LOCUS       NM_022704                874 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus mannose binding lectin 2 (Mbl2), mRNA.
ACCESSION   NM_022704
VERSION     NM_022704.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 874)
  AUTHORS   Liu,C.M., Chen,J., Yang,S., Mao,L.G., Jiang,T.T., Tu,H.H.,
            Chen,Z.L., Hu,Y.T., Gan,L., Li,Z.J. and Li,J.C.
  TITLE     The Chinese herbal formula Zhibai Dihuang Granule treat
            Yin-deficiency-heat syndrome rats by regulating the immune
            responses
  JOURNAL   J Ethnopharmacol 225, 271-278 (2018)
   PUBMED   29729385
REFERENCE   2  (bases 1 to 874)
  AUTHORS   Su,C., Lin,Y., Mao,Q., Wu,D., Zhu,L., Najera,I., Garcia-Alcalde,F.
            and Niu,J.
  TITLE     Association study between mannose-binding lectin haplotypes and X
            gene mutation of hepatitis B virus from treatment naive patients
  JOURNAL   Aging (Albany NY) 8 (11), 2862-2870 (2016)
   PUBMED   27824315
REFERENCE   3  (bases 1 to 874)
  AUTHORS   Ozaki,M., Kang,Y., Tan,Y.S., Pavlov,V.I., Liu,B., Boyle,D.C.,
            Kushak,R.I., Skjoedt,M.O., Grabowski,E.F., Taira,Y. and Stahl,G.L.
  TITLE     Human mannose-binding lectin inhibitor prevents Shiga toxin-induced
            renal injury
  JOURNAL   Kidney Int 90 (4), 774-782 (2016)
   PUBMED   27378476
REFERENCE   4  (bases 1 to 874)
  AUTHORS   Su,C., Lin,Y., Cai,L., Mao,Q. and Niu,J.
  TITLE     Association between mannose-binding lectin variants, haplotypes and
            risk of hepatocellular carcinoma: A case-control study
  JOURNAL   Sci Rep 6, 32147 (2016)
   PUBMED   27557564
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 874)
  AUTHORS   Wang,P.S., Kuai,J., Li,H., Wang,C.G., Shi,B.J. and Zhong,L.
  TITLE     Mannose-binding lectin 2 rs11003123 polymorphism is associated with
            the development of hepatocellular carcinoma in patients with
            hepatitis B-related cirrhosis in the Chinese population
  JOURNAL   Hepatobiliary Pancreat Dis Int 15 (3), 282-288 (2016)
   PUBMED   27298104
REFERENCE   6  (bases 1 to 874)
  AUTHORS   Ng,K.K., Drickamer,K. and Weis,W.I.
  TITLE     Structural analysis of monosaccharide recognition by rat liver
            mannose-binding protein
  JOURNAL   J Biol Chem 271 (2), 663-674 (1996)
   PUBMED   8557671
REFERENCE   7  (bases 1 to 874)
  AUTHORS   Wada,M., Itoh,N., Ohta,M. and Kawasaki,T.
  TITLE     Characterization of rat liver mannan-binding protein gene
  JOURNAL   J Biochem 111 (1), 66-73 (1992)
   PUBMED   1607365
REFERENCE   8  (bases 1 to 874)
  AUTHORS   Oka,S., Ikeda,K., Kawasaki,T. and Yamashina,I.
  TITLE     Isolation and characterization of two distinct mannan-binding
            proteins from rat serum
  JOURNAL   Arch Biochem Biophys 260 (1), 257-266 (1988)
   PUBMED   3124748
REFERENCE   9  (bases 1 to 874)
  AUTHORS   Oka,S., Itoh,N., Kawasaki,T. and Yamashina,I.
  TITLE     Primary structure of rat liver mannan-binding protein deduced from
            its cDNA sequence
  JOURNAL   J Biochem 101 (1), 135-144 (1987)
   PUBMED   3032924
REFERENCE   10 (bases 1 to 874)
  AUTHORS   Drickamer,K., Dordal,M.S. and Reynolds,L.
  TITLE     Mannose-binding proteins isolated from rat liver contain
            carbohydrate-recognition domains linked to collagenous tails.
            Complete primary structures and homology with pulmonary surfactant
            apoprotein
  JOURNAL   J Biol Chem 261 (15), 6878-6887 (1986)
   PUBMED   3009480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X05023.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022704.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: FQ210356.1, M14103.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5756307, SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..874
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /note="mannose binding lectin 2"
                     /db_xref="GeneID:64668"
                     /db_xref="RGD:67380"
     exon            1..185
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..745
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /note="mannose-binding protein C (liver); MBP-C;
                     RARF/P28A; mannan-binding protein; RA-reactive factor P28A
                     subunit; raRF p28A; ra-reactive factor
                     polysaccharide-binding component p28A; mannose binding
                     lectin 2 (protein C); mannose-binding lectin (protein C)
                     2; mannose-binding protein C-like"
                     /codon_start=1
                     /product="mannose-binding protein C precursor"
                     /protein_id="NP_073195.2"
                     /db_xref="GeneID:64668"
                     /db_xref="RGD:67380"
                     /translation="MSLFTSFLLLCVLTAVYAETLTEGAQSSCPVIACSSPGLNGFPG
                     KDGHDGAKGEKGEPGQGLRGLQGPPGKVGPAGPPGNPGSKGATGPKGDRGESVEFDTT
                     NIDLEIAALRSELRAMRKWVLLSMSENVGKKYFMSSVRRMPLNRAKALCSELQGTVAT
                     PRNAEENRAIQNVAKDVAFLGITDQRTENVFEDLTGNRVRYTNWNEGEPNNVGSGENC
                     VVLLTNGKWNDVPCSDSFLVVCEFSD"
     exon            186..302
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /inference="alignment:Splign:2.1.0"
     exon            303..371
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /inference="alignment:Splign:2.1.0"
     exon            372..869
                     /gene="Mbl2"
                     /gene_synonym="Ab2-001; Ab2-011"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgaggacc atgtccctgt tcacatcctt ccttctgctc tgcgtgctca cggcagtcta
       61 tgccgagacc ttaaccgaag gggctcaaag tagctgccct gtgattgcct gcagttctcc
      121 gggcctgaac ggcttcccag gcaaagatgg acacgacggt gccaagggag aaaagggaga
      181 accgggtcaa ggcctcagag gcttgcaggg ccctcctgga aaagtaggac ctgcagggcc
      241 cccagggaat cctgggtcaa aaggagcaac gggaccaaaa ggagaccgtg gagagagtgt
      301 agaatttgat actaccaaca ttgatttaga aattgcagcc ctgcgatcgg agctgagagc
      361 tatgagaaag tgggtgctcc tttctatgag tgaaaatgtt ggaaagaagt acttcatgag
      421 cagtgttaga aggatgcccc ttaacagagc gaaggctctg tgctccgaac tccagggcac
      481 tgtggccact cccaggaatg ctgaggaaaa tagggccatc cagaatgtgg ccaaagatgt
      541 tgccttcttg ggcataacgg accagaggac tgaaaacgtt tttgaggacc tgacaggaaa
      601 cagagtgcgc tacactaact ggaatgaggg tgagcccaac aatgtgggct ctggggaaaa
      661 ctgtgtggtg ctcttgacaa atgggaagtg gaatgacgtt ccttgctctg attctttttt
      721 ggtagtttgt gaattctctg actgagggtg cttgtttctc atccctcctt gatacttcag
      781 tgtattctat aagtccacag tttgttctga aaatataggc aattcaacat tggttaccta
      841 attaaactgt aacatttttc agaatagcaa aaaa
//
