LOCUS       NM_053569               3895 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus membrane-bound transcription factor peptidase,
            site 1 (Mbtps1), mRNA.
ACCESSION   NM_053569
VERSION     NM_053569.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Vanderhaeghen,T., Vandewalle,J. and Libert,C.
  TITLE     Spns2/S1P: it takes two to tango with inflammation and metabolic
            rewiring during sepsis
  JOURNAL   EMBO Rep 24 (8), e57615 (2023)
   PUBMED   37358010
  REMARK    GeneRIF: Spns2/S1P: it takes two to tango with inflammation and
            metabolic rewiring during sepsis.
REFERENCE   2  (bases 1 to 3895)
  AUTHORS   Han,L., Xu,Y. and Shi,Y.
  TITLE     Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling Pathway in
            Hippocampal Neuronal Apoptosis in SPS Rats
  JOURNAL   J Mol Neurosci 71 (12), 2487-2499 (2021)
   PUBMED   33738762
  REMARK    GeneRIF: Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling
            Pathway in Hippocampal Neuronal Apoptosis in SPS Rats.
REFERENCE   3  (bases 1 to 3895)
  AUTHORS   Kondo,Y., Fu,J., Wang,H., Hoover,C., McDaniel,J.M., Steet,R.,
            Patra,D., Song,J., Pollard,L., Cathey,S., Yago,T., Wiley,G.,
            Macwana,S., Guthridge,J., McGee,S., Li,S., Griffin,C., Furukawa,K.,
            James,J.A., Ruan,C., McEver,R.P., Wierenga,K.J., Gaffney,P.M. and
            Xia,L.
  TITLE     Site-1 protease deficiency causes human skeletal dysplasia due to
            defective inter-organelle protein trafficking
  JOURNAL   JCI Insight 3 (14), 121596 (2018)
   PUBMED   30046013
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3895)
  AUTHORS   Marschner,K., Kollmann,K., Schweizer,M., Braulke,T. and Pohl,S.
  TITLE     A key enzyme in the biogenesis of lysosomes is a protease that
            regulates cholesterol metabolism
  JOURNAL   Science 333 (6038), 87-90 (2011)
   PUBMED   21719679
REFERENCE   5  (bases 1 to 3895)
  AUTHORS   Osborne,T.F. and Espenshade,P.J.
  TITLE     Evolutionary conservation and adaptation in the mechanism that
            regulates SREBP action: what a long, strange tRIP it's been
  JOURNAL   Genes Dev 23 (22), 2578-2591 (2009)
   PUBMED   19933148
  REMARK    Review article
REFERENCE   6  (bases 1 to 3895)
  AUTHORS   Kawanabe,T., Kawakami,T., Yatomi,Y., Shimada,S. and Soma,Y.
  TITLE     Sphingosine 1-phosphate accelerates wound healing in diabetic mice
  JOURNAL   J Dermatol Sci 48 (1), 53-60 (2007)
   PUBMED   17643267
  REMARK    GeneRIF: S1P affects and sustains all key cellular processes
            responsible for wound repair and point to a unique potential for
            this molecule in the therapy of diabetic wounds, particularly as an
            angiogenic agent in treatment of diabetic wounds.
REFERENCE   7  (bases 1 to 3895)
  AUTHORS   Nagamori,I., Yabuta,N., Fujii,T., Tanaka,H., Yomogida,K.,
            Nishimune,Y. and Nojima,H.
  TITLE     Tisp40, a spermatid specific bZip transcription factor, functions
            by binding to the unfolded protein response element via the Rip
            pathway
  JOURNAL   Genes Cells 10 (6), 575-594 (2005)
   PUBMED   15938716
REFERENCE   8  (bases 1 to 3895)
  AUTHORS   Yang,J., Goldstein,J.L., Hammer,R.E., Moon,Y.A., Brown,M.S. and
            Horton,J.D.
  TITLE     Decreased lipid synthesis in livers of mice with disrupted Site-1
            protease gene
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13607-13612 (2001)
   PUBMED   11717426
REFERENCE   9  (bases 1 to 3895)
  AUTHORS   Ye,J., Rawson,R.B., Komuro,R., Chen,X., Dave,U.P., Prywes,R.,
            Brown,M.S. and Goldstein,J.L.
  TITLE     ER stress induces cleavage of membrane-bound ATF6 by the same
            proteases that process SREBPs
  JOURNAL   Mol Cell 6 (6), 1355-1364 (2000)
   PUBMED   11163209
REFERENCE   10 (bases 1 to 3895)
  AUTHORS   Seidah,N.G., Mowla,S.J., Hamelin,J., Mamarbachi,A.M., Benjannet,S.,
            Toure,B.B., Basak,A., Munzer,J.S., Marcinkiewicz,J., Zhong,M.,
            Barale,J.C., Lazure,C., Murphy,R.A., Chretien,M. and
            Marcinkiewicz,M.
  TITLE     Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed
            proprotein convertase with a unique cleavage specificity and
            cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1321-1326 (1999)
   PUBMED   9990022
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053569.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF094821.1, SRR26643294.59630.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000019.1  64521247-64521342   c
            97-580              JAXUCZ010000019.1  64509958-64510441   c
            581-838             JAXUCZ010000019.1  64508785-64509042   c
            839-1042            JAXUCZ010000019.1  64504286-64504489   c
            1043-1153           JAXUCZ010000019.1  64503625-64503735   c
            1154-1263           JAXUCZ010000019.1  64503199-64503308   c
            1264-1380           JAXUCZ010000019.1  64500601-64500717   c
            1381-1448           JAXUCZ010000019.1  64500089-64500156   c
            1449-1551           JAXUCZ010000019.1  64496683-64496785   c
            1552-1703           JAXUCZ010000019.1  64494726-64494877   c
            1704-1865           JAXUCZ010000019.1  64492462-64492623   c
            1866-2010           JAXUCZ010000019.1  64490593-64490737   c
            2011-2199           JAXUCZ010000019.1  64487009-64487197   c
            2200-2372           JAXUCZ010000019.1  64486063-64486235   c
            2373-2488           JAXUCZ010000019.1  64484451-64484566   c
            2489-2645           JAXUCZ010000019.1  64483682-64483838   c
            2646-2770           JAXUCZ010000019.1  64482913-64483037   c
            2771-2848           JAXUCZ010000019.1  64482216-64482293   c
            2849-2989           JAXUCZ010000019.1  64480162-64480302   c
            2990-3121           JAXUCZ010000019.1  64477790-64477921   c
            3122-3248           JAXUCZ010000019.1  64476109-64476235   c
            3249-3379           JAXUCZ010000019.1  64472645-64472775   c
            3380-3895           JAXUCZ010000019.1  64470545-64471060   c
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3895
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /note="membrane-bound transcription factor peptidase, site
                     1"
                     /db_xref="GeneID:89842"
                     /db_xref="RGD:70935"
     exon            1..96
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            97..580
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..3576
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /EC_number="3.4.21.112"
                     /note="membrane-bound transcription factor site-1
                     protease; S1P endopeptidase; subtilisin/kexin isozyme 1;
                     endopeptidase S1P; membrane-bound transcription factor
                     protease, site 1"
                     /codon_start=1
                     /product="membrane-bound transcription factor site-1
                     protease precursor"
                     /protein_id="NP_446021.2"
                     /db_xref="GeneID:89842"
                     /db_xref="RGD:70935"
                     /translation="MKLVNIWLLLLVVLLCGKKHLGDRLGKKAFEKAPCPSCSHLTLK
                     VEFSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFE
                     VIQIKEKQKAGLLTLEDHPNIKRVTPQRKVFRSLKFAESDPIVPCNETRWSQKWQSSR
                     PLKRASLSLGSGFWHATGRHSSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFD
                     TGLSEKHPHFKNVKERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFR
                     VFTNNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVS
                     AIGNDGPLYGTLNNPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRVKPDIV
                     TYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTLLVSTVQKRELVNPASVKQALIASA
                     RRLPGVNMFEQGHGKLDLLRAYQILSSYKPQASLSPSYIDLTECPYMWPYCSQPIYYG
                     GMPTIVNVTILNGMGVTGRIVDKPEWRPYLPQNGDNIEVAFSYSSVLWPWSGYLAISI
                     SVTKKAASWEGIAQGHIMITVASPAETELKNGAEHTSTVKLPIKVKIIPTPPRSKRVL
                     WDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHVHTNFRDMYQHLRSMGYFVEVLGAPF
                     TCFDATQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSLVVFSDWYNTSVMRKVKFYDE
                     NTRQWWMPDTGGANVPALNELLSVWNMGFSDGLYEGEFALANHDMYYASGCSIARFPE
                     DGVVITQTFKDQGLEVLKQETAVVDNVPILGLYQIPAEGGGRIVLYGDSNCLDDSHRQ
                     KDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGLAPPERMEGNHLHRYSKVLEA
                     HLGDPKPRPLPACPHLSWAKPQPLNETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQV
                     RPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVALAFFVVQISKAKSRPKR
                     RRPRAKRPQLAQQAHPARTPSV"
     exon            581..838
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1042
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1153
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1263
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1380
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1448
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1551
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1703
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1865
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2010
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2199
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2372
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2488
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2645
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2770
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2848
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2989
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3121
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3248
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3379
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3895
                     /gene="Mbtps1"
                     /gene_synonym="S1p; Ski-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgagtaaac atcccccgaa tggatacccg aggcgtgttc gcggcggagc cgccgttttc
       61 ccgggtccgc cgatcccgag cctgaggcgg acgcagatcg gctcagagcg gtggcttggg
      121 ctcctgctag atttgggtct gtggtacaaa tggagtttag gactcagtgg actcggccct
      181 aatgagagaa gcccctgtcc aagatggaga agaagcggag aaagaaatga aagcctcttt
      241 ttgggccaag ctgtgggtga ccatgggact gaggttttct ttacgttgga caagtctgta
      301 ggatggctga tcagtaaggt tgcagctttt agcgaaaaca gaaatccact tctgatcaag
      361 gaagagccta gtgcaatttg aatttatgca attttatgac catattcact taggaccatg
      421 aagctcgtca acatctggct tcttctgctg gtggttttgc tctgtgggaa aaagcatctg
      481 ggtgacaggc tggggaagaa agcttttgaa aaggccccat gccccagctg ttcccacctg
      541 actttgaagg tggaattctc ctcaactgtg gtggaatatg aatatattgt ggctttcaac
      601 ggatacttca cagccaaagc tagaaactca tttatttcaa gtgctctaaa aagcagtgaa
      661 gtggacaact ggagaataat acctcggaac aacccatcta gtgactaccc tagtgatttt
      721 gaggtgattc agataaaaga gaagcagaag gcggggctgc tcacacttga agatcaccca
      781 aacatcaagc gggtgacacc ccagcggaaa gtctttcgtt ccctgaagtt tgctgaatcc
      841 gaccccattg tgccctgtaa tgagacccgg tggagccaga agtggcagtc atcacgtccc
      901 ctgaaaagag ccagtctctc cctgggctct ggattctggc atgcaacagg aaggcattca
      961 agtcgacgat tgctgagagc cattcctcgc caggttgccc agacattgca ggcagatgtg
     1021 ctttggcaga tgggatacac aggtgctaat gtcagggttg ctgtttttga tactgggctc
     1081 agtgagaagc atccacattt caagaatgtg aaggaaagaa ccaactggac caatgagcgg
     1141 accctggacg atgggctggg ccatggcaca ttcgttgcag gtgtgattgc cagcatgaga
     1201 gagtgccaag gatttgcccc agatgcagag ctgcacatct tcagggtctt taccaacaat
     1261 caggtgtctt acacgtcttg gtttttggat gccttcaact atgccatcct aaagaagatt
     1321 gacgttctga accttagcat cggcgggcct gacttcatgg atcacccctt tgttgacaag
     1381 gtatgggaat taacagcgaa caatgtaatc atggtttctg ctattggcaa tgatggacct
     1441 ctctatggca ctctgaataa ccctgctgat cagatggatg tgattggagt gggtggcatt
     1501 gactttgaag acaacatcgc ccgcttctct tccaggggaa tgactacctg ggaactaccg
     1561 ggaggctatg gtcgtgtgaa gcctgacatt gtcacctatg gtgctggagt gcggggttct
     1621 ggtgtgaaag ggggctgccg tgcactctca gggaccagtg tcgcctcccc agtggttgct
     1681 ggggctgtca ccttgttagt aagcacagta cagaagcggg agctagtgaa tcctgccagt
     1741 gtgaagcaag ctttgatagc atcagcccgg agacttcctg gtgtcaacat gtttgagcaa
     1801 ggccatggca agttggatct actgcgagcc tatcagatcc tcagcagcta taaaccgcag
     1861 gcgagcctga gtcctagcta catcgacctg actgagtgtc cctacatgtg gccctactgc
     1921 tcccagccca tctactatgg aggaatgcca acaattgtta atgtcaccat cctcaatggc
     1981 atgggagtta caggaagaat tgtggataag cctgagtggc gaccctattt accacagaat
     2041 ggagacaaca ttgaagtggc cttctcctac tcctcagtgt tgtggccttg gtcaggttac
     2101 cttgccatct ccatttctgt gaccaagaag gcagcttcct gggaaggcat cgcgcagggc
     2161 cacatcatga tcacagtggc ttccccagca gagacggaat taaaaaatgg tgccgagcat
     2221 acttccacag tgaagctgcc catcaaggtg aagatcattc ccacccctcc tcggagcaag
     2281 agagtcctct gggaccagta ccacaacctc cgctacccac ccggctactt ccccagggac
     2341 aacttgcgga tgaagaatga tcctttagac tggaatggcg accacgtcca caccaacttc
     2401 agggacatgt accagcatct gcgcagcatg ggctactttg tggaggtgct tggtgcccca
     2461 ttcacatgct ttgacgccac gcagtacggc actctgctta tggtggacag tgaggaagag
     2521 tacttccctg aggagattgc taagctgagg agggacgtgg acaatggcct ttcccttgtc
     2581 gtcttcagtg actggtacaa cacttctgtt atgagaaaag tgaagtttta cgatgaaaac
     2641 acaaggcagt ggtggatgcc agatactgga ggagccaacg tcccagctct aaacgagctg
     2701 ctgtctgtgt ggaacatggg gttcagtgac ggcctgtatg aaggggagtt tgccctggca
     2761 aaccacgaca tgtactatgc atcggggtgc agcattgcca ggtttccaga agatggtgtg
     2821 gtgatcacac agactttcaa ggaccaagga ttggaagtct taaaacaaga gacagcagtt
     2881 gtcgacaatg tccccattct ggggctttat cagattccag ctgaaggtgg aggccggatt
     2941 gtgctgtatg gagactccaa ctgcttggat gacagtcaca gacagaagga ctgcttttgg
     3001 cttctggatg cactccttca gtacacatcc tatggtgtga cccctcccag cctcagccat
     3061 tcagggaacc ggcagcgccc acccagcggg gctggcttgg cccctcctga aaggatggaa
     3121 ggaaaccacc ttcatcgcta ctccaaagtt cttgaggccc acttgggaga cccgaaacct
     3181 cggccccttc cagcctgtcc acacttgtcg tgggccaagc cacagccttt gaatgagacg
     3241 gcgcccagta atctttggaa acaccagaag ctgctctcca ttgacctgga caaagtagtg
     3301 ttacccaact ttcgctcaaa tcgccctcaa gtgagacctt tgtcccctgg agaaagtggt
     3361 gcctgggaca ttcctggagg gatcatgcct ggccgctaca accaggaagt aggccagacc
     3421 atccctgttt ttgccttcct tggagccatg gtggccctgg ccttcttcgt ggtacagatc
     3481 agtaaggcca agagccggcc gaagcggagg aggcccaggg caaagcgtcc acaacttgca
     3541 cagcaggccc accctgcaag gaccccgtca gtgtgatcat cacagtggcc agacacagaa
     3601 gctgacaagc tttgaacccc tctggtggcc acacagcatc agagagcatc ctgggaagtg
     3661 cctgtttcca aggagcccta tctctggatt gtggctggct tagtgtgttc tgcccagacg
     3721 tctatgaggt acatcctgca gtgcctcact gtgtttggct ctggccgaag gtgcccagta
     3781 gctcagcctc cggtggcatc aggcccagtg acagtgcacc aaagacacag agcctggaag
     3841 ggctgtcggg acatactttc tacataatgc tacaaccctg accaagcgaa gacat
//
