LOCUS       NM_031758               1214 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus melanin-concentrating hormone receptor 1 (Mchr1),
            mRNA.
ACCESSION   NM_031758
VERSION     NM_031758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Ruiz-Viroga,V., de Ceglia,M., Morelli,L., Castano,E.M., Calvo,E.B.,
            Suarez,J., Rodriguez de Fonseca,F., Galeano,P. and Lagos,P.
  TITLE     Acute intrahippocampal administration of melanin-concentrating
            hormone impairs memory consolidation and decreases the expression
            of MCHR-1 and TrkB receptors
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 123, 110703 (2023)
   PUBMED   36565982
  REMARK    GeneRIF: Acute intrahippocampal administration of
            melanin-concentrating hormone impairs memory consolidation and
            decreases the expression of MCHR-1 and TrkB receptors.
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Kobayashi,Y., Okada,T., Miki,D., Sekino,Y., Koganezawa,N.,
            Shirao,T., Diniz,G.B. and Saito,Y.
  TITLE     Properties of primary cilia in melanin-concentrating hormone
            receptor 1-bearing hippocampal neurons in vivo and in vitro
  JOURNAL   Neurochem Int 142, 104902 (2021)
   PUBMED   33197527
  REMARK    GeneRIF: Properties of primary cilia in melanin-concentrating
            hormone receptor 1-bearing hippocampal neurons in vivo and in
            vitro.
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Diniz,G.B., Battagello,D.S., Klein,M.O., Bono,B.S.M.,
            Ferreira,J.G.P., Motta-Teixeira,L.C., Duarte,J.C.G., Presse,F.,
            Nahon,J.L., Adamantidis,A., Chee,M.J., Sita,L.V. and
            Bittencourt,J.C.
  TITLE     Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely
            distributed in the murine CNS in a sex-independent manner
  JOURNAL   J Neurosci Res 98 (10), 2045-2071 (2020)
   PUBMED   32530066
  REMARK    GeneRIF: Ciliary melanin-concentrating hormone receptor 1 (MCHR1)
            is widely distributed in the murine CNS in a sex-independent
            manner.
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Karlsson,C., Aziz,A.M., Rehman,F., Pitcairn,C., Barchiesi,R.,
            Barbier,E., Wendel Hansen,M., Gehlert,D., Steensland,P., Heilig,M.
            and Thorsell,A.
  TITLE     Melanin-Concentrating Hormone and Its MCH-1 Receptor: Relationship
            Between Effects on Alcohol and Caloric Intake
  JOURNAL   Alcohol Clin Exp Res 40 (10), 2199-2207 (2016)
   PUBMED   27579857
  REMARK    GeneRIF: data suggest a dual role of MCH and the MCH1-R in
            regulation of alcohol intake, possibly through mechanisms involving
            caloric intake and reward motivation.
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Bachner,D., Kreienkamp,H.J. and Richter,D.
  TITLE     MIZIP, a highly conserved, vertebrate specific
            melanin-concentrating hormone receptor 1 interacting zinc-finger
            protein
  JOURNAL   FEBS Lett 526 (1-3), 124-128 (2002)
   PUBMED   12208518
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   Lembo,P.M., Grazzini,E., Cao,J., Hubatsch,D.A., Pelletier,M.,
            Hoffert,C., St-Onge,S., Pou,C., Labrecque,J., Groblewski,T.,
            O'Donnell,D., Payza,K., Ahmad,S. and Walker,P.
  TITLE     The receptor for the orexigenic peptide melanin-concentrating
            hormone is a G-protein-coupled receptor
  JOURNAL   Nat Cell Biol 1 (5), 267-271 (1999)
   PUBMED   10559938
REFERENCE   8  (bases 1 to 1214)
  AUTHORS   Saito,Y., Nothacker,H.P., Wang,Z., Lin,S.H., Leslie,F. and
            Civelli,O.
  TITLE     Molecular characterization of the melanin-concentrating-hormone
            receptor
  JOURNAL   Nature 400 (6741), 265-269 (1999)
   PUBMED   10421368
REFERENCE   9  (bases 1 to 1214)
  AUTHORS   Lakaye,B., Minet,A., Zorzi,W. and Grisar,T.
  TITLE     Cloning of the rat brain cDNA encoding for the SLC-1 G
            protein-coupled receptor reveals the presence of an intron in the
            gene
  JOURNAL   Biochim Biophys Acta 1401 (2), 216-220 (1998)
   PUBMED   9531978
REFERENCE   10 (bases 1 to 1214)
  AUTHORS   Kolakowski,L.F. Jr., Jung,B.P., Nguyen,T., Johnson,M.P.,
            Lynch,K.R., Cheng,R., Heng,H.H., George,S.R. and O'Dowd,B.F.
  TITLE     Characterization of a human gene related to genes encoding
            somatostatin receptors
  JOURNAL   FEBS Lett 398 (2-3), 253-258 (1996)
   PUBMED   8977118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF008650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008650.1, CO405514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1214
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch-1r; Slc1"
                     /note="melanin-concentrating hormone receptor 1"
                     /db_xref="GeneID:83567"
                     /db_xref="RGD:619841"
     exon            1..104
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch-1r; Slc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1084
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch-1r; Slc1"
                     /note="MCHR; MCH1R; SLC-1; MCH-R1; MCHR-1; MCH receptor 1;
                     G-protein coupled receptor 24; somatostatin receptor-like
                     protein"
                     /codon_start=1
                     /product="melanin-concentrating hormone receptor 1"
                     /protein_id="NP_113946.1"
                     /db_xref="GeneID:83567"
                     /db_xref="RGD:619841"
                     /translation="MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMP
                     SVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQ
                     LMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMA
                     TLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFA
                     LPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQ
                     LTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQL
                     RTVSNAQTADEERTESKGT"
     exon            105..1214
                     /gene="Mchr1"
                     /gene_synonym="Gpr24; Mch-1r; Slc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggcgacc tgcaccggct gcatggatct gcaaacctcg ttgctgtcca ctggccccaa
       61 tgccagcaac atctccgatg gccaggataa tctcacattg ccggggtcac ctcctcgcac
      121 agggagtgtc tcctacatca acatcattat gccttccgtg tttggtacca tctgtctcct
      181 gggcatcgtg ggaaactcca cggtcatctt tgctgtggtg aagaagtcca agctacactg
      241 gtgcagcaac gtccccgaca tcttcatcat caacctctct gtggtggatc tgctcttcct
      301 gctgggcatg cctttcatga tccaccagct catggggaac ggcgtctggc actttgggga
      361 aaccatgtgc accctcatca cagccatgga cgccaacagt cagttcacta gcacctacat
      421 cctgactgcc atgaccattg accgctactt ggccaccgtc caccccatct cctccaccaa
      481 gttccggaag ccctccatgg ccaccctggt gatctgcctc ctgtgggcgc tctccttcat
      541 cagtatcacc cctgtgtggc tctacgccag gctcattccc ttcccagggg gtgctgtggg
      601 ctgtggcatc cgcctgccaa acccggacac tgacctctac tggttcactc tgtaccagtt
      661 tttcctggcc tttgcccttc cgtttgtggt cattaccgcc gcatacgtga aaatactaca
      721 gcgcatgacg tcttcggtgg ccccagcctc ccaacgcagc atccggcttc ggacaaagag
      781 ggtgacccgc acggccattg ccatctgtct ggtcttcttt gtgtgctggg caccctacta
      841 tgtgctgcag ctgacccagc tgtccatcag ccgcccgacc ctcacgtttg tctacttgta
      901 caacgcggcc atcagcttgg gctatgctaa cagctgcctg aacccctttg tgtacatagt
      961 gctctgtgag acctttcgaa aacgcttggt gttgtcagtg aagcctgcag cccaggggca
     1021 gctccgcacg gtcagcaacg ctcagacagc tgatgaggag aggacagaaa gcaaaggcac
     1081 ctgacaattc cccagtcgcc tccaagtcag gccaccccat caaaccgtgg ggagagatac
     1141 tgagattaaa cccaaggcta ccctgggaga atgcagaggc tggaggctgg gggcttgtag
     1201 caaccacatt ccac
//
