcta tcacatgtat gggcaacata
     2701 taggtgtttt aaatgtatat ctacgtttga aagggcagac gacaatagag aatcctctat
     2761 ggtcttcgag tgggaacaaa ggacaacgat ggaatgaagc tcatgttaat atatatccaa
     2821 ttacttcatt tcagttaatt tttgaaggca ttcggggtcc tgggatagaa ggtgacatcg
     2881 ccattgacga tgtgtcaatt gcagaaggag aatgtgcaaa acaagaccta ccaactaaga
     2941 attccgtgga tggtgctgtt gggatcttag ttcatatatg gctttttcca gttatcatcc
     3001 tcatctcgat cttaagccct cgaaggtgac cttatcctgg cagaggctat aaatgattca
     3061 ccaggcactg gcatgaagaa agagtctttg taaatggaca ctgaaaaaac aaactaccaa
     3121 agattcctcc actgactact gactcaaaaa ttaaataata agaacaacat tttttaagca
     3181 ctggggataa aaaaaagaca tcttggaaat ataacttatt ccaaactaca tatagaagat
     3241 attcttggcc tgggtacaaa agagcccttc aggtgctttt gtggctaaaa tgattacagc
     3301 ttcatctggt tgaactctgg aaaaagaaaa taaaagaaaa agaaagaaag aaaaa
//
