LOCUS       NM_001025270            1098 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus melanocortin 3 receptor (Mc3r), mRNA.
ACCESSION   NM_001025270 XM_575293
VERSION     NM_001025270.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Zhang,T., Wang,M., Liu,L., He,B., Hu,J. and Wang,Y.
  TITLE     Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK
            signaling pathway after weight loss in obese Sprague-Dawley rats
  JOURNAL   Peptides 119, 170080 (2019)
   PUBMED   31260713
  REMARK    GeneRIF: The increase in hypothalamic nesfatin-1 participates in
            regulating feeding behavior through the MC3/4R-ERK signaling
            especially after SG and RYGB.
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   You,P., Hu,H., Chen,Y., Zhao,Y., Yang,Y., Wang,T., Xing,R.,
            Shao,Y., Zhang,W., Li,D., Chen,H. and Liu,M.
  TITLE     Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy
            Homeostasis in Rats
  JOURNAL   Sci Rep 6, 34938 (2016)
   PUBMED   27713523
  REMARK    GeneRIF: MC3R deficiency caused a reduction of food intake and body
            weight, whereas at the same time exhibited additive effects on top
            of MC4R deficiency on lipid and glucose metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Pandit,R., Omrani,A., Luijendijk,M.C., de Vrind,V.A., Van
            Rozen,A.J., Ophuis,R.J., Garner,K., Kallo,I., Ghanem,A.,
            Liposits,Z., Conzelmann,K.K., Vanderschuren,L.J., la Fleur,S.E. and
            Adan,R.A.
  TITLE     Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons
            Increases the Motivation for Food Reward
  JOURNAL   Neuropsychopharmacology 41 (9), 2241-2251 (2016)
   PUBMED   26852738
  REMARK    GeneRIF: Study demonstrates an arcuate nucleus of the hypothalamus
            pro-opiomelanocortinergic projection onto ventral tegmental area
            dopaminergic neurons that modulates motivation for palatable food
            via activation of melanocortin 3 receptor signaling.
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Derkach,K.V., Moyseuk,I.V., Shpakova,E.A. and Sphakov,A.O.
  TITLE     [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM
            THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN
            RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR]
  JOURNAL   Zh Evol Biokhim Fiziol 51 (4), 243-250 (2015)
   PUBMED   26547948
  REMARK    GeneRIF: in rats immunized with M4R and M3R peptides the
            sensitivity of ACSS thyrocytes to TSH were decreased, whereas in
            rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones
            was associated with decreased level of TSH
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Tavares,E., Maldonado,R. and Minano,F.J.
  TITLE     Aminoprocalcitonin-mediated suppression of feeding involves the
            hypothalamic melanocortin system
  JOURNAL   Am J Physiol Endocrinol Metab 304 (12), E1251-E1262 (2013)
   PUBMED   23571710
  REMARK    GeneRIF: We showed that the melanocortin-3/4 receptor antagonist
            SHU 9119 attenuates the food intake-suppressive effect of
            aminoprocalcitonin.
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Kim,C.S., Lee,S.H., Kim,R.Y., Kim,B.J., Li,S.Z., Lee,I.H.,
            Lee,E.J., Lim,S.K., Bae,Y.S., Lee,W. and Baik,J.H.
  TITLE     Identification of domains directing specificity of coupling to
            G-proteins for the melanocortin MC3 and MC4 receptors
  JOURNAL   J Biol Chem 277 (35), 31310-31317 (2002)
   PUBMED   12045190
  REMARK    GeneRIF: Identification of domains directing specificity of
            coupling to G-proteins
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Kim,M.S., Small,C.J., Russell,S.H., Morgan,D.G., Abbott,C.R.,
            alAhmed,S.H., Hay,D.L., Ghatei,M.A., Smith,D.M. and Bloom,S.R.
  TITLE     Effects of melanocortin receptor ligands on thyrotropin-releasing
            hormone release: evidence for the differential roles of
            melanocortin 3 and 4 receptors
  JOURNAL   J Neuroendocrinol 14 (4), 276-282 (2002)
   PUBMED   11963824
  REMARK    GeneRIF: differential roles for the MC3 and MC4 receptors in TRH
            release; MC3-R agonism inhibiting and MC4-R agonism stimulating TRH
            release.
REFERENCE   8  (bases 1 to 1098)
  AUTHORS   Lee,Y.S., Poh,L.K. and Loke,K.Y.
  TITLE     A novel melanocortin 3 receptor gene (MC3R) mutation associated
            with severe obesity
  JOURNAL   J Clin Endocrinol Metab 87 (3), 1423-1426 (2002)
   PUBMED   11889220
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Kiefer,L.L., Veal,J.M., Mountjoy,K.G. and Wilkison,W.O.
  TITLE     Melanocortin receptor binding determinants in the agouti protein
  JOURNAL   Biochemistry 37 (4), 991-997 (1998)
   PUBMED   9454589
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Roselli-Rehfuss,L., Mountjoy,K.G., Robbins,L.S., Mortrud,M.T.,
            Low,M.J., Tatro,J.B., Entwistle,M.L., Simerly,R.B. and Cone,R.D.
  TITLE     Identification of a receptor for gamma melanotropin and other
            proopiomelanocortin peptides in the hypothalamus and limbic system
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8856-8860 (1993)
   PUBMED   8415620
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001025270.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY671938.1, SRR26360194.46517.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1098              JAXUCZ010000003.1  181434776-181435873
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1098
                     /gene="Mc3r"
                     /note="melanocortin 3 receptor"
                     /db_xref="GeneID:29310"
                     /db_xref="RGD:3056"
     exon            1..1098
                     /gene="Mc3r"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1071
                     /gene="Mc3r"
                     /note="MC3-R"
                     /codon_start=1
                     /product="melanocortin receptor 3"
                     /protein_id="NP_001020441.3"
                     /db_xref="GeneID:29310"
                     /db_xref="RGD:3056"
                     /translation="MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEV
                     FLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIVVIN
                     SDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRK
                     ALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHV
                     QRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCIC
                     YTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG"
ORIGIN      
        1 atccacaaga gaagcaccta gaagaagatt ttttttttcc cagcagcttg ctcaggaccc
       61 tgcaggagct gcagccggaa ctggtccccg ccgataacca tgaactcttc ctgctgcccg
      121 tcctcctctt atccgacgct gcctaacctc tcccagcacc ctgcagcccc ctctgccagc
      181 aaccggagtg gcagtgggtt ctgcgagcag gttttcatca agccagaggt cttcctggca
      241 ctgggcatcg tcagtctgat ggaaaacatc ctggtgatcc tggctgtggt gaggaacggc
      301 aacctgcact cccccatgta cttcttcctg tgcagcctgg ctgcggccga catgctggtg
      361 agcctgtcca actccctgga gaccatcatg atcgtggtta tcaacagcga ctccctgacc
      421 ttggaggacc aattcatcca gcacatggac aacatcttcg actctatgat ctgcatctcc
      481 ctggtggcct ccatctgcaa cctcctggcc atcgccgtgg acaggtacgt caccatcttc
      541 tatgccctcc gttaccacag catcatgacg gttaggaaag ccctctcctt gatcgtggcc
      601 atctgggtct gctgtggcat ctgcggcgtg atgttcatcg tctactccga gagcaagatg
      661 gtcatcgtgt gcctcatcac catgttcttc gccatggtgc tgctcatggg caccctgtac
      721 atccacatgt tcctcttcgc caggctgcac gtccagcgca tcgcggcact gccacctgct
      781 gacggggtag ccccgcagca gcactcgtgc atgaaggggg ccgtcaccat caccatcctg
      841 ctgggggttt tcatcttctg ctgggcgcct ttcttcctcc acctggtcct catcatcacc
      901 tgccccacca acccctactg catctgctac acggcgcact tcaacaccta cctggttctc
      961 atcatgtgca actctgtcat cgaccccctt atctacgcct tccgcagcct ggagctgcgg
     1021 aacaccttca aggagattct ctgcggttgc aatggcatga acgtgggcta ggacccccgt
     1081 ggaggtgttc cacggcta
//
