LOCUS       NM_001415043            4580 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus muscleblind-like splicing regulator 2 (Mbnl2),
            transcript variant 2, mRNA.
ACCESSION   NM_001415043 XM_039093646
VERSION     NM_001415043.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4580)
  AUTHORS   Nakagaki-Silva,E.E., Gooding,C., Llorian,M., Jacob,A.G.,
            Richards,F., Buckroyd,A., Sinha,S. and Smith,C.W.J.
  TITLE     Identification of RBPMS as a mammalian smooth muscle master
            splicing regulator via proximity of its gene with super-enhancers
  JOURNAL   Elife 8, e46327 (2019)
   PUBMED   31283468
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4580)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4580)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4580)
  AUTHORS   Kino,Y., Washizu,C., Oma,Y., Onishi,H., Nezu,Y., Sasagawa,N.,
            Nukina,N. and Ishiura,S.
  TITLE     MBNL and CELF proteins regulate alternative splicing of the
            skeletal muscle chloride channel CLCN1
  JOURNAL   Nucleic Acids Res 37 (19), 6477-6490 (2009)
   PUBMED   19720736
REFERENCE   5  (bases 1 to 4580)
  AUTHORS   Kim,J.S., Coon,S.L., Weller,J.L., Blackshaw,S., Rath,M.F.,
            Moller,M. and Klein,D.C.
  TITLE     Muscleblind-like 2: circadian expression in the mammalian pineal
            gland is controlled by an adrenergic-cAMP mechanism
  JOURNAL   J Neurochem 110 (2), 756-764 (2009)
   PUBMED   19457059
  REMARK    GeneRIF: Pineal Mbnl2 transcripts and protein levels exhibit marked
            circadian rhythms; both are neurally regulated by an
            adrenergic/cyclic adenosine monophosphate (cAMP) mechanism.
            GeneRIF: Mbnl2 is strongly expressed in the rat pineal gland. Mbnl2
            mRNA and protein exhibit a circadian rhythm with ~ sevenfold higher
            values at night than day levels. Mbnl2 mRNA and protein levels are
            controlled by an adrenergic/cAMP mechanism.
REFERENCE   6  (bases 1 to 4580)
  AUTHORS   Paul,S., Dansithong,W., Kim,D., Rossi,J., Webster,N.J., Comai,L.
            and Reddy,S.
  TITLE     Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in
            DM1-associated aberrant IR splicing
  JOURNAL   EMBO J 25 (18), 4271-4283 (2006)
   PUBMED   16946708
REFERENCE   7  (bases 1 to 4580)
  AUTHORS   Ho,T.H., Charlet-B,N., Poulos,M.G., Singh,G., Swanson,M.S. and
            Cooper,T.A.
  TITLE     Muscleblind proteins regulate alternative splicing
  JOURNAL   EMBO J 23 (15), 3103-3112 (2004)
   PUBMED   15257297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Dec 20, 2022 this sequence version replaced XM_039093646.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1045431.1,
                                           SRR26643288.54644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000015.1  103792188-103792386
            200-821             JAXUCZ010000015.1  103840005-103840626
            822-986             JAXUCZ010000015.1  103895811-103895975
            987-1187            JAXUCZ010000015.1  103905489-103905689
            1188-1451           JAXUCZ010000015.1  103908878-103909141
            1452-1505           JAXUCZ010000015.1  103915514-103915567
            1506-1659           JAXUCZ010000015.1  103916227-103916380
            1660-1695           JAXUCZ010000015.1  103922848-103922883
            1696-1790           JAXUCZ010000015.1  103924165-103924259
            1791-4580           JAXUCZ010000015.1  103947038-103949827
FEATURES             Location/Qualifiers
     source          1..4580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q24"
     gene            1..4580
                     /gene="Mbnl2"
                     /note="muscleblind-like splicing regulator 2"
                     /db_xref="GeneID:680445"
                     /db_xref="RGD:1591755"
     exon            1..199
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..821
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             648..1805
                     /gene="Mbnl2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     muscleblind-like protein 2; muscleblind-like 2"
                     /codon_start=1
                     /product="muscleblind-like protein 2 isoform 2"
                     /protein_id="NP_001401972.1"
                     /db_xref="GeneID:680445"
                     /db_xref="RGD:1591755"
                     /translation="MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQ
                     VENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQ
                     FMFPGTPLHPVPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSP
                     PVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVC
                     MDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKAL
                     KRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQHTAF
                     IPTGSVLCMTPATSIVPMMHSATSATVSAATTPATSVPFAATATANQIILK"
     exon            822..986
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1187
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1451
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1505
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1659
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1695
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1790
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..4580
                     /gene="Mbnl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgtctt tgcttcatca tctgaaggta aaattttcca gccacggccg gcggctcgca
       61 gagtacaata aacagggacg gagaactatt tgcatggacc ccccttcctc atgatgcggt
      121 ggagaagccg cggccactcg gtcctgccag atgttcttgg ggttactgta caaggggagg
      181 acgagcagag ctaaacaaga atttaaaaag gacgaaggaa ggagaccgcc atcctgctca
      241 gatacaaaga tctaagaggg ttgtttcccc cgcatcctcc aaagctgtga gcatcagaac
      301 taatattttc ccaaagagtg ccatcgtatt gaagtcactt tattaaggag ggggtgtatc
      361 cacaaaaacc gtcaggagac cagaaccctg ggagccggag atgacagtga gtacacattg
      421 cttgtggctc acagtcttcc agcggggcct gtggatcggt gactgacttc ctgcttgctg
      481 acacatttcc cctccccggt ttcctggatt gaactgcatc aaggaattca ttacttacct
      541 tccaactttc atgttggagt tttcacggca gtagtttcga gatccttgag acttggattg
      601 attccatcac ttaacacaaa ggaaccgagc ccaaagtagt tctcatcatg gccttgaacg
      661 ttgcccccgt gagagacaca aagtggctga cgctggaagt ctgcagacag taccagagag
      721 gaacgtgctc acgctccgat gaagaatgca aattcgctca ccccccaaaa agttgccagg
      781 ttgaaaatgg aagagtaatt gcctgctttg attccctcaa gggccgctgt tcaagagaga
      841 actgcaaata tcttcatcct ccaacacacc taaaaactca gctagaaatc aatgggagga
      901 acaatttgat ccagcaaaaa actgcagcag cgatgcttgc ccagcagatg caattcatgt
      961 ttccaggaac accgctccac cctgtgccca cttttcctgt aggtcccacc atagggacaa
     1021 atgcggccat tagctttgct ccttacttag cgcctgtcac ccctggagtg gggttagtcc
     1081 caacagaggt tctacccacc acacctgtca ttgttccggg aagtccgccg gtcactgtcc
     1141 cgggctcaac tgcaactcag aaacttctca ggaccgataa actggaggta tgcagggagt
     1201 tccagcgagg aaactgtgcc cggggagaga cagactgccg ctttgcacac ccggcagaca
     1261 gcaccatgat cgacacaaac gacaacaccg taaccgtttg tatggattac ataaaggggc
     1321 gttgcatgag ggagaaatgc aaatattttc accctcctgc acacttgcag gccaaaatca
     1381 aagctgcgca gcaccaagcc aaccaggccg cggtggccgc ccaggcagcc gcggccgcgg
     1441 ccacagtcat gactcagtcg actgccaaag cactgaagcg acctctcgaa gcaactgtag
     1501 acctggcctt ccctcccggt gctcttcacc ctttaccaaa gagacaagca cttgaaaaaa
     1561 gcaacggagc cagcacggtc ttcaacccca gcgtcttgca ctaccagcag gctttgacca
     1621 gtgcgcagtt gcagcaacac acggcgttca ttcccacagg gtcagttttg tgcatgacac
     1681 ccgctaccag tattgtaccc atgatgcaca gcgctacgtc cgccactgtc tctgcagcaa
     1741 caactcctgc aacaagtgtc cccttcgcag caacagccac agccaatcag ataattctga
     1801 aataatcaac agaaatggaa tggaatgcca agaatctgca ttgagaataa ctaaacattg
     1861 ttactgtaca tactatcccc tttgctcctc aatagaattg ccacaaactg catgctaaat
     1921 ttagttcttc cggacagacc gcaaccctaa ggctagttct gctatgtcat atacgagtat
     1981 taaatatggt atgcttagta tattccagcc taagatagtt aactacctga gaccagctgc
     2041 gatgttcaaa gacatacagg atgaggtttt cttttacagg gttctgagcg tagtttctgt
     2101 cccaggaata ttgtcttatc tccataacta tagccgatgc agaaagccca cccagtatac
     2161 acatttcgac tcagaatact tcaaatttag caataagcag ttagctttag tttaagtacc
     2221 tattccaagg gcaggttcga ttctaattcc aatcaccacc atttcatttc ctgactggat
     2281 cataagggta tgatttcact tcctgaggag acggacactc gaagcaggag acgggaagtg
     2341 aagtaaaaca cgcacctgcc tcgcaggtct aaaatctgag tggcagttca agcacagttg
     2401 ccggggacac atcaagagtg tggggttcgc tttgccagga gatgccacac tgaatcatgg
     2461 gattctagaa taacattgca tagatcgaaa aaaaaaaaaa aaaaaacttt gcacggtatg
     2521 accttcatac ccaacccgac aaagtcttgg aggtattatt tcacaagtat atttttaaag
     2581 ttgttttata agagagactt tgtagaagtg cctagatttt gccagacttc atccagcttg
     2641 acaagaatga aaggctcatg ccgacagtcg aatctaaggg attggtcttt caaactcacc
     2701 ctccggttgc ctgttactga gtaactcctc taaactaaaa cctagtcaaa cagggaagct
     2761 gtaggtgagg aggtctgtat aatattccag tttaagtacg tctgagttta gtcactacag
     2821 atgcaaactg tgactttaat ctaaattact atgtaaacaa acaaacaaaa aaaaaagaag
     2881 tagatagttt cactttttaa aaaatccatt actgtttttg cattttaaaa gttggattaa
     2941 agggttgtaa ctaactacag catggaaaaa aatagttctt ttaattcttt caccttaaag
     3001 catattttat gtctcaaaag tataaaaaac tttaatacaa gtacatacat attatatata
     3061 cgcatacata tatatactat atatggatga aacatatttt aatgttgttt acttttttta
     3121 aatacttggt tgatcttcaa ggtaatagcg atacaattaa attttgttca gaaggtttgt
     3181 tttaaagttt attttaagca ctatcgtacc aaatatttca tatttcacat tttatatgtt
     3241 gcacatagcc tacacagtac ctagttttta aattattgtt taagaaatga aacaactgtt
     3301 ataaatggat attatgtgta attgtttaaa acatccattt tctttgtgaa cattttagtg
     3361 attgaagtat tttgactttt gagattgaat gtaaaatatt ttaaattttt ggtatcattg
     3421 cctgttctga aaactaaagg catccaacca tatcattttt gttttgattg agaaaaaaac
     3481 tgcatttaat tcatgttggt caaagtctaa ttactatcta tttatcttac atcatagatc
     3541 tgataactgt atcaaagaga aatcccattc tgagtgtaat cttgagtagt gcttgtatcg
     3601 tgtttgtttt taatttgtgg aaaggtattg tatctaactt gtatcacttc catagttctc
     3661 atcttcatgt attattgata cttgtaactc tctcagctat aacaatgtag ttacgctaca
     3721 acttgcctaa aacactcaga cttatttttt tttctttact tactcattta aacgcattaa
     3781 aaagatagta gactaaaaag gtaaattatg ggaatcaccg aaatattttt gtagactaat
     3841 tgttgtaact gtcttctttt tctttctttt catgattttt tattttaaaa attactagca
     3901 catagctatt ttcagccctt taataattga gcatcaaaac atcacctcta tcccccagca
     3961 aatatagatg actgtatttt tactatgata tccattttcc agaattgtga ttataatatg
     4021 cagagtcaaa tacgccattt ccaataagga ggaagcaagg caaatgcata gatgtacaaa
     4081 tatatgtaca acagattttg ctttttattt atttataatg taattttata gaataattct
     4141 gggatttgag aggatctaaa actatttttc tgtataaata ttatttgcca aaagtttgtt
     4201 tatattcaga agtctgacta tgatggataa atcttaaatg ctttgtttaa ttacaaaaac
     4261 aaaatcacca atatccaaga caggaagata tcagttcaac agcttactga agttaggaaa
     4321 ctaactccac tcgtatggga actccatttc actcttggtt ttcaggatat aacagcactt
     4381 cacagaaata ttctttcagc catatgccac tggtcacatt tctactaaat ctttctgtaa
     4441 cacttcttaa agaattccct cattcgttat ctcacggtgt aagcaggact ctaatttgta
     4501 tcaattctat gttttggttg taatattcag ttcactcacc caatgtacaa ccaatgaaat
     4561 aaaagaagca tttaaaagga
//
