LOCUS       NM_001012059            1934 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus mucolipin TRP cation channel 3 (Mcoln3), mRNA.
ACCESSION   NM_001012059 XM_039102138 XM_217683
VERSION     NM_001012059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1934)
  AUTHORS   Calderon,A., Derr,A., Stagner,B.B., Johnson,K.R., Martin,G. and
            Noben-Trauth,K.
  TITLE     Cochlear developmental defect and background-dependent hearing
            thresholds in the Jackson circler (jc) mutant mouse
  JOURNAL   Hear Res 221 (1-2), 44-58 (2006)
   PUBMED   16962269
REFERENCE   2  (bases 1 to 1934)
  AUTHORS   Di Palma,F., Belyantseva,I.A., Kim,H.J., Vogt,T.F., Kachar,B. and
            Noben-Trauth,K.
  TITLE     Mutations in Mcoln3 associated with deafness and pigmentation
            defects in varitint-waddler (Va) mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14994-14999 (2002)
   PUBMED   12403827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Mar 10, 2021 this sequence version replaced
            XM_039102138.1, NM_001012059.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.12443.1,
                                           SRR26643292.11117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000002.1  237669006-237669275
            271-500             JAXUCZ010000002.1  237679292-237679521
            501-668             JAXUCZ010000002.1  237681963-237682130
            669-822             JAXUCZ010000002.1  237686126-237686279
            823-907             JAXUCZ010000002.1  237686713-237686797
            908-1004            JAXUCZ010000002.1  237686920-237687016
            1005-1104           JAXUCZ010000002.1  237690591-237690690
            1105-1217           JAXUCZ010000002.1  237693004-237693116
            1218-1367           JAXUCZ010000002.1  237693194-237693343
            1368-1469           JAXUCZ010000002.1  237698366-237698467
            1470-1592           JAXUCZ010000002.1  237698555-237698677
            1593-1799           JAXUCZ010000002.1  237700556-237700762
            1800-1934           JAXUCZ010000002.1  237703041-237703175
FEATURES             Location/Qualifiers
     source          1..1934
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1934
                     /gene="Mcoln3"
                     /note="mucolipin TRP cation channel 3"
                     /db_xref="GeneID:308022"
                     /db_xref="RGD:1308420"
     exon            1..270
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            271..500
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1934
                     /gene="Mcoln3"
                     /note="mucolipin 3"
                     /codon_start=1
                     /product="mucolipin-3"
                     /protein_id="NP_001012059.1"
                     /db_xref="GeneID:308022"
                     /db_xref="RGD:1308420"
                     /translation="MANPEVVVSSCSSHQDESPCTFYPSSSQSEQLLLEDQMRRKLKF
                     FFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLF
                     LKGYMDRMDDTYAVYTQNDVYDQIIFAVTRYLQLRNISVGNHAYENKGTKQSAMAVCQ
                     HFYRQGTICPGNDTFDIDPEVETDCFLIEPEEAFHMGTPGENKLNLTLDFHRLLTVEL
                     QFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSG
                     SIQKNTHYMMIFDAFVILTCLSSLVLCARSVIRGLQLQQEFVNFFLLHYKKEVSASDQ
                     MEFINGWYIMIIVSDILTIVGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYL
                     GFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNKVSEC
                     LFSLINGDDMFSTFAKMQQKSYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETI
                     KHYQQDGFPETELRKFIAECKDLPNSGKYRLEDDPPGSLFCCCKK"
     exon            501..668
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..822
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            823..907
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1004
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1104
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1217
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1367
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1469
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1592
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1799
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1934
                     /gene="Mcoln3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaggaaca ggaaatgttg agtgatttct tcacgttgca gattcatgat tgacatcttc
       61 tttggtgggt gtgtccagca gaccgggtga aggcgactag tgaacaccta tgcactctca
      121 gaggacatgg attaactttg cctcaaactt gaatatattc aaaaagtagt tttagttttg
      181 ttagttaagg gaagaggcag cgagtcacag aatgacagtg ggaaataacg gctagagaaa
      241 tttcaaatcg agtttactgc agaaaatctg agatggcaaa tcctgaggtg gtggtaagca
      301 gctgcagttc tcaccaggat gaaagtccct gcactttcta cccgagctca tcccagtccg
      361 agcagcttct cttagaagat cagatgaggc ggaaactcaa attctttttt atgaatcctt
      421 gcgagaagtt ctgggctcgg ggtaggaagc catggaaact tgccatacag attctgaaaa
      481 tcgctatggt gactatccag ctggttctgt ttggactaag taaccagatg gtagtagctt
      541 tcaaggaaga gaacacgata gccttcaaac acctcttcct gaaaggctac atggaccgaa
      601 tggacgacac ctacgcggtg tacactcaga atgatgtgta cgaccagatc atctttgcag
      661 tgacccggta cttgcaactt cgaaacatct ccgtcggcaa ccatgcttat gagaacaagg
      721 ggactaagca gtcagcaatg gcagtctgtc agcacttcta caggcaaggc accatctgcc
      781 ccgggaacga taccttcgac atcgatccag aagtcgaaac agactgtttc cttatagagc
      841 cagaggaagc tttccacatg ggaacacctg gagaaaacaa actcaacctg accctggact
      901 tccacagact tctgacagtg gagctccaat ttaagctcaa agccatcaac ctgcagacag
      961 ttcgccacca ggagcttcct gactgttacg actttaccct gactataaca ttcgacaaca
     1021 aggcacacag tggaagaatc aaaataagtt tagacaacga catttctatc agagaatgca
     1081 aagattggca cgtgtctgga tcaattcaga agaacaccca ctacatgatg atcttcgatg
     1141 cctttgttat cctgacctgc ttgtcctcgc tggtgctctg cgccaggtct gtgattcggg
     1201 gtcttcagct tcagcaggag tttgtcaact ttttccttct tcactacaag aaggaagttt
     1261 cggcctctga tcagatggag ttcatcaacg ggtggtacat tatgatcatc gttagtgaca
     1321 tactgacgat cgttggatcg attctgaaaa tggaaatcca agccaagagt cttacaagct
     1381 acgatgtctg tagcatactt cttgggactt ccaccatgct cgtgtggctt ggcgttatcc
     1441 gatacctggg tttctttgcg aagtacaatc tccttatcct gaccctccag gcagcgctgc
     1501 ccaatgtcat caggttctgt tgctgtgcgg ctatgatcta tcttgggtat tgcttttgcg
     1561 gatggattgt gctgggccct taccatgaga agttccgctc tctgaacaag gtctctgagt
     1621 gcctattctc actgataaat ggagacgaca tgttttccac gttcgcgaaa atgcagcaga
     1681 aaagttacct ggtgtggctg ttcagccgcg tctacctgta ctcgttcatc agcctcttca
     1741 tctacatgat cttgagcctt ttcatcgcgc tcatcacaga cacgtacgaa accattaagc
     1801 actaccagca agatggcttc ccagagacgg aacttcgaaa gtttatcgct gaatgcaaag
     1861 acctccccaa ctctggaaaa tacagattgg aagatgaccc tccaggttct ttattctgct
     1921 gctgcaaaaa gtaa
//
