LOCUS       NM_023983               2933 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus melanoma cell adhesion molecule (Mcam),
            transcript variant 1, mRNA.
ACCESSION   NM_023983 XM_346823
VERSION     NM_023983.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2933)
  AUTHORS   Yamchi,N.N., Rahbarghazi,R., Bedate,A.M., Mahdipour,M., Nouri,M.
            and Khanbabaee,R.
  TITLE     Menstrual blood CD146+ mesenchymal stem cells reduced fibrosis rate
            in the rat model of premature ovarian failure
  JOURNAL   Cell Biochem Funct 39 (8), 998-1008 (2021)
   PUBMED   34477225
  REMARK    GeneRIF: Menstrual blood CD146(+) mesenchymal stem cells reduced
            fibrosis rate in the rat model of premature ovarian failure.
REFERENCE   2  (bases 1 to 2933)
  AUTHORS   Marr,N., Meeson,R., Kelly,E.F., Fang,Y., Peffers,M.J.,
            Pitsillides,A.A., Dudhia,J. and Thorpe,C.T.
  TITLE     CD146 Delineates an Interfascicular Cell Sub-Population in Tendon
            That Is Recruited during Injury through Its Ligand Laminin-alpha4
  JOURNAL   Int J Mol Sci 22 (18), 9729 (2021)
   PUBMED   34575887
  REMARK    GeneRIF: CD146 Delineates an Interfascicular Cell Sub-Population in
            Tendon That Is Recruited during Injury through Its Ligand
            Laminin-alpha4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2933)
  AUTHORS   Obara,M., Sato,S., Takahashi,K., Kondo,Y., Hirose,M., Nata,K. and
            Taira,E.
  TITLE     Expression of cell adhesion molecule, Gicerin/CD146 during the
            formation of heart and in the cardiac hypertrophy
  JOURNAL   Mol Cell Biochem 476 (5), 2021-2028 (2021)
   PUBMED   33515199
  REMARK    GeneRIF: Expression of cell adhesion molecule, Gicerin/CD146 during
            the formation of heart and in the cardiac hypertrophy.
REFERENCE   4  (bases 1 to 2933)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 2933)
  AUTHORS   Liu,G., Sun,X., Bian,J., Wu,R., Guan,X., Ouyang,B., Huang,Y.,
            Xiao,H., Luo,D., Atala,A., Zhang,Y. and Deng,C.
  TITLE     Correction of diabetic erectile dysfunction with adipose derived
            stem cells modified with the vascular endothelial growth factor
            gene in a rodent diabetic model
  JOURNAL   PLoS One 8 (8), e72790 (2013)
   PUBMED   24023647
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2933)
  AUTHORS   Taira,E., Kohama,K., Tsukamoto,Y., Okumura,S. and Miki,N.
  TITLE     Gicerin/CD146 is involved in neurite extension of NGF-treated PC12
            cells
  JOURNAL   J Cell Physiol 204 (2), 632-637 (2005)
   PUBMED   15880440
  REMARK    GeneRIF: Increase of gicerin expression by NGF promotes the
            gicerin-gicerin homophilic interaction resulting in the neurite
            extension.
REFERENCE   7  (bases 1 to 2933)
  AUTHORS   Taira,E., Kohama,K., Tsukamoto,Y., Okumura,S. and Miki,N.
  TITLE     Characterization of Gicerin/MUC18/CD146 in the rat nervous system
  JOURNAL   J Cell Physiol 198 (3), 377-387 (2004)
   PUBMED   14755543
REFERENCE   8  (bases 1 to 2933)
  AUTHORS   Okumura,S., Kohama,K., Kim,S., Iwao,H., Miki,N. and Taira,E.
  TITLE     Induction of gicerin/CD146 in the rat carotid artery after balloon
            injury
  JOURNAL   Biochem Biophys Res Commun 313 (4), 902-906 (2004)
   PUBMED   14706627
  REMARK    GeneRIF: expression of gicerin was increased in the rat carotid
            arteries after balloon injury. Gicerin might be involved in the
            arteriosclerotic neointima formation in the artery.
REFERENCE   9  (bases 1 to 2933)
  AUTHORS   Tsukamoto,Y., Egawa,M., Hiroi,S., Furuya,M., Tsuchiya,S.,
            Sasaki,F., Miki,N. and Taira,E.
  TITLE     Gicerin, an Ig-superfamily cell adhesion molecule, promotes the
            invasive and metastatic activities of a mouse fibroblast cell line
  JOURNAL   J Cell Physiol 197 (1), 103-109 (2003)
   PUBMED   12942546
REFERENCE   10 (bases 1 to 2933)
  AUTHORS   Li,B.S., Su,Q.N., Kiyama,H., Miki,N., Robinow,D.R. and Zhang,L.
  TITLE     Expression of gicerin, a novel cell adhesion molecule, is
            upregulated in the astrocytes after hypoglossal nerve injury in
            rats
  JOURNAL   Neurosci Lett 260 (3), 149-152 (1999)
   PUBMED   10076889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070916.1 and AB035506.1.
            
            On Oct 6, 2005 this sequence version replaced NM_023983.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035506.1, SRR8487230.91818.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1595              BC070916.1         1-1595
            1596-2108           AB035506.1         1594-2106
            2109-2933           BC070916.1         1991-2815
FEATURES             Location/Qualifiers
     source          1..2933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..2933
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /note="melanoma cell adhesion molecule"
                     /db_xref="GeneID:78967"
                     /db_xref="RGD:620463"
     exon            1..85
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1965
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell surface glycoprotein MUC18; gicerin;
                     melanoma-associated antigen MUC18; l-gicerin"
                     /codon_start=1
                     /product="cell surface glycoprotein MUC18 isoform 1
                     precursor"
                     /protein_id="NP_076473.2"
                     /db_xref="GeneID:78967"
                     /db_xref="RGD:620463"
                     /translation="MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGN
                     TALLKCGPAHPSGNFSQVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGAT
                     LALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEV
                     ATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKED
                     KDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLT
                     DGNPQPHFTINKKNPSTEEMEEESTDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLS
                     SDPLELLVNYVSDVQVDPTAPEVQEGDSLTLTCKAESNQDLEFEWLRDKTGQLLGKGP
                     ILQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGIFGSPWMAAKERKVWAQENAML
                     NLSCEASGHPQPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLG
                     SNTTVIILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVA
                     VIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMA
                     LLQGSNGDKRAPGDQGEKYIDLRH"
     exon            86..216
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            217..424
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            425..495
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            496..583
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            584..763
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            764..885
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1048
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1167
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1309
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1431
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1573
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1669
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1817
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1935
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2907
                     /gene="Mcam"
                     /gene_synonym="CD146; Muc18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctccgtc ggggaagcat ggggctgccc aggctggtct gcgccttctt attcgctgcc
       61 tgctgctgct gtcgcagcgc cacgggtgtg ccaggagagg aaaagcagcc cacacccacg
      121 ccggacccgg tggaggtaga agtgggcaac acggcccttc tgaagtgtgg ccccgcacat
      181 ccctcaggca acttcagcca agtggaatgg tttttgattc acaaggagag gcagataccc
      241 attttccgtg tgcaccaggg caagggccag agtgaacctg gggaatatga acaccgcctc
      301 agcctccacg gcccaggagc tactctggcc ctgagtcaag tcactcccca tgatgatcgg
      361 atgttcctgt gtaagagcaa gcagccacgg ccccaggatc actatgttca gctgcaagtc
      421 tacaaggctc cagaggagcc aactatccaa gccaacgtgc tgggcatcca cgtggacata
      481 caagagctta aggaggttgc tacctgtgtg gggaggaatg gctaccccat tcctcaagtc
      541 atctggtaca agaatggccg gcccttgcaa gaggaggaga accgcgttca tatccagtcg
      601 tcacagaccg tggagtccag tggcttgtac accttgaaga gtgttctaag tgcacggcta
      661 gtcaaggagg acaaagatgc ccagttttac tgtgaactca gctaccggct gcccagtggg
      721 aaccgcatga aggaatctaa ggaggtcact gtccctgtct tataccctgc agaaaaagtg
      781 tgggtggagg tagaacccgt gggactgctg aaggaagggg accatgtgaa gatcaggtgt
      841 ctgactgacg gcaaccctca accccacttc actatcaaca agaagaaccc cagcactgag
      901 gagatggaag aggaaagcac cgatgaaaac ggtctcctgt ccttggagcc cgcccagaag
      961 caccacagtg gggtctacca atgtcagagc ctagacttgg aaactacagt tatgctgtcg
     1021 agtgaccccc tggagctgct ggtgaactat gtgtctgatg ttcaagtgga tccaactgcc
     1081 cctgaagtcc aggaaggtga tagcctcaca ctgacctgta aggcagagag taaccaggac
     1141 cttgagtttg agtggctgag agacaagaca ggccagcttc tgggaaaggg gcccatcctt
     1201 cagctaaaca acgtgaaaag ggaagcaggg ggaagatatc tctgtgtggc atctgtcccc
     1261 agcgttcctg gcttgaatcg cacacggcgg gtcagcgtgg gcatttttgg gtccccgtgg
     1321 atggcagcaa aggagaggaa ggtgtgggcg caagagaatg caatgctgaa tctgtcttgt
     1381 gaggcttcag gccatcctca gcccaccatc tcctggaata tcaatggctc ggcaactgaa
     1441 tggaacccag atcctcagac agtagtgagc accttgaatg tccttgtgac cccagagctt
     1501 ctggagaccg gtgcagaatg tacagcctcc aactccctgg gctcaaacac cacggtcatc
     1561 attctgaagc tcgtcacttt aaccaccctc acacctgact ccagccaaac cactggcctc
     1621 agcaccccca cagtcagtcc tcacagcaga gccaacagca cctccacaga gaaaaagctg
     1681 ccacagcagg agagcaaagg tgtggtcatc gtggctgtga tagtatgtac gctggtgctt
     1741 gctgtactgg gcgctaccct ctattacttc tacaagaagg gcaaactgcc ttgtggacgc
     1801 tcaggaaaac aggagatcac gctgcccccg actcgtaaga gtgaatttgt agttgaagtt
     1861 aagtcagata agctcccaga agagatggct ctccttcagg gcagcaacgg tgacaagagg
     1921 gctccaggag accagggaga gaaatacatc gatctgaggc attagccggt tcaccaatgt
     1981 tttgggctcc ctgctcagtc ttcaccccaa gctaaagcct ccagagggac agcggggaag
     2041 atccttactc aactgccctg tagaccaggt ccagagagct gcaacaagag tcacctggaa
     2101 gacctcactt ggccacggag gcctggtttt agagaccaag acctcctctg tgtccactga
     2161 gttatgctta tcccaagggg cctgtctccc agggcttttg ttcctccctt acacagccag
     2221 tggtggcaaa tccccccacc cacccacccc tgcccctggc cttaagctgt gtgggcttgc
     2281 ctctctctcc cctcacagtc tgtcttcctg acagctgtgt cacatgatac aggaccgggg
     2341 cacatggtca cattatcctg ttcacattgg ttccttacga gaatcgcctg caactcattc
     2401 agggcctcat ttggaacgct ttccctttgg gcagaagtca ggaggtggcg tgagtcctca
     2461 gatacatccc tgagtaagga agctgggcac tgtttctgat ttttgtcgtt gttttggtgt
     2521 tttttgaagg ctactgagcc caagcttcct gcatttcctt agtgggtaat gggaatggaa
     2581 agacaagaga cagaacagag aggtctactg ttcatgggtt atggtatgtt agtaccaaat
     2641 ttttacatgt gagctctggg gcccaggtcc taagagagcc caagtgggag aatggtgctt
     2701 agatgaaagg ctgacctggc aagagcttgt gaggtatgta tctgtgagag agagagagag
     2761 agagagagag agagagagag agagagagag tgtgtgtgtg tgtgtgtgtg tgcacctata
     2821 tatgtatata tatggttttg tctgtaaatt tgcagattat ttccttttat atgtgtgtta
     2881 ggaaaataaa gtgttattgt tccaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
