LOCUS       NM_001035007            2091 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus membrane-bound transcription factor peptidase,
            site 2 (Mbtps2), mRNA.
ACCESSION   NM_001035007 XM_228964
VERSION     NM_001035007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Han L, Xu Y and Shi Y.
  TITLE     Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling Pathway in
            Hippocampal Neuronal Apoptosis in SPS Rats
  JOURNAL   J Mol Neurosci 71 (12), 2487-2499 (2021)
   PUBMED   33738762
  REMARK    GeneRIF: Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling
            Pathway in Hippocampal Neuronal Apoptosis in SPS Rats.
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Lindert U, Cabral WA, Ausavarat S, Tongkobpetch S, Ludin K, Barnes
            AM, Yeetong P, Weis M, Krabichler B, Srichomthong C, Makareeva EN,
            Janecke AR, Leikin S, Rothlisberger B, Rohrbach M, Kennerknecht I,
            Eyre DR, Suphapeetiporn K, Giunta C, Marini JC and Shotelersuk V.
  TITLE     MBTPS2 mutations cause defective regulated intramembrane
            proteolysis in X-linked osteogenesis imperfecta
  JOURNAL   Nat Commun 7, 11920 (2016)
   PUBMED   27380894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Osborne TF and Espenshade PJ.
  TITLE     Evolutionary conservation and adaptation in the mechanism that
            regulates SREBP action: what a long, strange tRIP it's been
  JOURNAL   Genes Dev 23 (22), 2578-2591 (2009)
   PUBMED   19933148
  REMARK    Review article
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Oeffner F, Fischer G, Happle R, Konig A, Betz RC, Bornholdt D,
            Neidel U, Boente Mdel C, Redler S, Romero-Gomez J, Salhi A,
            Vera-Casano A, Weirich C and Grzeschik KH.
  TITLE     IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane
            zinc metalloprotease essential for cholesterol homeostasis and ER
            stress response
  JOURNAL   Am J Hum Genet 84 (4), 459-467 (2009)
   PUBMED   19361614
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Ye J, Rawson RB, Komuro R, Chen X, Dave UP, Prywes R, Brown MS and
            Goldstein JL.
  TITLE     ER stress induces cleavage of membrane-bound ATF6 by the same
            proteases that process SREBPs
  JOURNAL   Mol Cell 6 (6), 1355-1364 (2000)
   PUBMED   11163209
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000387.1.
            
            [WARNING] On Mar 26, 2024 this sequence was replaced by
            NM_001035007.2.
            
            On Oct 22, 2005 this sequence version replaced XM_228964.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JACYVU010000387.1  1639863-1640029
            168-316             JACYVU010000387.1  1644646-1644794
            317-530             JACYVU010000387.1  1646844-1647057
            531-634             JACYVU010000387.1  1659472-1659575
            635-762             JACYVU010000387.1  1662972-1663099
            763-881             JACYVU010000387.1  1675569-1675687
            882-1062            JACYVU010000387.1  1678447-1678627
            1063-1157           JACYVU010000387.1  1681623-1681717
            1158-1353           JACYVU010000387.1  1682078-1682273
            1354-1429           JACYVU010000387.1  1684367-1684442
            1430-2091           JACYVU010000387.1  1686894-1687555
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2091
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /note="membrane-bound transcription factor peptidase, site
                     2"
                     /db_xref="GeneID:302705"
                     /db_xref="RGD:1566171"
     exon            1..167
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1652
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /EC_number="3.4.24.85"
                     /note="membrane-bound transcription factor protease, site
                     2"
                     /codon_start=1
                     /product="membrane-bound transcription factor site-2
                     protease"
                     /protein_id="NP_001030179.1"
                     /db_xref="GeneID:302705"
                     /db_xref="RGD:1566171"
                     /translation="MIPVSLVVVVVGGWTAVYLADLVLKSSVYFKHSYEDWLENNGLS
                     ISPFHIRWQTSIFNRAFYSWGRRKARMLYQWFNFGMVFGVIAMFSSFFLLGKTLMQTL
                     AQMMADSPSPYSSSSSSSSSSSSSSSSSSSSSSSLHNDQVLQVVVPGINLPVNQLTYF
                     FAAVLISGVVHEIGHGIAAIREQVRFNGFGIFLFIIYPGAFVDLFTTHLQLISPVQQL
                     RIFCAGIWHNFVLALLGILALVLLPVILLPFYYTGVGVLITEVAEDSPAIGPRGLFVG
                     DLVTHLQDCPVTNVQDWNECLDTIAYEPQIGYCISASTLQQLSFPVRAYKRLDGSTEC
                     CNNHSLTDVCFSYRNNFNKRLHTCLPARKAVEATQVCRSNKDCKSSSSSSFCIVPSLE
                     THTRLIKVKHPPQIDMLYVGHPLHLHYTVSITSFIPRFNFLSIDLPVIVETFVKYLIS
                     LSGALAIVNAVPCFALDGQWILNSFLDATLTSVIGDNDVKDLIGFFILLGGSVLLAAN
                     VTLGLWMVTAR"
     exon            168..316
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            317..530
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            531..634
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            635..762
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            763..881
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1062
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1157
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1353
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1429
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..2091
                     /gene="Mbtps2"
                     /gene_synonym="LRRGT00063"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggatgct ggagctgtaa ggctccgtgc aggcggctga ttgtggatcg cagaaggagg
       61 acgctggggc ccgccgtcca tccgctgcta ctatgattcc ggtgtcgctg gtggtggtgg
      121 tggtgggtgg ttggactgcc gtctacctgg ccgacttggt gttgaagtca tctgtgtatt
      181 ttaaacattc ttatgaagac tggctggaaa acaatggatt gagcatctct ccttttcata
      241 taagatggca aacttcaatt tttaatcgtg ccttttacag ttggggacgg cggaaagcaa
      301 ggatgcttta ccaatggttc aattttggaa tggtgtttgg tgtgattgcc atgttcagct
      361 ctttttttct ccttggaaaa acactgatgc agactttggc acaaatgatg gctgactctc
      421 cctctcctta ttcttcctct tcttcctctt cctcttcctc ttcctcttcc tcttcctctt
      481 cttcttcctc ctcctcctct cttcacaatg atcaggtgtt gcaagttgtg gttcctggta
      541 taaatttacc tgtcaatcag ctgacttact tcttcgctgc agtcctcatt agtggtgttg
      601 tacatgaaat tggacacggt atagcagcca ttagggaaca agttcgattt aatggctttg
      661 gaattttcct cttcattatt tatcctggag catttgttga tctgttcacc acccatttgc
      721 aacttatatc accagtccag cagctaagga tattttgtgc aggtatatgg cataattttg
      781 tccttgctct ccttggtatt ttagctcttg ttctcctccc agtaatcctc ttgccttttt
      841 actacactgg agttggggta cttatcactg aagtcgcaga ggactcacct gccattggac
      901 ccagaggcct ttttgtggga gaccttgtta ctcatctaca ggattgtccc gttactaatg
      961 tgcaagattg gaacgaatgt ttagacacca ttgcatatga gccccaaatt gggtactgta
     1021 taagtgcatc aacgttacaa caattaagct tcccagttag agcatacaaa cgactagatg
     1081 gttctactga atgctgtaac aatcacagcc tcacagatgt gtgcttttcc tacagaaata
     1141 attttaataa acgtttgcat acatgtctac ctgcccggaa agcagttgaa gccactcaag
     1201 tttgtagaag caataaagat tgcaaaagca gctcaagctc aagcttctgt atagtgccat
     1261 ccttggaaac tcacactcgg ttaataaagg tgaaacaccc cccacagatt gatatgctct
     1321 atgtagggca cccactgcac cttcactaca cagtgagcat tacaagtttt atcccacgtt
     1381 tcaactttct aagcatagat ctgccagtaa ttgtggagac atttgtcaaa tacctgattt
     1441 ctctttctgg agccctggct attgttaatg cagtgccctg ctttgccttg gacggtcaat
     1501 ggattttaaa ctctttcctg gatgctaccc tgacttcagt gattggagac aacgatgtca
     1561 aagatctaat aggatttttc atcctgcttg gtggcagtgt acttttggct gccaatgtga
     1621 cactgggact ctggatggtt acagcacggt aatatttgct cttatccaac agaattaaaa
     1681 agtatagcta catggtaata tctgttgcca ttgaaattct tactaggtat gaaatgtaaa
     1741 gtgtttcctt aaaacatctt ggccaacctc tttgagctcc taatatctag agaatccaaa
     1801 aactctgtaa aagacaaatg gaggaaatga aaaacataat tcctgactac attctactct
     1861 gaaagattga atgtgaaaac tctgaatgtc tgttgaataa tttgtaaaca agtgaaaatt
     1921 cattcatgca ataccatttt gtgtgactat atagcatttt gaagtagtaa aaggaaaagc
     1981 agaaaacgtg tgtgcacgca tatatgcgtg cgtgcatgtg ttctactagt atttgaaacc
     2041 agcttgccta tcccaggtaa aatgtactga aaagtgcaat taagatgatg t
//
