LOCUS       NM_001170534            3347 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus MCC regulator of WNT signaling pathway (Mcc),
            mRNA.
ACCESSION   NM_001170534
VERSION     NM_001170534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Pangon,L., Mladenova,D., Watkins,L., Van Kralingen,C., Currey,N.,
            Al-Sohaily,S., Lecine,P., Borg,J.P. and Kohonen-Corish,M.R.
  TITLE     MCC inhibits beta-catenin transcriptional activity by sequestering
            DBC1 in the cytoplasm
  JOURNAL   Int J Cancer 136 (1), 55-64 (2015)
   PUBMED   24824780
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Arnaud,C., Sebbagh,M., Nola,S., Audebert,S., Bidaut,G., Hermant,A.,
            Gayet,O., Dusetti,N.J., Ollendorff,V., Santoni,M.J., Borg,J.P. and
            Lecine,P.
  TITLE     MCC, a new interacting protein for Scrib, is required for cell
            migration in epithelial cells
  JOURNAL   FEBS Lett 583 (14), 2326-2332 (2009)
   PUBMED   19555689
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Fukuyama,R., Niculaita,R., Ng,K.P., Obusez,E., Sanchez,J.,
            Kalady,M., Aung,P.P., Casey,G. and Sizemore,N.
  TITLE     Mutated in colorectal cancer, a putative tumor suppressor for
            serrated colorectal cancer, selectively represses
            beta-catenin-dependent transcription
  JOURNAL   Oncogene 27 (46), 6044-6055 (2008)
   PUBMED   18591935
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Kinzler,K.W., Nilbert,M.C., Vogelstein,B., Bryan,T.M., Levy,D.B.,
            Smith,K.J., Preisinger,A.C., Hamilton,S.R., Hedge,P., Markham,A. et
            al.
  TITLE     Identification of a gene located at chromosome 5q21 that is mutated
            in colorectal cancers
  JOURNAL   Science 251 (4999), 1366-1370 (1991)
   PUBMED   1848370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Sep 27, 2014 this sequence version replaced NM_001170534.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000018.1  37505772-37505915   c
            145-389             JAXUCZ010000018.1  37433524-37433768   c
            390-601             JAXUCZ010000018.1  37391700-37391911   c
            602-715             JAXUCZ010000018.1  37173261-37173374   c
            716-858             JAXUCZ010000018.1  37150676-37150818   c
            859-1001            JAXUCZ010000018.1  37128588-37128730   c
            1002-1165           JAXUCZ010000018.1  37114714-37114877   c
            1166-1372           JAXUCZ010000018.1  37112509-37112715   c
            1373-1519           JAXUCZ010000018.1  37096799-37096945   c
            1520-1609           JAXUCZ010000018.1  37095712-37095801   c
            1610-1758           JAXUCZ010000018.1  37094211-37094359   c
            1759-1899           JAXUCZ010000018.1  37089069-37089209   c
            1900-2003           JAXUCZ010000018.1  37084435-37084538   c
            2004-2187           JAXUCZ010000018.1  37079932-37080115   c
            2188-2422           JAXUCZ010000018.1  37069882-37070116   c
            2423-2629           JAXUCZ010000018.1  37066483-37066689   c
            2630-2727           JAXUCZ010000018.1  37063587-37063684   c
            2728-2850           JAXUCZ010000018.1  37051107-37051229   c
            2851-3347           JAXUCZ010000018.1  37049253-37049749   c
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..3347
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /note="MCC regulator of WNT signaling pathway"
                     /db_xref="GeneID:307449"
                     /db_xref="RGD:1561988"
     exon            1..144
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..3031
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /note="mutated in colorectal cancers; MCC, WNT signaling
                     pathway regulator"
                     /codon_start=1
                     /product="colorectal mutant cancer protein"
                     /protein_id="NP_001164005.2"
                     /db_xref="GeneID:307449"
                     /db_xref="RGD:1561988"
                     /translation="MAAASACSSNGSSSDTSSTDEEERLRRLFQTCDSDGDGFISWND
                     LLMVCRQVNMEESVAEIMSQLGTDENGKISFQDFTRCHTQLVREIRKEEVDLFMKSDK
                     SGKKKLRERITSWPTRSDNSLGALSATRESWAYDSGARDLQSPDLQSQLPLQKLLEYG
                     ESSLPQQAVLHKLLTQSPNFGTSTGGSYLELASTLHLAALASLKGDIVELNKRLQQTE
                     RERDLLEKTLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSIIAELNKKIDRLQG
                     TTIREEDEYSELRSELSQSQQEVNEDSRSVDQDQTSVSIPENQSTMVTADMDNCSDLN
                     SELQRVLTGLESVVCGRKKSSCSLSVAEVDRHIEQLTTASEHCDLAIKTVEEIEGVLG
                     RDLYPNLTEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRR
                     RVRELQTRLQSVQATGPSSPGRLTPANRPINPSTGELSTSSSSNDIPIAKIAERVKLS
                     KTRSESSSSDRPVLGSEISSVGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISES
                     KIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLAL
                     QYSEQCIEAYELLLALAETEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRK
                     TAENAAKALLMKLDGSCGGAFTVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKED
                     EQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELM
                     AMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRS
                     LSSTSSSGKEKPGKESADAASPALSLAELRTNSDSELATEFANAIRREKKLKARVQEL
                     VSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMV
                     ERHETQVRMLKQRIALLEEEHSRPHTNETSL"
     exon            145..389
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            390..601
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            602..715
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            716..858
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1001
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1165
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1372
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1519
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1609
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1758
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1899
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2003
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2187
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2422
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2629
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2727
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2850
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3347
                     /gene="Mcc"
                     /gene_synonym="RGD1561988"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccctggggc gggagcgcga tggcggctgc aagcgcttgc agcagcaacg gtagcagcag
       61 cgacacgtcc agcaccgacg aggaggagcg tctgcggcgg ctcttccaga cgtgcgacag
      121 cgacggcgat ggcttcatca gctggaatga cttgctaatg gtctgccgac aggtgaatat
      181 ggaagagtca gtggctgaga tcatgagcca actgggcaca gatgagaacg ggaagatttc
      241 cttccaagac ttcacaaggt gccacacgca gcttgttaga gagattagga aggaggaagt
      301 agacctgttc atgaagtcag acaagtctgg taaaaagaag ctgagggaaa gaatcacttc
      361 ctggcctacg agaagtgaca acagtctggg tgctttgtca gcaaccaggg agagctgggc
      421 gtatgattca ggtgccaggg atctccagag ccccgacttg cagagccagc tgcccctcca
      481 gaagctgctg gagtatggtg aaagctcttt gcctcagcag gctgtgctcc acaagcttct
      541 cacgcagtcc ccgaattttg gcacttctac aggcggaagc tatctagagc tggccagtac
      601 cctccacttg gcagccctgg catcactcaa gggagacata gtagagctga acaaacgtct
      661 gcaacaaaca gagcgtgaac gagacctcct ggaaaagacg ttggccaagg cacagtgtga
      721 gcagtcacac ctcatgagag agcatgaaga tgttcaggaa cgcacgacac tccgctatga
      781 ggagcgcatc acagagctcc acagcatcat tgcagaactc aacaagaaga tagaccgctt
      841 gcaaggtacc accatcaggg aggaagatga gtactcagaa cttcggtcag agctcagcca
      901 gagtcaacaa gaggtcaatg aagactccag aagtgtggac caagaccaga cctctgtgtc
      961 catccctgag aaccagtcta ctatggtcac tgctgacatg gacaactgca gtgacttgaa
     1021 ctcagaactg cagagagtgc tgactggtct ggagagcgtt gtctgtggca ggaagaagag
     1081 cagctgcagc ctctctgtgg ccgaggtgga caggcacatt gagcagctca ctacggccag
     1141 cgagcactgt gacttggcca ttaagacagt tgaggagatc gagggagtcc ttggtcggga
     1201 tctgtatccc aacctgactg aggagcggtc ccggtgggag aaagagctgg ctggattgcg
     1261 ggaagagaat gaaagtctga cagccatgct gtgcagcaaa gaggaggagc tgaaccgaac
     1321 caaggccact atgaatgcca tccgtgagga gcgggacagg cttcggaggc gggtccgaga
     1381 gctccaaact cggctgcaga gtgtacaagc tactggacct tctagcccgg gtcgcctcac
     1441 tcctgccaat cgcccaatta accccagcac tggggagcta agcaccagca gtagcagcaa
     1501 tgacatcccc atcgctaaga ttgccgagag agtaaagcta tcgaagacga gatctgaatc
     1561 ctcatcatct gacagaccag tcctgggctc agaaatcagt agtgttgggg tttccagcag
     1621 tgtggcagag cacctggccc actcacttca ggactgctcc aatatccagg aaatttttca
     1681 aacactctac tcacacggat ctgccatctc tgaaagcaag attagagagt ttgaggtgga
     1741 aacggagcgg ttgaatagtc gtattgaaca cctcaaatcg caaaatgatc ttctcaccat
     1801 aaccctggag gaatgtaaaa gcaacgccga aaggatgagc atgctggtgg ggaagtacga
     1861 gtccaatgcc acagccctaa ggctggcctt gcagtacagt gagcagtgca tagaagccta
     1921 tgaactcctg ctggccctgg ctgagacaga gcagagcctt atcctggggc aattccgggc
     1981 agctggtgtg ggctcctccc ctggagacca gtcaggggat gagaatatca ctcagatgct
     2041 taagagggct cacgactgcc ggaagactgc tgagaacgcc gccaaagccc tgctcatgaa
     2101 gctggatggc agctgtgggg gagccttcac agtggctggc tgcagtgtgc agccctggga
     2161 gagcctgtcc tccaacagcc ataccagcac aactagctct acagccagca gctgtgacac
     2221 agaattcact aaagaagatg aacaaaggct gaaggattat atccagcagc tcaagaatga
     2281 cagagctgca gtcaagctga ccatgctgga gttggagagc atccacattg atccactcag
     2341 ctatgatgtc aagccaagag gcgacagcca gaggctggac ctggagaatg ccgtgctgat
     2401 gcaggagctg atggccatga aggaggagat ggctgagctg aaagcccagc tctatctgct
     2461 ggagaaagag aagaaagccc tggagctgaa gctgagcacg agggaagcac aggagcaggc
     2521 ctatctggtg cacatcgagc acctcaagtc tgaagtggag gaacagaagg agcaacggat
     2581 gcggtccctg agctccacaa gcagcagcgg caaagagaag cctggcaagg agagtgctga
     2641 tgctgcctcc ccagctttgt cactggctga actaaggact aacagtgaca gtgagctggc
     2701 cactgagttt gccaacgcca tccgacggga aaagaagctg aaggctagag ttcaagagct
     2761 ggtcagcgcc ttggaaagac tcaccaaaag cagtgaaatc agacaccagc agtcggcaga
     2821 gtttgttaat gacctgaaac gggccaacag caatctggta gctgcctatg aaaaagcaaa
     2881 gaagaagcat caaaacaagc tgaagaagct ggaatctcag atgatggcca tggtggagcg
     2941 acatgagacc caagtgagaa tgctgaagca gagaatagca ctgctggagg aagagcattc
     3001 caggccacat accaacgaaa cttcactgta acaggcacta tggtggcaaa gctctgcccg
     3061 caagaggcta acctggagca gctctggagc ccaaggaagg agggactgtt gggatgaaga
     3121 gtggaaaggg atagaggcta caggctccac ccttgggggt gtgggtattg tggattatgt
     3181 atgcataggt tccagctgct ctaggcctgg ccgcaaaggg catctacaat ggcttcagcc
     3241 acaagattag ccacaccttg tttctgcttt ccccattaca gttctcaatt gttctgtgct
     3301 gcagtgggaa tccaagcatt tgtggatctc caagactccc caccccc
//
