LOCUS       NM_001105903            2070 bp    mRNA    linear   ROD 19-JUN-2023
DEFINITION  Rattus norvegicus mucolipin TRP cation channel 1 (Mcoln1), mRNA.
ACCESSION   NM_001105903 XM_001057747 XM_213684
VERSION     NM_001105903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2070)
  AUTHORS   Shi J, Li X, Ding J, Lian J, Zhong Y, Li H, Shen H, You W, Fu X and
            Chen G.
  TITLE     Transient Receptor Potential Mucolipin-1 Participates in
            Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing
            Neuroinflammation and Neuronal Cell Death
  JOURNAL   Neuromolecular Med 25 (2), 272-285 (2023)
   PUBMED   36737508
  REMARK    GeneRIF: Transient Receptor Potential Mucolipin-1 Participates in
            Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing
            Neuroinflammation and Neuronal Cell Death.
REFERENCE   2  (bases 1 to 2070)
  AUTHORS   Zhang J, Tang Y, Hu Z, Xu W, Ma Y, Xu P, Xing H and Niu Q.
  TITLE     The inhibition of TRPML1/TFEB leads to lysosomal biogenesis
            disorder, contributes to developmental fluoride neurotoxicity
  JOURNAL   Ecotoxicol Environ Saf 250, 114511 (2023)
   PUBMED   36608573
  REMARK    GeneRIF: The inhibition of TRPML1/TFEB leads to lysosomal
            biogenesis disorder, contributes to developmental fluoride
            neurotoxicity.
REFERENCE   3  (bases 1 to 2070)
  AUTHORS   Tedeschi V, Sisalli MJ, Petrozziello T, Canzoniero LMT and Secondo
            A.
  TITLE     Lysosomal calcium is modulated by STIM1/TRPML1 interaction which
            participates to neuronal survival during ischemic preconditioning
  JOURNAL   FASEB J 35 (2), e21277 (2021)
   PUBMED   33484198
  REMARK    GeneRIF: Lysosomal calcium is modulated by STIM1/TRPML1 interaction
            which participates to neuronal survival during ischemic
            preconditioning.
REFERENCE   4  (bases 1 to 2070)
  AUTHORS   Schmiege P, Fine M, Blobel G and Li X.
  TITLE     Human TRPML1 channel structures in open and closed conformations
  JOURNAL   Nature 550 (7676), 366-370 (2017)
   PUBMED   29019983
REFERENCE   5  (bases 1 to 2070)
  AUTHORS   Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC and Jiang Y.
  TITLE     Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
  JOURNAL   Nature 550 (7676), 415-418 (2017)
   PUBMED   29019981
REFERENCE   6  (bases 1 to 2070)
  AUTHORS   Curcio-Morelli C, Charles FA, Micsenyi MC, Cao Y, Venugopal B,
            Browning MF, Dobrenis K, Cotman SL, Walkley SU and Slaugenhaupt SA.
  TITLE     Macroautophagy is defective in mucolipin-1-deficient mouse neurons
  JOURNAL   Neurobiol Dis 40 (2), 370-377 (2010)
   PUBMED   20600908
REFERENCE   7  (bases 1 to 2070)
  AUTHORS   Wu LJ, Sweet TB and Clapham DE.
  TITLE     International Union of Basic and Clinical Pharmacology. LXXVI.
            Current progress in the mammalian TRP ion channel family
  JOURNAL   Pharmacol Rev 62 (3), 381-404 (2010)
   PUBMED   20716668
  REMARK    Review article
REFERENCE   8  (bases 1 to 2070)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   9  (bases 1 to 2070)
  AUTHORS   Zhang F and Li PL.
  TITLE     Reconstitution and characterization of a nicotinic acid adenine
            dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from
            liver lysosomes of rats
  JOURNAL   J Biol Chem 282 (35), 25259-25269 (2007)
   PUBMED   17613490
REFERENCE   10 (bases 1 to 2070)
  AUTHORS   Bargal R, Avidan N, Ben-Asher E, Olender Z, Zeigler M, Frumkin A,
            Raas-Rothschild A, Glusman G, Lancet D and Bach G.
  TITLE     Identification of the gene causing mucolipidosis type IV
  JOURNAL   Nat Genet 26 (1), 118-123 (2000)
   PUBMED   10973263
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474084.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213684.4, XM_001057747.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2070
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..2070
                     /gene="Mcoln1"
                     /note="mucolipin TRP cation channel 1"
                     /db_xref="GeneID:288371"
                     /db_xref="RGD:1308953"
     exon            1..158
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1870
                     /gene="Mcoln1"
                     /note="mucolipin 1"
                     /codon_start=1
                     /product="mucolipin-1"
                     /protein_id="NP_001099373.1"
                     /db_xref="GeneID:288371"
                     /db_xref="RGD:1308953"
                     /translation="MATAAGRRGSETEQLLTPNPGYGTQAGTSPAPTTPPEEEDLRRR
                     LKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLVVTFREENTIAFR
                     HLFLLGYSDGSDDTFAAYTREQLYQAIFYAVDQYLTLPEISLGRYAYVRGGGGPWANG
                     SALALCQRYYHRGHVDPANDTFDIDPRVVTDCIQVDPPDRPPDIPSEDLDFLDGSTSY
                     KNITLKFHKLINVTIHFQLKTINLQSLINNEIPDCYTFSILITFDNKAHSGRIPIRLE
                     TQTHIQECKHPSVSRHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFM
                     WRRRGREISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGT
                     STLLVWVGVIRYLTFFHKYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPY
                     HVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYM
                     VLSLFIALITGAYDTIKHPGGTGTEKSELQAYIEQCQDSPTSGKFRRGSGSTCSLLCC
                     CGRNSPEDHSLLVN"
     exon            159..364
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..532
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..698
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..807
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..904
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1004
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1111
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1261
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1363
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1486
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1702
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1833
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2070
                     /gene="Mcoln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcacgtg accgcggcgc atgtcagctg atgccggagg gtttgaagcg gcgccgggag
       61 ggagcgaggc cgcagtgacc gcggtgcgcg cacggacccg cccgcatccc gcgctcaccg
      121 tgcggccatg gccaccgcgg cgggccggcg cggctcagag accgagcaat tgctgacccc
      181 caatcctggg tatgggaccc aggcggggac ctcaccagcc cccacaaccc ccccagaaga
      241 ggaagacctc cgccgccgcc tcaagtactt ttttatgagt ccatgtgaca agttccgggc
      301 caaaggtcgc aagccctgca agttgatgct gcaggtggtc aagatcttgg tggtcactgt
      361 gcagctcatt ctctttggac tcagcaacca gctggtggtg acattccggg aagagaacac
      421 cattgccttc cgacacctct tcctgctggg ttactctgat gggtctgatg acacctttgc
      481 ggcctacaca cgggagcagc tctaccaagc catcttctat gctgtggacc agtacctgac
      541 actacccgag atatccctgg gccggtatgc ctatgtccgt ggtgggggcg ggccttgggc
      601 caatggctca gctctggctc tctgccagcg atattaccac cgtggccatg tggacccagc
      661 caacgatacc tttgacattg atccaagggt agtcactgac tgtatccagg tggatcctcc
      721 tgacagacct cctgacatcc ccagtgagga cttggacttc ttggatggca gcaccagtta
      781 caagaacatc acattgaaat tccacaagct gatcaacgtc accatccact tccaactgaa
      841 gacaattaac ctgcagagcc tcatcaacaa cgagatccct gactgttaca ccttcagtat
      901 cctgatcaca tttgacaata aagcacacag tgggcgaatc cccatccgcc tggagaccca
      961 gacccacatc caggagtgta aacaccccag tgtctccaga cacggagaca acagcttccg
     1021 gcttctgttt gatgtggtgg tcatcctcac ctgctccctg tccttcctgc tgtgtgcccg
     1081 ctcactgctc cgtggcttcc tgctgcagaa cgagtttgtt gtattcatgt ggcggcggcg
     1141 gggccgggaa atcagcctct gggaacggct ggagtttgtc aatggctggt acatcctgct
     1201 ggtcaccagt gacgtgctta ccatctcggg gactatcatg aagattggca ttgaggcaaa
     1261 gaacctagcc agctatgatg tctgcagcat cctcctgggt acctccactc tgctggtctg
     1321 ggttggtgtc attcgctacc tgacattttt ccacaagtac aatatcctga ttgccacgtt
     1381 gcgagtggca ctgcccagtg tcatgcgttt ctgctgctgt gtggctgtca tctacctggg
     1441 ctattgcttc tgcggctgga ttgtcctggg accctaccat gtgaagttcc gctcgctgtc
     1501 catggtttcc gagtgcctgt tctccctcat caacggggac gacatgttcg tgacgtttgc
     1561 agccatgcag gcccagcagg gtcgcagtag cctggtgtgg ctcttctcgc agctctacct
     1621 ctactccttc atcagcctct tcatctacat ggtgctgagt ctcttcatcg cactcatcac
     1681 cggcgcctac gacactatca agcacccagg aggcactggc acagagaaga gtgagctcca
     1741 ggcctacatt gagcagtgcc aggatagccc cacgtctggc aagttccgtc gtggaagtgg
     1801 ctccacttgt agccttctgt gctgctgtgg aaggaactct ccggaggacc attcactgct
     1861 ggtgaactga tccaagatga ttgccactag actttatccc catgtactgc tgggacccca
     1921 gcttatttat ttttagaatt cgctttaaaa gatctgcttc tgacaggcct tgtgagggct
     1981 tgggcagatc gaatcggaca ctggggaagg gagggcatgg agggtggctg ttaaataaaa
     2041 gggaacataa atgcggtggt ctaatttgta
//
