LOCUS       NM_001105668            3418 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus MyoD family inhibitor domain containing (Mdfic),
            mRNA.
ACCESSION   NM_001105668 XM_001058321 XM_342643
VERSION     NM_001105668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3418)
  AUTHORS   Martindill DM, Risebro CA, Smart N, Franco-Viseras Mdel M, Rosario
            CO, Swallow CJ, Dennis JW and Riley PR.
  TITLE     Nucleolar release of Hand1 acts as a molecular switch to determine
            cell fate
  JOURNAL   Nat Cell Biol 9 (10), 1131-1141 (2007)
   PUBMED   17891141
REFERENCE   2  (bases 1 to 3418)
  AUTHORS   Gautier VW, Sheehy N, Duffy M, Hashimoto K and Hall WW.
  TITLE     Direct interaction of the human I-mfa domain-containing protein,
            HIC, with HIV-1 Tat results in cytoplasmic sequestration and
            control of Tat activity
  JOURNAL   Proc Natl Acad Sci U S A 102 (45), 16362-16367 (2005)
   PUBMED   16260749
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):826]
REFERENCE   3  (bases 1 to 3418)
  AUTHORS   Ishiguro A, Inoue T, Mikoshiba K and Aruga J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
REFERENCE   4  (bases 1 to 3418)
  AUTHORS   Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K
            and Aruga J.
  TITLE     Myogenic repressor I-mfa interferes with the function of Zic family
            proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 233-240 (2004)
   PUBMED   15207726
REFERENCE   5  (bases 1 to 3418)
  AUTHORS   Young TM, Wang Q, Pe'ery T and Mathews MB.
  TITLE     The human I-mfa domain-containing protein, HIC, interacts with
            cyclin T1 and modulates P-TEFb-dependent transcription
  JOURNAL   Mol Cell Biol 23 (18), 6373-6384 (2003)
   PUBMED   12944466
REFERENCE   6  (bases 1 to 3418)
  AUTHORS   Kusano S and Raab-Traub N.
  TITLE     I-mfa domain proteins interact with Axin and affect its regulation
            of the Wnt and c-Jun N-terminal kinase signaling pathways
  JOURNAL   Mol Cell Biol 22 (18), 6393-6405 (2002)
   PUBMED   12192039
REFERENCE   7  (bases 1 to 3418)
  AUTHORS   Thebault S, Basbous J, Gay B, Devaux C and Mesnard JM.
  TITLE     Sequence requirement for the nucleolar localization of human I-mfa
            domain-containing protein (HIC p40)
  JOURNAL   Eur J Cell Biol 79 (11), 834-838 (2000)
   PUBMED   11139147
REFERENCE   8  (bases 1 to 3418)
  AUTHORS   Thebault S, Gachon F, Lemasson I, Devaux C and Mesnard JM.
  TITLE     Molecular cloning of a novel human I-mfa domain-containing protein
            that differently regulates human T-cell leukemia virus type I and
            HIV-1 expression
  JOURNAL   J Biol Chem 275 (7), 4848-4857 (2000)
   PUBMED   10671520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN932316.1, CV106654.1, CB785173.1, CB325630.1, AC097143.9,
            DV725464.1 and AI029676.1.
            
            On or before Oct 2, 2007 this sequence version replaced
            XM_342643.3, XM_001058321.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               DN932316.1         28-478
            452-814             CV106654.1         253-615
            815-1015            CB785173.1         105-305             c
            1016-1504           CB325630.1         16-504              c
            1505-2379           AC097143.9         45991-46865         c
            2380-3185           DV725464.1         48-853
            3186-3418           AI029676.1         1-233               c
FEATURES             Location/Qualifiers
     source          1..3418
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3418
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /note="MyoD family inhibitor domain containing"
                     /db_xref="GeneID:362325"
                     /db_xref="RGD:1309532"
     exon            1..273
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..451
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1101
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /note="kidney cell line derived transcript 1; MyoD family
                     inhibitor domain containing protein"
                     /codon_start=1
                     /product="myoD family inhibitor domain-containing protein"
                     /protein_id="NP_001099138.1"
                     /db_xref="GeneID:362325"
                     /db_xref="RGD:1309532"
                     /translation="MSGAGEALPPGPVGQQCPAEAGGGRLGSPAHEECNEDTTEKEKR
                     QTTSSHTRCGLIRDQSIWRNPSDGELVRTQPERLPQLQTSAQEPSKEETSKIQNGGHT
                     TMNNGNGIPHRAKHMSMDNHKMSSPVSQKMHRKIQSSLSVNNDVNKKSKVNAVFSQKS
                     ASSPEDCCVHCILACLFCEFLTLCNIVLGQASCGVCTSEACCCCCGDEMGDDCSCPCD
                     MDCSIMDACCESSDCLEICMECCGICFPS"
     exon            452..574
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..853
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..3402
                     /gene="Mdfic"
                     /gene_synonym="Kdt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagtgtt tgaagagtgt aggagtggca gcccgagggt gaaagagacg cacaagtgga
       61 tcctaaagtc cttcccggag agggactgcc cggagggaag ggacagagtg cacggagtca
      121 gagcgggcgg ctgccaccgt cgccgccact ctgggagacc gctggacctg gtcagactga
      181 ccggacgtga tgggcccgcg gcccgagcct cgctgacggc cggcggtggg aggaaggact
      241 cggagctgcc tgcagggttg gggtgatgca gagaggcagg cagtttcctg cacccagcac
      301 ctaagtagcc ggggtcggtg caccccgcgg ggacggcgcg ggctccgagc gtggcccatg
      361 tccggcgcgg gtgaagccct ccctccaggg cccgtggggc agcagtgccc agccgaggcg
      421 ggcggtggcc ggctgggctc cccagcccac gaagagtgta atgaagacac taccgagaaa
      481 gaaaaaagac aaactaccag tagccacact aggtgtgggc tgattcggga ccagtccatt
      541 tggagaaatc cttcagatgg cgaacttgtc agaacccaac ctgagcgtct gcctcaactg
      601 cagacatcag cacaggagcc cagcaaggag gaaaccagca agatacagaa tggtggccac
      661 acaactatga acaatgggaa tggaattcct cacagagcca aacatatgtc tatggataat
      721 cacaaaatgt catctcctgt ctctcagaaa atgcatagaa aaattcagtc cagcttgtct
      781 gtaaacaatg acgtcaataa gaagagtaaa gtaaatgctg tcttttccca aaaatcagct
      841 tcctcacctg aagactgttg tgtccactgt atcctggcat gcttgttctg tgaattcctg
      901 accctctgca acattgtcct gggacaagct tcgtgtggcg tctgcacctc cgaagcctgc
      961 tgctgctgct gtggagacga gatgggtgat gactgtagct gcccctgtga catggactgc
     1021 agcatcatgg atgcctgttg tgaatcctca gactgtttag agatctgcat ggaatgctgt
     1081 ggcatctgct ttccttcata aagatttatc tcttgtttgt actaaaactg gagacaactt
     1141 tacagtattt cttgtagggg aaaggaaagc acatggtgag atttccagga agcagctcag
     1201 tatttgcact gtttaactca ttcctcttag gtaatctctg aaattcttcc tctttcacca
     1261 gtcgtgtatg atttaatatg tgaagttcta accaactaac tggtttttga agcttcttcg
     1321 taggggaata ataatcggaa gacattttga cacacacagc ctgaaatgtt aaatgtcttc
     1381 tttttgttga catgtctgtt ttccctaacc gttctgagca gctctttgtt ctaaatacga
     1441 cattgctcaa tatgtattta aaccagatca ctttgttgtt tatctattaa aggttaaaag
     1501 caaacatttt ttttttattc taagtaagca tgaacatggg gcagaacctt aaacagatgt
     1561 gggactctcc gtgctggtct gctctgggct ttgcccctct cttgttctgc ccagagcaca
     1621 ctgaggaaga tggtgtagct cttgtccaga acagcaggaa gtataactga ggagggcagg
     1681 atgggagggg ttaaggttaa ccaggttgca aggcatgctg gtttcaggac tgtaaaggcc
     1741 ataggaacaa acagaagtga ataaagggtt actgaggaaa gcctggagga ggaggatgtg
     1801 gcattgtgga tgccctagga agagctactt aaatttagga aaaagttgaa ggtggagggc
     1861 ctgaactgtc tgcgctctgt acaagtgaaa agaatttgcc ttcattgcac attgaagcaa
     1921 cacagctttc ttagaactat aaaatctgaa ctaatgcaaa catgcacttt cctacacata
     1981 atttaagtgt tataaatttt aatgaaaaca taataccttg ttaacataac tatattttac
     2041 caaaaaatgt agaacacttt ttaacaacgt ttatttaaat gagctttttt tttttaagat
     2101 taaaaagtcc cagtattcat tggggttttt ccaaagctgg cttatatttg gaaagactca
     2161 gttctttatc ttgtagggtt ggtgtgtgtg tgtggggggg ggcctattta ttttcattgg
     2221 cttgtagttc tagccttgtt gtatttcata agtacgtaag ttttggatcc actacaggag
     2281 gacttcggat ggctatcacc attagcagat attaggattc caatggtgtg tgaaattatg
     2341 ccaacaggca ggttataaag atactaaagt atgaagaagt gaatctgcca tgagactaat
     2401 gctatagtga cggagtgagc tcatgtggaa gggagagttc ggtttctctc acatcctcac
     2461 atgtgtcttt tttttttctc tctagatttg aaatttggtt aaattgacta attcctcata
     2521 ggctcttggg agtatgtttt tgttagtggt cctttctagt tctggatgag tattagattg
     2581 ttagaaatag tgcgttttta ggaagccttt tgtcagccta gaactttagg agacctgaac
     2641 atattttttt tttaattcat gaagaatgtc aatatcacca gtgtctttcc tttgaaagtt
     2701 agcctagctc acaattaaat tactatttta aatattcttt gaaaaaggaa agcaagtgtg
     2761 tctccttttc tagtgcaatt tacacgtgca tatattttaa atacgatgct agtggacagc
     2821 tgccttcttc cttttctttg aaacagaagc tttgattcgc taagtcaagt ataacggcaa
     2881 ccttagtatt tccatatacc caatgttagc ttgtgcttat atcgtaggac gaagaagagc
     2941 catctgttta tggataagcc tcctaatggt tgttaaaata tttgcctcgt tatcctgtaa
     3001 aactgtttaa ccaagaggct tgtctgaagc ctgaatatat cttgccatga tttgcaatga
     3061 aaatgttagt gcattagaaa tgtttttctg taacagagag cattagtgaa taccagaatt
     3121 taatttccat acttgtacgt gtaggacttt tcttcagctc tctactccag gcaagccgtt
     3181 ccttaaggca tcttgtataa ttcaaaagaa aaataggcaa atgtgaaaac agttttagca
     3241 tatttcagaa ttttggtatg taaagtgttt tgttgaatct tatgggcgtc aagactaatt
     3301 gcgatagttt acacctagac attcagtctc attttaaatg tggcatattt tcaaactgga
     3361 tcctggctat tttaaaatta aaaatatata catgactact taaaaaaaaa aaaaaaaa
//
