LOCUS       NM_001277668            1049 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus mast cell protease 1-like 1 (Mcpt1l1), mRNA.
ACCESSION   NM_001277668 XM_002728284 XM_003752803
VERSION     NM_001277668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1049)
  AUTHORS   Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
  TITLE     Secretory granule proteases in rat mast cells. Cloning of 10
            different serine proteases and a carboxypeptidase A from various
            rat mast cell populations
  JOURNAL   J Exp Med 185 (1), 13-29 (1997)
   PUBMED   8996238
REFERENCE   2  (bases 1 to 1049)
  AUTHORS   Rouleau,A., Garbarg,M., Schwartz,J.C. and Ruat,M.
  TITLE     Molecular cloning of rat mast cell protease 1 and development of
            specific probes for its gene transcript
  JOURNAL   Biochem Biophys Res Commun 199 (2), 593-602 (1994)
   PUBMED   8135800
REFERENCE   3  (bases 1 to 1049)
  AUTHORS   Nelson,R.B., Siman,R., Iqbal,M.A. and Potter,H.
  TITLE     Identification of a chymotrypsin-like mast cell protease in rat
            brain capable of generating the N-terminus of the Alzheimer amyloid
            beta-protein
  JOURNAL   J Neurochem 61 (2), 567-577 (1993)
   PUBMED   8336143
REFERENCE   4  (bases 1 to 1049)
  AUTHORS   Le Trong,H., Parmelee,D.C., Walsh,K.A., Neurath,H. and
            Woodbury,R.G.
  TITLE     Amino acid sequence of rat mast cell protease I (chymase)
  JOURNAL   Biochemistry 26 (22), 6988-6994 (1987)
   PUBMED   3122823
REFERENCE   5  (bases 1 to 1049)
  AUTHORS   Woodbury,R.G., Everitt,M., Sanada,Y., Katunuma,N., Lagunoff,D. and
            Neurath,H.
  TITLE     A major serine protease in rat skeletal muscle: evidence for its
            mast cell origin
  JOURNAL   Proc Natl Acad Sci U S A 75 (11), 5311-5313 (1978)
   PUBMED   103093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ229802.1, U67915.1 and BM383497.1.
            
            On or before Apr 18, 2013 this sequence version replaced
            XM_002728284.2, XM_003752803.1.
            
            Sequence Note: This RefSeq record was created from Sprague-Dawley
            transcripts because BN/SsNHsdMCW transcripts covering the full
            length of the gene were not available. The extent of the transcript
            is supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229802.1, FQ219938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                FQ229802.1         1-11
            12-1027             U67915.1           2-1017
            1028-1049           BM383497.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..1049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1049
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /note="mast cell protease 1-like 1"
                     /db_xref="GeneID:100360872"
                     /db_xref="RGD:2321286"
     exon            1..92
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..820
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /EC_number="3.4.21.39"
                     /note="chymotrypsin-like protease; CLIP protein; mast cell
                     protease I; chymase; mast cell protease 1; protease
                     1-like"
                     /codon_start=1
                     /product="mast cell protease 1 preproprotein"
                     /protein_id="NP_001264597.1"
                     /db_xref="GeneID:100360872"
                     /db_xref="RGD:2321286"
                     /translation="MQALLFLMALLLPSGAGAEEIIGGVESRPHSRPYMAHLEITTER
                     GYKATCGGFLVTRQFVMTAAHCKGRETTVTLGVHDVSKTESTQQKIKVEKQIVHPNYN
                     FYSNLHDIMLLKLQKKAKVTPAVDVIPLPQPSDFLKPGKMCRAAGWGQTGVTKPTSNT
                     LREVKQRIMDKEACKNYFHYNYNFQVCVGSPRKIRSAYKGDSGGPLVCAGVAHGIVSY
                     GRGDAKPPAVFTRISPYVPWINKVIKGKDLTSLSLHESESPS"
     exon            93..243
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /inference="alignment:Splign:2.1.0"
     exon            244..379
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /inference="alignment:Splign:2.1.0"
     exon            380..634
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /inference="alignment:Splign:2.1.0"
     exon            635..1032
                     /gene="Mcpt1l1"
                     /gene_synonym="Mcpt1; rMCP-1; rMCP-I"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctcac cccaggctgc accactggca acaaaaaatg caggccctac tattcctgat
       61 ggctcttctc ttgccttctg gagctggagc tgaggagatt atcggtggtg tggagtctag
      121 accacactcc cgtccttaca tggcccatct ggagatcacc actgagagag gttacaaggc
      181 cacctgtggt gggtttcttg tgacccgcca atttgtgatg actgccgcac actgtaaggg
      241 aagagaaacc actgttaccc ttggagttca tgatgtgagc aagacagaat ccacacagca
      301 gaagataaaa gtcgaaaaac aaattgttca cccaaattat aacttctatt ccaatctcca
      361 tgatatcatg ttactgaagc ttcaaaagaa agccaaggtg actcctgctg tggatgtaat
      421 tcccctgcct cagccctctg actttctcaa gcctgggaag atgtgccggg cagctggctg
      481 ggggcaaact ggagtgacaa aaccaacctc aaatacactg agggaggtga aacagagaat
      541 catggataaa gaggcctgta aaaactattt tcattataac tataacttcc aggtctgcgt
      601 gggcagtcca agaaagataa gatcagcata taagggagac tccggaggac cactagtgtg
      661 tgctggggtg gcccatggta ttgtatctta tggacgtgga gatgcaaagc cccctgcagt
      721 cttcacccga atctccccat atgtgccctg gattaataaa gtcataaagg gcaaggatct
      781 gaccagcctg agtctgcacg agtcagagtc tccaagctag agaactcttt tgatatccct
      841 tgggatcaac aaagcctgtc cccagcctgt cacctgcttg tcccatacct gttcccagcc
      901 tgcccccaac ttgcccccag cccatcccca gcctgtccca agcctgtccc taggatgatc
      961 tcaacaatac acaagtctgt ggtgatggat tgttccctgt aaagcacctc aataaagaca
     1021 taacctccag caaaaaaaaa aaaaaaaaa
//
