LOCUS       NM_001115025            1665 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus methyl-CpG binding domain protein 2 (Mbd2), mRNA.
ACCESSION   NM_001115025 XM_001055992 XM_001069159
VERSION     NM_001115025.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1665)
  AUTHORS   Basta,J. and Rauchman,M.
  TITLE     The nucleosome remodeling and deacetylase complex in development
            and disease
  JOURNAL   Transl Res 165 (1), 36-47 (2015)
   PUBMED   24880148
  REMARK    Review article
REFERENCE   2  (bases 1 to 1665)
  AUTHORS   Xie,B., Yu,Y., Meng,X., Yu,Q., Shi,J., Sang,H. and Kou,C.
  TITLE     Genetic association study between methyl-CpG-binding domain genes
            and schizophrenia among Chinese family trios
  JOURNAL   Psychiatr Genet 24 (5), 221-224 (2014)
   PUBMED   24849540
REFERENCE   3  (bases 1 to 1665)
  AUTHORS   Weaver,I.C., Hellstrom,I.C., Brown,S.E., Andrews,S.D., Dymov,S.,
            Diorio,J., Zhang,T.Y., Szyf,M. and Meaney,M.J.
  TITLE     The methylated-DNA binding protein MBD2 enhances NGFI-A
            (egr-1)-mediated transcriptional activation of the glucocorticoid
            receptor
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 369 (1652) (2014)
   PUBMED   25135974
REFERENCE   4  (bases 1 to 1665)
  AUTHORS   Pan,J.R., Wang,C., Yu,Q.L., Zhang,S., Li,B. and Hu,J.
  TITLE     Effect of Methyl-CpG binding domain protein 2 (MBD2) on AMD-like
            lesions in ApoE-deficient mice
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (3), 408-414 (2014)
   PUBMED   24939308
REFERENCE   5  (bases 1 to 1665)
  AUTHORS   Cramer,J.M., Scarsdale,J.N., Walavalkar,N.M., Buchwald,W.A.,
            Ginder,G.D. and Williams,D.C. Jr.
  TITLE     Probing the dynamic distribution of bound states for
            methylcytosine-binding domains on DNA
  JOURNAL   J Biol Chem 289 (3), 1294-1302 (2014)
   PUBMED   24307175
REFERENCE   6  (bases 1 to 1665)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   7  (bases 1 to 1665)
  AUTHORS   Sekimata,M., Takahashi,A., Murakami-Sekimata,A. and Homma,Y.
  TITLE     Involvement of a novel zinc finger protein, MIZF, in
            transcriptional repression by interacting with a methyl-CpG-binding
            protein, MBD2
  JOURNAL   J Biol Chem 276 (46), 42632-42638 (2001)
   PUBMED   11553631
REFERENCE   8  (bases 1 to 1665)
  AUTHORS   Hendrich,B., Guy,J., Ramsahoye,B., Wilson,V.A. and Bird,A.
  TITLE     Closely related proteins MBD2 and MBD3 play distinctive but
            interacting roles in mouse development
  JOURNAL   Genes Dev 15 (6), 710-723 (2001)
   PUBMED   11274056
REFERENCE   9  (bases 1 to 1665)
  AUTHORS   Guy,J., Hendrich,B., Holmes,M., Martin,J.E. and Bird,A.
  TITLE     A mouse Mecp2-null mutation causes neurological symptoms that mimic
            Rett syndrome
  JOURNAL   Nat Genet 27 (3), 322-326 (2001)
   PUBMED   11242117
REFERENCE   10 (bases 1 to 1665)
  AUTHORS   Hendrich,B. and Bird,A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158877.1.
            
            On or before May 2, 2008 this sequence version replaced
            XM_001069159.1, XM_001055992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158877.1, CF110915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1665
                     /gene="Mbd2"
                     /note="methyl-CpG binding domain protein 2"
                     /db_xref="GeneID:680172"
                     /db_xref="RGD:1595452"
     exon            1..551
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1245
                     /gene="Mbd2"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 2"
                     /protein_id="NP_001108497.1"
                     /db_xref="GeneID:680172"
                     /db_xref="RGD:1595452"
                     /translation="MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPS
                     PVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGVS
                     GLGGDGGAGGCGVGSSGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPPGW
                     KKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMPSK
                     LQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPNNKVKSDPQRMN
                     EQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSS
                     APITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDDDIRKQEERVQQVRKKLEEALMADI
                     LSRAVDTEEVDIDMDSGDEE"
     exon            552..711
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..849
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..940
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1118
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1257
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1631
                     /gene="Mbd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggatgc gcgcgcaccc ggggggaggc cgctgctgcc cggagcagga ggagggggag
       61 agcgcggcgg gcggcagcgg cgctggcggc gactccgcca tagagcaggg gggccagggc
      121 agcgcgctcg ctccgtcccc ggtgagcggc gtgcgcaggg aaggcgctcg gggcggcggc
      181 cgtggccggg ggcggtggaa gcaggcggcc cggggcggcg gcgtctgtgg ccgtggccgt
      241 ggccgtggcc ggggtcgggg ccgtggccgg ggccggggcc ggggccgcgg ccgtccccag
      301 agtggcgtca gcggccttgg cggcgacggc ggcgcgggcg gctgcggcgt cggcagcagt
      361 ggcggcgtcg ccccccggcg ggatcctgtc cctttcccgt ccgggagctc gggaccgggg
      421 cccaggggac cccgggccac ggagagcggg aagaggatgg actgcccggc cctccccccc
      481 ggatggaaga aggaggaagt gatccgaaaa tcagggctca gtgctggcaa gagcgatgtc
      541 tactacttca gtccaagtgg taagaagttc agaagtaaac cacagctggc gagatacctg
      601 ggaaatgctg ttgaccttag cagttttgac ttcagaaccg gcaagatgat gcctagtaaa
      661 ttacagaaga acaaacagag gctgcggaac gatcccctca atcagaacaa gggtaaacca
      721 gacctgaaca caacattgcc aattagacag actgcatcca ttttcaagca accagtcacc
      781 aaagtcacaa accacccgaa caataaagtg aagtcagacc ctcagcggat gaatgaacaa
      841 ccacgtcagc ttttctggga gaagaggcta caaggactta gcgcatcaga tgtaacagaa
      901 caaattataa aaaccatgga gctacctaaa ggtcttcaag gagtcggccc aggtagtaat
      961 gatgagaccc ttctgtctgc cgtggccagt gctttgcata caagctctgc acccatcacc
     1021 ggacaggtct ctgcggccgt ggaaaagaac cctgctgttt ggcttaacac atctcaaccc
     1081 ctctgcaaag ctttcattgt tacagatgat gacattagga aacaggaaga gcgagtccaa
     1141 caagtccgaa agaaactaga ggaagcactc atggcggaca tcctgtcccg ggccgtggac
     1201 acggaggaag tagacattga catggacagt ggagatgagg agtaagaata tgaccaggta
     1261 actttcgact gaccttcccc aagagcaaat tgctagaaac ggaattcaaa catttccacc
     1321 gggtttcgcc tgtaaggaga agagtacctg agcacacagc tttttaatag cactaaccaa
     1381 tgcctttcta gatgtatttt tgatgtatat atctattatt ccaaatgatg tttattttga
     1441 atcctaggac ttcaaattag tcttttataa taccaagcag gacctaagat gcaatgacgc
     1501 tttccgtgcc aggtgcgatc gactggaaat gtagcgctta ccgagatatt cgtttccccc
     1561 acagttttaa tataaacaga tcaggagtac caaatacgtt tcccaattaa agattattat
     1621 acttcactgt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
