LOCUS       NM_013099               1888 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus melanocortin 4 receptor (Mc4r), mRNA.
ACCESSION   NM_013099
VERSION     NM_013099.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1888)
  AUTHORS   Carniglia,L., Turati,J., Saba,J., Lopez Couselo,F., Romero,A.C.,
            Caruso,C., Durand,D. and Lasaga,M.
  TITLE     Melanocortin-receptor 4 activation modulates proliferation and
            differentiation of rat postnatal hippocampal neural precursor cells
  JOURNAL   Neuropharmacology 257, 110058 (2024)
   PUBMED   38960135
  REMARK    GeneRIF: Melanocortin-receptor 4 activation modulates proliferation
            and differentiation of rat postnatal hippocampal neural precursor
            cells.
REFERENCE   2  (bases 1 to 1888)
  AUTHORS   Dabeer,S. and Raisuddin,S.
  TITLE     Perinatal exposure to environmental endocrine disruptor bisphenol A
            aggravates the onset of non-alcoholic fatty liver disease (NAFLD)
            in weanling F1 offspring of obese rats
  JOURNAL   Environ Sci Pollut Res Int 30 (2), 3146-3165 (2023)
   PUBMED   35945320
REFERENCE   3  (bases 1 to 1888)
  AUTHORS   Sharfman,N.M., Kelley,L.K., Secci,M.E. and Gilpin,N.W.
  TITLE     Melanocortin-4 receptor signaling in the central amygdala mediates
            chronic inflammatory pain effects on nociception
  JOURNAL   Neuropharmacology 210, 109032 (2022)
   PUBMED   35304172
  REMARK    GeneRIF: Melanocortin-4 receptor signaling in the central amygdala
            mediates chronic inflammatory pain effects on nociception.
REFERENCE   4  (bases 1 to 1888)
  AUTHORS   Quintanilla,R.A., Perez,M.J., Aranguiz,A., Tapia-Monsalves,C. and
            Mendez,G.
  TITLE     Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage
            and Mitochondrial Dysfunction in Cultured Hippocampal Neurons
            Exposed to Ethanol
  JOURNAL   Neurotox Res 38 (2), 421-433 (2020)
   PUBMED   32378055
  REMARK    GeneRIF: Activation of the Melanocortin-4 Receptor Prevents
            Oxidative Damage and Mitochondrial Dysfunction in Cultured
            Hippocampal Neurons Exposed to Ethanol.
REFERENCE   5  (bases 1 to 1888)
  AUTHORS   Upadhya,M.A., Upadhya,H.M., Borkar,C.D., Choudhary,A.G., Singh,U.,
            Chavan,P., Sakharkar,A., Singru,P., Subhedar,N.K. and Kokare,D.M.
  TITLE     Nicotine-induced Brain Stimulation Reward is Modulated by
            Melanocortin-4 Receptors in Ovariectomized Rats
  JOURNAL   Neuroscience 431, 205-221 (2020)
   PUBMED   32035118
  REMARK    GeneRIF: Nicotine-induced Brain Stimulation Reward is Modulated by
            Melanocortin-4 Receptors in Ovariectomized Rats.
REFERENCE   6  (bases 1 to 1888)
  AUTHORS   Mergen,M., Mergen,H., Ozata,M., Oner,R. and Oner,C.
  TITLE     A novel melanocortin 4 receptor (MC4R) gene mutation associated
            with morbid obesity
  JOURNAL   J Clin Endocrinol Metab 86 (7), 3448 (2001)
   PUBMED   11443223
REFERENCE   7  (bases 1 to 1888)
  AUTHORS   Kiefer,L.L., Veal,J.M., Mountjoy,K.G. and Wilkison,W.O.
  TITLE     Melanocortin receptor binding determinants in the agouti protein
  JOURNAL   Biochemistry 37 (4), 991-997 (1998)
   PUBMED   9454589
REFERENCE   8  (bases 1 to 1888)
  AUTHORS   Chagnon,Y.C., Chen,W.J., Perusse,L., Chagnon,M., Nadeau,A.,
            Wilkison,W.O. and Bouchard,C.
  TITLE     Linkage and association studies between the melanocortin receptors
            4 and 5 genes and obesity-related phenotypes in the Quebec Family
            Study
  JOURNAL   Mol Med 3 (10), 663-673 (1997)
   PUBMED   9392003
REFERENCE   9  (bases 1 to 1888)
  AUTHORS   Huszar,D., Lynch,C.A., Fairchild-Huntress,V., Dunmore,J.H.,
            Fang,Q., Berkemeier,L.R., Gu,W., Kesterson,R.A., Boston,B.A.,
            Cone,R.D., Smith,F.J., Campfield,L.A., Burn,P. and Lee,F.
  TITLE     Targeted disruption of the melanocortin-4 receptor results in
            obesity in mice
  JOURNAL   Cell 88 (1), 131-141 (1997)
   PUBMED   9019399
REFERENCE   10 (bases 1 to 1888)
  AUTHORS   Alvaro,J.D., Tatro,J.B., Quillan,J.M., Fogliano,M., Eisenhard,M.,
            Lerner,M.R., Nestler,E.J. and Duman,R.S.
  TITLE     Morphine down-regulates melanocortin-4 receptor expression in brain
            regions that mediate opiate addiction
  JOURNAL   Mol Pharmacol 50 (3), 583-591 (1996)
   PUBMED   8794897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 23, 2015 this sequence version replaced NM_013099.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U67863.2, SRR26360176.190729.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1888              JAXUCZ010000018.1  62689798-62691685   c
FEATURES             Location/Qualifiers
     source          1..1888
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1888
                     /gene="Mc4r"
                     /note="melanocortin 4 receptor"
                     /db_xref="GeneID:25635"
                     /db_xref="RGD:3057"
     exon            1..1888
                     /gene="Mc4r"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1407
                     /gene="Mc4r"
                     /note="MC4-R"
                     /codon_start=1
                     /product="melanocortin receptor 4"
                     /protein_id="NP_037231.1"
                     /db_xref="GeneID:25635"
                     /db_xref="RGD:3057"
                     /translation="MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQL
                     FVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETI
                     VITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI
                     MTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLM
                     ARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPY
                     CVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY"
ORIGIN      
        1 atgctcggga agctcaactt ctgagaggct gcgctgtgag tgtgggcgcg cagatgcaga
       61 cgcggctccc agctctccag cgactctcag gaaaaggact ctgaaaagac cccgagtgaa
      121 tactacggct aaagggaaag ccacaaaaaa cgaactgcag actggtcagc cgagagtgag
      181 ctttcagtag cgccagcttc taaagaaatg atgagcaaag ctgaacccag aagagaccaa
      241 caactccttt gcaagctccg ctgcttctga ccctgttcac cgcaggcgcc aactgcagcc
      301 tcccaacttc tacaggcaga caggctggga gaaaaaccac tcggggcttc cctgacctag
      361 gaggttggac cacttcaagg aggattcgaa tccagctgct gcaggaagat gaactccacc
      421 caccaccatg gcatgtatac ttccctccac ctctggaacc gcagcagcca cgggctgcac
      481 ggcaatgcca gcgagtctct ggggaagggg cactcagacg gaggatgcta tgagcaactt
      541 tttgtctccc ccgaggtgtt tgtgactctg ggtgtcataa gcctgttgga gaacattcta
      601 gtgatcgtgg cgatagccaa gaacaagaac ctgcactcac ccatgtactt tttcatctgt
      661 agtctggctg tggcggacat gctggtgagc gtttcgaacg ggtcagaaac catcgtcatc
      721 accctgctaa acagtacgga cacggacgcc cagagcttca ccgtgaatat tgataatgtc
      781 attgactctg tgatctgtag ctccttgctc gcatccattt gcagcctgct ttccattgca
      841 gtggacaggt atttcactat cttttacgcg ctccagtacc ataacattat gacggttagg
      901 cgggtcggga tcatcatcag ttgtatctgg gcagcttgca cagtatcggg cgttcttttt
      961 atcatttact cggacagcag cgctgtcatc atctgcctca ttaccatgtt cttcaccatg
     1021 ctggttctca tggcctctct ctatgtccac atgttcctga tggcgaggct tcacattaag
     1081 aggatcgctg tcctcccggg cacgggtacc atccgtcagg gtgccaacat gaagggcgca
     1141 attaccttga ccattctgat tggagtgttt gttgtctgct gggccccgtt tttcctccat
     1201 ttactgttct acatctcttg tcctcagaat ccatactgcg tgtgcttcat gtctcatttt
     1261 aacttgtatc tcatactgat catgtgtaac gctgtcatcg accctctcat ttatgccctg
     1321 cggagtcaag aactgaggaa aaccttcaaa gagatcatct gtttctaccc cctgggaggc
     1381 atctgtgagt tacctggcag gtattaagtg gggacagagt gcatactagg tagagacctg
     1441 cagaatttgt cactcaggca caacctgagc agtgtacttc ccaacagctg cctctactgt
     1501 atagtgcttt ggttggaaaa tatctactgt ataaaatgta agtttatgac ttttgacgtg
     1561 gggaaaaagt ctcaacgtgt tatgtttatt gaccttactt tttttgtgtg taaactgctt
     1621 atttatgttc tacagcgtgg gcgctatgga gttccataaa agaaaaagac acccttatta
     1681 aaactttgac agtgtttctt tccatgttat ttatcaagag tcaacccttg ttctttctgt
     1741 ggtagcagaa atcagagcct tctgaaaagc tgtttccatt gcatcacccc cacagcacag
     1801 cagaagcctg attccactgt ttatggggaa atatttaaac actggatgct cgatcattta
     1861 atgagtcagc tctactcgtg aaatttca
//
