LOCUS       NM_017026               1976 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myelin basic protein (Mbp), transcript variant 5,
            mRNA.
ACCESSION   NM_017026
VERSION     NM_017026.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Darling,J.S. and Daniel,J.M.
  TITLE     Pubertal hormones mediate sex differences in levels of myelin basic
            protein in the orbitofrontal cortex of adult rats
  JOURNAL   Neuroscience 406, 487-495 (2019)
   PUBMED   30926549
  REMARK    GeneRIF: Gonadectomy prior to puberty onset resulted in a
            significant reduction of myelin basic protein levels in the
            orbitofrontal cortex in females but not males.
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Oberoi,R., Chu,T., Mellen,N., Jagadapillai,R., Ouyang,H.,
            Devlin,L.A. and Cai,J.
  TITLE     Diverse changes in myelin protein expression in rat brain after
            perinatal methadone exposure
  JOURNAL   Acta Neurobiol Exp (Wars) 79 (4), 367-373 (2019)
   PUBMED   31885393
  REMARK    GeneRIF: All pups with exposure to methadone demonstrated decreased
            expression of MBP in the cerebral cortex and hippocampus.In the
            cerebellum, PLP expression was downregulated without apparent
            alteration of CNP and MBP expression. PLP and MBP expression, but
            not CNP expression, were significantly inhibited in the brainstem.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Chin,J.P., Chen,C.M., Lee,T.H., Chou,C.W. and Lu,C.Y.
  TITLE     Angiostrongylus Cantonensis-Conditioned Culture Medium Induces
            Myelin Basic Protein Alterations via Erk1/2 and NF-kappaB
            Activation in Rat RSC96 Schwann Cells
  JOURNAL   Chin J Physiol 61 (3), 137-143 (2018)
   PUBMED   29742816
  REMARK    GeneRIF: Angiostrongylus cantonensis-conditioned culture medium
            induced suppression of the Erk1/2-NF-kappaB signaling pathway
            leading to reduced MBP production in RSC96 Schwann cells.
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Herbert,A.L., Fu,M.M., Drerup,C.M., Gray,R.S., Harty,B.L.,
            Ackerman,S.D., O'Reilly-Pol,T., Johnson,S.L., Nechiporuk,A.V.,
            Barres,B.A. and Monk,K.R.
  TITLE     Dynein/dynactin is necessary for anterograde transport of Mbp mRNA
            in oligodendrocytes and for myelination in vivo
  JOURNAL   Proc Natl Acad Sci U S A 114 (43), E9153-E9162 (2017)
   PUBMED   29073112
  REMARK    GeneRIF: A role for the retrograde dynein/dynactin motor complex in
            anterograde mbp mRNA transport.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Griffiths,I.R., Scott,I., McCulloch,M.C., Barrie,J.A., McPhilemy,K.
            and Cattanach,B.M.
  TITLE     Rumpshaker mouse: a new X-linked mutation affecting myelination:
            evidence for a defect in PLP expression
  JOURNAL   J Neurocytol 19 (2), 273-283 (1990)
   PUBMED   1694232
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Boylan,K.B., Takahashi,N., Paty,D.W., Sadovnick,A.D., Diamond,M.,
            Hood,L.E. and Prusiner,S.B.
  TITLE     DNA length polymorphism 5' to the myelin basic protein gene is
            associated with multiple sclerosis
  JOURNAL   Ann Neurol 27 (3), 291-297 (1990)
   PUBMED   1691612
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Brunner,C., Lassmann,H., Waehneldt,T.V., Matthieu,J.M. and
            Linington,C.
  TITLE     Differential ultrastructural localization of myelin basic protein,
            myelin/oligodendroglial glycoprotein, and 2',3'-cyclic nucleotide
            3'-phosphodiesterase in the CNS of adult rats
  JOURNAL   J Neurochem 52 (1), 296-304 (1989)
   PUBMED   2462020
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Schaich,M., Budzinski,R.M. and Stoffel,W.
  TITLE     Cloned proteolipid protein and myelin basic protein cDNA.
            Transcription of the two genes during myelination
  JOURNAL   Biol Chem Hoppe Seyler 367 (8), 825-834 (1986)
   PUBMED   2429678
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   McFarlin,D.E., Blank,S.E., Kibler,R.F., McKneally,S. and Shapira,R.
  TITLE     Experimental allergic encephalomyelitis in the rat: response to
            encephalitogenic proteins and peptides
  JOURNAL   Science 179 (4072), 478-480 (1973)
   PUBMED   4122324
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB586909.1, BC094522.1 and
            AI145512.1.
            
            On Jul 7, 2005 this sequence version replaced NM_017026.1.
            
            Summary: The protein encoded by the classic Mbp gene is a major
            constituent of the myelin sheath of oligodendrocytes and Schwann
            cells in the nervous system. However, Mbp-related transcripts are
            also present in the bone marrow and the immune system. These mRNAs
            arise from the long Mbp gene (otherwise called 'Golli-Mbp') that
            contains 3 additional exons located upstream of the classic Mbp
            exons. Alternative splicing from the Golli and the Mbp
            transcription start sites gives rise to 2 sets of Mbp-related
            transcripts and gene products. The Golli mRNAs contain 3 exons
            unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They
            encode hybrid proteins that have N-terminal Golli aa sequence
            linked to Mbp aa sequence. The second family of transcripts contain
            only Mbp exons and produce the well characterized myelin basic
            proteins. This complex gene structure is conserved among species
            suggesting that the Mbp transcription unit is an integral part of
            the Golli transcription unit and that this arrangement is important
            for the function and/or regulation of these genes. Mutation of the
            Mbp gene is associated with the 'shiverer' and 'myelin deficient'
            phenotypes in mouse. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5) lacks exons 2 and 6 compared
            to transcript variant 1 and encodes one of the classic Mbp isoforms
            (5) that is missing a 26 aa and a 41 aa segment compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB720346.1, BC094522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132293, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                CB586909.1         29-72
            45-1949             BC094522.1         1-1905
            1950-1976           AI145512.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..1976
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /note="myelin basic protein"
                     /db_xref="GeneID:24547"
                     /db_xref="RGD:3054"
     exon            1..254
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..464
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /note="isoform 5 is encoded by transcript variant 5;
                     myelin basic protein S; myelin basic protein Golli-mbp;
                     Golli-Mbp; MBP S"
                     /codon_start=1
                     /product="myelin basic protein isoform 5"
                     /protein_id="NP_058722.1"
                     /db_xref="GeneID:24547"
                     /db_xref="RGD:3054"
                     /translation="MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGR
                     FFSGDRGAPKRGSGKDSHTRTTHYGSLPQKSQRTQDENPVVHFFKNIVTPRTPPPSQG
                     KGRGLSLSRFSWGGRDSRSGSPMARR"
     exon            255..350
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /inference="alignment:Splign:2.1.0"
     exon            351..386
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /inference="alignment:Splign:2.1.0"
     exon            387..419
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /inference="alignment:Splign:2.1.0"
     exon            420..1959
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1930..1935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbp"
                     /gene_synonym="Mbps"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mbp"
                     /gene_synonym="Mbps"
     polyA_site      1959
                     /gene="Mbp"
                     /gene_synonym="Mbps"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 aagacaggcc ctcagagtcc gacgagcttc agaccatcca agaagatccc acagcagctt
       61 ccgaaggcct ggatgtgatg gcatcacaga agagaccctc acagcgacac ggatccaagt
      121 acttggccac agcaagtacc atggaccatg cccggcatgg cttcctccca aggcacagag
      181 acacgggcat ccttgactcc atcgggcgct tctttagcgg tgacaggggt gcgcccaagc
      241 ggggctctgg caaggactca cacacaagaa ctacccacta cggctccctg ccccagaagt
      301 cgcagaggac ccaagatgaa aacccagtag tccacttctt caagaacatt gtgacacctc
      361 gtacaccccc tccatcccaa ggaaagggga gaggcctgtc cctcagcaga tttagctggg
      421 gaggaagaga cagccgctct ggatctccca tggcaagacg ctgagagcct ccctgctcag
      481 ccttcccgaa tcctgccctc ggcttcttaa tataactgcc ttaaacgttt aattctactt
      541 gcaccaaata gctagttaga gcagaccctc tcttaatccc gtggggctgt gaacgcggcg
      601 gggccaggcc cacggcaccc tgactggcta aaactgtttg tcccttttta tttgaagatt
      661 gagtttcctc ggggtcttct ctgccccgac ttgctccccg tgtaccttgg tcgactccgg
      721 aggttcaggt gcacggacac cctttcaagt tcacccctac tccatcctca gactttcttt
      781 tcacggcgag gcgcacccct ccagcttccg tgggcactgc ggatagacag gcacaccgcc
      841 aaggagccag agagcatggc gcaggggact gtgtggtcca ggcttccttt gttttctttc
      901 ccctaaagag ctttgttttt cctaacagga tcagacagtc ttggagtggc ttacacaacg
      961 ggggcttgtg gtatgtgagc acaggctggg cagctgtgag agtccagagt ggggtggccc
     1021 tggggacgct tccaggccag cggttccctg caccccacca gctgatttcg agcgtggcag
     1081 agggaaggaa aggggcgagc gggctgggca atggacccga caggaaacgg ggacttaggg
     1141 gaacacgctg gagatgccat gtgtggctgc cgaaggtcac catctctcct cagtggctcc
     1201 ccagagcagg tgcttttaag aaccctgttt cctctcagag cccagggaga gtccaaggac
     1261 atggcgcatc aggaagtggg actgcaggag ttctctggtg gcctcgtgct gtccctctgg
     1321 ccacttctca ctttagggtg gtcagcggca gctcgccatg gcagtgccca ttggtgcaca
     1381 ctaacctcag tggaaaagta accattccct gcctcttaga aagaactcat tcttagtttt
     1441 aggagggttc ctgtcgctga atcaagtcgc tgccctggat gcagggctgg cctgggcgac
     1501 cctccaggga tgaggagctc agaattccag tcttctaatg tccacggaca cctccccatc
     1561 cctctaacgt actgactatg tcttttgatt tagcatgtct tctatagacc ttccaaagag
     1621 acccacactg gcactgtcac cccctaggag ggaaggtgat ggttgatgta gcccgacgcg
     1681 catcttgtta atccgttcta attccgagga gagtgtgggt ttaagataac acctattaat
     1741 gcattgccac aataatgtgg gggtaagaga aacgcaggga cgaaacttcc agaaacaaac
     1801 cctccagatc gttccacagg agtgttcgcc ctccggtgtg actgaacgac cgaccttgcc
     1861 catggcttca tccagacagc acagctgcag tatggctgga cagaagcacc tactgttctt
     1921 ggatattgaa ataaaataat aaacttgcaa tgatctttga aaaaaaaaaa aaaaaa
//
