LOCUS       NM_012599               1226 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus mannose binding lectin 1 (Mbl1), mRNA.
ACCESSION   NM_012599
VERSION     NM_012599.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Nakamura,A., Okigaki,M., Miura,N., Suzuki,C., Ohno,N., Kametani,F.
            and Hamaoka,K.
  TITLE     Involvement of mannose-binding lectin in the pathogenesis of
            Kawasaki disease-like murine vasculitis
  JOURNAL   Clin Immunol 153 (1), 64-72 (2014)
   PUBMED   24721319
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Orsini,F., Villa,P., Parrella,S., Zangari,R., Zanier,E.R.,
            Gesuete,R., Stravalaci,M., Fumagalli,S., Ottria,R., Reina,J.J.,
            Paladini,A., Micotti,E., Ribeiro-Viana,R., Rojo,J., Pavlov,V.I.,
            Stahl,G.L., Bernardi,A., Gobbi,M. and De Simoni,M.G.
  TITLE     Targeting mannose-binding lectin confers long-lasting protection
            with a surprisingly wide therapeutic window in cerebral ischemia
  JOURNAL   Circulation 126 (12), 1484-1494 (2012)
   PUBMED   22879370
  REMARK    GeneRIF: Our data show an important role for MBL in the
            pathogenesis of brain ischemic injury and provide a strong support
            to the concept that MBL inhibition may be a relevant therapeutic
            target.
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Miller,A., Phillips,A., Gor,J., Wallis,R. and Perkins,S.J.
  TITLE     Near-planar solution structures of mannose-binding lectin oligomers
            provide insight on activation of lectin pathway of complement
  JOURNAL   J Biol Chem 287 (6), 3930-3945 (2012)
   PUBMED   22167201
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Yang,Y.X., Huang,S.M., Yan,X.Y. and Wu,W.H.
  TITLE     [Relationship between activation of mannan-binding lectin
            complement and NF-kappaB in diabetic nephropathy]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 42 (4), 490-493 (2011)
   PUBMED   21866632
  REMARK    GeneRIF: The expression of MBL was positively correlated with
            NF-kappaB expression in diabetic nephropathy.
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   La Bonte,L.R., Dokken,B., Davis-Gorman,G., Stahl,G.L. and
            McDonagh,P.F.
  TITLE     The mannose-binding lectin pathway is a significant contributor to
            reperfusion injury in the type 2 diabetic heart
  JOURNAL   Diab Vasc Dis Res 6 (3), 172-180 (2009)
   PUBMED   20216929
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Weis,W.I., Drickamer,K. and Hendrickson,W.A.
  TITLE     Structure of a C-type mannose-binding protein complexed with an
            oligosaccharide
  JOURNAL   Nature 360 (6400), 127-134 (1992)
   PUBMED   1436090
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Weis,W.I., Kahn,R., Fourme,R., Drickamer,K. and Hendrickson,W.A.
  TITLE     Structure of the calcium-dependent lectin domain from a rat
            mannose-binding protein determined by MAD phasing
  JOURNAL   Science 254 (5038), 1608-1615 (1991)
   PUBMED   1721241
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Ikeda,K., Sannoh,T., Kawasaki,N., Kawasaki,T. and Yamashina,I.
  TITLE     Serum lectin with known structure activates complement through the
            classical pathway
  JOURNAL   J Biol Chem 262 (16), 7451-7454 (1987)
   PUBMED   3584121
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Drickamer,K. and McCreary,V.
  TITLE     Exon structure of a mannose-binding protein gene reflects its
            evolutionary relationship to the asialoglycoprotein receptor and
            nonfibrillar collagens
  JOURNAL   J Biol Chem 262 (6), 2582-2589 (1987)
   PUBMED   3029088
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Drickamer,K., Dordal,M.S. and Reynolds,L.
  TITLE     Mannose-binding proteins isolated from rat liver contain
            carbohydrate-recognition domains linked to collagenous tails.
            Complete primary structures and homology with pulmonary surfactant
            apoprotein
  JOURNAL   J Biol Chem 261 (15), 6878-6887 (1986)
   PUBMED   3009480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088159.1.
            
            On Mar 13, 2005 this sequence version replaced NM_012599.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088159.1, FQ218582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1226
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /note="mannose binding lectin 1"
                     /db_xref="GeneID:24548"
                     /db_xref="RGD:3055"
     exon            1..62
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..223
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..789
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /note="Mannose binding protein A, serum; mannose binding
                     lectin 2, protein C; mannose-binding protein A; mannose
                     binding lectin 1, protein A; MBP-A; mannan-binding
                     protein; mannose binding lectin (A); mannose-binding
                     lectin (protein A) 1"
                     /codon_start=1
                     /product="mannose-binding protein A precursor"
                     /protein_id="NP_036731.2"
                     /db_xref="GeneID:24548"
                     /db_xref="RGD:3055"
                     /translation="MLLLPLLVLLCVVSVSSSGSQTCEETLKTCSVIACGRDGRDGPK
                     GEKGEPGQGLRGLQGPPGKLGPPGSVGAPGSQGPKGQKGDRGDSRAIEVKLANMEAEI
                     NTLKSKLELTNKLHAFSMGKKSGKKFFVTNHERMPFSKVKALCSELRGTVAIPRNAEE
                     NKAIQEVAKTSAFLGITDEVTEGQFMYVTGGRLTYSNWKKDEPNDHGSGEDCVTIVDN
                     GLWNDISCQASHTAVCEFPA"
     exon            224..340
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..415
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..1192
                     /gene="Mbl1"
                     /gene_synonym="Mbpa; Mlb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaagctg ggctggagac acagtttctc ttccactgct cctttacttt gacgaaaccc
       61 taggaaggga ccatgctcct gcttccactg ctcgtccttc tctgtgtagt gagcgtgtcc
      121 tcatcagggt cacaaacctg tgaggaaacc ctgaagactt gctctgtgat agcctgcggc
      181 agagacggga gagatgggcc caaaggggag aagggagaac caggtcaagg gctcaggggc
      241 ttgcagggcc ctccagggaa actggggcct ccaggaagtg taggagcccc tggaagtcaa
      301 ggaccaaaag gccaaaaagg ggatcgtgga gacagcagag ccattgaggt gaagctggca
      361 aatatggagg cagagataaa caccctgaag tcaaaactgg agctaaccaa caagttgcat
      421 gccttctcca tgggtaaaaa gtctgggaag aagttctttg tgaccaacca tgaaaggatg
      481 cccttttcca aagtcaaggc cctgtgctca gagctccgag gcactgtggc tatccccagg
      541 aatgctgagg agaacaaggc catccaagaa gtggctaaaa cctctgcctt cctaggcatc
      601 acggacgagg tgactgaagg ccaattcatg tatgtgacag gggggaggct cacctacagc
      661 aactggaaaa aggatgagcc caatgaccat ggctctgggg aagactgtgt cactatagta
      721 gacaacggtc tgtggaatga catctcctgc caagcttccc acacggctgt ctgcgagttc
      781 ccagcctgag gaaaccagtg cctccatcgt ctccttggct ctcagtcgct tccaaaaaaa
      841 attcagttac tggtttctca agtttagtgt taagtgattc ttttgatggg agagaatgta
      901 tttgcttgtg gcatgaggac acgaatagaa gctgaccggg aggcaccagg atctggttga
      961 gcacggagca aaggtcacat ccattttgct aggaacacag caagaagtca actatggaaa
     1021 acctacaata aatatcccct gcccttttca ccagaggacc aaaggtggtc cttatctgtg
     1081 ccagagtggc agctgatctc agccataaaa gcacccaatt ccctttctcc atgaattgtc
     1141 actaagtggt gtcaaacgtg cctgtttgaa gtcatcctca gtctacaagg tgaaaaaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
