LOCUS       NM_001166275            4072 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mediator of DNA damage checkpoint 1 (Mdc1), mRNA.
ACCESSION   NM_001166275 XM_001072849 XM_227971
VERSION     NM_001166275.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4072)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
REFERENCE   2  (bases 1 to 4072)
  AUTHORS   Khoury-Haddad,H., Guttmann-Raviv,N., Ipenberg,I., Huggins,D.,
            Jeyasekharan,A.D. and Ayoub,N.
  TITLE     PARP1-dependent recruitment of KDM4D histone demethylase to DNA
            damage sites promotes double-strand break repair
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), E728-E737 (2014)
   PUBMED   24550317
REFERENCE   3  (bases 1 to 4072)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   4  (bases 1 to 4072)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   5  (bases 1 to 4072)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   6  (bases 1 to 4072)
  AUTHORS   Becherel,O.J., Jakob,B., Cherry,A.L., Gueven,N., Fusser,M.,
            Kijas,A.W., Peng,C., Katyal,S., McKinnon,P.J., Chen,J., Epe,B.,
            Smerdon,S.J., Taucher-Scholz,G. and Lavin,M.F.
  TITLE     CK2 phosphorylation-dependent interaction between aprataxin and
            MDC1 in the DNA damage response
  JOURNAL   Nucleic Acids Res 38 (5), 1489-1503 (2010)
   PUBMED   20008512
REFERENCE   7  (bases 1 to 4072)
  AUTHORS   Bartkova,J., Horejsi,Z., Sehested,M., Nesland,J.M., Rajpert-De
            Meyts,E., Skakkebaek,N.E., Stucki,M., Jackson,S., Lukas,J. and
            Bartek,J.
  TITLE     DNA damage response mediators MDC1 and 53BP1: constitutive
            activation and aberrant loss in breast and lung cancer, but not in
            testicular germ cell tumours
  JOURNAL   Oncogene 26 (53), 7414-7422 (2007)
   PUBMED   17546051
REFERENCE   8  (bases 1 to 4072)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   9  (bases 1 to 4072)
  AUTHORS   Polci,R., Peng,A., Chen,P.L., Riley,D.J. and Chen,Y.
  TITLE     NIMA-related protein kinase 1 is involved early in the ionizing
            radiation-induced DNA damage response
  JOURNAL   Cancer Res 64 (24), 8800-8803 (2004)
   PUBMED   15604234
REFERENCE   10 (bases 1 to 4072)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085955.1.
            
            On or before Oct 17, 2009 this sequence version replaced
            XM_227971.4, XM_001072849.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4035              BC085955.1         1-4035
            4036-4072           BC085955.1         4037-4073
FEATURES             Location/Qualifiers
     source          1..4072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4072
                     /gene="Mdc1"
                     /note="mediator of DNA damage checkpoint 1"
                     /db_xref="GeneID:309595"
                     /db_xref="RGD:1559468"
     exon            1..171
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..309
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..4013
                     /gene="Mdc1"
                     /codon_start=1
                     /product="mediator of DNA damage checkpoint protein 1"
                     /protein_id="NP_001159747.1"
                     /db_xref="GeneID:309595"
                     /db_xref="RGD:1559468"
                     /translation="MENTQVIDWDAEEEEETEISSGSLGYSVEPIGRLRFFSGTHGPE
                     RDFPLYLGKNVVGRSPDCSVALPFPSISKQHAVIEISAWNKAPILQDCGSLNGTQIVK
                     PPRVLAPGVSHRLRDQELILFADFPCQYHRLNVPPPLVPRSLLTIEKTPRIRGRSQNS
                     RVLLAEDSEEEGDFPSGRSVANGSRNTASPSATVVPESDEEGSSPGPSVPGPSSPFGL
                     GSDTDESQGQQPGVEESSLADNSGAAGEPEQPEVNGVTTGTLAQPTKDKFKDTKMKEE
                     AGSAGVPVGSVVEGSPTLGEDSDTEADEERQPSGSGDSDTDVEEERVPVKKNQVLLGV
                     GIGGPGARGVAHLQDSPTGSDTDVEEDKTALAAPPERSHTAMVINSDTDEEERGEEEE
                     VSAALTLARLKERGIALWSGEPGTEEVKSQPQVLVERSQSASGRDSDTDVEEGSSGGK
                     REIVPDSPMDVDETLTVTQPESQPPCRPNDVDEDVDMSSPGSHLEGKKASSALVDKNR
                     AQVEEEVPGPSVTLGEKHQVPLEGAQPPEEARETAVQEGSSSPVADIRMSQQPVAEDA
                     GTECAAAVSEQKSALEVGAQSRSPAAPVEQVVVRTDTSGDPTLPQREGAQTPTGRERE
                     AHVGGTKHAKECCDEPEDLCLSATQCFVEGESQHPGAVQSLEDEPTQVFPCLPQEPGP
                     SHLSLPTPGADTLDVPWEVLATQPFCLREQTETSEPIDTHEAHGSQPSLPGEPPGHQH
                     PVPTSLDHTELLRIDDREMQTVEKAMGHLSCQMMPDGKASGDDPEPSDHRLFSPVPEA
                     SASPQSLLTSQSQKQSTPQPMFPTSSSELALPETLHTKPNVRPRRSSRMTPSPHSSAA
                     LKPYTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPTGPELQPSTSTEQPGIPNL
                     TSQVTEGRAHSTSVNMPEPVLTGPEAQPLTSAEQSVTSNLNPRAQPLTLEPVPQTSHQ
                     RRRRATGKQGSRTAPVGPKSYSTPAEPEPQSSASQSSGASEADSPHQKRPRRQVTQKT
                     VVVKEEDPGEIQVKEEPQETAIPTPGKRKRDPAEGETQGNPTRSRRTKPNQEAAAPKV
                     LFTGVVDSRGERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCAVGKGIPILSLNWL
                     YQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLSRARERRLLEDYEIHVTPGVQPPP
                     PQMGEIISCCGGTVLPSMPHSYKLHRVVITCTEDLPRCAIASRLGLPLLSPEFLLTGV
                     LKQEATPEAFVLSNLEM"
     exon            310..690
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..766
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..2088
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2154
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2244
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2472
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2516
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..3045
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3216
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3311
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3434
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3617
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3743
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3854
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..4045
                     /gene="Mdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggcgagg cgggggcggg gctttctact tgggctttga atcaatcggc gcgctttcag
       61 tagtaaaaga cagttccagg agccaatcag ccaacccact ctcttccggg attcgcactc
      121 ccgccactcg ggtagcggcc gttactggtg gcgcgcgcgc ggattcagtc gatatggaaa
      181 acactcaggt gattgactgg gatgctgaag aagaggaaga gacagaaata tccagtggat
      241 ccttggggta tagtgtggag cctatagggc ggctgcgatt cttcagtggt acccatggac
      301 cagaacgaga tttcccactc taccttggca agaatgtagt tggtcgaagc cctgactgct
      361 ctgtggccct gccttttcca tccatctcca aacagcacgc agtgattgaa atctcagctt
      421 ggaacaaagc ccctatcctt caggattgtg ggagcctcaa tggcactcaa atcgtaaagc
      481 ctcctagggt cctagctcct ggagtgagcc atcgtctgag ggaccaggaa ttaattctgt
      541 ttgcagactt tccctgccag taccatcgcc tgaatgtccc accacccttg gtccctcgga
      601 gtcttctaac tatagagaag acccccagaa tacggggaag atcccaaaat tccagagttt
      661 tgttggctga ggattcagag gaagaaggag attttccttc tggaaggtct gtggcaaatg
      721 gatcaaggaa tacagcatcc ccttcagcaa cagtagttcc agaaagtgat gaagagggct
      781 cttctccagg cccaagtgtc cctgggccat cttcaccctt tggtttggga agtgacacag
      841 atgaatcaca aggtcagcaa ccaggagtag aggaatcttc tttagctgac aacagtggtg
      901 ccgcagggga gcctgagcag cctgaagtga atggagtgac aactggcaca ctggctcagc
      961 ctaccaagga caagttcaag gacacaaaga tgaaggagga ggcaggcagt gcaggggttc
     1021 cagttgggtc agttgtggag gggagcccca ctcttgggga agacagtgac acagaagcgg
     1081 atgaagagcg tcagccttct ggttctgggg atagtgatac ggacgtagaa gaagagaggg
     1141 tccctgtgaa gaagaaccaa gtactgcttg gggttggtat agggggtcca ggagcacgtg
     1201 gtgtggcaca tctgcaggac agcccaactg gtagtgacac agatgtggag gaggacaaga
     1261 ctgcactggc tgcccctcca gagagaagcc acacagccat ggtgatcaac agtgatacag
     1321 acgaggagga gaggggtgag gaggaagagg tctcggcagc actcaccttg gcccgtctga
     1381 aggagagagg aattgctttg tggagtggag agccaggcac agaggaggtc aagtcccaac
     1441 cacaggtcct tgtagaacga agccagagtg cctctgggag agacagtgac actgacgtgg
     1501 aggagggatc ctcaggggga aagagagaga ttgtccctga cagccccatg gatgtagatg
     1561 agactcttac tgtcacacag ccagagagcc agcctccctg taggcccaat gatgtagacg
     1621 aggatgtgga tatgagctcc cctggcagcc atctagaggg aaagaaggcc tcctctgctc
     1681 tggtagacaa gaacagagca caagtggagg aggaagtccc agggccatct gttaccctgg
     1741 gggagaaaca ccaggtgcct ctagagggag cccagcctcc tgaggaagcc cgggaaacag
     1801 ctgtgcagga aggctcatcc tcaccagtgg cagacataag aatgagccag cagccagtag
     1861 cggaagatgc tgggacagag tgtgctgcag ctgtttctga acagaaaagt gctcttgagg
     1921 tcggggctca gagcaggtca cctgcagcac ccgtggagca ggtggtggta cgcacagata
     1981 cttcagggga tcctaccctg ccacagagag agggagccca gacccccaca ggaagggaaa
     2041 gagaagcaca tgtgggcggg accaagcatg ccaaagagtg ctgtgatgaa cctgaggatc
     2101 tgtgcctttc agccacccag tgctttgtgg aaggggagag ccagcaccca ggagctgtcc
     2161 agagtttgga agatgagcct acccaagtct tcccatgcct tccccaagag cctggacctt
     2221 cccatctcag cctcccgact ccaggtgcag ataccttgga tgtgccttgg gaagtcttgg
     2281 ctacacagcc gttctgtctg agagaacaga cagagacctc tgagcccatt gacacccatg
     2341 aagctcatgg atctcaacca tctctacctg gggaaccacc aggacaccaa catccggtcc
     2401 ctaccagcct agatcacaca gagctgttga gaattgatga cagagagatg cagactgtgg
     2461 agaaagccat gggccaccta agttgccaga tgatgccaga tggaaaggct tccggggatg
     2521 acccagagcc ctcagaccat cgcctgtttt ctccagtgcc tgaagcttca gcttcacctc
     2581 agagtctcct cacctctcag agccaaaagc aatctacacc tcagcctatg tttcccactt
     2641 cttcttctga gctagccctt cctgagactc ttcacacaaa gcctaatgtc aggccacggc
     2701 ggtcctccag gatgaccccc tccccacatt cctctgctgc ccttaagcct tatactacct
     2761 gccccacaaa ccagcctgct gcttctaggc caacatctcg ccccactcgg ggcagggcaa
     2821 ataggtcctc taccaggacc ccagaactga ttgtccctac aggccctgag ctccagcctt
     2881 ccacctccac agaacagcct ggcattccaa acctcacttc tcaggtcact gagggcaggg
     2941 cacatagtac ctctgttaat atgcctgaac cagttctcac aggtcccgaa gcccagcctc
     3001 tcacctccgc agaacaatct gtcacctcaa acctcaatcc tcgggcccag cctcttaccc
     3061 tggagccagt tccacaaacc agtcaccaaa ggaggcgaag ggctactggg aagcagggct
     3121 cccgcacagc tcctgttggt cctaagtctt actctacccc cgctgaacct gaaccccagt
     3181 cttcagccag ccaaagctca ggagcatcag aagcagattc accccatcaa aaacgtcccc
     3241 gaagacaagt cacccagaaa actgtagtcg tcaaggaaga agatcctgga gaaatacaag
     3301 tgaaggaaga gcctcaggag acagcaattc caacaccagg caagagaaag agggaccctg
     3361 cagaggggga aacccaggga aacccaactc gaagccggcg aactaagcct aaccaggaag
     3421 cagcagcccc caaggtactg ttcacaggag tggtggattc tcgtggagag cgtgcagtgc
     3481 tggctctagg aggcagtctg gccagctcag taaatgaggc ctcccacttg gttactgatc
     3541 gcatccgcag gacagtcaag ttcttgtgtg ccgtggggaa gggaattccc atcctgtccc
     3601 tgaactggct ctatcagtcc cgaaaggctg gttgcttctt gccgcctgat gactacttgg
     3661 tgactgatcc tgaacaagag aagaatttta gcttcagcct tcgggattcc ctgagccggg
     3721 ctcgggaacg aagactactg gaggactatg agattcatgt gacccctgga gtgcagccac
     3781 ctccacctca gatgggagag atcatcagct gctgtggagg cactgtcctg cccagcatgc
     3841 cccattccta caagcttcac agagttgtca taacgtgcac tgaagaccta cctcgatgtg
     3901 ctattgcatc tcgcctgggg ctacccctcc tctctcctga gttcctcctg actggagtgc
     3961 tgaagcagga agccacacca gaggcctttg tcctctccaa tttggaaatg tagtctacct
     4021 aaaaaaaaaa aaaaatgtac ctctaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
