LOCUS       NP_001020441             323 aa            linear   ROD 30-MAR-2024
DEFINITION  melanocortin receptor 3 [Rattus norvegicus].
ACCESSION   NP_001020441 XP_575293
VERSION     NP_001020441.3
DBSOURCE    REFSEQ: accession NM_001025270.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 323)
  AUTHORS   Zhang,T., Wang,M., Liu,L., He,B., Hu,J. and Wang,Y.
  TITLE     Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK
            signaling pathway after weight loss in obese Sprague-Dawley rats
  JOURNAL   Peptides 119, 170080 (2019)
   PUBMED   31260713
  REMARK    GeneRIF: The increase in hypothalamic nesfatin-1 participates in
            regulating feeding behavior through the MC3/4R-ERK signaling
            especially after SG and RYGB.
REFERENCE   2  (residues 1 to 323)
  AUTHORS   You,P., Hu,H., Chen,Y., Zhao,Y., Yang,Y., Wang,T., Xing,R.,
            Shao,Y., Zhang,W., Li,D., Chen,H. and Liu,M.
  TITLE     Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy
            Homeostasis in Rats
  JOURNAL   Sci Rep 6, 34938 (2016)
   PUBMED   27713523
  REMARK    GeneRIF: MC3R deficiency caused a reduction of food intake and body
            weight, whereas at the same time exhibited additive effects on top
            of MC4R deficiency on lipid and glucose metabolism.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 323)
  AUTHORS   Pandit,R., Omrani,A., Luijendijk,M.C., de Vrind,V.A., Van
            Rozen,A.J., Ophuis,R.J., Garner,K., Kallo,I., Ghanem,A.,
            Liposits,Z., Conzelmann,K.K., Vanderschuren,L.J., la Fleur,S.E. and
            Adan,R.A.
  TITLE     Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons
            Increases the Motivation for Food Reward
  JOURNAL   Neuropsychopharmacology 41 (9), 2241-2251 (2016)
   PUBMED   26852738
  REMARK    GeneRIF: Study demonstrates an arcuate nucleus of the hypothalamus
            pro-opiomelanocortinergic projection onto ventral tegmental area
            dopaminergic neurons that modulates motivation for palatable food
            via activation of melanocortin 3 receptor signaling.
REFERENCE   4  (residues 1 to 323)
  AUTHORS   Derkach,K.V., Moyseuk,I.V., Shpakova,E.A. and Sphakov,A.O.
  TITLE     [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM
            THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN
            RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR]
  JOURNAL   Zh Evol Biokhim Fiziol 51 (4), 243-250 (2015)
   PUBMED   26547948
  REMARK    GeneRIF: in rats immunized with M4R and M3R peptides the
            sensitivity of ACSS thyrocytes to TSH were decreased, whereas in
            rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones
            was associated with decreased level of TSH
REFERENCE   5  (residues 1 to 323)
  AUTHORS   Tavares,E., Maldonado,R. and Minano,F.J.
  TITLE     Aminoprocalcitonin-mediated suppression of feeding involves the
            hypothalamic melanocortin system
  JOURNAL   Am J Physiol Endocrinol Metab 304 (12), E1251-E1262 (2013)
   PUBMED   23571710
  REMARK    GeneRIF: We showed that the melanocortin-3/4 receptor antagonist
            SHU 9119 attenuates the food intake-suppressive effect of
            aminoprocalcitonin.
REFERENCE   6  (residues 1 to 323)
  AUTHORS   Kim,C.S., Lee,S.H., Kim,R.Y., Kim,B.J., Li,S.Z., Lee,I.H.,
            Lee,E.J., Lim,S.K., Bae,Y.S., Lee,W. and Baik,J.H.
  TITLE     Identification of domains directing specificity of coupling to
            G-proteins for the melanocortin MC3 and MC4 receptors
  JOURNAL   J Biol Chem 277 (35), 31310-31317 (2002)
   PUBMED   12045190
  REMARK    GeneRIF: Identification of domains directing specificity of
            coupling to G-proteins
REFERENCE   7  (residues 1 to 323)
  AUTHORS   Kim,M.S., Small,C.J., Russell,S.H., Morgan,D.G., Abbott,C.R.,
            alAhmed,S.H., Hay,D.L., Ghatei,M.A., Smith,D.M. and Bloom,S.R.
  TITLE     Effects of melanocortin receptor ligands on thyrotropin-releasing
            hormone release: evidence for the differential roles of
            melanocortin 3 and 4 receptors
  JOURNAL   J Neuroendocrinol 14 (4), 276-282 (2002)
   PUBMED   11963824
  REMARK    GeneRIF: differential roles for the MC3 and MC4 receptors in TRH
            release; MC3-R agonism inhibiting and MC4-R agonism stimulating TRH
            release.
REFERENCE   8  (residues 1 to 323)
  AUTHORS   Lee,Y.S., Poh,L.K. and Loke,K.Y.
  TITLE     A novel melanocortin 3 receptor gene (MC3R) mutation associated
            with severe obesity
  JOURNAL   J Clin Endocrinol Metab 87 (3), 1423-1426 (2002)
   PUBMED   11889220
REFERENCE   9  (residues 1 to 323)
  AUTHORS   Kiefer,L.L., Veal,J.M., Mountjoy,K.G. and Wilkison,W.O.
  TITLE     Melanocortin receptor binding determinants in the agouti protein
  JOURNAL   Biochemistry 37 (4), 991-997 (1998)
   PUBMED   9454589
REFERENCE   10 (residues 1 to 323)
  AUTHORS   Roselli-Rehfuss,L., Mountjoy,K.G., Robbins,L.S., Mortrud,M.T.,
            Low,M.J., Tatro,J.B., Entwistle,M.L., Simerly,R.B. and Cone,R.D.
  TITLE     Identification of a receptor for gamma melanotropin and other
            proopiomelanocortin peptides in the hypothalamus and limbic system
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8856-8860 (1993)
   PUBMED   8415620
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On May 26, 2007 this sequence version replaced NP_001020441.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY671938.1, SRR26360194.46517.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..323
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     Protein         1..323
                     /product="melanocortin receptor 3"
                     /note="MC3-R"
                     /calculated_mol_wt=35626
     Site            2
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32244.2)"
     Site            16
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32244.2)"
     Site            28
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P32244.2)"
     Site            38..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Region          39..310
                     /region_name="7tmA_MC3R"
                     /note="melanocortin receptor subtype 3, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15352"
                     /db_xref="CDD:320474"
     Region          40..66
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320474"
     Region          73..99
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320474"
     Site            76..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Site            order(95,120..121,124..125,128,192,255,262,282,285)
                     /site_type="other"
                     /note="putative ligand binding site [chemical binding]"
                     /db_xref="CDD:320474"
     Region          117..147
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320474"
     Site            119..140
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Region          159..179
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320474"
     Site            161..181
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Region          184..213
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320474"
     Site            187..210
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Region          235..265
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320474"
     Site            246..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     Region          278..303
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320474"
     Site            278..301
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P32244.2)"
     CDS             1..323
                     /gene="Mc3r"
                     /coded_by="NM_001025270.4:100..1071"
                     /db_xref="GeneID:29310"
                     /db_xref="RGD:3056"
ORIGIN      
        1 mnssccpsss yptlpnlsqh paapsasnrs gsgfceqvfi kpevflalgi vslmenilvi
       61 lavvrngnlh spmyfflcsl aaadmlvsls nsletimivv insdsltled qfiqhmdnif
      121 dsmicislva sicnllaiav dryvtifyal ryhsimtvrk alslivaiwv ccgicgvmfi
      181 vyseskmviv clitmffamv llmgtlyihm flfarlhvqr iaalppadgv apqqhscmkg
      241 avtitillgv fifcwapffl hlvliitcpt npycicytah fntylvlimc nsvidpliya
      301 frslelrntf keilcgcngm nvg
//
