LOCUS       NM_001191566            5543 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus muscleblind-like splicing regulator 1 (Mbnl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001191566 XM_002729038 XM_039101837
VERSION     NM_001191566.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5543)
  AUTHORS   Nakagaki-Silva,E.E., Gooding,C., Llorian,M., Jacob,A.G.,
            Richards,F., Buckroyd,A., Sinha,S. and Smith,C.W.J.
  TITLE     Identification of RBPMS as a mammalian smooth muscle master
            splicing regulator via proximity of its gene with super-enhancers
  JOURNAL   Elife 8, e46327 (2019)
   PUBMED   31283468
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5543)
  AUTHORS   Gooding,C., Edge,C., Lorenz,M., Coelho,M.B., Winters,M.,
            Kaminski,C.F., Cherny,D., Eperon,I.C. and Smith,C.W.
  TITLE     MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3
  JOURNAL   Nucleic Acids Res 41 (9), 4765-4782 (2013)
   PUBMED   23511971
  REMARK    GeneRIF: The data suggest that the smooth muscle splicing of Tpm1
            is mediated by allosteric assembly of an RNA-protein complex
            minimally comprising PTB, MBNL and their cognate RNA-binding sites.
REFERENCE   3  (bases 1 to 5543)
  AUTHORS   Braunschweig,U., Gueroussov,S., Plocik,A.M., Graveley,B.R. and
            Blencowe,B.J.
  TITLE     Dynamic integration of splicing within gene regulatory pathways
  JOURNAL   Cell 152 (6), 1252-1269 (2013)
   PUBMED   23498935
  REMARK    Review article
REFERENCE   4  (bases 1 to 5543)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 5543)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 5543)
  AUTHORS   Ladd,A.N., Stenberg,M.G., Swanson,M.S. and Cooper,T.A.
  TITLE     Dynamic balance between activation and repression regulates
            pre-mRNA alternative splicing during heart development
  JOURNAL   Dev Dyn 233 (3), 783-793 (2005)
   PUBMED   15830352
REFERENCE   7  (bases 1 to 5543)
  AUTHORS   Ho,T.H., Charlet-B,N., Poulos,M.G., Singh,G., Swanson,M.S. and
            Cooper,T.A.
  TITLE     Muscleblind proteins regulate alternative splicing
  JOURNAL   EMBO J 23 (15), 3103-3112 (2004)
   PUBMED   15257297
REFERENCE   8  (bases 1 to 5543)
  AUTHORS   Kanadia,R.N., Johnstone,K.A., Mankodi,A., Lungu,C., Thornton,C.A.,
            Esson,D., Timmers,A.M., Hauswirth,W.W. and Swanson,M.S.
  TITLE     A muscleblind knockout model for myotonic dystrophy
  JOURNAL   Science 302 (5652), 1978-1980 (2003)
   PUBMED   14671308
REFERENCE   9  (bases 1 to 5543)
  AUTHORS   Kanadia,R.N., Urbinati,C.R., Crusselle,V.J., Luo,D., Lee,Y.J.,
            Harrison,J.K., Oh,S.P. and Swanson,M.S.
  TITLE     Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2
            and Mbnl3
  JOURNAL   Gene Expr Patterns 3 (4), 459-462 (2003)
   PUBMED   12915312
REFERENCE   10 (bases 1 to 5543)
  AUTHORS   Miller,J.W., Urbinati,C.R., Teng-Umnuay,P., Stenberg,M.G.,
            Byrne,B.J., Thornton,C.A. and Swanson,M.S.
  TITLE     Recruitment of human muscleblind proteins to (CUG)(n) expansions
            associated with myotonic dystrophy
  JOURNAL   EMBO J 19 (17), 4439-4448 (2000)
   PUBMED   10970838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 4, 2022 this sequence version replaced
            XM_039101837.1, NM_001191566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.9854.1,
                                           SRR26643296.6175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000002.1  146820034-146820189
            157-1183            JAXUCZ010000002.1  146846732-146847758
            1184-1354           JAXUCZ010000002.1  146929890-146930060
            1355-1555           JAXUCZ010000002.1  146937860-146938060
            1556-1813           JAXUCZ010000002.1  146947299-146947556
            1814-1867           JAXUCZ010000002.1  146948713-146948766
            1868-2021           JAXUCZ010000002.1  146949639-146949792
            2022-2116           JAXUCZ010000002.1  146956135-146956229
            2117-2191           JAXUCZ010000002.1  146959052-146959126
            2192-5543           JAXUCZ010000002.1  146960785-146964136
FEATURES             Location/Qualifiers
     source          1..5543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     gene            1..5543
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /note="muscleblind-like splicing regulator 1"
                     /db_xref="GeneID:282635"
                     /db_xref="RGD:628668"
     exon            1..156
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            157..1183
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             1010..2173
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     muscleblind-like protein 1; muscleblind-like 1"
                     /codon_start=1
                     /product="muscleblind-like protein 1 isoform 1"
                     /protein_id="NP_001178495.1"
                     /db_xref="GeneID:282635"
                     /db_xref="RGD:628668"
                     /translation="MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQ
                     VENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQL
                     ANAMMPGAPLQPVPMFSVAPSLATNASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNP
                     GVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVT
                     VCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMTQSAVKSL
                     KRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAF
                     LPPVPMVHGATPATVSAATTSATSVPFAATATANQIPIISAEHLTSHKYVTQM"
     exon            1184..1354
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1555
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1813
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1867
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2021
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2116
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2191
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..5543
                     /gene="Mbnl1"
                     /gene_synonym="Mbnl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcaacgc agcccgacga gtcggggcgc tagccatgct ccggtgaccc ggacccggcc
       61 agtttccttt cccgtggcgg gcatcccgga gtagcgatcc cacaatgccc cgggcagtcg
      121 gggccccggc gggcagcctg cacggccacg tgagaggttg gtactaagaa gtgcctttcc
      181 tgacgtctct gctgcttgga accgcttcta gagcagcctc tgcttttgcc ttgcttgctg
      241 ccagctagac tgtgacgaca gcacatccgc cctccacctc tagcccagac acccccattt
      301 ctacttctaa tcaggagaaa agctctgagt atctgccatt gccctaggct gctttagttt
      361 agaagaaaag tttgctgaaa aagtaagata ccttctgcca ggaaatcaag gaggaaaaaa
      421 aaatcatttt ctcgattttg ctctaaactg ctgcatctgt ctatgccaaa ctaatcaata
      481 ccgattgcac caccaaactc catcgcaaat cagctgtgag gagatcccct gtcagacaac
      541 tttgctgaga gcagcttgga aattcggtgt caaagggtct gccacgtttt catgcttgca
      601 ttttgggctc caaattggca ctgggaaggg gttacgagca caaggctgat tccaggccct
      661 cctttaaaca cccatctact tacaaccgtg gtatttctct aaaaaccaaa acctctttga
      721 attaacagtt tcatgctgtg aatttctagc ggaggtcttt cccttgatat tgaagtcaca
      781 cttttccatg tgccgttaaa gcggggactg gggaagcagc ctttcggaca ttttcacagt
      841 catctcacac ttctgagttt tatcagttcc tattttgttt agtttttgtc ttttgttttg
      901 ggttgctgat ttttttcttt tcttttcttt tttccttttt tttttttttt ttgagaggga
      961 ttgggtttgt tggtttcatt gaacatttaa ctacctgtaa aatataaaca tggctgttag
     1021 tgtcacacca attcgggaca caaaatggct aacactggaa gtatgtagag agtttcaaag
     1081 ggggacttgc tcacgaccag acacggaatg taaatttgca catccttcga aaagctgcca
     1141 agttgaaaat ggacgagtaa tcgcctgctt tgattcactg aaaggtcgtt gctccagaga
     1201 aaactgcaaa tatcttcatc caccccctca tttaaaaaca caattggaga taaatgggcg
     1261 gaataacttg attcagcaga agaacatggc catgctggcc cagcaaatgc agttagccaa
     1321 cgccatgatg cccggtgccc cactgcagcc cgtgccaatg ttttcagttg caccaagctt
     1381 agccaccaat gcatcagcag cctttaatcc ctacctgggg cctgtttccc caagcctggt
     1441 tccagcagag atcttgccga ctgcaccaat gttggtcacg gggaatcctg gagttccggt
     1501 gccagcagct gctgcagctg ctgcacagaa gttaatgcgg acagacagac tggaggtgtg
     1561 ccgagagtac cagcgtggca attgcaaccg aggagaaaat gactgtcgat ttgctcatcc
     1621 tgctgacagc acaatgattg ataccaatga caacacagtc actgtctgca tggattacat
     1681 caaggggaga tgctctcggg aaaagtgcaa atacttccat ccccccgcac acctgcaagc
     1741 caagatcaag gctgctcaat accaggtcaa ccaggctgca gcagcgcagg ctgcagctac
     1801 tgcagctgcc atgactcagt cggctgtcaa atcactgaag cgacccctcg aggcaacctt
     1861 tgacctggga attcctcaag ctgtacttcc cccattgcca aagaggcctg ctcttgaaaa
     1921 aaccaacggt gccaccgcag tctttaacac gggtattttc caataccaac aggctctagc
     1981 caacatgcag ttacagcagc atacagcgtt cctcccacca gttcccatgg tgcacggtgc
     2041 tacgccagcc actgtgtccg cagcaacaac atctgccaca agtgttccct tcgctgcaac
     2101 agccacagcc aaccagatac ccataatatc tgccgaacat ctgactagcc acaagtatgt
     2161 tacccagatg tagagctgtc gtcacaaaac aatcatacaa agaggaaagg acagtgtgct
     2221 tgattagagt aaggacgacg tcattagcca tattgtatat accgtcaagc aacacacaca
     2281 aaaatccctc agccacaaga catccacata ttgcatgtta accagaagaa aagacaacat
     2341 gggaacctgc tgcacactgt tgcctacaca ctttgtacat ccaattggta tttgtgctga
     2401 ggtgatattc ctatctaaaa caacaacatt gtctttcttt tgtagcacag agttatgcat
     2461 taaaatatgc atacataatt agtttcctat atattcatgc catcttgaaa agacagactg
     2521 tggtgtaacc atgattctat tatgtattgg tacgtctgta gaccaagata taatttttta
     2581 aaaataagtt tatttctttc aaggtttaca agtaacaaag gtgcaccttg tatttaaaat
     2641 cgccattaga gctgagagcg cgcatgcaca gtcatttttg tttaagagta atatttttac
     2701 tgtaatagat tgtaagacat ggtgagggag ggatctgaca gagatgaatg tgccaagcaa
     2761 aaccacaact gtgtatattt taaagcacat catggcttta agtaccatgt tgttaaggat
     2821 tctcatgaag tgccatagac tgtacatcag attagagtat tatttcttca gtgttattgt
     2881 tttcggagcc acattctgtt gcttatttgc tagaactaat caatcaaagg gcaccattct
     2941 tttctttttt tttttgtttt tgaaaccaaa gctgtctcag aaatggccaa tttaactcta
     3001 cagtaacaat agacagcaca acacaaactc aatacagata acctttcaca tactggagat
     3061 atatataata gatatatgaa attattttaa tgcattgtag tgtaatattt atgcatactc
     3121 tactatataa catgttattc aaaagggata tgccatttct gagacacaat aacaaaaaat
     3181 gtttgaggaa attattttgc ttctatttat agcctctgtc aaaagtcaaa agactataaa
     3241 tgctttgcag aaatgggttc acgtttgcgt aaatgcttca tcacagtcac attcaaaata
     3301 gtgactctaa accaagagaa cagcactgtc atcagatgca tgataaacca aaatatgaaa
     3361 atgggaaatg tttaattaac ctagtaattg ggtgggttaa gtacatgggt gaattttata
     3421 tgtgattctt ttgttcagat taactgctta tagccttaga aagcctttta aaaattttaa
     3481 aatagatgtg cattcagttt ttaagaatgg attcatccaa aggaattccc ctttttgtgg
     3541 tttggatgtt acagctagta aaggatattt ttgctctgct cagcagttct agaaatcgct
     3601 gagtaggggc caggtcactg gcagtgctag tgtgggatgg gagaggtgag agttctgtta
     3661 tagaactttc catactccca agtttactgc aagtttttac gcttgagaga gacgctttct
     3721 aatataagac tgatgtgttg attttactga ttgtactgta catctattaa agccttagat
     3781 tattacatta cgggttggaa cccataccaa tgtaatttca atcgtgttaa gagagtaatg
     3841 gtgacttcac atgttattgt agttagttac attatagaat attacttatt tttcttgtta
     3901 aaatgtagtt tttcatttcc tacatttctt agattttcat tttctattaa cagttgaata
     3961 ccatttcagt ttttagatta ttgttttatt agattttacc aatgaatttt tcaaaataca
     4021 aaaaaattaa agtagttttt cttcataaca taatcagttt taaattacat gtagtgtcat
     4081 atgaatatcc atattattgt caactaaatg atttatattt tactgattta atattacagt
     4141 gtaagaatgt cagtcattgt tcttgtctag ttttcattaa aagaacaaag atcttttata
     4201 tggatatctt ataaatatat aatcattgct aagtaagaag ttaagttgtt gctatggcaa
     4261 caatcctggc agacaattga gtaatatttt gatgatttat tttgtttgta attagttatt
     4321 atgagaagat ctagatccta gatattagaa taaaatttat tttctactgt atccatttca
     4381 aatgttaaag tattgtttaa tatttttgaa atccctgaat atcaggcctt gttataaata
     4441 agctgcataa tcaataaata gaacaaggga cgttttgttg ataatccaaa tactcaaagt
     4501 ttacgtgagg agaattttag cgtgtgtgca aactcttgag ggttgatgat gctgcaattt
     4561 agcatgttgg gaagtctaga gagaaggttg actttttgca cttctgtata tagtcaaaag
     4621 agagaaacct gtataatagc aagatcttat tttgaataaa aacgtctata attaccagga
     4681 gttttgttaa ggctaatgaa atgacagact gagcaaaatt gcttgcaaaa gtggcacaga
     4741 gttagcactc catacccttc aaacacgttg ctttgctttt gtggacagct tgtagtttgc
     4801 caggattttc cagctggaaa gatttgccat ccttccgaga tctcatgact gacaaaactc
     4861 cattgggcca aatctgcctg aagatcatta ccaaaaaata gcaggtactt cagtcactaa
     4921 gatgaaatcg tggatcagat attccttaca ttgttttcaa atctactgca tgtttaaaac
     4981 ttcaacaaaa agagagaaag aactatgcta aggacatata ttattcagat cgatatctac
     5041 caatttcaat ggtttaatgt tcacaaaatg aaatcttcaa aacaactatt gactttcaca
     5101 aaatgtaaac cataagcagg cagaccagac agcacacctg tagtccttct gtggttgttt
     5161 taaccgcttt agagcttgtt ctttccgcag gtgaaaacaa actccaaatt tcacagtttt
     5221 aatttccaac tcagagcact caaaagagca aaatgtgaca atggccactt gtttaatgac
     5281 ctggttgccc agctgcccct ccagctggct actgatgttg cacttaccag caacccacac
     5341 tttcatctgc tgaaaggaca atgtgctcgg ctttactatt atgtaatcac aacttacttt
     5401 gcttgtagtt gcttacaatt atgtattctg tctagggctg cgatttgttt tatgcttact
     5461 ttattattac tgcagtagtt gactttgctg tatggaaaaa taaagtgaaa ttgccctaat
     5521 aaaacttctc tttcttaagt ata
//
