LOCUS       NM_139253               1742 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus multiple coagulation factor deficiency 2, ER
            cargo receptor complex subunit (Mcfd2), mRNA.
ACCESSION   NM_139253
VERSION     NM_139253.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Jayandharan,G., Spreafico,M., Viswabandya,A., Chandy,M.,
            Srivastava,A. and Peyvandi,F.
  TITLE     Mutations in the MCFD2 gene are predominant among patients with
            hereditary combined FV and FVIII deficiency (F5F8D) in India
  JOURNAL   Haemophilia 13 (4), 413-419 (2007)
   PUBMED   17610559
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Feng,Y., Gao,Y.L., Ding,F. and Liu,Y.
  TITLE     Expression change of stem cell-derived neural stem/progenitor cell
            supporting factor gene in injured spinal cord of rats
  JOURNAL   Neurosci Bull 23 (3), 165-169 (2007)
   PUBMED   17612595
  REMARK    GeneRIF: SDNSF is expressed in the gray matter of spinal cord. The
            expression of SDNSF mRNA in the spinal cord varies with injured
            time. (2) The nestin-positive cells proliferate accompanied with
            spinal cord injury repair, but do not secrete SDNSF.
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Toda,H., Tsuji,M., Nakano,I., Kobuke,K., Hayashi,T., Kasahara,H.,
            Takahashi,J., Mizoguchi,A., Houtani,T., Sugimoto,T., Hashimoto,N.,
            Palmer,T.D., Honjo,T. and Tashiro,K.
  TITLE     Stem cell-derived neural stem/progenitor cell supporting factor is
            an autocrine/paracrine survival factor for adult neural
            stem/progenitor cells
  JOURNAL   J Biol Chem 278 (37), 35491-35500 (2003)
   PUBMED   12832409
  REMARK    GeneRIF: role as an autocrine/paracrine factor in maintaining stem
            cell potential and lifelong neurogenesis in adult central nervous
            system
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139253.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF475282.1, FQ212530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                JAXUCZ010000006.1  13028050-13028118
            70-226              JAXUCZ010000006.1  13036076-13036232
            227-386             JAXUCZ010000006.1  13036918-13037077
            387-1742            JAXUCZ010000006.1  13038033-13039388
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1742
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /note="multiple coagulation factor deficiency 2, ER cargo
                     receptor complex subunit"
                     /db_xref="GeneID:246117"
                     /db_xref="RGD:628690"
     exon            1..69
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     exon            70..226
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..518
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /note="multiple coagulation factor deficiency protein 2
                     homolog; neural stem cell-derived neuronal survival
                     protein; stem cell derived neuronal survival protein"
                     /codon_start=1
                     /product="multiple coagulation factor deficiency protein 2
                     homolog precursor"
                     /protein_id="NP_640346.2"
                     /db_xref="GeneID:246117"
                     /db_xref="RGD:628690"
                     /translation="MASLQLLRGPFLCVLLWAFCVPGARAQEHGAGVHYGSVGLDKST
                     VHDQEHIMEHLEGVINQPEAEMSPQELQLHYFKMHDYDGNSLLDGLELSTAITHVHKE
                     EGSEQVPPMSEDELISIIDGVLRDDDKNNDGYIDYAEFAKSLQ"
     exon            227..386
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /inference="alignment:Splign:2.1.0"
     exon            387..1742
                     /gene="Mcfd2"
                     /gene_synonym="Sdnsf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcagggg gacggcagct ggcaaggttc atccagaagt gcttcgcgac tgcgtcaggg
       61 attatcaggg tactggaagc atggcatccc tgcagctgct cagaggtccc ttcctgtgtg
      121 ttctgctctg ggccttttgt gttcctggtg ccagggccca ggagcatggg gctggtgtcc
      181 actatggcag cgtgggcctg gacaagagca cagtgcacga ccaagagcac attatggaac
      241 atctggaagg tgtcatcaac cagccagagg cggagatgtc cccacaggaa ctacagctcc
      301 attatttcaa aatgcatgat tacgatggca acagtttgct tgatggctta gagctctcga
      361 cggccatcac tcacgtgcac aaggaggagg ggagtgagca ggtcccaccc atgagcgagg
      421 acgagctcat cagcatcata gacggtgtcc tgagagacga cgacaagaac aatgacggct
      481 acatcgacta tgcagagttt gccaagtcgc tgcagtaggc ggcaggccct ttcctgtatg
      541 cacacgtgac ccttgctaat gtgatggaca ttctggtaat gagaagcagc ttatttctgt
      601 ctactgctgc agcgctggta aagcctgtgg cagtctgtta gactggggta gggggaagcc
      661 acaaggaata cggagagaag tggggcagtg tcaatgtgtg tttaaacctg ttggacaaga
      721 gctcgaacct tccgaagggt ggtggggtat ctcaagctcc cgggaacctg actctagatg
      781 ccactctaac ttcttgatgt tatttcatgc tacctgaaaa gtaaagacag tctgctttgc
      841 caagtggaga cttcagtgac ggtggaggga gagccaaaag ccgcgtatct tcccagttgg
      901 gtcctgctct gggcagatgt ggtcagtatg ctgttcccca ggcatacagc atcacgtcct
      961 aaagccacag caggagaaga atgtcaccca cggagtccac cagacacaga gtgaagactc
     1021 cttacccact ggcattttgg aagcgaagca ccactggcct gaatacttag ccttttcaga
     1081 tcttcagttt ccttcacaac tactgccaca ccctgtgctc tgtcatttca gcccgagaga
     1141 aaccttgaat tgggtgtgct ctccgctcac cacccaccgt ttgagctccc tgaccttgtg
     1201 ttttatcctt gctcccaggg ctcccttctt ggcttatgaa ctattaactt ggtatcgcag
     1261 gtttaaactg tcagctgctc tagcctaagt cagaccagaa aagatcagtc attaagggtg
     1321 gtggctaacc ttatccaagt tttgaaggaa tgtttttaaa attacctctt tgagcctgaa
     1381 tatgataatt cttttaattt cagggaagaa cagaaaagga agagcagtag tagctgaaag
     1441 agaaacagcc ataggtcgta ctttgcgttg tgaaacgtca tagacttact gtaaacgaat
     1501 ccagaatgat ggtgggatca gaaaaagaaa ctgaatcaaa tttgctttac gatgtataga
     1561 gacttatttt ctttattaaa gtattcttgt aagaaaactt acgtatttgt aaaacagttt
     1621 tctgtgtcaa gtatttgtgc aatcggagct gacttgtaaa ctattcttgt aagatctcat
     1681 tattttgaaa gatttatata atgaactctg actatctgac aataaaatgg atgaaaaagt
     1741 aa
//
