LOCUS       NM_001305178            1032 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus mitochondrial calcium uniporter regulator 1
            (Mcur1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001305178
VERSION     NM_001305178.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1032)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1032)
  AUTHORS   Tomar,D., Dong,Z., Shanmughapriya,S., Koch,D.A., Thomas,T.,
            Hoffman,N.E., Timbalia,S.A., Goldman,S.J., Breves,S.L.,
            Corbally,D.P., Nemani,N., Fairweather,J.P., Cutri,A.R., Zhang,X.,
            Song,J., Jana,F., Huang,J., Barrero,C., Rabinowitz,J.E.,
            Luongo,T.S., Schumacher,S.M., Rockman,M.E., Dietrich,A., Merali,S.,
            Caplan,J., Stathopulos,P., Ahima,R.S., Cheung,J.Y., Houser,S.R.,
            Koch,W.J., Patel,V., Gohil,V.M., Elrod,J.W., Rajan,S. and Madesh,M.
  TITLE     MCUR1 Is a Scaffold Factor for the MCU Complex Function and
            Promotes Mitochondrial Bioenergetics
  JOURNAL   Cell Rep 15 (8), 1673-1685 (2016)
   PUBMED   27184846
REFERENCE   3  (bases 1 to 1032)
  AUTHORS   Vais,H., Tanis,J.E., Muller,M., Payne,R., Mallilankaraman,K. and
            Foskett,J.K.
  TITLE     MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium
            Uniporter
  JOURNAL   Cell Metab 22 (4), 533-535 (2015)
   PUBMED   26445506
REFERENCE   4  (bases 1 to 1032)
  AUTHORS   Mallilankaraman,K., Cardenas,C., Doonan,P.J., Chandramoorthy,H.C.,
            Irrinki,K.M., Golenar,T., Csordas,G., Madireddi,P., Yang,J.,
            Muller,M., Miller,R., Kolesar,J.E., Molgo,J., Kaufman,B.,
            Hajnoczky,G., Foskett,J.K. and Madesh,M.
  TITLE     MCUR1 is an essential component of mitochondrial Ca2+ uptake that
            regulates cellular metabolism
  JOURNAL   Nat Cell Biol 14 (12), 1336-1343 (2012)
   PUBMED   23178883
  REMARK    Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.57454.1,
                                           SRR26643289.39638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               JAXUCZ010000017.1  21348490-21348835
            347-466             JAXUCZ010000017.1  21353627-21353746
            467-570             JAXUCZ010000017.1  21357080-21357183
            571-672             JAXUCZ010000017.1  21357712-21357813
            673-714             JAXUCZ010000017.1  21359240-21359281
            715-786             JAXUCZ010000017.1  21360199-21360270
            787-840             JAXUCZ010000017.1  21363152-21363205
            841-955             JAXUCZ010000017.1  21364296-21364410
            956-1032            JAXUCZ010000017.1  21365538-21365614
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1032
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /note="mitochondrial calcium uniporter regulator 1"
                     /db_xref="GeneID:291034"
                     /db_xref="RGD:1307673"
     CDS             1..1011
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /EC_number="1.1.1.41"
                     /note="coiled-coil domain-containing protein 90A,
                     mitochondrial; coiled-coil domain containing 90A"
                     /codon_start=1
                     /product="mitochondrial calcium uniporter regulator 1"
                     /protein_id="NP_001292107.1"
                     /db_xref="GeneID:291034"
                     /db_xref="RGD:1307673"
                     /translation="MDSGSLAAERPKRTPGRQRLLSSGCGVPVRPGVSTLPGGRSWLR
                     PRGRTARASRLLLLLLVPSPRLAATAPRRTLAERSRPGLVIPAAALGAGRNALGRLRL
                     GARRVAALVSSRRELSLSARCHQLEPRKGNLPTSVSRQLYFDTHALVCLLEANGFTIQ
                     QAEIIVSALVKITETNMDIIYKDMVSKMQQEITLQQIISKIANVKKDMIILEKSEFSA
                     LRAENEKIKLELHQLKQQVMDEVTKVRTDTKLNFNLEKSRVKELYSLNEKKMLELRTE
                     IVSLHAQQDRALTQTDRKIETEVAGLKTMLEAHKLDTIKYLAGSVFTCLTVALGFYRL
                     WI"
     exon            1..346
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            347..466
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            467..570
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            571..672
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            673..714
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            715..786
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            787..840
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            841..955
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1032
                     /gene="Mcur1"
                     /gene_synonym="Ccdc90a; RGD1307673"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggacagcg gctccttggc ggccgagcgg ccgaagcgca caccgggtcg ccagcggctc
       61 ctgtcctccg gctgcggagt tccggtgcgc cccggcgtct ccacgctgcc cggcggacga
      121 agctggctaa ggcctcgagg acggaccgcc cgcgcgtccc ggctgctgct cctcttgctc
      181 gtgccctccc cgcgcctggc cgccaccgcc ccgcgtagga cgctggctga gcgctcgcgc
      241 ccggggctcg tcatccccgc ggccgcgctc ggcgctggca ggaacgcgct gggccgtctg
      301 cggctgggtg cccggcgcgt ggccgcgctc gtgagcagcc ggagagagct aagcctgtct
      361 gctaggtgcc atcagctgga gcccagaaag gggaacttgc ccacctctgt gagtcggcag
      421 ctctactttg acacccacgc tctggtgtgc ttacttgaag caaatgggtt taccattcaa
      481 caagcagaaa tcattgtgtc ggcattggtc aagattacgg agaccaacat ggacatcatc
      541 tacaaagaca tggtcagcaa gatgcaacag gaaatcactc ttcagcaaat tatatctaag
      601 attgctaacg tgaagaaaga tatgatcatc ttggagaaga gtgagttttc tgccctcaga
      661 gcagaaaatg agaaaataaa acttgaacta caccagttaa agcagcaagt aatggatgaa
      721 gtgaccaaag tccggacaga taccaaatta aacttcaatc tagaaaagag cagagtaaaa
      781 gaattgtact cattgaatga gaagaagatg ctggaactga ggacagaaat agtgtccctg
      841 catgcccagc aggatagagc cctgacgcag accgacagga agatagagac cgaggtggct
      901 ggcctcaaga caatgctgga agcccacaag cttgacacaa tcaaatactt agcagggtct
      961 gtgtttacgt gcctaacagt agctctggga ttttaccgcc tgtggatata ataaagtgtc
     1021 tatttaaaga aa
//
