LOCUS       NM_017287               2929 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus minichromosome maintenance complex component 6
            (Mcm6), mRNA.
ACCESSION   NM_017287 XM_001055953 XM_344135
VERSION     NM_017287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2929)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   2  (bases 1 to 2929)
  AUTHORS   Akiyama,K., Morita,H., Suetsugu,S., Kuraba,S., Numata,Y.,
            Yamamoto,Y., Inui,K., Ideura,T., Wakisaka,N., Nakano,K., Oniki,H.,
            Takenawa,T., Matsuyama,M. and Yoshimura,A.
  TITLE     Actin -related protein 3 (Arp3) is mutated in proteinuric BUF/Mna
            rats
  JOURNAL   Mamm Genome 19 (1), 41-50 (2008)
   PUBMED   18064521
REFERENCE   3  (bases 1 to 2929)
  AUTHORS   Sakwe,A.M., Nguyen,T., Athanasopoulos,V., Shire,K. and Frappier,L.
  TITLE     Identification and characterization of a novel component of the
            human minichromosome maintenance complex
  JOURNAL   Mol Cell Biol 27 (8), 3044-3055 (2007)
   PUBMED   17296731
REFERENCE   4  (bases 1 to 2929)
  AUTHORS   Tsuji,T., Ficarro,S.B. and Jiang,W.
  TITLE     Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the
            initiation of DNA replication in mammalian cells
  JOURNAL   Mol Biol Cell 17 (10), 4459-4472 (2006)
   PUBMED   16899510
REFERENCE   5  (bases 1 to 2929)
  AUTHORS   You,Z. and Masai,H.
  TITLE     DNA binding and helicase actions of mouse MCM4/6/7 helicase
  JOURNAL   Nucleic Acids Res 33 (9), 3033-3047 (2005)
   PUBMED   15917436
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2929)
  AUTHORS   Olds,L.C. and Sibley,E.
  TITLE     Lactase persistence DNA variant enhances lactase promoter activity
            in vitro: functional role as a cis regulatory element
  JOURNAL   Hum Mol Genet 12 (18), 2333-2340 (2003)
   PUBMED   12915462
REFERENCE   7  (bases 1 to 2929)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   8  (bases 1 to 2929)
  AUTHORS   Fang,R., Santiago,N.A., Olds,L.C. and Sibley,E.
  TITLE     The homeodomain protein Cdx2 regulates lactase gene promoter
            activity during enterocyte differentiation
  JOURNAL   Gastroenterology 118 (1), 115-127 (2000)
   PUBMED   10611160
REFERENCE   9  (bases 1 to 2929)
  AUTHORS   Ishimi,Y.
  TITLE     A DNA helicase activity is associated with an MCM4, -6, and -7
            protein complex
  JOURNAL   J Biol Chem 272 (39), 24508-24513 (1997)
   PUBMED   9305914
  REMARK    Erratum:[J Biol Chem 1998 Sep 4;273(36):23616]
REFERENCE   10 (bases 1 to 2929)
  AUTHORS   Sykes,D.E. and Weiser,M.M.
  TITLE     Rat intestinal crypt-cell replication factor with homology to early
            S-phase proteins required for cell division
  JOURNAL   Gene 163 (2), 243-247 (1995)
   PUBMED   7590274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB737064.1, EV766384.1, CD371511.1, CD373304.1, CF109502.1,
            BQ194934.1 and BE096847.1.
            
            On or before Oct 28, 2007 this sequence version replaced
            XM_001055953.1, XM_344135.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166822.1, SRR8487227.54727.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                CB737064.1         48-121
            75-830              EV766384.1         19-774
            831-1124            CD371511.1         109-402
            1125-1824           CD373304.1         37-736
            1825-2573           CF109502.1         91-839
            2574-2900           BQ194934.1         19-345              c
            2901-2929           BE096847.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..2929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2929
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /note="minichromosome maintenance complex component 6"
                     /db_xref="GeneID:29685"
                     /db_xref="RGD:61967"
     exon            1..215
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2574
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /EC_number="3.6.4.12"
                     /note="intestinal DNA replication protein; mini chromosome
                     maintenance deficient 6; minichromosome maintenance
                     deficient 6 (MIS5 homolog, S. pombe)"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM6"
                     /protein_id="NP_058983.1"
                     /db_xref="GeneID:29685"
                     /db_xref="RGD:61967"
                     /translation="MDLAAAAEPGAGSQHPEVRDEVAEKCQKLFLDFLEEFQGSDGEI
                     KYLQFAEELIRPERNTLVVSFADLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK
                     EIPFAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLD
                     CQTVIKDVEQQFKYTQPSICRNPVCANRKRFLLDTNKSRFVDFQKVRIQETQAELPRG
                     SIPRSLEVVLRAEAVESAQAGDRCDFTGTLIVVPDVSKLSTPGARAETNSRVSGADGY
                     ETEGIRGLRALGVRDLSYRLVFLACYVAPTNPRFGGKELRDEEQTAESIKNQMTVKEW
                     EKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINV
                     CIVGDPSTAKSQFLKHVDEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALM
                     LADNGVCCIDEFDKMDMRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVSG
                     HYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRV
                     YSLDDIRRYLLFARQFKPKISKESEDFIVEQYKRLRQRDGSGITKSSWRITVRQLESM
                     IRLSESMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMETDEGPGG
                     INGHADSPAPVNGFNGSGEDASQETVPKPSLRLGFAEYCRISNLIVLHLRKMEEEEDE
                     SALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVVHRLTHYDHVLIELTQAGLKGS
                     SEGSESYEEDPYLVVNPNYLLED"
     exon            216..362
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            363..473
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            474..723
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..889
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1035
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1186
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1328
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1470
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1578
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1734
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1863
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2025
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2161
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2317
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2457
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2913
                     /gene="Mcm6"
                     /gene_synonym="Mcmd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcggtggc gcggaaggag ctacgcgtgg agcttgcggc taggccttcc gctgctgcgg
       61 cttctcggcg gtggtctttc ttcagcagtg cgtactttta gcgctgccat ggacctcgca
      121 gcggctgcgg agcccggtgc gggaagccag cacccggagg tgcgcgatga ggtggccgag
      181 aaatgtcaga agctgttcct agacttcctg gaagagttcc agggtagcga tggagaaatt
      241 aaatacttgc agttcgcaga ggagctgatt cgtcctgaga gaaacacact ggttgtgagt
      301 tttgcagacc tggaacaatt taaccaacaa ctttctacca ccattcagga agagttctac
      361 agagtctacc cttacctgtg tcgagccttg aagacctttg tcaaagaccg aaaggagatc
      421 ccttttgcta aggattttta tgttgcgttc caagacctac ccactagaca caagattcgt
      481 gagctcactt cctccaggat cgggctactc actcgcatca gtgggcaggt ggtgcgcact
      541 cacccagtgc accccgagct tgtgagtggg actttcctgt gcctcgactg ccaaacagtg
      601 atcaaggacg tagagcagca gttcaaatac acacagccga gcatctgccg caatccagta
      661 tgcgccaaca ggaagaggtt ccttctagac accaataaat cgagattcgt tgattttcaa
      721 aaggttcgta ttcaagagac tcaagcggag cttccccggg gaagcatccc ccggagtttg
      781 gaggttgtcc tgagggccga agccgtggag tcagcccagg ctggtgacag gtgtgacttc
      841 acggggacgc tgattgttgt gccggacgtc tccaagctta gcacaccagg agcacgtgcg
      901 gagaccaact cccgagtcag tggcgctgac gggtatgaga cagaaggcat ccgagggctc
      961 cgagccctgg gtgtcagaga cctgtcatac aggctggtct tccttgcctg ctatgttgca
     1021 ccaaccaacc cacgatttgg agggaaagaa ctcagagatg aggagcagac agctgagagc
     1081 attaagaacc aaatgacggt gaaggaatgg gaaaaggtgt ttgaaatgag tcaggacaaa
     1141 aacctgtacc acaatctctg cactagcctc ttccctacga tccacggcaa tgatgaagta
     1201 aaacgtggcg tcttgctgat gctgttcggt ggcgttccca agacaacagg ggaaggaacc
     1261 tctcttcgtg gggatataaa tgtttgcatt gttggggatc caagtacagc taagagccag
     1321 tttctcaagc atgtggatga gttcagtccc agagctgtgt ataccagtgg caaggcctcc
     1381 agtgctgccg gcttgacagc agctgtggtg agagatgagg aatctcacga gtttgtcatc
     1441 gaggctggag cgttgatgct ggctgataac ggtgtctgtt gcattgatga gtttgataag
     1501 atggacatgc gggaccaagt tgctattcac gaagctatgg agcagcagac catatctatc
     1561 actaaagccg gagtgaaggc aactctgaat gccaggacat ccattttagc tgcagcaaac
     1621 cctgtcagcg gacactacga caggtcaaaa tctctgaaac agaacatcaa tctgtcagcg
     1681 cccatcatgt cccgctttga cctcttcttc attttggtgg atgagtgcaa tgaggtgaca
     1741 gattatgcta ttgccaggcg catagtagac ttgcattcga ggatcgaaga atcgatagac
     1801 cgggtttatt cccttgatga tataagaagg tatcttctct tcgcccgaca gtttaagccc
     1861 aagatttcca aagagtcaga ggacttcatt gtggagcagt acaaacgcct ccgccagagg
     1921 gatggctctg ggatcaccaa gtcgtcgtgg agaatcactg tgagacagct tgagagcatg
     1981 atccgactct cagaatcgat ggcccgcatg cactgctgtg atgaggtcca gcctaaacat
     2041 gtgaaggaag cttttcgatt actgaataaa tcgatcatcc gtgtagaaac gcctgacgtc
     2101 aatctagatc aagaggaaga gatccagatg gagacggatg agggaccagg aggcatcaat
     2161 ggtcatgctg acagccctgc ccctgtgaac gggttcaatg gctctggtga agatgccagt
     2221 caggagaccg ttcccaagcc ctcccttagg ctgggctttg ctgaatactg ccgaatctct
     2281 aacctcatcg tgcttcacct caggaaaatg gaagaagagg aggatgagtc agccctaaag
     2341 aggagcgagc tggtcaactg gtacctgaag gaaatcgagt cggaaatcga ctctgaagaa
     2401 gagctcataa ataagaagag gatcatagag aaggttgttc atcgtctcac acactacgat
     2461 cacgttctga ttgagctcac ccaggctgga ctgaaaggct ccagtgaagg aagcgagagc
     2521 tatgaggaag atccttacct ggtagtcaac ccgaactact tgcttgaaga ttgagatata
     2581 gaaggtgact tacggccagg aaccgggggt ggcctacctt agccgggacc tgggcagcac
     2641 tgagaccgtt tctggagcga tgcttgggga cagttgagaa gagacagctg agttcatggc
     2701 cgtggatttc atgctggcac atgcgtgggc actttgtgct tgtcctgttg aagttggatc
     2761 ccaatcatgt tttctgaaag actttttatt tcatgtgtag gaaaagcctg ctgcatttgt
     2821 catacatgtg actgcgggaa ttgctttttc ctgtttccag ccactgcttt tactcgtgaa
     2881 aataaagcaa ttgttctgtg gttgtctgtt ggaaaaaaaa aaaaaaaaa
//
