LOCUS       NM_001100491            1148 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus melanocortin 2 receptor (Mc2r), mRNA.
ACCESSION   NM_001100491 XM_001067549 XM_574167
VERSION     NM_001100491.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1148)
  AUTHORS   Tang,X., Liu,Y., Xiao,Q., Yao,Q., Allen,M., Wang,Y., Gao,L., Qi,Y.
            and Zhang,P.
  TITLE     Pathological cyclic strain promotes proliferation of vascular
            smooth muscle cells via the ACTH/ERK/STAT3 pathway
  JOURNAL   J Cell Biochem 119 (10), 8260-8270 (2018)
   PUBMED   29943847
  REMARK    GeneRIF: The data demonstrated that the abnormal proliferation of
            vascular smooth muscle cells induced by conditions of high cyclic
            strain is in part attributed to ACTH and its receptor MC2R.
REFERENCE   2  (bases 1 to 1148)
  AUTHORS   Shah,A.J., Kriska,T., Gauthier,K.M., Falck,J.R. and Campbell,W.B.
  TITLE     Effect of Angiotensin II and ACTH on Adrenal Blood Flow in the Male
            Rat Adrenal Gland In Vivo
  JOURNAL   Endocrinology 159 (1), 217-226 (2018)
   PUBMED   29140411
  REMARK    GeneRIF: Data suggest that increases in adrenal blood flow induced
            by Ang II (angiotensin II)/Agtr2 signaling are mediated by release
            of nitric oxide and EETs (epoxyeicosatrienoic acids); increases in
            adrenal blood flow with ACTH (adrenocorticotropic hormone)/Mc2r
            receptor signaling are mediated by EETs only. (Agtr2 = angiotensin
            II receptor; Mc2r = ACTH receptor)
REFERENCE   3  (bases 1 to 1148)
  AUTHORS   Cai,G., Ziko,I., Barwood,J., Soch,A., Sominsky,L., Molero,J.C. and
            Spencer,S.J.
  TITLE     Overfeeding during a critical postnatal period exacerbates
            hypothalamic-pituitary-adrenal axis responses to immune challenge:
            a role for adrenal melanocortin 2 receptors
  JOURNAL   Sci Rep 6, 21097 (2016)
   PUBMED   26868281
  REMARK    GeneRIF: Overfeeding during a critical postnatal period exacerbates
            hypothalamic-pituitary-adrenal axis responses to immune challenge:
            a role for adrenal melanocortin 2 receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1148)
  AUTHORS   Malik,I.A., Triebel,J., Posselt,J., Khan,S., Ramadori,P.,
            Raddatz,D. and Ramadori,G.
  TITLE     Melanocortin receptors in rat liver cells: change of gene
            expression and intracellular localization during acute-phase
            response
  JOURNAL   Histochem Cell Biol 137 (3), 279-291 (2012)
   PUBMED   22183812
REFERENCE   5  (bases 1 to 1148)
  AUTHORS   Catania,A., Lonati,C., Sordi,A., Carlin,A., Leonardi,P. and
            Gatti,S.
  TITLE     The melanocortin system in control of inflammation
  JOURNAL   ScientificWorldJournal 10, 1840-1853 (2010)
   PUBMED   20852827
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1148)
  AUTHORS   Nankova,B.B., Kvetnansky,R. and Sabban,E.L.
  TITLE     Adrenocorticotropic hormone (MC-2) receptor mRNA is expressed in
            rat sympathetic ganglia and up-regulated by stress
  JOURNAL   Neurosci Lett 344 (3), 149-152 (2003)
   PUBMED   12812827
REFERENCE   7  (bases 1 to 1148)
  AUTHORS   Fluck,C.E., Martens,J.W., Conte,F.A. and Miller,W.L.
  TITLE     Clinical, genetic, and functional characterization of
            adrenocorticotropin receptor mutations using a novel receptor assay
  JOURNAL   J Clin Endocrinol Metab 87 (9), 4318-4323 (2002)
   PUBMED   12213892
REFERENCE   8  (bases 1 to 1148)
  AUTHORS   Piedboeuf,B., Johnston,C.J., Watkins,R.H., Hudak,B.B., Lazo,J.S.,
            Cherian,M.G. and Horowitz,S.
  TITLE     Increased expression of tissue inhibitor of metalloproteinases
            (TIMP-I) and metallothionein in murine lungs after hyperoxic
            exposure
  JOURNAL   Am J Respir Cell Mol Biol 10 (2), 123-132 (1994)
   PUBMED   8110467
REFERENCE   9  (bases 1 to 1148)
  AUTHORS   Clark,A.J., McLoughlin,L. and Grossman,A.
  TITLE     Familial glucocorticoid deficiency associated with point mutation
            in the adrenocorticotropin receptor
  JOURNAL   Lancet 341 (8843), 461-462 (1993)
   PUBMED   8094489
REFERENCE   10 (bases 1 to 1148)
  AUTHORS   Abe,S., Matsumi,M., Tsukioki,M., Mizukawa,S., Takahashi,T.,
            Iijima,Y., Itano,Y. and Kosaka,F.
  TITLE     Metallothionein and zinc metabolism in endotoxin shock rats
  JOURNAL   Experientia Suppl 52, 587-594 (1987)
   PUBMED   2822467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_574167.2, XM_001067549.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM047384.1, FM040676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000018.1  64290640-64290763   c
            125-1148            JAXUCZ010000018.1  64280224-64281247   c
FEATURES             Location/Qualifiers
     source          1..1148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1148
                     /gene="Mc2r"
                     /note="melanocortin 2 receptor"
                     /db_xref="GeneID:282839"
                     /db_xref="RGD:628649"
     exon            1..124
                     /gene="Mc2r"
                     /inference="alignment:Splign:2.1.0"
     exon            125..1148
                     /gene="Mc2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1110
                     /gene="Mc2r"
                     /note="melanocortin 2 receptor (adrenocorticotropic
                     hormone)"
                     /codon_start=1
                     /product="adrenocorticotropic hormone receptor"
                     /protein_id="NP_001093961.1"
                     /db_xref="GeneID:282839"
                     /db_xref="RGD:628649"
                     /translation="MKHIINSYEHTNNTARNNSDCPDVVVPEEIFFTISIIGVLENLI
                     VLLAVIKNKNLQSPVYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSLESTA
                     DDIIDCMFVLSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTVITLTVIWMFCTG
                     SGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRANMKGA
                     MTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIY
                     AFRSPELREAFKKMLFCNRY"
ORIGIN      
        1 aaacgaagcc tcacagcggc tcctgcaaag aacgaagtcc gtgaggttgc acacagagcg
       61 acaaaccttt tttggtggga tcccctcggg ccaggggcag gacaaggggg gaggcagaaa
      121 ctggatcctt ccgcacaaag aaaacattct gaagagccga tcaggatttc tgtaggtcaa
      181 cagcaagcac catccccttc ttaaccgcaa gcaagaaaaa tgaagcacat tatcaattcg
      241 tatgaacaca ccaacaacac agcaagaaat aactctgatt gtcctgatgt agttgtgcca
      301 gaagagatat ttttcacaat ctccatcatt ggagttttgg agaacctgat cgtcctcctg
      361 gccgtgatca aaaataaaaa tctccagtcc cccgtgtact ttttcatctg cagtttggcc
      421 atttccgaca tgttgggcag tctgtataag atcttggaaa atatcctgat catgttcaga
      481 aacatgggct atctcaagcc tcgtggcagt ttggaaagta cagcagatga catcattgac
      541 tgcatgttcg tcctctcttt gctgggctcg atcttcagcc tgtctgtgat tgcagctgac
      601 cgctacatca ccatcttcca tgccctgcaa taccacagca ttgtgaccat gcgacgcacc
      661 gtcatcaccc taacggttat ctggatgttc tgtacaggga gcggcatcac catggtgatc
      721 ttctcccacc atatccccac agtgctcacc ttcacctcgc tattcccttt gatgctggtt
      781 tttatcctgt gtctctacat ccacatgttc ttacttgccc gctcccatgc tcggaagatc
      841 tctacccttc ctagagccaa catgaagggt gccatgacat tgaccatcct tcttggagtc
      901 ttcatcttct gttgggctcc ctttgtgctc catgttctct taatgacctt ctgcccaaat
      961 aacccttact gtgtttgcta catgtctctc ttccaggtca atggcatgtt gattatgtgc
     1021 aacgcagtta ttgatccctt tatatatgcc tttcggagcc cagagctcag agaggcattc
     1081 aaaaagatgc tcttctgcaa cagatattag tagagctttt gatccctgct ttgagtgttg
     1141 taaaggaa
//
