LOCUS       NM_001107873            3261 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus minichromosome maintenance complex component 2
            (Mcm2), mRNA.
ACCESSION   NM_001107873 XM_001072364 XM_232168
VERSION     NM_001107873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3261)
  AUTHORS   Gao,J., Wang,Q., Dong,C., Chen,S., Qi,Y. and Liu,Y.
  TITLE     Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene
            for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family
  JOURNAL   PLoS One 10 (7), e0133522 (2015)
   PUBMED   26196677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3261)
  AUTHORS   Huang,W., She,L., Chang,X.Y., Yang,R.R., Wang,L., Ji,H.B.,
            Jiao,J.W. and Poo,M.M.
  TITLE     Protein kinase LKB1 regulates polarized dendrite formation of adult
            hippocampal newborn neurons
  JOURNAL   Proc Natl Acad Sci U S A 111 (1), 469-474 (2014)
   PUBMED   24367100
REFERENCE   3  (bases 1 to 3261)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   4  (bases 1 to 3261)
  AUTHORS   Bronze-da-Rocha,E., Lin,C.M., Shimura,T. and Aladjem,M.I.
  TITLE     Interactions of MCP1 with components of the replication machinery
            in mammalian cells
  JOURNAL   Int J Biol Sci 7 (2), 193-208 (2011)
   PUBMED   21383955
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3261)
  AUTHORS   Bonda,D.J., Evans,T.A., Santocanale,C., Llosa,J.C., Vina,J.,
            Bajic,V., Castellani,R.J., Siedlak,S.L., Perry,G., Smith,M.A. and
            Lee,H.G.
  TITLE     Evidence for the progression through S-phase in the ectopic cell
            cycle re-entry of neurons in Alzheimer disease
  JOURNAL   Aging (Albany NY) 1 (4), 382-388 (2009)
   PUBMED   19946466
REFERENCE   6  (bases 1 to 3261)
  AUTHORS   Zhang,C., McNeil,E., Dressler,L. and Siman,R.
  TITLE     Long-lasting impairment in hippocampal neurogenesis associated with
            amyloid deposition in a knock-in mouse model of familial
            Alzheimer's disease
  JOURNAL   Exp Neurol 204 (1), 77-87 (2007)
   PUBMED   17070803
REFERENCE   7  (bases 1 to 3261)
  AUTHORS   Tsuji,T., Ficarro,S.B. and Jiang,W.
  TITLE     Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the
            initiation of DNA replication in mammalian cells
  JOURNAL   Mol Biol Cell 17 (10), 4459-4472 (2006)
   PUBMED   16899510
REFERENCE   8  (bases 1 to 3261)
  AUTHORS   Geng,Y., Yu,Q., Sicinska,E., Das,M., Schneider,J.E.,
            Bhattacharya,S., Rideout,W.M., Bronson,R.T., Gardner,H. and
            Sicinski,P.
  TITLE     Cyclin E ablation in the mouse
  JOURNAL   Cell 114 (4), 431-443 (2003)
   PUBMED   12941272
REFERENCE   9  (bases 1 to 3261)
  AUTHORS   Chen,J.F., Huang,Z., Ma,J., Zhu,J., Moratalla,R., Standaert,D.,
            Moskowitz,M.A., Fink,J.S. and Schwarzschild,M.A.
  TITLE     A(2A) adenosine receptor deficiency attenuates brain injury induced
            by transient focal ischemia in mice
  JOURNAL   J Neurosci 19 (21), 9192-9200 (1999)
   PUBMED   10531422
REFERENCE   10 (bases 1 to 3261)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 11, 2008 this sequence version replaced NM_001107873.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.17240.1,
                                           SRR26643298.24088.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                JAXUCZ010000004.1  122918055-122918094 c
            41-273              JAXUCZ010000004.1  122916896-122917128 c
            274-449             JAXUCZ010000004.1  122913121-122913296 c
            450-710             JAXUCZ010000004.1  122912728-122912988 c
            711-930             JAXUCZ010000004.1  122911764-122911983 c
            931-1138            JAXUCZ010000004.1  122911455-122911662 c
            1139-1273           JAXUCZ010000004.1  122909566-122909700 c
            1274-1465           JAXUCZ010000004.1  122908845-122909036 c
            1466-1559           JAXUCZ010000004.1  122908187-122908280 c
            1560-1810           JAXUCZ010000004.1  122907561-122907811 c
            1811-1937           JAXUCZ010000004.1  122907343-122907469 c
            1938-2050           JAXUCZ010000004.1  122906849-122906961 c
            2051-2302           JAXUCZ010000004.1  122905748-122905999 c
            2303-2485           JAXUCZ010000004.1  122904872-122905054 c
            2486-2641           JAXUCZ010000004.1  122904546-122904701 c
            2642-3261           JAXUCZ010000004.1  122903682-122904301 c
FEATURES             Location/Qualifiers
     source          1..3261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3261
                     /gene="Mcm2"
                     /note="minichromosome maintenance complex component 2"
                     /db_xref="GeneID:312538"
                     /db_xref="RGD:1305577"
     exon            1..40
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2752
                     /gene="Mcm2"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient 2 mitotin"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM2"
                     /protein_id="NP_001101343.2"
                     /db_xref="GeneID:312538"
                     /db_xref="RGD:1305577"
                     /translation="MAESSESFSAASSPAPQRRRISDPLTSSPGRSSRRADALTSSPG
                     RDLPPFEDESEGLLGTEGPVEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDED
                     VEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRHIERATE
                     DGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKE
                     RISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYD
                     RITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCN
                     FILGPFCQSQNQEVKPGSCPECQSTGPFEINMEETIYQNYQRIRIQESPGKVAAGRLP
                     RSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTTNGFPVFATIILANHVAKKDN
                     KVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNP
                     GGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPV
                     SREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQAR
                     CTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVG
                     SHVRHHPSNKKDEGLTNGGTTEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMD
                     QDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRV
                     MLESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQ
                     DTIEIPEKDLMDKARQINIHNLSAFYDSDLFKINKFSRDLKRKLILQQF"
     exon            41..273
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            274..449
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..710
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..930
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1138
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1273
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1465
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1559
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1810
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1937
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2050
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2302
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2485
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2641
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..3261
                     /gene="Mcm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtggcagc tggtgcggtg aagctagcgc agggatggcg gagtcttctg agtccttctc
       61 ggcagcatct agccctgccc ctcagcggcg acggatcagt gatcccctca cttccagccc
      121 aggccgcagc tccagacgtg ctgacgctct tacctccagc cctggcagag acctcccccc
      181 atttgaggat gagtccgagg ggctgctggg cacggagggg cctgtggagg aagaagagga
      241 tggagaggaa ctcattggtg atggcatgga gagagactac cgtcccattc ccgagctcga
      301 tgtctacgag gcagagggat tggccctgga tgatgaagat gtggaggagc tgacagccag
      361 tcagagggag gcagctgagc gggctatgag gcagcgggac cgtgaggctg gcagaggcct
      421 gggtcgcatg cgtcgtgggc tgctgtatga cagcgacgaa gaagatgagg agcggcctgc
      481 ccgtaagcgc cgccacatag agcgtgccac agaggatggc gaggaggatg aagagatgat
      541 tgagagtatt gagaacctgg aggacctcaa gggccactcg gtgcgagagt gggtgagcat
      601 ggcagggccc agactggaga tccaccaccg tttcaagaac ttcttgcgca cccacgtgga
      661 cagccatggc cacaacgtct tcaaggagcg tatcagtgat atgtgcaaag agaaccggga
      721 gagtttggtg gtaaattatg aagacctggc agcccgggaa catgtgttgg catacttcct
      781 acccgaggca cccgctgagc tgctgcagat cttcgatgag gctgccctgg aggttgtgct
      841 ggccatgtac cctaaatatg accgcatcac caaccacatt cacgtgcgca tctcccacct
      901 gcctctggtg gaggagctgc gttcactgag gcagctacac ctgaaccagc tcatccgtac
      961 cagcggtgtg gtgaccagct gcactggagt cctgccccag ctcagcatgg tcaagtataa
     1021 ctgtagcaag tgcaacttta tactggggcc tttctgccag tctcagaacc aggaggtgaa
     1081 gcctggttcc tgccctgagt gccagtcaac tgggcccttt gagatcaaca tggaggagac
     1141 catctatcag aactaccaac ggatccgcat ccaggagagt cccggcaagg tggcagctgg
     1201 ccggctgccc cgttccaagg atgccatcct ccttgctgat ctggtggaca gctgcaagcc
     1261 aggagacgag atagagctga ccggcattta ccacaataat tatgatggct cacttaacac
     1321 caccaacggc tttcccgtct tcgccaccat catcctggcc aaccacgttg ccaagaagga
     1381 caacaaagtg gccgtgggtg agctcactga tgaggacgtg aagatgatca ccagtctttc
     1441 caaggatcag caaatcggag agaagatctt tgccagcatt gcgccctcca tctatgggca
     1501 tgaagacatc aagagaggcc tggctctggc tctgtttgga ggggagccca agaacccagg
     1561 tggaaagcac aaagttcgag gtgacatcaa tgtgctcctg tgtggggacc ctggcacagc
     1621 gaagtcccag ttcctcaaat acatcgagaa agtatctagc cgtgccattt tcaccaccgg
     1681 ccagggtgcg tcagccgtgg gtctcacagc gtatgttcag cggcatcctg tcagcagaga
     1741 gtggacctta gaggctggag ccctggttct ggccgaccgg ggagtgtgtc tcattgatga
     1801 gtttgacaag atgaatgacc aggacaggac cagcatccac gaggccatgg agcagcaaag
     1861 catctccatc tccaaggccg gcatcgttac ctcactgcaa gcccgctgca ccgtcatagc
     1921 tgctgccaac cccataggag gccgctacga cccttcactg accttctcag agaatgtaga
     1981 cctcacagag cccatcattt cccgctttga tgtcctgtgt gtggtgaggg acactgttga
     2041 tcctgttcag gatgagatgc tggcccgctt tgtggttggc agccacgtca gacaccaccc
     2101 cagcaacaag aaggacgaag ggctgaccaa cggtggcacc acagagccag ccatgcccaa
     2161 cacatacggt gtggagcccc tgcctcagga ggtcctgaag aagtatatca tctatgccaa
     2221 ggaacgggtc cgcccaaagc tcaaccagat ggaccaggac aaagtggcca ggatgtacag
     2281 cgacctgagg aaggagtcca tggcaacggg cagtattccc atcacagtgc gacacatcga
     2341 gtccatgatc cgcatggcag aggcccatgc acgcatgcac ctgcgagact acgtgatgga
     2401 agatgatgtc aacatggcca tccgcgtgat gctggagagc ttcattgaca cccaaaagtt
     2461 cagtgtcatg cgcagcatgc gcaagacttt tgcccggtat ctctccttcc gtcgggataa
     2521 caatgacctg ctgctcttca tactgaagca gttggtggct gagcaggtga cataccaacg
     2581 taaccgcttt ggggcccaac aggacaccat cgaaatacct gagaaggacc tgatggacaa
     2641 ggccaggcag atcaatatcc acaacctgtc cgccttctac gacagcgacc tcttcaaaat
     2701 caacaagttc agccgtgacc tgaaacgcaa gctgatccta cagcagttct gaggtcagca
     2761 caggactctg tctggacgag gctcagtcac actctgcaga cacagcccac ttccaccagg
     2821 ggctctgtgt cctgtggggg tggggtgatg ctcaatgcag acctttaccc atgagcccct
     2881 gggccaagga tgaaatgact gtacttattc tcctgcccct ctctagagca ctcttcttga
     2941 ccagcccctc tgtcccaggc tccttaaaaa gctgaggttg tgttcaggtg acagaattta
     3001 ccaaaaccat tgctgctttg ccatgagttg tgtttctgga ctgtttcttc cccttttaga
     3061 ttaaagagca acttagaagt gtttgcacac ttttccagaa cgttcttgga gcctgtgatg
     3121 gaggagcaca agagcctgcc taccgaggga gggcccatgc tccttgtgct gactttcttc
     3181 ctgcctagcc agtgccttca ttcgcttctt gtacagtttc ttatagttta ttttttaata
     3241 aatttgaata caacttaaat a
//
