LOCUS       NM_001004203            2357 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus minichromosome maintenance complex component 7
            (Mcm7), mRNA.
ACCESSION   NM_001004203 XM_213728
VERSION     NM_001004203.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Yen CS, Su ZR, Lee YP, Liu IT and Yen CJ.
  TITLE     miR-106b promotes cancer progression in hepatitis B
            virus-associated hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 22 (22), 5183-5192 (2016)
   PUBMED   27298561
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Reed C, Hutcheson J, Mayhew CN, Witkiewicz AK and Knudsen ES.
  TITLE     RB tumor suppressive function in response to xenobiotic
            hepatocarcinogens
  JOURNAL   Am J Pathol 184 (6), 1853-1859 (2014)
   PUBMED   24726645
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Qi F, Huang M, Pan Y, Liu Y, Liu J, Wen J, Xie K, Shen H, Ma H,
            Miao Y and Hu Z.
  TITLE     A genetic variant in the promoter region of miR-106b-25 cluster
            predict clinical outcome of HBV-related hepatocellular carcinoma in
            Chinese
  JOURNAL   PLoS One 9 (1), e85394 (2014)
   PUBMED   24416400
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Chen J, Cui Z, Li W, Shen A, Xu G, Bao G, Sun Y, Wang L, Fan J,
            Zhang J, Yang L and Cui Z.
  TITLE     MCM7 expression is altered in rat after spinal cord injury
  JOURNAL   J Mol Neurosci 51 (1), 82-91 (2013)
   PUBMED   23526403
  REMARK    GeneRIF: MCM7 expression and distribution change in injured spinal
            cord tissue.
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Bronze-da-Rocha E, Lin CM, Shimura T and Aladjem MI.
  TITLE     Interactions of MCP1 with components of the replication machinery
            in mammalian cells
  JOURNAL   Int J Biol Sci 7 (2), 193-208 (2011)
   PUBMED   21383955
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Tsao CC, Geisen C and Abraham RT.
  TITLE     Interaction between human MCM7 and Rad17 proteins is required for
            replication checkpoint signaling
  JOURNAL   EMBO J 23 (23), 4660-4669 (2004)
   PUBMED   15538388
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Khalili K, Del Valle L, Muralidharan V, Gault WJ, Darbinian N, Otte
            J, Meier E, Johnson EM, Daniel DC, Kinoshita Y, Amini S and Gordon
            J.
  TITLE     Puralpha is essential for postnatal brain development and
            developmentally coupled cellular proliferation as revealed by
            genetic inactivation in the mouse
  JOURNAL   Mol Cell Biol 23 (19), 6857-6875 (2003)
   PUBMED   12972605
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Bruemmer D, Yin F, Liu J, Berger JP, Kiyono T, Chen J, Fleck E, Van
            Herle AJ, Forman BM and Law RE.
  TITLE     Peroxisome proliferator-activated receptor gamma inhibits
            expression of minichromosome maintenance proteins in vascular
            smooth muscle cells
  JOURNAL   Mol Endocrinol 17 (6), 1005-1018 (2003)
   PUBMED   12677008
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle A, Graf K
            and Law RE.
  TITLE     Atorvastatin inhibits expression of minichromosome maintenance
            proteins in vascular smooth muscle cells
  JOURNAL   Eur J Pharmacol 462 (1-3), 15-23 (2003)
   PUBMED   12591091
REFERENCE   10 (bases 1 to 2357)
  AUTHORS   Ishimi Y.
  TITLE     A DNA helicase activity is associated with an MCM4, -6, and -7
            protein complex
  JOURNAL   J Biol Chem 272 (39), 24508-24513 (1997)
   PUBMED   9305914
  REMARK    Erratum:[J Biol Chem 1998 Sep 4;273(36):23616]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078973.1.
            
            On Jun 10, 2007 this sequence version replaced NM_001004203.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078973.1, DQ278199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2357
                     /gene="Mcm7"
                     /note="minichromosome maintenance complex component 7"
                     /db_xref="GeneID:288532"
                     /db_xref="RGD:1303018"
     exon            1..90
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2219
                     /gene="Mcm7"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient 7;
                     minichromosome maintenance protein 7"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM7"
                     /protein_id="NP_001004203.3"
                     /db_xref="GeneID:288532"
                     /db_xref="RGD:1303018"
                     /translation="MALKDYAIEKEKVKKFLQEFYYDDELGKKQFKYGTQLVHLAHRE
                     QVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEYKEKEVVNKDVLDVY
                     IEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFQGPSSSKPRVIREVRADSVGKL
                     LTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGG
                     RLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGI
                     FLPVLRTGFQQMAQGLLSETYLEAHRVVKMTKSEDDVSGAGELSAEELKQIAEEDFYE
                     KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLS
                     YIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKM
                     AEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLP
                     AALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMC
                     RERQPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDI
                     VEKEDVNEAIRLMEMSKDSLLGEKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQ
                     RCISRGFTPAQFQAALDEYEELNVWQVNTSRTRITFV"
     exon            91..170
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            171..460
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            461..641
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            642..779
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            780..929
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1044
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1176
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1260
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1654
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1738
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1907
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2017
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2332
                     /gene="Mcm7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccccgg agtgagactt cagaaccatt taagtcttgc cgcacggtcc ccggcagcga
       61 tggcgcttaa ggactatgcg attgagaaag aaaaagtgaa gaagttcctg caagagtttt
      121 attatgatga tgagcttgga aagaagcagt tcaagtatgg gacccagttg gttcatctgg
      181 ctcatcggga acaagtggca ttgtacgtgg acctagatga tgtagctgaa gatgaccctg
      241 agttggtcga ctcaatttgc gagaatgcca agcgctactc gaggctgttt gctgacgtag
      301 tacaggagct tctgcctgag tacaaggaga aggaggtggt gaataaggat gtcctggatg
      361 tttacattga acaccgattg atgatggagc agcggagcag agaccctggg gcagtccgga
      421 accctcaaaa ccagtatcct tctgagctca tgcgtagatt tgagttgtat ttccaaggcc
      481 caagtagcag caagcctcga gtgatccggg aagtacgggc tgattctgta gggaaattgt
      541 taactgtgcg tgggattgtc actcgtgtgt ctgaagtcaa gcccaggatg gtggtggcca
      601 catacacttg cgatcaatgt ggggcagaga cctaccagcc gatccagtct cccaccttca
      661 tgcctctgat catgtgcccc agccaggagt gccaaaccaa ccgctcaggg gggcggctgt
      721 acctacagac tcgtggctcc aaatttatta aattccagga aatgaagatt caagaacata
      781 gtgaccaagt tccggtggga aacatccctc ggagcatcac agtggttcta gaaggagaga
      841 acacaaggat tgcccagcct ggtgaccatg tcagcgtcac tggcatcttc ttgccagtct
      901 tgcgcacagg gttccaacag atggcacagg gcttactctc ggaaacttac ctggaagccc
      961 atcgggttgt gaagatgacg aagagcgagg atgatgtgtc tggggccgga gagctgagtg
     1021 ccgaggagct gaagcagatt gccgaggaag atttctatga aaagctggct gcttctattg
     1081 ctccggagat ctatggtcat gaagatgtga agaaggcgct cttactgctc ctggtgggtg
     1141 gtgtggacca gtctcctcaa ggcatgaaga taagaggaaa catccacatc tgccttatgg
     1201 gagatcctgg tgtggccaag tctcagctcc tgtcttacat tgaccgtctg gcgccccgaa
     1261 gtcagtacac aacgggccgg ggctcctctg gtgtagggct cacagcagct gtgttgagag
     1321 actctgtgag tggggaattg accttagagg gtggtgccct ggtgctggct gaccagggcg
     1381 tgtgctgcat tgatgagttt gacaagatgg cagaagctga ccgcacagcc atccatgagg
     1441 ttatggagca gcagaccatc tccattgcca aggcaggaat tctcaccaca ctcaatgccc
     1501 gatgctctat cctggctgct gccaaccctg cctatggacg gtataacccc cgccgcagtt
     1561 tggagcagaa catacagctt cctgctgctc tgctctcccg attcgacctc ctctggctga
     1621 ttcaggaccg gcccgacaga gacaacgacc tccggttggc ccagcacata acctatgtcc
     1681 accagcacag ccggcagccc cctgctcaat ttgaaccttt ggacatgaaa cttatgagac
     1741 ggtacattgc catgtgccgc gagaggcagc ccacagtgcc tgactctctg gctgactaca
     1801 tcactgcagc gtatgtggag atgaggcgag aggcccgggc cagtaaggat gccacctaca
     1861 cttctgcccg gaccctgctg gccattctcc gactttctac tgctctggct cgccttcgga
     1921 tggtagatat tgtggagaag gaagatgtga atgaagccat aaggttgatg gagatgtcaa
     1981 aggactccct tctgggtgaa aagggacaaa cggctaggac ccagaggcca gcagatgtga
     2041 tatttgctac cgtccgtgag ttggtatcag ggggacggag tgtccgcttt tctgaggctg
     2101 aacagcgctg catatcacgt ggcttcacac cagcccagtt ccaggcagct ctggatgaat
     2161 atgaggagct aaatgtctgg caggtcaata cttctcggac acggatcacc tttgtctgac
     2221 agccagtttt tgagccctac tgcctacccc agaaagtttg cgtgatgccc cctgagagga
     2281 caatttccca tgctgcactt ttttattctg ccaataaagt gttttgactg ccaaaaaaaa
     2341 aaaaaaaaaa aaaaaaa
//
