LOCUS       NM_001170566            3995 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 6 (Mbd6), mRNA.
ACCESSION   NM_001170566 XM_001055890 XM_343219
VERSION     NM_001170566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3995)
  AUTHORS   Cukier,H.N., Lee,J.M., Ma,D., Young,J.I., Mayo,V., Butler,B.L.,
            Ramsook,S.S., Rantus,J.A., Abrams,A.J., Whitehead,P.L.,
            Wright,H.H., Abramson,R.K., Haines,J.L., Cuccaro,M.L.,
            Pericak-Vance,M.A. and Gilbert,J.R.
  TITLE     The expanding role of MBD genes in autism: identification of a
            MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1
  JOURNAL   Autism Res 5 (6), 385-397 (2012)
   PUBMED   23055267
REFERENCE   2  (bases 1 to 3995)
  AUTHORS   Laget,S., Joulie,M., Le Masson,F., Sasai,N., Christians,E.,
            Pradhan,S., Roberts,R.J. and Defossez,P.A.
  TITLE     The human proteins MBD5 and MBD6 associate with heterochromatin but
            they do not bind methylated DNA
  JOURNAL   PLoS One 5 (8), e11982 (2010)
   PUBMED   20700456
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1, DY314707.1, CB777944.1 and BI296976.1.
            
            On Sep 27, 2014 this sequence version replaced NM_001170566.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.31011.1,
                                           SRR26643295.28277.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000007.1  64998544-64998589   c
            47-183              JAXUCZ010000007.1  64998301-64998437   c
            184-286             JAXUCZ010000007.1  64997985-64998087   c
            287-449             JAXUCZ010000007.1  64997712-64997874   c
            450-1496            JAXUCZ010000007.1  64996454-64997500   c
            1497-2155           JAXUCZ010000007.1  64995626-64996284   c
            2156-2309           JAXUCZ010000007.1  64995290-64995443   c
            2310-2479           JAXUCZ010000007.1  64995006-64995175   c
            2480-2563           JAXUCZ010000007.1  64994821-64994904   c
            2564-3249           DY314707.1         1-686
            3250-3561           CB777944.1         11-322
            3562-3995           BI296976.1         1-434               c
FEATURES             Location/Qualifiers
     source          1..3995
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3995
                     /gene="Mbd6"
                     /note="methyl-CpG binding domain protein 6"
                     /db_xref="GeneID:362892"
                     /db_xref="RGD:1311050"
     exon            1..46
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            47..183
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3088
                     /gene="Mbd6"
                     /note="WAS/WASL-interacting protein family member 1-like"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 6"
                     /protein_id="NP_001164037.2"
                     /db_xref="GeneID:362892"
                     /db_xref="RGD:1311050"
                     /translation="MNGGNESSAADRAGGPAATAVPIGWQRCVREGAVYYISPSGTEL
                     SSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCN
                     HRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPASVRPSCRVPPTTPLNGG
                     PGSIPQEPPSVPQAFPPLTGPAGLFPPRLPDPVPSAGSSSPCFLPRGNAPSPAPPPPS
                     AISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSPPSDSPLFHCSDALTPPPVPPSN
                     NLPGPPGPPGSTTQPPVSSATMHLPLVLGSLGGGPTVEGPGAPPFLASSLLSAAAKAQ
                     QPQLPPPSTLQGRRPRAQAPSASHASPRPSQRRPRRPPTVLRLLEGGGPQSPRRSRPR
                     APAPVPQPFPLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPALSSG
                     SPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPCDKGLGLGAGP
                     ACPLPPLAGEEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLSHSLFGV
                     LAGAGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLSPPPSDLLPPPAPPSNLLA
                     SFLPLLALGPTAGDGEGSAEGAGGPNGEPFSGLGDLPPLLFPPLSAPPTLIALNSALL
                     AASLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPL
                     LSASLLGDLSSLTSSPGTLPSLLQPPGPLLSSQLGLQLLPGGGAPPTLSEASSPLACL
                     LQSLQIPPEQPDAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSG
                     KRGRRGGGGLRGINGETRPGRGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHW
                     QHNGELAEGGAEPKDPPLPGPHPEDLKVSPGIVRKSRRGRRRKYNPARNSSSSSRQDV
                     TLEPSPTTRAAVPLPPRARPGRPAKNKRRKLAP"
     exon            184..286
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            287..449
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            450..1496
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..2155
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2309
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2479
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2893
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2946
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3013
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3977
                     /gene="Mbd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccggctt tagagtggac cccacaatgt ttgcagagat gttcaggcac aagggagctg
       61 atcgcacaca atgaatggag ggaatgagag cagtgcagca gacagagccg ggggccctgc
      121 ggccacggct gtccccatcg ggtggcagcg ctgtgtacga gaaggtgctg tgtactatat
      181 cagcccaagt ggcacagagc tgtcttcctt ggagcaaacc cgtagctacc tcctcagcga
      241 tgggacctgc aagtgcggtc tggagtgtcc actcaatgta cccaaggttt tcaactttga
      301 ccctctggcc ccggtgaccc cgggtggggc tggggtgggg cctgcatcgg aggaggacat
      361 gaccaagctg tgcaaccaca ggcggaaagc tgttgccatg gcaactctgt accgcagcat
      421 ggagaccacc tgctcacatt cttctcctgg agagggagca agcccccaaa tgttccacac
      481 tgtgtcccca gggcctgcct ctgtccgccc ttcttgtcga gttcctccta caactccact
      541 taatgggggt cctggctcca ttccccaaga accaccttca gttccccagg ccttccctcc
      601 tctaacaggc cctgcagggc tcttcccacc ccggcttcct gatccagttc cttctgcagg
      661 cagcagcagc ccttgtttcc ttccaagagg caatgctccc tctccagccc cacctcctcc
      721 atctgcgatc agcctcaatg ccccttccta caactgggga gcttccctcc gatccaacct
      781 ggtgccctct gacctgggct ctcctccagc ccctcatgcc tcctcttcac caccttcaga
      841 ctctcctctc ttccactgta gtgatgcctt aacacctcct cccgtgcccc caagcaataa
      901 tctccctggt ccccctggtc cccctggttc caccactcag ccaccagtgt cttcagccac
      961 tatgcacctg cccttggtcc tgggatcctt gggagggggc cccacagtgg aggggcctgg
     1021 ggcaccccca ttccttgcta gcagcctgct ctctgcagca gccaaggccc agcaacccca
     1081 gctgccccct cccagcactt tacagggccg aaggccccgt gcccaggccc cctcagcttc
     1141 ccatgcatca ccccgtccct ctcagcggcg tcctcgccgg cccccaactg tcttgaggtt
     1201 gctagaaggg ggaggccctc aaagccctag acggagccgt cctcgggccc ctgctcctgt
     1261 ccctcagccc tttcctctcc cagagccgtc ccagcctatt ctcccctctg tgctgtccct
     1321 actgggactc cccacccctg gcccttccca ctcggatgga agctttaacc ttttggggtc
     1381 agatgcacac cttcctcctc ccccagccct ctcctcaggg agccctcccc agcccaggca
     1441 ccccattcag ccctctctgc ctgggaccac cagtggcagc ctcagcagtg tgccaggtgc
     1501 ccctgcccca ccagctgcct ccaaagcccc cgtagtcccc agccctgtgc ttcaaagccc
     1561 atgtgacaaa gggctggggt tgggggcagg cccagcctgc cctctgcctc ccttggctgg
     1621 tgaagaggct ttccctttcc ccagccctga gcagggcctg gcgctcagcg gagctggctt
     1681 cccggggatg ctgggggcct tgcctctccc tctgagtctg ggacagcctc caccttctcc
     1741 attacttagc cacagtttat ttggtgtgct ggctggggca gggcagcctc ctcctgagcc
     1801 cctgctgccc ccaccagggg gacctggccc tcccttagcc ccaggcgagc ctgaagggcc
     1861 ttcactcttg gtggcttctc tgctctcacc acccccttct gacctcctcc cccctcctgc
     1921 accccctagc aacctccttg cctcttttct gcccctgttg gccctgggcc ccacagctgg
     1981 ggatggagaa ggatctgcag agggagctgg gggtccaaat ggggagccat tttcaggttt
     2041 gggagacctg ccccccctac tattcccccc actttcagcc ccacccaccc tcatagcttt
     2101 aaattctgcg ctgctggctg ccagcctgga tcccccctcg gggacacccc cccagccctg
     2161 tgtcctgagt gccccccaac ctggaccacc tacctccagt gtcaccacgg caactactga
     2221 cccgggggcc tcctctctgg gcaaggcccc ctccaactca gggagacccc ctcaacttct
     2281 tagccctctg ctgagtgcca gcctgctggg tgatctgtct tcactgacca gcagccctgg
     2341 aaccctcccc agcctgttgc agcctcctgg ccctcttctt tccagccagt taggattgca
     2401 gctcctccct ggggggggag cgcctcccac cctatcagag gcctctagtc ccctagcctg
     2461 cctgctacag agtctccaga tccctccaga gcagccagac gctccttgtc tgccccctga
     2521 gagccccgcc tcagcccttg aaccggagcc tgcccggcct cccctcagtg ccttagcccc
     2581 accccatggt tctcctgacc ccccagtccc tgagctgctc actgggaggg ggtcagggaa
     2641 acggggccgg aggggaggag ggggacttag gggcattaac ggtgagacca ggcctggcag
     2701 aggccgaaag ccgggcagcc gccgagagcc tggccggctg gcactcaaat gggggacacg
     2761 tggtggcttc aatggacaaa tggaacggtc cccaagaagg actcaccatt ggcagcataa
     2821 tggggagcta gctgaagggg gtgctgagcc caaggatcca ccccttcctg ggccccatcc
     2881 tgaggacctt aaggtgtccc cggggatagt cagaaagtct cgtcgtggcc ggaggagaaa
     2941 atacaaccct gcccggaaca gcagcagcag ctcccgccag gacgttacct tggagcccag
     3001 ccctacaacc cgagcggctg tccctctgcc tccccgggcc cgccctggac gtcctgccaa
     3061 aaataagagg aggaaactgg ccccatagca gccaaacctg gagctggaat ctgaccctga
     3121 ctggggagag ctgagtgctg agccttggga gcccctgcca gccacgtgca cctgtggaca
     3181 gtgggtgggg gcactaatcc ccactcagag cacaaacgca accccttccc ctacaaatcc
     3241 tatcctgagc cattgcaggg ggtagggaag ctcaccccct cccccccaaa gccatgtcac
     3301 tgaagaggcc tgggggggtg gtatatggcc ctctccccat caggcgctaa ggggaacacc
     3361 ccttccccag gtcttttatt tgtttaagtt atttttgcac aaatgactct tttatattta
     3421 attcgacttt tcattgcctc ccttcttaaa gccagcaggc tcagtttaca aacctgtgag
     3481 ctactgttgg ctgctgccct cctcctcccc agtgaaaggt acagagcaat aagcatcatg
     3541 cacctccccg caccccactg catccctctg cctctggctc aggttgctca aagcacagat
     3601 cccctcttat ccctatctcc aggatcgaaa cacatagcct catttcaaag tgtagccagg
     3661 ttccctctgc tttcctctgg gatatgaaaa gggggccaag aggactttgg atctctcctc
     3721 ccatacacac tacactggcc cttctccccc atcaaacgct cagagacgtt gtgatgatgc
     3781 cactgaggat tatgcagcgt ggtccaaccg gagcggccag catgaccagc tgaccagggg
     3841 ctgcctcctg cctttttttt gtaaagacaa gacccttggg agttttaatt ctgttttgta
     3901 cttgccctgt ggggcctcca ctgcttttct atgggagaca ctcttaattt aacagatgag
     3961 aatattttga aactctgaaa aaaaaaaaaa aaaaa
//
