LOCUS       NM_001009653            2409 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus methylcrotonyl-CoA carboxylase subunit 1 (Mccc1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001009653 XM_215554
VERSION     NM_001009653.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Chu,C.H. and Cheng,D.
  TITLE     Expression, purification, characterization of human
            3-methylcrotonyl-CoA carboxylase (MCCC)
  JOURNAL   Protein Expr Purif 53 (2), 421-427 (2007)
   PUBMED   17360195
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Stadler,S.C., Polanetz,R., Meier,S., Mayerhofer,P.U.,
            Herrmann,J.M., Anslinger,K., Roscher,A.A., Roschinger,W. and
            Holzinger,A.
  TITLE     Mitochondrial targeting signals and mature peptides of
            3-methylcrotonyl-CoA carboxylase
  JOURNAL   Biochem Biophys Res Commun 334 (3), 939-946 (2005)
   PUBMED   16023992
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088473.1.
            
            On Jan 13, 2005 this sequence version replaced XM_215554.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..2409
                     /gene="Mccc1"
                     /note="methylcrotonyl-CoA carboxylase subunit 1"
                     /db_xref="GeneID:294972"
                     /db_xref="RGD:1310615"
     exon            1..95
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2166
                     /gene="Mccc1"
                     /EC_number="6.4.1.4"
                     /note="methylcrotonoyl-Coenzyme A carboxylase 1 (alpha);
                     MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1;
                     3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha;
                     3-methylcrotonyl-CoA carboxylase biotin-containing
                     subunit; methylcrotonoyl-CoA carboxylase 1 (alpha)"
                     /codon_start=1
                     /product="methylcrotonoyl-CoA carboxylase subunit alpha,
                     mitochondrial"
                     /protein_id="NP_001009653.1"
                     /db_xref="GeneID:294972"
                     /db_xref="RGD:1310615"
                     /translation="MAAAALLAAVDRNQLRRVPILLLQPREWPWKHRTVKYGTTPGGS
                     ITKVLIANRGEIACRVIRTARKMGVQSVAVYSEADRNSMHVDMADEAYSIGPAPSQQS
                     YLAMEKIIQVAKSSAAQAIHPGYGFLSENMEFAEFCKQEGIIFIGPPSTAIRDMGIKS
                     TSKSIMAAAGVPVVEGYHGNDQSDECLKEHAGKIGYPVMIKAIRGGGGKGMRIIRSEK
                     EFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQR
                     RHQKIIEEAPAPGIDPEVRRRLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFYFMEMNT
                     RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIPLQGHAFEARIYAEDPDNNFM
                     PGAGPLVHLSTPPPDMSTRIETGVRQGDEVSVHYDPMIAKLVVWASDRQSALSKLRYS
                     LHQYNIVGLRTNVDFLLRLSGHSEFEAGNVHTDFIPQHHKDLLPTHSTIAKESVCQAA
                     LGLILKEKEMTSAFKLHTQDQFSPFSFSSGRRLNISYTRNMTLRSGKNDIIIAVTYNR
                     DGSYDMQIENKLFRVLGDLSNEDGYTYLKSSVNGVASKSKFILLDNTIYLFSMEGSIE
                     VGIPVPKYLSPVSAEGTQGGTIAPMTGTIEKVFVKAGDRVKAGDALMVMIAMKMEHTI
                     KAPKDGRIKKVFFSEGAQANRHAPLVEFEEEEV"
     exon            96..142
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..279
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..375
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..497
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..645
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..767
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..879
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..961
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1089
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1273
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1383
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1600
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1687
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1737
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1875
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1983
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2055
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2386
                     /gene="Mccc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacaaggca gtgcggagat ggcggcggcg gctctgttgg ctgcggtgga caggaaccag
       61 ttgcggcggg tcccgatcct gctgctgcag ccgagggaat ggccttggaa gcacagaacc
      121 gtgaaatatg gaacaacccc aggaggaagc atcaccaagg tcctcattgc aaacagagga
      181 gaaattgcct gcagggtgat acgaacagcc agaaaaatgg gtgtacaatc tgtggctgtt
      241 tacagcgagg ccgacaggaa ttccatgcat gtagatatgg cagacgaggc gtattccatt
      301 ggccctgcgc catctcagca gagctacctc gcaatggaga aaatcatcca agtggccaag
      361 agctctgcag cacaggccat ccatccagga tatggttttc tttcagaaaa tatggagttt
      421 gctgaatttt gtaagcaaga aggaattatt tttataggtc ctccttcaac tgcaattaga
      481 gacatgggta taaagagcac atccaagtcc atcatggctg ccgctggagt acctgttgtg
      541 gaaggttacc atggcaacga ccaatctgat gagtgcctga aagagcatgc agggaaaatc
      601 gggtatcctg tgatgatcaa agccatccgt ggtggaggag gaaaaggcat gaggatcatt
      661 aggtcagaaa aagaattcca agagcagcta gaatcagccc ggagggaggc aaagaagtct
      721 ttcaacgatg acgcaatgct gatcgagaag ttcgtggaca cgccaaggca tgtggaagtc
      781 caggtgtttg gtgatcacca tggcaatgca gtgtacttgt ttgaaagaga ctgtagtgtg
      841 cagaggcgac atcagaagat cattgaggag gccccagcgc ctggtattga tcctgaagta
      901 agaaggaggc tgggagaggc tgcagtcaga gctgcgaagg ctgtcaacta tgtgggagca
      961 ggaactgtgg aattcattat ggactcaaag cacaattttt atttcatgga gatgaacaca
     1021 aggctacaag tggagcatcc ggtcactgag atgatcacgg ggactgactt ggtggagtgg
     1081 cagctcagga ttgcagcagg ggaaaagatc cctttgagcc aggaagaaat ccctctgcag
     1141 ggccatgcct ttgaggccag aatctatgca gaggatcctg acaataactt catgccagga
     1201 gctggaccat tagttcacct ctctacccct ccgccagaca tgtctacaag gatcgaaact
     1261 ggagtacggc aaggagatga agtctcggtg cattacgacc ccatgatcgc aaagctggtg
     1321 gtgtgggcct cagatcgcca gtcagccctg tcaaaactga gatacagtct tcatcagtac
     1381 aacattgttg gcttgcgcac caatgtggac ttcctgctcc ggctctccgg ccactcagag
     1441 tttgaagctg ggaatgtaca cactgacttc atccctcaac accacaagga cctgctgccc
     1501 actcacagca ccatagccaa ggaatctgtg tgccaggcag ccttggggct tatcctcaaa
     1561 gagaaagaaa tgaccagcgc ttttaaactc cacactcaag atcaattctc tccgttttca
     1621 ttcagcagtg ggagaagact gaatatctct tacaccagga acatgacttt aagaagtggt
     1681 aaaaacgata taatcatagc tgtgacgtat aaccgagatg ggtcatatga catgcagatt
     1741 gaaaataagt tattccgagt cctgggcgat ctttccaatg aggatggcta tacctacctg
     1801 aagtcttctg ttaatggagt agccagtaaa tccaagttca tcctcctgga caacaccatc
     1861 tacctgtttt ctatggaagg cagtattgaa gttggcattc cagtacccaa gtacttgtct
     1921 ccagtgagtg cagaaggaac tcagggaggc accatcgctc ccatgactgg aaccattgaa
     1981 aaggtgttcg tgaaggctgg agacagagta aaggctggag acgctctgat ggttatgatc
     2041 gccatgaaga tggagcacac cataaaagcc ccaaaggacg gcaggataaa aaaggtgttt
     2101 ttcagtgaag gagcccaagc caacagacat gcacctttag tggagtttga agaggaggaa
     2161 gtctgacaaa tgccagtcac agtgaactgt gtccccagag aaatggtcta ctgcacagcg
     2221 ccttacctgt ctgcaaacag caagtgcctc ttcggtctcg atcttggaaa gaagagcttt
     2281 attaaatcaa tgatggtgtg attgtattta aaccctttta tatgtataaa ttatctcaaa
     2341 agatttcata gaaataaaac cgagttgtat tttctttatt tggaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaa
//
