LOCUS       NM_021846               2130 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus MCL1 apoptosis regulator, BCL2 family member
            (Mcl1), mRNA.
ACCESSION   NM_021846
VERSION     NM_021846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Tian,X., Zhang,Y., Peng,M. and Hou,Y.
  TITLE     Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid
            cell leukemia 1 attenuates inflammation and apoptosis in
            caerulein-treated AR42J cells
  JOURNAL   Funct Integr Genomics 24 (5), 140 (2024)
   PUBMED   39160285
  REMARK    GeneRIF: Regulatory axis of circular RNA DTNB, microRNA-485-5p, and
            myeloid cell leukemia 1 attenuates inflammation and apoptosis in
            caerulein-treated AR42J cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Wang,D., Guan,H., Wang,Y., Song,G. and Xia,Y.
  TITLE     N6-methyladenosine modification in trophoblasts promotes circSETD2
            expression, inhibits miR-181a-5p, and elevates MCL1 transcription
            to reduce apoptosis of trophoblasts
  JOURNAL   Environ Toxicol 38 (2), 422-435 (2023)
   PUBMED   36260529
  REMARK    GeneRIF: N6-methyladenosine modification in trophoblasts promotes
            circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1
            transcription to reduce apoptosis of trophoblasts.
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Mhaidat,N.M., Amawi,H. and Alzoubi,K.H.
  TITLE     Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms
            and Chemotherapy Response in Jordanian Patients with Colorectal
            Cancer
  JOURNAL   Curr Pharm Biotechnol 22 (5), 646-653 (2021)
   PUBMED   32619164
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Cai,C.L., Jin,L., Lang,X.L. and Li,B.L.
  TITLE     Long noncoding RNA XIST regulates cardiomyocyte apoptosis by
            targeting miR-873-5p/MCL1 axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (24), 12878-12886 (2020)
   PUBMED   33378038
  REMARK    GeneRIF: Long noncoding RNA XIST regulates cardiomyocyte apoptosis
            by targeting miR-873-5p/MCL1 axis.
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Yu,X., Gao,F., Li,W., Zhou,L., Liu,W. and Li,M.
  TITLE     Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1
            axis in non-small cell lung cancer
  JOURNAL   J Exp Clin Cancer Res 39 (1), 62 (2020)
   PUBMED   32276600
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Hsu,S.Y., Lin,P. and Hsueh,A.J.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Hsu,S.Y., Kaipia,A., McGee,E., Lomeli,M. and Hsueh,A.J.
  TITLE     Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
            reproductive tissues and heterodimerizes with selective
            anti-apoptotic Bcl-2 family members
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12401-12406 (1997)
   PUBMED   9356461
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Li,L., Krajewski,S., Reed,J.C. and Choi,Y.S.
  TITLE     The apoptosis and proliferation of SAC-activated B cells by IL-10
            are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression
  JOURNAL   Cell Immunol 178 (1), 33-41 (1997)
   PUBMED   9184696
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Yang,T., Kozopas,K.M. and Craig,R.W.
  TITLE     The intracellular distribution and pattern of expression of Mcl-1
            overlap with, but are not identical to, those of Bcl-2
  JOURNAL   J Cell Biol 128 (6), 1173-1184 (1995)
   PUBMED   7896880
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078835.1.
            
            On Aug 8, 2004 this sequence version replaced NM_021846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078835.1, CF110454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2130
                     /gene="Mcl1"
                     /note="MCL1 apoptosis regulator, BCL2 family member"
                     /db_xref="GeneID:60430"
                     /db_xref="RGD:620525"
     exon            1..696
                     /gene="Mcl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1061
                     /gene="Mcl1"
                     /note="myeloid cell leukemia sequence 1; BCL2 family
                     apoptosis regulator; myeloid cell leukemia 1; MCL1, BCL2
                     family apoptosis regulator"
                     /codon_start=1
                     /product="induced myeloid leukemia cell differentiation
                     protein Mcl-1 homolog"
                     /protein_id="NP_068618.2"
                     /db_xref="GeneID:60430"
                     /db_xref="RGD:620525"
                     /translation="MFGLRRNAVIGLNLYCGGASLGAGGGSPAGTRLAAEEAKARREG
                     GGEAALLPGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASAAAIMSP
                     EEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYRQSLE
                     IISRYLREQATGSKDAKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIK
                     NEDDVKSFSRVMTHVFKDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITD
                     VLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR"
     exon            697..944
                     /gene="Mcl1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..2107
                     /gene="Mcl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctgcctc gagtctggag tcgcggcctt ccccgctctc gccccccctg agcctgcggc
       61 gtcccaccat gtttggcctt cggagaaacg cggtaatcgg cttgaacctg tactgcggcg
      121 gcgctagcct cggcgcgggc ggcggctctc cggccgggac gcgcctggcg gccgaggagg
      181 ccaaggcgcg gcgcgagggg ggaggggagg ccgctctgct gcccggcgcg cgggtggtcg
      241 cccggccgcc tccggtgggc gccgaggacc ccgacgtcac cgcgtcggca gagaggcggc
      301 tgctcaagtc gcccggcctc ctcgccgtgc cgcctgagga gatggccgcg tcggccgccg
      361 ccatcatgtc tcccgaggag gagctggacg gctgcgagcc ggaggtgctc agcaaacgcc
      421 cggcggtgct gcccctactg gagcgcgtga gcgaggcggc taagagctcc ggagctgacg
      481 gctcgctgcc ctccacgccg ccgccgcctg aggaggaaga cgacgagctg taccgccagt
      541 cgctggagat catctcccgc tacctgcggg agcaggcgac gggctccaag gacgcgaagc
      601 ctctgggcga ggccggcgca gcgggccgga gggcgctgga gaccctgcgg cgcgtgggcg
      661 acggcgtgca gcgcaaccac gagacggcct tccagggcat gcttcggaaa ctggacatta
      721 aaaacgagga cgatgttaaa tctttttctc gagtgatgac ccatgttttc aaagatggcg
      781 taacaaactg gggcaggatt gtgactctta tttcttttgg tgcctttgtg gccaaacact
      841 taaagagcat aaaccaagaa agctgcatcg aacctttagc agaaagtatc acagacgttc
      901 ttgtaaggac gaagcgggac tggcttgtga aacaaagagg ctgggatggg tttgtggagt
      961 tcttccacgt acaggaccta gaaggcggca tcagaaatgt gctgctggct tttgcgggtg
     1021 ttgctggagt aggggctggt ctggcatatc taataaggta gcttgtgagt gcaatagggg
     1081 actctaaaac ctccagccac caactacatg cttctgtgag aacaaatgtg tttatgaagg
     1141 tgcacttgaa gctgcccagg attataacac ggcagaaaga aagtggctac agaattgtgg
     1201 ctaacgagaa taaatacatg ggaaaagtgc tccctctgga agagtcactg tctgaatgaa
     1261 gcaaagttca ctctcagcaa actttgggag gccatggagg acttctagaa tgaatgaaaa
     1321 gggtgaatgg aaaggtttga tttccttgtc tggagatgga agagtggcca gtcaccaggc
     1381 tagtcctaga gttcaataag tatgcagcac cctttacttt gctcctagtg ctgacagaga
     1441 agccctaaca atggtggtga cttgtgtaaa atggatgttt aacctacaaa taaccaattt
     1501 ggctagaagc tgcagtgctg tacaagaggg tgaaggagga tgtgctctga gcaggcccag
     1561 gtgtgcgtaa gtttattagt ctagtgatgg ccaaaaagta cttgacttaa taaggttcat
     1621 taattagtta caaaactgaa cagcctcaat ttttaagaaa acttatgaaa tgtatttgtc
     1681 tgtaaaaatt gtatatattt ttacagaaag tctatttctt tgaacataaa aaggaagtct
     1741 tggatttagt ttttccatac ccttttgaaa tttgcaactt ctctagttag aaatgtattt
     1801 cttacagctt tttaaaactt tgtcatgatc agttctagtg tatatgcaga gccagttgtg
     1861 tgtgtggact ggttgtagta gaacaaatcc gagttataac tatgcagggt taattatcca
     1921 atctgtttct gtatttaagg atcacaggta gatgtaagac atttgatccc ctgttgactt
     1981 actaaattgt aaaatgcttt gggaaagcag actaatcttt accacggtgc tattcacagg
     2041 ctttacttgt ttaacacaag tttaagcctg gtgtcaataa aacaaatatg tatttctttt
     2101 ctactaaaaa aaaaaaaaaa aaaaaaaaaa
//
