LOCUS       NM_013182               4113 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus melanocortin 5 receptor (Mc5r), mRNA.
ACCESSION   NM_013182 XM_017600861
VERSION     NM_013182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Shukla,C., Britton,S.L., Koch,L.G. and Novak,C.M.
  TITLE     Region-specific differences in brain melanocortin receptors in rats
            of the lean phenotype
  JOURNAL   Neuroreport 23 (10), 596-600 (2012)
   PUBMED   22643233
  REMARK    GeneRIF: Compared with low-activity rats, high-activity rats show
            enhanced mRNA expression of MCRs in the brain, specifically of MC3R
            in the paraventricular nucleus, and MC4R and MC5R in the
            perifornical lateral hypothalamus.
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Malik,I.A., Triebel,J., Posselt,J., Khan,S., Ramadori,P.,
            Raddatz,D. and Ramadori,G.
  TITLE     Melanocortin receptors in rat liver cells: change of gene
            expression and intracellular localization during acute-phase
            response
  JOURNAL   Histochem Cell Biol 137 (3), 279-291 (2012)
   PUBMED   22183812
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Catania,A., Lonati,C., Sordi,A., Carlin,A., Leonardi,P. and
            Gatti,S.
  TITLE     The melanocortin system in control of inflammation
  JOURNAL   ScientificWorldJournal 10, 1840-1853 (2010)
   PUBMED   20852827
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Chan,L.F., Webb,T.R., Chung,T.T., Meimaridou,E., Cooray,S.N.,
            Guasti,L., Chapple,J.P., Egertova,M., Elphick,M.R., Cheetham,M.E.,
            Metherell,L.A. and Clark,A.J.
  TITLE     MRAP and MRAP2 are bidirectional regulators of the melanocortin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 106 (15), 6146-6151 (2009)
   PUBMED   19329486
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Wachira,S.J., Temoney,S., Ramlochansingh,C. and Hughes-Darden,C.A.
  TITLE     Prevalence of melanocortin system transcripts in rat salt
            homeostasis endocrine tissues
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 53 (4), 8-14 (2007)
   PUBMED   17531155
  REMARK    GeneRIF: Expression levels of melanocortin 3 receptor (MC3R) and
            melanocortin 5 receptor (MC5R) were not significantly affected by
            high dietary salt intake in either WKY or SP-SHR tissues
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Lindqvist,N., Napankangas,U., Lindblom,J. and Hallbook,F.
  TITLE     Proopiomelanocortin and melanocortin receptors in the adult rat
            retino-tectal system and their regulation after optic nerve
            transection
  JOURNAL   Eur J Pharmacol 482 (1-3), 85-94 (2003)
   PUBMED   14660008
  REMARK    GeneRIF: Mc5 receptor expression is localized to the ganglion cell
            and inner nuclear layers in adult retina and superior colliculus
            and is decreased after optic nerve transection.
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Buggy,J.J.
  TITLE     Binding of alpha-melanocyte-stimulating hormone to its
            G-protein-coupled receptor on B-lymphocytes activates the Jak/STAT
            pathway
  JOURNAL   Biochem J 331 (Pt 1) (Pt 1), 211-216 (1998)
   PUBMED   9512481
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Chagnon,Y.C., Chen,W.J., Perusse,L., Chagnon,M., Nadeau,A.,
            Wilkison,W.O. and Bouchard,C.
  TITLE     Linkage and association studies between the melanocortin receptors
            4 and 5 genes and obesity-related phenotypes in the Quebec Family
            Study
  JOURNAL   Mol Med 3 (10), 663-673 (1997)
   PUBMED   9392003
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Griffon,N., Mignon,V., Facchinetti,P., Diaz,J., Schwartz,J.C. and
            Sokoloff,P.
  TITLE     Molecular cloning and characterization of the rat fifth
            melanocortin receptor
  JOURNAL   Biochem Biophys Res Commun 200 (2), 1007-1014 (1994)
   PUBMED   8179577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before May 31, 2019 this sequence version replaced
            XM_017600861.1, NM_013182.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224332.1, SRR26643295.56795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               JAXUCZ010000018.1  64185013-64185562
            551-4113            JAXUCZ010000018.1  64186492-64190054
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4113
                     /gene="Mc5r"
                     /note="melanocortin 5 receptor"
                     /db_xref="GeneID:25726"
                     /db_xref="RGD:3058"
     exon            1..550
                     /gene="Mc5r"
                     /inference="alignment:Splign:2.1.0"
     exon            551..4113
                     /gene="Mc5r"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..1568
                     /gene="Mc5r"
                     /note="MC5-R"
                     /codon_start=1
                     /product="melanocortin receptor 5"
                     /protein_id="NP_037314.1"
                     /db_xref="GeneID:25726"
                     /db_xref="RGD:3058"
                     /translation="MNSSSHLTLLDLTLNASEDNILGQNVNNKSSACEDMGIAVEVFL
                     TLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETITIYLINNK
                     HVVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSG
                     VIIACIWTFCISCGIVFIIYYESKYVIVCLISMFFTMLFFMVSLYIHMFLLARNHVKR
                     IAASPRYNSVRQRASMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCACFMSY
                     FNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIICCHGFRRTCTLLGRY"
ORIGIN      
        1 agaacagggc agatcagttc attgaactgg acagttttaa tcagtgagtt agaagaaagg
       61 ggggaggggg aagacaaagc gaatcagtag ctggaaaacc catctgtgcg cacctaggga
      121 gaaagatttg taactttgga agcacctccg atctaagagc agtgctttgc aagaacctag
      181 cggtggacca ctaggtggca ctgcaaacac gactcctagg ctcccaagct ggtggctgca
      241 agttgctgga gacctgaact cagaagtccg agaggcggcg atctgggcgg gcggaggagg
      301 ctgtttaaaa gcagagtggt gaggtgccag ttgaggtcgg gaggagactg cgccctggcg
      361 atggccctac tctctcgccg aggtctgcgc aggtggacat caggtgccca ggcagagcaa
      421 agcgtccagt gaggacgcct ggcccggatg caagatcaga gctgggtaaa ggacacaact
      481 cgatctccca gaaaccgcct ggaacccgtg aggaatcatg cttacctttg cgtggagcag
      541 agcagaatgg taagtttgag gccaagaagt ggaggcattt tcttccagcg atgaactcct
      601 cgtctcacct gactttattg gatcttaccc tgaacgcctc ggaggacaac atcctaggac
      661 aaaatgtcaa taacaagtct tccgcctgcg aagacatggg cattgccgtg gaggtgttcc
      721 taactctggg tctcgtcagc ctcttggaga acatcctggt catcggggcc atagtgaaaa
      781 acaagaacct gcactcacct atgtacttct ttgtgggcag cctagcggtg gccgacatgc
      841 tggtgagcat gtccaacgcc tgggagacca tcaccatata cttgataaat aacaaacacg
      901 tggtgatagc agacaccttt gtgcgccaca tcgacaacgt gttcgactcc atgatctgca
      961 tttctgtggt ggcctccatg tgcagcctgt tggccattgc ggtggacagg tacatcacca
     1021 tcttctacgc cctgcgctac caccacatca tgacggccag gcgctcgggg gtgattatcg
     1081 cctgcatctg gaccttttgc ataagctgcg gtatcgtctt catcatttac tacgaatcca
     1141 agtacgtgat cgtctgcctc atctccatgt tcttcaccat gctgttcttc atggtgtctc
     1201 tctatataca catgttcctc ctggcccgga accatgtcaa gcggatagcg gcttccccca
     1261 gatacaactc tgtgaggcaa agggccagca tgaagggtgc tatcaccctc accatgctgc
     1321 tggggatttt cattgtctgc tggtccccct tcttccttca ccttatccta atgatctcgt
     1381 gccctcagaa cgtctattgc gcttgcttta tgtcttactt taacatgtac cttatactga
     1441 tcatgtgcaa ttccgtgatc gatcccctca tctacgccct ccgcagccaa gagatgcgga
     1501 ggacctttaa ggagatcatc tgttgtcatg ggttcaggcg aacttgtacg ctccttggca
     1561 ggtattaaaa caccttcccc tctcggtgcc tctcatctct cagtcaatta ggttcagcca
     1621 gggcatgagc agggccgcta aggagctcag atggactcct cctccttatc tccttggcag
     1681 ctcggtttgg ttatgtcgtg ttggaagtgc gcatgtgtga gtcgtctccg tggtgagact
     1741 ggcctgagac agttgtcttt ttactccttg ctcactctct gctccccagt tccattttta
     1801 gaaggtttca ccattctctg cttgacctgg taagtggcct caggagatgc ataacctcct
     1861 gggtgagttg tcattgaaag aaacgccgtg gcggcctata ttaccattag tggcctttgt
     1921 gtttctctag cttccctcac gctgcagtcc atttttgcag aattgcacct tttgccttct
     1981 ttcgggaatg gggagacatc cggctgcttt tcatttgaaa cttttatctg ctgtgggcgt
     2041 ctctacagtt tgcctatcct agacttctgg tttaccaccc tcatttagaa ttgtctggga
     2101 accaacctta actacctata cttctgtagt tttggactta gacgaaaatg tctatgctac
     2161 gaaccttgct tcgtgttctg tgaaaacctc gaggactctc actgtcttat ttttgactca
     2221 attcagcgtt tccaagaaat ttaggggggt ggggtcatac cggggattct gggtacaaac
     2281 ccaccctcac tccatttagc acatgcccag agtccaacta ggttggcgtt ctcccacgta
     2341 gtcatccagc atctcctggt gtctgaaacg tcctcactag atgctttgca gcatcttaac
     2401 ctgcctgtag ccatcatcaa aggcccctgt tccacaagag agagacacca ttttctccag
     2461 tctgacgtgg aggaaagata tgtaagcagt aaccatgaag acactggctg tgtgtcctta
     2521 attccactct gggccccaca tctgtgctga cctctcagat ccaaactcca catctgtgct
     2581 gacctctcag aatggccaaa agagctatct gaaagaaaaa aaaaaggtag aacgtcttgt
     2641 aaaaattaac acgtaggata tttttttttt ttttttagtt atttaaaaga gctgaaccac
     2701 ttgggtggga ttggacaagg taacgtgaag ttaccgtaca gaggtcagtg gtcagagcag
     2761 tgttttggac gccaagagac ttgctgtgct caacagagag ccacgtggcc ctctggatcc
     2821 cagggaagat cccaggggta gaataagaca tcaatcttgg tggttacact gctcatccgg
     2881 acgcccaacc atcactaggc tgattctctg ctccgggtgc taaaatgact taactgcaaa
     2941 tcttgacctt tattattaag gcgattaaga acacgctcga ctgcatttta atctcaatgt
     3001 aaacaaaatg gtccttgtgt tccaatgctg ttacgcttgg gatcttcgtc tgaagtgaag
     3061 ggcacgagtc cttacagctc tcagattcca ttcacagtag tgtgctggaa ttagtatttt
     3121 ctctttcgtt ggacacttga catctaggct ttttctaaat gaaagaaaaa tgtaaatcag
     3181 gcagcagaca tagaggcgat cccacagtga actctggatg taagagggcc ctgtctactg
     3241 aagattgtaa gagaatagtg tcataattaa cttgtgaaca tgatcggtga cccctctagg
     3301 agctcagcat agaaaagaat agtgctggaa ttaacagcaa ggagcatgaa tgagatgtcc
     3361 aaacctttac aaaatggaaa acaagcagat tgtttgcaac tgatttgcaa agagcctcta
     3421 agcctttcaa aatgttgcct gttggtagct gctggatatt ctcatgcagg aggtaaaaat
     3481 tctcattgta gccattagaa agcagagtcc atgttgccgt ggaggtcaca gggacaggat
     3541 gggcttcctc ccatctgtac agagcaagcg cttacttgca gggttggtaa tttccaagtc
     3601 aaatcttctg cctagcgtcc atgaggatta agtaaggtga ctggagttct gatcacaatg
     3661 gtagactaga catcgacctt ggtggttaga ctgctcatcc ggacacccaa ccgtcactag
     3721 tctaattctc tgctccgggt gctaaaagga cttactacaa atcttgacct ttatattaag
     3781 gtatttaaga acacgctcga ctgcatttta atctctacgt aaacagaatg gcccttgtgt
     3841 tccaatgttg ttatgcttgg gaaaatatat gcgtgtagca acttgttaca tttatgcaag
     3901 taagctgacc tcaaaatgaa gtccccttac caacaacaaa aaaagaatac acaggcatgt
     3961 caaacatgtg gcattgtatg ttagctttat gtttccgtgg gaaataaatt tgctgtaaaa
     4021 tatgtgttca aagaaattgt tagtaaagta gaatgattca atttgtacta ataaacatat
     4081 atgaaattaa taaaatggat ggattgaact ata
//
