LOCUS       NM_001108735            1744 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 3 (Mbd3), mRNA.
ACCESSION   NM_001108735 XM_001076468 XM_343162
VERSION     NM_001108735.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1744)
  AUTHORS   Bednarczyk,J., Debski,K.J., Bot,A.M. and Lukasiuk,K.
  TITLE     MBD3 expression and DNA binding patterns are altered in a rat model
            of temporal lobe epilepsy
  JOURNAL   Sci Rep 6, 33736 (2016)
   PUBMED   27650712
  REMARK    GeneRIF: data demonstrate for the first time alterations in the
            MBD3 expression and DNA occupancy in the experimental model of
            epilepsy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1744)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   3  (bases 1 to 1744)
  AUTHORS   Yamada,T., Yang,Y., Hemberg,M., Yoshida,T., Cho,H.Y., Murphy,J.P.,
            Fioravante,D., Regehr,W.G., Gygi,S.P., Georgopoulos,K. and Bonni,A.
  TITLE     Promoter decommissioning by the NuRD chromatin remodeling complex
            triggers synaptic connectivity in the mammalian brain
  JOURNAL   Neuron 83 (1), 122-134 (2014)
   PUBMED   24991957
  REMARK    GeneRIF: Endogenous Mta1/2 forms a complex with chromodomain
            helicase (Chd)4, histone deacetylase (Hdac)1/2, RbAp46/48, and Mbd3
            in the rat cerebellum
REFERENCE   4  (bases 1 to 1744)
  AUTHORS   Cramer,J.M., Scarsdale,J.N., Walavalkar,N.M., Buchwald,W.A.,
            Ginder,G.D. and Williams,D.C. Jr.
  TITLE     Probing the dynamic distribution of bound states for
            methylcytosine-binding domains on DNA
  JOURNAL   J Biol Chem 289 (3), 1294-1302 (2014)
   PUBMED   24307175
REFERENCE   5  (bases 1 to 1744)
  AUTHORS   Qin,J., Whyte,W.A., Anderssen,E., Apostolou,E., Chen,H.H.,
            Akbarian,S., Bronson,R.T., Hochedlinger,K., Ramaswamy,S.,
            Young,R.A. and Hock,H.
  TITLE     The polycomb group protein L3mbtl2 assembles an atypical
            PRC1-family complex that is essential in pluripotent stem cells and
            early development
  JOURNAL   Cell Stem Cell 11 (3), 319-332 (2012)
   PUBMED   22770845
REFERENCE   6  (bases 1 to 1744)
  AUTHORS   Kantor,B., Makedonski,K., Shemer,R. and Razin,A.
  TITLE     Expression and localization of components of the histone
            deacetylases multiprotein repressory complexes in the mouse
            preimplantation embryo
  JOURNAL   Gene Expr Patterns 3 (6), 697-702 (2003)
   PUBMED   14643676
REFERENCE   7  (bases 1 to 1744)
  AUTHORS   Jung,B.P., Zhang,G., Nitsch,R., Trogadis,J., Nag,S. and
            Eubanks,J.H.
  TITLE     Differential expression of methyl CpG-binding domain containing
            factor MBD3 in the developing and adult rat brain
  JOURNAL   J Neurobiol 55 (2), 220-232 (2003)
   PUBMED   12672019
  REMARK    GeneRIF: MBD3 displays a selective spatial and temporal pattern of
            expression in the embryonic and adult brain, thereby strengthening
            the possibility of MBD3 playing an important role in neuronal
            development
            GeneRIF: Methyl CpG binding protein 3 (Mecp3, MBD3)displays a
            selective spatial and temporal pattern of expression in the
            embryonic and adult brain, thereby strengthening the possibility of
            MBD3 playing an important role in neuronal development.
REFERENCE   8  (bases 1 to 1744)
  AUTHORS   Jung,B.P., Zhang,G., Ho,W., Francis,J. and Eubanks,J.H.
  TITLE     Transient forebrain ischemia alters the mRNA expression of methyl
            DNA-binding factors in the adult rat hippocampus
  JOURNAL   Neuroscience 115 (2), 515-524 (2002)
   PUBMED   12421618
REFERENCE   9  (bases 1 to 1744)
  AUTHORS   Francis,J., Jung,B., Zhang,G., Cheng,J., Ho,W., Burnham,W.M. and
            Eubanks,J.H.
  TITLE     Kindling induces the mRNA expression of methyl DNA-binding factors
            in the adult rat hippocampus
  JOURNAL   Neuroscience 113 (1), 79-87 (2002)
   PUBMED   12123686
REFERENCE   10 (bases 1 to 1744)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343162.3, XM_001076468.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV766706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1744
                     /gene="Mbd3"
                     /note="methyl-CpG binding domain protein 3"
                     /db_xref="GeneID:362834"
                     /db_xref="RGD:1307389"
     exon            1..411
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1162
                     /gene="Mbd3"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3"
                     /protein_id="NP_001102205.1"
                     /db_xref="GeneID:362834"
                     /db_xref="RGD:1307389"
                     /translation="MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFR
                     SKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVR
                     QTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMD
                     LPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAF
                     MVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEE
                     EEEEPEPERV"
     exon            412..571
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..709
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..800
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..978
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1744
                     /gene="Mbd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccccccggg gaggaggggc ggggcccact ccgcgcctgc gcagacgagt cccacgcgcg
       61 ggcgggtggg cggagcggcc cccctagcgg gggctgtgaa gcacggggag ggggccgagc
      121 gggtggcaaa gccggcgcgc gcccggctgg gggcggaggc ccgcgggacg gaacagccgc
      181 ggcgagtggt ggtggcggcg aagggaaccg agccggcgac gagcccgggg gtcgcgactt
      241 gcagaagcgg cggcggcatc ggcggcggca ggcccgaagg cgggcggaga gccggggcgc
      301 aatggagcgg aagaggtggg agtgcccggc gctcccgcag ggctgggaaa gggaagaagt
      361 gcccaggagg tcggggctgt cggccggcca cagggatgtc ttttactata gccccagcgg
      421 gaagaagttt cgcagcaagc cacagctggc acggtacctg ggcggctcca tggatctcag
      481 caccttcgat ttccgcacgg gaaagatgct gatgaacaag atgaataaga gccgccagcg
      541 cgtgcgctat gactcctcca accaggtcaa gggcaagcct gacctgaaca ctgcactgcc
      601 tgtacggcag actgcatcca tcttcaagca accggtgacc aagatcacca accaccccag
      661 caacaaggtc aagagcgacc cacagaaggc agtggaccag ccgaggcagc ttttctggga
      721 gaagaaactg agtggactga gtgccttcga cattgcggaa gaactggtca gaaccatgga
      781 cttgcccaag ggcctgcagg gggtaggccc cggctgcaca gatgagacgc tgctgtccgc
      841 catcgccagt gcgctgcaca ccagcaccct gcccattaca ggccagctct ctgcggctgt
      901 ggagaagaac cctggtgtgt ggctgaacac tgcgcagcca ctgtgcaaag ccttcatggt
      961 gacagatgac gacatcagga agcaggagga gctggtacag caggtgcgca agcgcctgga
     1021 ggaggcgctg atggcggaca tgctggcgca tgtggaggag ctggcccgtg atggggaggc
     1081 accactggac aaggcctgtg ctgaggagga ggaggaagaa gaggaggaag aggaagagga
     1141 accggagccg gagcgtgtgt agcataggta cctgccacag gccaggatgt tggatgtcag
     1201 ccatcctcta gtcaggctgc taacagcttc ccttctgcct tgcagatgcc ctgcccaagt
     1261 ctgggctgca gaccacctcc catggccacc tccagacttc tcagccttgc ctggactagg
     1321 tggggaccag gccagcaaga ggcaggcatc catcttcttc ccaaggctgc ctcctcccag
     1381 gtctcagtgc agggagcccc tgtggacctt gaactcgctt gtccctgcac tgcctggcag
     1441 ggagctcaca ctgacaactg aagagcagtg ccccaactga gaggccactt tgacaccgtc
     1501 acctccctgc ttccttacca taggacaagg ccctgcttgg caccaaggag ctgtgggcct
     1561 tgctgggcac tggaggaagt ttctggaaac acacctggct atgcctacct tgcattgtcc
     1621 ctaaggctgt tacgggccag ggtctgaact gctcctgccc atagggctgc ccagcctctc
     1681 catgctgagg gccagcagcc aaccaggaag tcactttcct tcaataaact gatggtagga
     1741 actt
//
