LOCUS       NM_001419705            3303 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus multiciliate differentiation and DNA synthesis
            associated cell cycle protein (Mcidas), mRNA.
ACCESSION   NM_001419705 XM_001068366
VERSION     NM_001419705.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Boon,M., Wallmeier,J., Ma,L., Loges,N.T., Jaspers,M., Olbrich,H.,
            Dougherty,G.W., Raidt,J., Werner,C., Amirav,I., Hevroni,A.,
            Abitbul,R., Avital,A., Soferman,R., Wessels,M., O'Callaghan,C.,
            Chung,E.M., Rutman,A., Hirst,R.A., Moya,E., Mitchison,H.M., Van
            Daele,S., De Boeck,K., Jorissen,M., Kintner,C., Cuppens,H. and
            Omran,H.
  TITLE     MCIDAS mutations result in a mucociliary clearance disorder with
            reduced generation of multiple motile cilia
  JOURNAL   Nat Commun 5, 4418 (2014)
   PUBMED   25048963
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Pefani,D.E., Dimaki,M., Spella,M., Karantzelis,N., Mitsiki,E.,
            Kyrousi,C., Symeonidou,I.E., Perrakis,A., Taraviras,S. and
            Lygerou,Z.
  TITLE     Idas, a novel phylogenetically conserved geminin-related protein,
            binds to geminin and is required for cell cycle progression
  JOURNAL   J Biol Chem 286 (26), 23234-23246 (2011)
   PUBMED   21543332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 14, 2023 this sequence version replaced XM_001068366.6.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840106,
                              SAMN12840107 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               JAXUCZ010000002.1  46370017-46370201
            186-282             JAXUCZ010000002.1  46370296-46370392
            283-374             JAXUCZ010000002.1  46370563-46370654
            375-447             JAXUCZ010000002.1  46373091-46373163
            448-689             JAXUCZ010000002.1  46373625-46373866
            690-800             JAXUCZ010000002.1  46374982-46375092
            801-3303            JAXUCZ010000002.1  46375245-46377747
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..3303
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /note="multiciliate differentiation and DNA synthesis
                     associated cell cycle protein"
                     /db_xref="GeneID:688802"
                     /db_xref="RGD:1584164"
     exon            1..185
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1235
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /note="Protein Idas; multiciliate cell differentiation 1"
                     /codon_start=1
                     /product="multicilin"
                     /protein_id="NP_001406634.1"
                     /db_xref="GeneID:688802"
                     /db_xref="RGD:1584164"
                     /translation="MHACEGSAAGRRAFDSICPNRMLDLSRRSLGKPGKPERKFVPPW
                     KSFPGCGGGSPVSVYEDPLDAEPAPLPALTTIDLQDLADCTSLLGTEAPPSGDSPASQ
                     NPSLQTEADFNLQNFRDAVDDLIADSSSLTSPPLTDGDFPFSPCDVPSFGSCLSPSLD
                     PPALGSPLLPPPPCAPDLPPPPTEQYWKEVADQNQRALGTALIENNQLHVTLTQKQEE
                     IASLRERNVQLKELACRTRHLASVLDKLMITQSPAEPFQLKATTKRSLEELFSATGQA
                     GQGCAEVDAILRDISQRCEEALQNRDPKRPRLQQEPDSKDCSTRNLHGVFRGLRTDCG
                     ASSVNLSHSELEEGGSFSTPIRSHSTIRTLAFPQGKAFTIRTVTGGYKFRWVPS"
     exon            186..282
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     exon            283..374
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     exon            375..447
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     exon            448..689
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     exon            690..800
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
     exon            801..3303
                     /gene="Mcidas"
                     /gene_synonym="Idas; Mci; Mcin; Multicilin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacgcgctg tcgcccgtct caggccccaa caggtgcagc ggcactggct gcgggtcttc
       61 atcccaggat gcacgcgtgc gagggcagcg ccgccggacg ccgggccttc gacagcatct
      121 gtccgaatag gatgctggac ctgtctcggc ggtccctcgg caagcccggg aagccggaga
      181 ggaagttcgt tcctccgtgg aagtccttcc caggatgcgg cggtggcagc ccagtgtcgg
      241 tgtacgagga ccccctggac gcagaacccg ctccgctgcc agctctcacc accatagacc
      301 tgcaggacct tgcagactgc acctcgctac tcggaaccga agcgcctcct agtggtgatt
      361 ctcccgcatc tcagaatccc tccttgcaaa ctgaagccga tttcaacctg cagaatttca
      421 gagatgcggt ggatgacctc attgcagatt cgtcctcttt gacatcgcct cccctgaccg
      481 acggtgactt tcccttttcc ccttgtgatg ttccgtcttt tgggtcctgt ctctcgccat
      541 cgctggaccc acctgccttg gggtctccac tgctaccccc accgccttgt gctccagacc
      601 tgccaccgcc accaacggag cagtactgga aggaggtggc tgaccagaac cagagggcac
      661 tcgggactgc tctcatagag aataaccaac tgcacgtgac gctgacgcag aaacaggagg
      721 agatagcctc actcagggag aggaacgtac agctcaaaga actcgcttgc cggacccggc
      781 acctggcctc agtgctggat aagctgatga tcacgcagtc tccggccgag cccttccagc
      841 tcaaggcaac gacgaaaagg agcctggagg agctgttctc tgccacgggg caagccgggc
      901 agggttgcgc ggaagtggac gccatcctca gggacatctc ccagcgctgc gaggaagccc
      961 tgcagaaccg tgaccccaag cggccccggc tgcaacagga gcccgacagc aaggattgca
     1021 gcaccaggaa cctccatggt gtcttccgag ggctgcgcac cgactgcggc gccagctcgg
     1081 tgaatctgag tcacagtgag ctggaggaag gcggttcctt cagcacgccc atccgcagcc
     1141 atagcaccat ccgcactctg gccttccccc agggcaaagc cttcaccatc cggacagtca
     1201 ctggcggtta caaattccgc tgggtcccca gctgatcagg gatgtgtttt cccctaaaac
     1261 actgccctgt gtgcagaggg aagcgtctgc cagcaagtgg gactagctag aaatatttcc
     1321 cacatccggt ttccagaatt ctctgcaaat gccactccga aacttttttt tttttcagaa
     1381 acagacgtgt cttgcagtgc agtcttacct gtgcagtgga gttctgctcc gaagctgtgt
     1441 actgttcacc ttatcacggt gaaattgtgt gtgtacacac gcacacctgc ggctaagcac
     1501 acatcacagt caaacttaga agtatttatt ttctagtgct ttgatatttg tttgtttgtt
     1561 tgagacaggt acaggaggca catagcccag gctgcctcag acgtattatg attgcttctt
     1621 tttctttctg cttccgtttc cggagtgctg ggattacagg tactcaccac cataactggc
     1681 tgttttagcc ttcttctttt tttaaagtca tagagtagtc tagatttgta agaagagaga
     1741 aagtgcaagg aatgacgtga tttttccact agaggagaat catccaatca cagtcattta
     1801 agtgttctgg attcaaaacc ctgggatctg ggtgtttcaa cacatcaacc aattccccca
     1861 tcttcagagt acacctacca aaactaccgg aatatgttcg ttcagttggg aaaacaacga
     1921 caacaacacc accccctaaa cagcctggca gttgtggagc atggccaccc tagcgatgca
     1981 gtggccatcc cagcactggg gaggcagagg caggcagagt tccaggccaa cctggtctaa
     2041 caaagtgagt tccgggacag ccaaagttat gcagagaacc ctatcttgaa aagcaaagaa
     2101 acgaaaccag gcaaggccac acagttaggc aaacgctgat gcaggacatg tgctaaacac
     2161 atttgtttga aataatcatc ctataatttt acaagagtta caagtgcttg ctgctctcag
     2221 agagggcttg gacttcagta cccagaatcc atttcaatgg ctcagaatgg ggagctccag
     2281 tccaaggagc agggaggggg ggtggtatct ggcattctcc tttggttttt gtgggcatct
     2341 gtatactcct gggccacgca cgcatgcacc cccctccgcg cgcgcgcaca cacacacaca
     2401 cacacacaca cacacacaca cactcgcaca cacacacaca cacacactga gtcatataag
     2461 caaaattctt ttttaaaaaa tttatttatg tttcatgtat gtgggtacac tgttgctgtc
     2521 ttcggacaca ccagaagagg gcataggatg cccatatgga tggttgtgag ccaccatgtg
     2581 gttgctggga attgaactca ggacctctgg aagagcagtc agtgctctta acccctgagc
     2641 catttctcca gccccgcaaa attcttttaa aaagatttat agcaatgttt ccatgcattc
     2701 aactttatca gtgcaaacag aaccacctcc aaaccaaact tagttacgaa gaaagactgg
     2761 tcgagttaag caaatgatgc gtactacaca aactgggcca ctcaccatac ctcatgtggc
     2821 tagatcttct aagcaaggtg tactgaactt cccttcattc ttcctgttgt ttgcgggtcc
     2881 cccccactct gttctgaaat cacccaaatg gcatatgtca tatgtgattt ctctccacct
     2941 ccacaggctc gttctatggg ctctccctcc tcctggggct cagctgggca agcgtccaga
     3001 tgcattgcac catagtgcac agctggctct tcagtctgag tggaaatata cggtagcagg
     3061 tgggttggtt aaggcagcaa gacccgctcc tccggtctgt tacgtgtact gttatctgta
     3121 cttaaatagc catttaggaa caaaaaaaaa atgataaaac agaccacatt tcctcatatt
     3181 ttgtctaaca aatggactga aaaagtaggt tgttcagatt ttcctccata ggctcaaata
     3241 tacagttacc acaggtcaag atcaaacaaa acaaactccg aaatgaacaa acaaaacctt
     3301 tta
//
