LOCUS       NM_033651               3339 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus minichromosome maintenance complex component 4
            (Mcm4), mRNA.
ACCESSION   NM_033651 XM_001068436 XM_344048
VERSION     NM_033651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3339)
  AUTHORS   Guo,Y., Fan,Y., Zhang,J., Chang,L., Lin,J.D. and Chen,Y.E.
  TITLE     Peroxisome proliferator-activated receptor gamma coactivator 1beta
            (PGC-1beta) protein attenuates vascular lesion formation by
            inhibition of chromatin loading of minichromosome maintenance
            complex in smooth muscle cells
  JOURNAL   J Biol Chem 288 (7), 4625-4636 (2013)
   PUBMED   23264620
  REMARK    GeneRIF: Peroxisome proliferator-activated receptor gamma
            coactivator 1beta (PGC-1beta) protein attenuates vascular lesion
            formation by inhibition of chromatin loading of minichromosome
            maintenance complex in smooth muscle cells
REFERENCE   2  (bases 1 to 3339)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3339)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   4  (bases 1 to 3339)
  AUTHORS   Sakwe,A.M., Nguyen,T., Athanasopoulos,V., Shire,K. and Frappier,L.
  TITLE     Identification and characterization of a novel component of the
            human minichromosome maintenance complex
  JOURNAL   Mol Cell Biol 27 (8), 3044-3055 (2007)
   PUBMED   17296731
REFERENCE   5  (bases 1 to 3339)
  AUTHORS   You,Z. and Masai,H.
  TITLE     DNA binding and helicase actions of mouse MCM4/6/7 helicase
  JOURNAL   Nucleic Acids Res 33 (9), 3033-3047 (2005)
   PUBMED   15917436
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3339)
  AUTHORS   Ishimi,Y.
  TITLE     A DNA helicase activity is associated with an MCM4, -6, and -7
            protein complex
  JOURNAL   J Biol Chem 272 (39), 24508-24513 (1997)
   PUBMED   9305914
  REMARK    Erratum:[J Biol Chem 1998 Sep 4;273(36):23616]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Dec 13, 2009 this sequence version replaced
            XM_001068436.1, XM_344048.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ226176.1, SRR26360176.850890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000011.1  98762599-98762861
            264-425             JAXUCZ010000011.1  98763221-98763382
            426-589             JAXUCZ010000011.1  98763659-98763822
            590-691             JAXUCZ010000011.1  98763915-98764016
            692-787             JAXUCZ010000011.1  98764771-98764866
            788-883             JAXUCZ010000011.1  98764950-98765045
            884-1022            JAXUCZ010000011.1  98765508-98765646
            1023-1243           JAXUCZ010000011.1  98767781-98768001
            1244-1364           JAXUCZ010000011.1  98768300-98768420
            1365-1624           JAXUCZ010000011.1  98770448-98770707
            1625-1990           JAXUCZ010000011.1  98771187-98771552
            1991-2118           JAXUCZ010000011.1  98772149-98772276
            2119-2326           JAXUCZ010000011.1  98772746-98772953
            2327-2555           JAXUCZ010000011.1  98774094-98774322
            2556-2689           JAXUCZ010000011.1  98774928-98775061
            2690-3339           JAXUCZ010000011.1  98775651-98776300
FEATURES             Location/Qualifiers
     source          1..3339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3339
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /note="minichromosome maintenance complex component 4"
                     /db_xref="GeneID:29728"
                     /db_xref="RGD:3060"
     exon            1..263
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..2782
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient 4 homolog;
                     mini chromosome maintenance deficient 4 homolog"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM4"
                     /protein_id="NP_387500.1"
                     /db_xref="GeneID:29728"
                     /db_xref="RGD:3060"
                     /translation="MSSPASTPSRRSSRRGRVTPTQSLRSEESRSSPSGRRRGEDSST
                     GELLPMPTSPGADLQSPAAQNALFSSPPQMHSSAIPLEFDVSSPLTYGTPSSRVEGTP
                     RSGVRGTPMRQRPDLGSARKGLQVDLQSDGAAAEDTVASEQSLGQKLVIWGTDVNVAT
                     CKEHFQRFLQCFTDPLAKEEENVGIDITQPLYMQRLGEINITGEPFLNVNCEHIKSFG
                     KNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKSMRNLNPE
                     DIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPCTCVHCHTTH
                     SMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVVLFAHNDLVDKVQPGDRVNVTGI
                     YRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKE
                     LSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLC
                     GDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSD
                     NGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWN
                     PKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEQEFLD
                     MAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLA
                     EAHAKVRFSDKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKE
                     ELAEALRKLILSKGKTPALKYQQLFEDIRGQSDTAITKDMFEEALRALADDDFLTVTG
                     KTVRLL"
     exon            264..425
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            426..589
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..691
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            692..787
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            788..883
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1022
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1243
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1364
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1624
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1990
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2118
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2326
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2555
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2689
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..3339
                     /gene="Mcm4"
                     /gene_synonym="Mcmd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctctga ttggtcagaa gctgctgggc gctgtgacga cagagcggct ggcgggaatc
       61 gcttcaacct gcgagccagg aacgcactcc tgggtgtgcg tgtttgcaac taacccggat
      121 ccgaagtacg agaagtcccg taacgggaca actgagagcc agatttctct agtcgcgcag
      181 ctaccacagc accatgtcgt ccccggcatc caccccaagt cgccgcagca gccgacgcgg
      241 acgagtcacc ccaacccagt cgcttcgaag tgaggaaagc cgatcatctc ccagtgggag
      301 acgtagaggc gaagattctt ccaccggaga gttgctgcca atgcccacct caccaggagc
      361 agacctgcag agcccagctg cacagaatgc cttgttttcc agccctcctc agatgcattc
      421 ttcagctatt cctttggaat ttgatgttag ttcgccattg acatatggca ctcccagctc
      481 tcgagtggaa ggaaccccaa gaagtggggt gagaggcaca cccatgaggc agaggccaga
      541 cctgggctca gcacgaaagg gtttgcaggt ggatctgcag tctgacggag cagcagcaga
      601 agacacagta gcaagtgaac agtctctagg ccaaaagctt gtgatttggg gaacagacgt
      661 gaatgtggca acatgcaaag aacattttca gagattcctt caatgtttta ctgatcctct
      721 ggccaaagaa gaagaaaatg ttggcataga tattacgcaa cctttgtaca tgcaacgact
      781 tggagagatt aatattacag gagagccatt tttaaatgtg aactgtgaac acataaaatc
      841 atttggcaaa aacttgtata gacagctcat ctcctaccca caggaggtta taccaacctt
      901 tgacatggct gtcaatgaga tcttctttga ccgttatcct gactccatct tagaacatca
      961 gattcaagtc agacctttta atgcattgaa gacaaagagt atgagaaact tgaatccaga
     1021 agacattgat cagctcatca ccatcagtgg catggttatc agaacgtcac agctgattcc
     1081 cgagatgcag gaggcctttt tccagtgcca agtctgtgcc cataccaccc gggtagagat
     1141 ggaccgaggc cgaattgctg agccctgcac ttgcgtacac tgccacacta cccacagtat
     1201 ggcactgatc cacaaccgtt cactattctc tgacaagcag atgatcaagc ttcaagagtc
     1261 tcctgaagat atgcctgctg ggcagacacc tcacactgtt gtcctttttg cccacaatga
     1321 tcttgtagac aaggttcagc caggggacag agtgaatgtc acaggcatat atcgagcagt
     1381 acctattcga gttaatccaa gagtgagcaa cgtgaagtct gtctataaaa cccacattga
     1441 tgtcatccat tatcggaaaa cggatgcaaa acgtctgcat ggccttgatg aagaagcaga
     1501 acagaaactt ttttcagaga aacgtgtgaa attgcttaag gaactttcca ggaagccaga
     1561 tatttatgag cggcttgctt cagccttggc tcccagcatt tatgaacatg aagatataaa
     1621 aaagggaatc ctacttcaac tctttggtgg aacaaggaag gatttcagtc acactggaag
     1681 gggtaaattc cgtgctgaga ttaacatcct tctgtgtggt gaccctggca ccagcaagtc
     1741 ccagctgcta cagtatgtat acaacctggt tcccagaggc cagtacacat ctggaaaagg
     1801 ctccagtgca gttggcctca cagcctatgt gatgaaagac cctgagacca ggcagcttgt
     1861 cctccagaca ggtgcccttg tactgagtga caatggcata tgttgcattg atgagtttga
     1921 caaaatgaat gaaagcacaa ggtccgtgct gcatgaggtc atggaacagc agactctgtc
     1981 cattgcaaag gctgggatca tctgtcagct caatgcacga acctctgtcc tggcagcagc
     2041 aaaccctatt gagtcccagt ggaaccctaa aaaaacaacc attgaaaata tccaactacc
     2101 acacacactg ttgtcaaggt ttgatctcat tttcctcatg ctagaccctc aagatgaggc
     2161 atatgaccga cgcctagccc accacctggt ttcattgtac taccaaagtg aggagcaggt
     2221 ggagcaggag ttcctggaca tggcagtgct gaaagactac attgcctatg cacatagtac
     2281 tatcatgccc cggctgagtg aggaggccag ccaggctctc attgaggctt atgtaaacat
     2341 gaggaagatc gggagtagtc gggggatggt ttctgcttac cctcgacagc tagagtcatt
     2401 aattcgctta gcagaagccc atgctaaagt aagattttca gacaaagttg aagcaatcga
     2461 tgtggaagag gcaaaacgcc ttcaccggga ggctctgaag cagtctgcca ctgaccctcg
     2521 cactggcatt gtggacatat ctattcttac tacaggaatg agtgccactt ctcgtaaacg
     2581 gaaagaagaa ttagctgaag cactgagaaa acttatttta tctaagggta aaacaccagc
     2641 cttaaagtac caacagctat ttgaggatat tcggggacaa tctgacacag caattaccaa
     2701 ggacatgttt gaagaggccc tgcgtgcttt ggctgatgat gatttcctaa cagtgactgg
     2761 gaagactgtc cgcctactct gagctgcatg ttccttggac tagagtcagt cactattgtt
     2821 actgatgcaa atggagtctg aaaggcagta ttccactata taaacatttt ctatagggat
     2881 gtgttttgtt agtaaatgta tgttttcacc tttaaatttt aaattatatc agcatataca
     2941 ggagaggtta tattttcaat atgccatagt ttttaagcag cttgcatctt acctgtttaa
     3001 atgcaaagag cctaagccca gttttggatt tttttttttt ttttttttaa tctgggggct
     3061 tttcctttgt tgtgctgcag ggctggggat agagctaaga gtaccatgca tgctgtatgt
     3121 ctaattatgt gcgtggaggt aacaaattgg ccgagataca tcctttattg tgatgtgaag
     3181 ggctaaggat ttttatagca cctggactta actttcttta tagagagttt tccccctatt
     3241 attagaacaa aaatatgctt gaaaaattat tagatcaagt tgccttctgt tttttcctaa
     3301 tatgtaaaac atgttcctaa ataaatgata gaaaagtaa
//
