LOCUS       NM_001399204            3093 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus minichromosome maintenance complex component 5
            (Mcm5), mRNA.
ACCESSION   NM_001399204 XM_039097563
VERSION     NM_001399204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Hicks,S.D., Lewis,L., Ritchie,J., Burke,P., Abdul-Malak,Y.,
            Adackapara,N., Canfield,K., Shwarts,E., Gentile,K., Meszaros,Z.S.
            and Middleton,F.A.
  TITLE     Evaluation of cell proliferation, apoptosis, and DNA-repair genes
            as potential biomarkers for ethanol-induced CNS alterations
  JOURNAL   BMC Neurosci 13, 128 (2012)
   PUBMED   23095216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Sakwe,A.M., Nguyen,T., Athanasopoulos,V., Shire,K. and Frappier,L.
  TITLE     Identification and characterization of a novel component of the
            human minichromosome maintenance complex
  JOURNAL   Mol Cell Biol 27 (8), 3044-3055 (2007)
   PUBMED   17296731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 4, 2022 this sequence version replaced XM_039097563.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166442.1, SRR26360194.1315290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000019.1  13488813-13488865
            54-228              JAXUCZ010000019.1  13488979-13489153
            229-355             JAXUCZ010000019.1  13489346-13489472
            356-484             JAXUCZ010000019.1  13489558-13489686
            485-657             JAXUCZ010000019.1  13493693-13493865
            658-813             JAXUCZ010000019.1  13495284-13495439
            814-980             JAXUCZ010000019.1  13496902-13497068
            981-1152            JAXUCZ010000019.1  13498873-13499044
            1153-1264           JAXUCZ010000019.1  13500157-13500268
            1265-1408           JAXUCZ010000019.1  13501537-13501680
            1409-1474           JAXUCZ010000019.1  13501972-13502037
            1475-1651           JAXUCZ010000019.1  13502301-13502477
            1652-1764           JAXUCZ010000019.1  13503835-13503947
            1765-1893           JAXUCZ010000019.1  13504950-13505078
            1894-2036           JAXUCZ010000019.1  13506870-13507012
            2037-2164           JAXUCZ010000019.1  13508285-13508412
            2165-3093           JAXUCZ010000019.1  13509203-13510131
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3093
                     /gene="Mcm5"
                     /note="minichromosome maintenance complex component 5"
                     /db_xref="GeneID:291885"
                     /db_xref="RGD:1306616"
     exon            1..53
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            54..228
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2266
                     /gene="Mcm5"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient 5, cell
                     division cycle 46"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM5"
                     /protein_id="NP_001386133.1"
                     /db_xref="GeneID:291885"
                     /db_xref="RGD:1306616"
                     /translation="MSGFDDPGIFYSDSFGGDPGAEEGQARKSHLQKRFKEFLRQYRV
                     GTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEELADYLYKQPAEHLQLLEEA
                     AKEVADEVTRPRPAGDELLQDIQVMLKSDASPSSIRILKSDMMSHLVKIPGIIISASA
                     VRAKATRISIQCRSCHNTLTNIAMRPGLEGYALPRKCNMDQAGRPKCPLDPYFIMPDK
                     CKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGM
                     NPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGSVSPQEEEEFRRLAALPNIYEL
                     VSRSVSPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLK
                     FVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGGVVCIDEFDKM
                     REDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMP
                     TILSRFDMIFIVKDEHNEERDMMLAKHVITLHVSALTQTQAVEGEIDLAKMKKFIAYC
                     RARCGPRLSAEAAEKLKNRYIIMRSGARQHERDIDRRSSIPITVRQLEAIVRIAEALS
                     KMKLQPFATEADVEEALRLFQVSTLDAALSGNLSGVEGFTTQEDQEMLSRIEKQLKRR
                     FAIGSQVSEHSIVQDFTKQKYPEHAIRKVLQLMLRRGEIQHRMQRKVLYRLK"
     exon            229..355
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            356..484
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..657
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            658..813
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            814..980
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1152
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1264
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1408
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1474
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1651
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1764
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1893
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2036
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2164
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..3093
                     /gene="Mcm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaagtcggc ttcctctagg agggtggagg ttcgtgtggc gcggctctgt gaggtacagt
       61 catgtcgggc ttcgacgatc cgggcatttt ctacagcgac agcttcggtg gcgacccggg
      121 tgcggaagag ggccaggctc gcaagtcgca cctacagaag cgcttcaagg agttcctacg
      181 acagtaccga gtgggcaccg atcgcacggg cttcaccttc aagtacaggg atgaactcaa
      241 gcggcattac aacctgggtg aatactggat cgaggtggaa atggaagacc tggccagctt
      301 tgacgaggaa ctggctgatt acttgtataa acagccagcc gagcacctgc aactgcttga
      361 ggaagctgcc aaggaggtag ctgatgaggt gacccggccc cggcctgctg gagatgagct
      421 gctccaggac attcaggtca tgctcaagtc agatgccagc ccgtccagca ttcggattct
      481 gaagtcagac atgatgtcac acctggtgaa gatccctggc atcatcatct cggcctctgc
      541 agtccgtgcc aaggctaccc gtatctccat tcagtgccgc agctgccaca acaccctcac
      601 caacatcgcc atgcgcccag gcctagaggg ctatgccctt cccaggaagt gtaatatgga
      661 tcaggctggg cgcccaaagt gcccactgga cccatatttc atcatgcctg acaagtgcaa
      721 gtgtgtggac ttccagaccc tgaaactgca ggaactgcct gatgcagtcc ctcatggtga
      781 gatgcccagg cacatgcagc tgtattgtga caggtacctg tgtgacaagg ttgttcctgg
      841 gaacagggtc accatcatgg gcatttattc catcaagaag tttggcatga accccagcaa
      901 gggccgggac agagtgggtg tgggcattcg gagctcctat atccgggtgc tgggcatcca
      961 ggtagacaca gatggttctg gccgcagctt tgctgggtct gtcagcccac aggaagagga
     1021 ggaattccgt cgcctggctg ccctccccaa catatatgag cttgtctcca ggagtgtttc
     1081 tccctccatc tttgggggca tggacatgaa gaaggccatt gcctgcctgc tctttggcgg
     1141 ttcccgaaag aggctcccag atggactcac tcgccgaggt gatatcaacc tgctgatgtt
     1201 gggggaccct ggcacagcca agtcacagct tctgaagttt gtggagaagt gctctcctat
     1261 tggggtgtac acatctggga aaggcagcag tgctgctggc ttgactgcct ctgtgatacg
     1321 ggacccctca tcgcgaaact tcatcatgga aggtggagcc atggttctgg ctgatggtgg
     1381 ggttgtctgt attgatgagt tcgacaagat gcgggaagat gaccgtgtag caatccatga
     1441 ggctatggag cagcagacca tctccattgc caaggctggg atcactacca ccttgaactc
     1501 tcgctgctct gttctggctg cagccaattc agtatttggc cgatgggatg agacaaaagg
     1561 ggaggacaat attgacttca tgcctaccat cttgtcccga tttgacatga tctttatcgt
     1621 caaagatgag cacaatgagg agagggacat gatgctggcc aaacatgtga tcactctgca
     1681 tgtgagtgca ctgacacaga cacaggctgt ggagggtgag atcgaccttg ccaagatgaa
     1741 gaagttcatt gcttactgcc gagcgaggtg tggacctcgg ctatcagcag aggcagcaga
     1801 gaagctgaag aaccgctaca tcatcatgcg gagtggggct cgtcagcatg agagggatat
     1861 tgaccgtcgt tccagcatcc ccatcacagt gcggcagctg gaggcgatcg tgcgcatcgc
     1921 cgaggccctc agcaagatga aactgcagcc ctttgctacg gaggccgacg tcgaggaggc
     1981 gctgaggctc ttccaggtgt ccacgctgga cgccgctttg tctggcaatc tgtcgggggt
     2041 ggaaggcttc acgacccagg aggaccagga gatgctgagt cgcattgaga agcaactcaa
     2101 gcgccgtttt gctatcggct cccaggtgtc tgaacacagc attgtccagg atttcaccaa
     2161 acagaagtat ccagagcatg ccatccggaa ggtgctgcag ctcatgctgc gcagggggga
     2221 gatccagcac cgcatgcagc gcaaggtgct ttaccgcctc aagtgagccc cgcccatcaa
     2281 ctgcccatca acctcgggcc tgggaagctg ccccacccac ctctagtcag tgtcctcgct
     2341 accacaagcc tccttctgcc ctcccccctg cctcagactg ctgtatgccg cacagctgca
     2401 gcccctggaa atgtgctctg gttgttggcc tcatgtactg tgtttgggtg tctgagggct
     2461 ctgtctggtc tgggtgccta gtccctgtct gcctccacga caggatgagt ctggagcagg
     2521 aacaggctct ggaggtagaa aggtctgtat gttggctcct gggccactga ctgtcaagct
     2581 tcttcgtgtg tacagaggaa ataaagtgcg tgagtccctg gctgctaagg acagcggagc
     2641 caataccaca gtagtgctgt gcgaagtcta aggttgactc actcagctcc ccagcagcac
     2701 ctatatgaga actggatcat taatttcgct atctgtgcct cagtttccta atctgcaaac
     2761 aaatttgatg aatatgagct cagtgagtga ttggctgtca agtgaaaacc caagcaggcc
     2821 acaatggaga aagtctccat ggctttcttt acagcaagtg agcctcagtg ctgtgtatca
     2881 ctgggggagg gaccagacct cagggttatc agtgaaggag ctgtaggccc ttccccgagt
     2941 cagcacggca ggagatacta gtgacaacac tgttaaagga aggtacccca gcactttgta
     3001 ttgccaaatg ccaaaaaccg tgcttctaga aatctaggat ttacaagatt atggaaaagt
     3061 cagtgaaata aagtgtttgt tatttaaagt aca
//
