LOCUS       NM_001401091            2928 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus melanocortin 1 receptor (Mc1r), mRNA.
ACCESSION   NM_001401091 XM_006255795
VERSION     NM_001401091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Lu,J., Wang,J., Ni,H., Li,B., Yang,J., Zhu,J., Qian,J., Gao,R. and
            Xu,R.
  TITLE     Activation of the melanocortin-1 receptor attenuates neuronal
            apoptosis after traumatic brain injury by upregulating Merlin
            expression
  JOURNAL   Brain Res Bull 207, 110870 (2024)
   PUBMED   38185389
  REMARK    GeneRIF: Activation of the melanocortin-1 receptor attenuates
            neuronal apoptosis after traumatic brain injury by upregulating
            Merlin expression.
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Thapa,K., Kadiri,J.J., Saukkonen,K., Pennanen,I., Ghimire,B.,
            Cai,M., Savontaus,E. and Rinne,P.
  TITLE     Melanocortin 1 receptor regulates cholesterol and bile acid
            metabolism in the liver
  JOURNAL   Elife 12, e84782 (2023)
   PUBMED   37490042
  REMARK    GeneRIF: Melanocortin 1 receptor regulates cholesterol and bile
            acid metabolism in the liver.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Chen,B., Guan,X., Gunning,W.T., Ge,Y., Gohara,A.F., Dworkin,L.D.
            and Gong,R.
  TITLE     Negative Modulation of B Cell Activation by Melanocortin 1 Receptor
            Signaling Protects against Membranous Nephropathy
  JOURNAL   J Am Soc Nephrol 34 (3), 467-481 (2023)
   PUBMED   36446431
  REMARK    GeneRIF: Negative Modulation of B Cell Activation by Melanocortin 1
            Receptor Signaling Protects against Membranous Nephropathy.
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Xu,W., Mo,J., Ocak,U., Travis,Z.D., Enkhjargal,B., Zhang,T., Wu,P.,
            Peng,J., Li,T., Zuo,Y., Shao,A., Tang,J., Zhang,J. and Zhang,J.H.
  TITLE     Activation of Melanocortin 1 Receptor Attenuates Early Brain Injury
            in a Rat Model of Subarachnoid Hemorrhage viathe Suppression of
            Neuroinflammation through AMPK/TBK1/NF-kappaB Pathway in Rats
  JOURNAL   Neurotherapeutics 17 (1), 294-308 (2020)
   PUBMED   31486022
  REMARK    GeneRIF: Activation of Melanocortin 1 Receptor Attenuates Early
            Brain Injury in a Rat Model of Subarachnoid Hemorrhage viathe
            Suppression of Neuroinflammation through AMPK/TBK1/NF-kappaB
            Pathway in Rats.
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Bergwall,L., Wallentin,H., Elvin,J., Liu,P., Boi,R., Sihlbom,C.,
            Hayes,K., Wright,D., Haraldsson,B., Nystrom,J. and Buvall,L.
  TITLE     Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome
            Identifies a Target for Podocyte Cytoskeleton Stabilization
  JOURNAL   Sci Rep 8 (1), 15731 (2018)
   PUBMED   30356069
  REMARK    GeneRIF: found that glomerular MC1R expression was increased in
            nephrotic syndrome, both in humans and in a rat model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Kiefer,L.L., Veal,J.M., Mountjoy,K.G. and Wilkison,W.O.
  TITLE     Melanocortin receptor binding determinants in the agouti protein
  JOURNAL   Biochemistry 37 (4), 991-997 (1998)
   PUBMED   9454589
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   .
  TITLE     British Society of Audiology short papers meeting on experimental
            studies of hearing and deafness. Cambridge, United Kingdom, 22-23
            September 1996. Abstracts
  JOURNAL   Br J Audiol 31 (2), 73-132 (1997)
   PUBMED   9183385
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Valverde,P., Healy,E., Sikkink,S., Haldane,F., Thody,A.J.,
            Carothers,A., Jackson,I.J. and Rees,J.L.
  TITLE     The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is
            associated with melanoma
  JOURNAL   Hum Mol Genet 5 (10), 1663-1666 (1996)
   PUBMED   8894704
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Ozeki,H., Ito,S., Wakamatsu,K. and Hirobe,T.
  TITLE     Chemical characterization of hair melanins in various coat-color
            mutants of mice
  JOURNAL   J Invest Dermatol 105 (3), 361-366 (1995)
   PUBMED   7665913
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Piedboeuf,B., Johnston,C.J., Watkins,R.H., Hudak,B.B., Lazo,J.S.,
            Cherian,M.G. and Horowitz,S.
  TITLE     Increased expression of tissue inhibitor of metalloproteinases
            (TIMP-I) and metallothionein in murine lungs after hyperoxic
            exposure
  JOURNAL   Am J Respir Cell Mol Biol 10 (2), 123-132 (1994)
   PUBMED   8110467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 2, 2022 this sequence version replaced XM_006255795.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: LC579562.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2928              JAXUCZ010000019.1  68360950-68363877
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2928
                     /gene="Mc1r"
                     /note="melanocortin 1 receptor"
                     /db_xref="GeneID:102552838"
                     /db_xref="RGD:1312046"
     exon            1..2928
                     /gene="Mc1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             792..1745
                     /gene="Mc1r"
                     /note="alpha melanocyte stimulating hormone receptor"
                     /codon_start=1
                     /product="melanocyte-stimulating hormone receptor"
                     /protein_id="NP_001388020.1"
                     /db_xref="GeneID:102552838"
                     /db_xref="RGD:1312046"
                     /translation="MPTQGPPKRLLGSLNSTSITTSHLGLATNQTGSWCLHVSIPDGL
                     FLSLGLVSLVENVLVVVAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLE
                     AGILVARAALVQQLDNVIDVLICGSMVSSLCFLGVIAIDRYISIFYALRYHSIVTLSR
                     ARRAVVGIWVVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYVHMLSRACQHA
                     QGIARLHKRRHSIRQGFCLKGAATLTILLGIFFLCWAPFFLHLLLIVLCPQHPTCSCI
                     FKNFNLFLILIILSSIVDPLIYAFRSQELRMTLKEVLLCSW"
ORIGIN      
        1 actgccatgc ttctaacaga gcgtgtgagt gatggtggga ggcagggggg cctcattcac
       61 aggcagcaca gcatgggagt ggaaggaggt tttggacgac tcaggaaagt gatttttgag
      121 atgggtttgg aagtttaggt agggctacac agggcaggtt ctatctagtg aggctggatg
      181 cctgaaaggg attgtcaagt cacaggggct ttgaacacaa aagggagatg caagaccccg
      241 ggttggagtc tgaagctagg ttttccagtt tctccttgct acttatgccc cctagaggca
      301 gtctagggtg ctgggacact cgcacatgcc catcatgtgg ctaccctcag aaggaggggc
      361 tccagggaca gttaaaagat tcagagaaag gcattcttcc ccagacctca gcctaccctg
      421 gcttggcgag gcaaggaacc gagaagttgg aggtgtcaag tttagaaatg tctctacctg
      481 agccacttgg ggagagacat ggggaacagc agaaagctaa gctccttcac actggcagtg
      541 agactccgtg agtagagctc agggtcctag ccaggaagtg tctagactgc ctatgccatg
      601 cctaggctga cctgtccagg cagacagggc acatgtgtga aggaacatcg gagcatgccc
      661 gtatggaaag aggaaggtct ggggaatgtc agagacccct gacaacaaca tgagctgagt
      721 cggaagctgg aagctcatac cacctggagc tgcagcctcc acggactgct tcctacttcc
      781 ggaacaagac tatgcccact caggggcccc cgaagaggct tctgggttct ctcaactcca
      841 cttccatcac cacctctcac ctcggactgg ccaccaacca gacagggtct tggtgcctgc
      901 atgtgtctat cccagatggc ctcttcctca gcctggggct ggtgagcctg gtggagaacg
      961 tgttggttgt ggtagccatc accaaaaacc gcaacctgca ctcgcccatg tattacttca
     1021 tctgctgtct ggccctgtct gacctgatgg tgagtgtgag catcgtgctg gagaccacta
     1081 tcatcctgct gctggaggca ggcatcctgg tggcccgcgc ggctctggtg cagcagctgg
     1141 acaatgtcat cgacgtgctc atctgtggct ccatggtgtc cagtctctgc ttcctgggtg
     1201 tcatcgccat agaccgctac atctccatct tctacgcgct gcgttaccac agcattgtga
     1261 cactgtcccg ggcacgaagg gccgtcgtgg gcatctgggt ggtcagcatc gtctccagca
     1321 ccctcttcat cacctactac aaacacacgg ccgtcctgct ctgcctcgtc actttcttcc
     1381 tagccatgct ggcactcatg gcaattctgt atgtccacat gctctctcga gcgtgccagc
     1441 atgctcaggg cattgcccgg ctccacaaaa ggcggcactc catccgacaa ggcttctgtc
     1501 tgaagggcgc cgccaccctt actatccttc tggggatttt cttcctgtgc tgggcccctt
     1561 tcttcctgca cctcttgctc atcgttctct gccctcagca ccccacctgc agctgcatct
     1621 tcaagaactt caacctcttc ctcatcctca ttatcctcag ctccatcgtg gaccccctca
     1681 tctacgcttt tcgaagccag gagctccgca tgacactcaa ggaggtgctg ctgtgctcgt
     1741 ggtgagcaga gaagtggctt tcggtctcac ggccaggacg ctgggcagag ggtgacagtg
     1801 atatccagtg gcccacatcc tgttgagatc acaggtactc atcccttcct gatctccctt
     1861 tgtctaaggg tggactggat gaactttaaa atagaaacac aatgtgcccg gggccaggag
     1921 aaagggtagc tgtgactgca gggtcaccca gggcggccat gggaagtgga ggaaacaggg
     1981 atggggactc tatccctggg caagggtcaa accataggct cctggagagc ttcacctctc
     2041 cacactgaca aggcaacccc tactcagccc ttcgggtcat tcagcttggg ccctctgctg
     2101 ctgggacaga caggaagtct ctaagttaaa agaataacag acaagagctg tggtggaaca
     2161 ttctttctgg aggaggcttc tgataggaag atttgtggcc acaaaaaccc agccagagcc
     2221 atgctgtaga ctgcttaagg aagtgaggcc cctcctcaac acacggatca gaattgtaaa
     2281 atgtgcatct tgaacaaggg acctgcccat ttgcccaagc ggtgtgggac tgacttaaag
     2341 acccatagta cggctcatgg gaatccaaag aggtggggac ccagctgccc aaacccacag
     2401 gctactgttt caagtgcctc ctctggcctc aggagggact gttggcttat cactgaccac
     2461 agcctgtggc tctgagccag gatgcagttg aaatgctaag gttggatgga gcctcttcac
     2521 catcttccct agctctctcc agaagttgaa gtttgggtgg gaggacaggg agaggagtca
     2581 cgttagggag aggtgagtct cagaggccac agtcctaaag ggcaccaagt accccccaat
     2641 caggccctct tggcttcctc tctctgacta caaactccag ctcagagcaa gcagctgtgg
     2701 gttccccttg cctctacggt gacaagactc tctttgttca ggctccttcc agtgcatgca
     2761 cacacagtag caggaccgca gcatctcagc ccctgatatg acccatccgt aaccttggcc
     2821 agagcctgtc cctttcctgc ccccattgtg tagcaccttc atcctacttt gagttgcccc
     2881 gagaatccca gaggtggaga gaccctgaag cacctgtagt gtggacca
//
