LOCUS       NM_021588               1015 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus myoglobin (Mb), mRNA.
ACCESSION   NM_021588
VERSION     NM_021588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1015)
  AUTHORS   Wang,X., Qiao,O., Han,L., Li,N. and Gong,Y.
  TITLE     A Novel Rabbit Anti-Myoglobin Monoclonal Antibody's Potential
            Application in Rhabdomyolysis Associated Acute Kidney Injury
  JOURNAL   Int J Mol Sci 24 (9), 7822 (2023)
   PUBMED   37175528
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1015)
  AUTHORS   Zhang,Y., Li,H., Zhang,J., Cao,Y., Zhao,X., Yu,N., Gao,Y., Ma,J.,
            Zhang,H., Zhang,J., Guo,X. and Liu,X.
  TITLE     The clinical characteristics and outcomes of patients with diabetes
            and secondary hyperglycaemia with coronavirus disease 2019: A
            single-centre, retrospective, observational study in Wuhan
  JOURNAL   Diabetes Obes Metab 22 (8), 1443-1454 (2020)
   PUBMED   32406594
REFERENCE   3  (bases 1 to 1015)
  AUTHORS   Ruan,Q., Yang,K., Wang,W., Jiang,L. and Song,J.
  TITLE     Clinical predictors of mortality due to COVID-19 based on an
            analysis of data of 150 patients from Wuhan, China
  JOURNAL   Intensive Care Med 46 (5), 846-848 (2020)
   PUBMED   32125452
  REMARK    Erratum:[Intensive Care Med. 2020 Jun;46(6):1294-1297. doi:
            10.1007/s00134-020-06028-z.. PMID: 32253449]
REFERENCE   4  (bases 1 to 1015)
  AUTHORS   Ishikawa,Y., Kitagawa,H., Sawada,T., Seto,T., Takahashi,K. and
            Yamazaki,T.
  TITLE     Deuterium oxide protects against myocardial injury induced by
            ischemia and reperfusion in rats
  JOURNAL   Scand Cardiovasc J 53 (6), 329-336 (2019)
   PUBMED   31455109
REFERENCE   5  (bases 1 to 1015)
  AUTHORS   Traa,W.A., Strijkers,G.J., Bader,D.L. and Oomens,C.W.J.
  TITLE     Myoglobin and troponin concentrations are increased in early stage
            deep tissue injury
  JOURNAL   J Mech Behav Biomed Mater 92, 50-57 (2019)
   PUBMED   30658240
  REMARK    GeneRIF: Myoglobin and troponin concentrations are increased in
            early stage deep tissue injury
REFERENCE   6  (bases 1 to 1015)
  AUTHORS   Doeller,J.E. and Wittenberg,B.A.
  TITLE     Myoglobin function and energy metabolism of isolated cardiac
            myocytes: effect of sodium nitrite
  JOURNAL   Am J Physiol 261 (1 Pt 2), H53-H62 (1991)
   PUBMED   1858930
  REMARK    Erratum:[Am J Physiol 1991 Oct;261(4 Pt 2):followi]
REFERENCE   7  (bases 1 to 1015)
  AUTHORS   Arduini,A., Eddy,L. and Hochstein,P.
  TITLE     Detection of ferryl myoglobin in the isolated ischemic rat heart
  JOURNAL   Free Radic Biol Med 9 (6), 511-513 (1990)
   PUBMED   2079231
REFERENCE   8  (bases 1 to 1015)
  AUTHORS   Nomoto,K., Mori,N., Shoji,T. and Nakamura,K.
  TITLE     Early loss of myocardial myoglobin detected immunohistochemically
            following occlusion of the coronary artery in rats
  JOURNAL   Exp Mol Pathol 47 (3), 390-402 (1987)
   PUBMED   3315739
REFERENCE   9  (bases 1 to 1015)
  AUTHORS   Lundin,L., Hallgren,R., Landelius,J., Roxin,L.E. and Venge,P.
  TITLE     Myocardial and skeletal muscle function in habitual alcoholics and
            its relation to serum myoglobin
  JOURNAL   Am J Cardiol 58 (9), 795-799 (1986)
   PUBMED   3766421
REFERENCE   10 (bases 1 to 1015)
  AUTHORS   Finch,C.A., Miller,L.R., Inamdar,A.R., Person,R., Seiler,K. and
            Mackler,B.
  TITLE     Iron deficiency in the rat. Physiological and biochemical studies
            of muscle dysfunction
  JOURNAL   J Clin Invest 58 (2), 447-453 (1976)
   PUBMED   956378
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070511.1.
            
            On Jun 20, 2004 this sequence version replaced NM_021588.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070511.1, FQ224695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1015
                     /gene="Mb"
                     /gene_synonym="Glng"
                     /note="myoglobin"
                     /db_xref="GeneID:59108"
                     /db_xref="RGD:620411"
     exon            1..122
                     /gene="Mb"
                     /gene_synonym="Glng"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..492
                     /gene="Mb"
                     /gene_synonym="Glng"
                     /note="globin g; pseudoperoxidase MB; nitrite reductase
                     MB"
                     /codon_start=1
                     /product="myoglobin"
                     /protein_id="NP_067599.1"
                     /db_xref="GeneID:59108"
                     /db_xref="RGD:620411"
                     /translation="MGLSDGEWQMVLNIWGKVEGDLAGHGQEVLISLFKAHPETLEKF
                     DKFKNLKSEEEMKSSEDLKKHGCTVLTALGTILKKKGQHAAEIQPLAQSHATKHKIPV
                     KYLEFISEVIIQVLKKRYSGDFGADAQGAMSKALELFRNDIAAKYKELGFQG"
     exon            123..345
                     /gene="Mb"
                     /gene_synonym="Glng"
                     /inference="alignment:Splign:2.1.0"
     exon            346..947
                     /gene="Mb"
                     /gene_synonym="Glng"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccttttgt cctctttaga agccaccatg gggctcagtg atggggagtg gcagatggtg
       61 ctgaacatct gggggaaagt ggagggcgac cttgctggcc atggacagga agtcctcatc
      121 agtctattta aggctcaccc cgagaccctg gaaaagttcg acaagttcaa gaacctgaaa
      181 tccgaggaag agatgaagag ttcagaggac ctgaagaagc acggctgcac cgtgctcaca
      241 gccctgggta ccatcctgaa gaagaaggga caacatgctg ctgagatcca gcctctggcc
      301 cagtcccacg ccaccaagca caagatcccg gtcaagtacc tggagtttat ctcagaagtc
      361 atcatccaag tcctgaagaa gagatattcc ggggactttg gagcagatgc tcagggcgcc
      421 atgagcaagg ccctggagct gttccggaat gacattgctg ccaagtacaa ggagctgggc
      481 ttccagggct gagccatggg ctcccactgt ccagcccagc aagctgggac ccaatgttgt
      541 gtagaaggta gagtgtgctg tgccctaggt tagcagagaa cagaagaggg gagcatagtg
      601 tggcatctac ccacacccct ggggacagag ctctgggcag cattgtcctg gaacccagag
      661 gtgcaaagtg gcctctgctt cctcagctct gctgggtcat gctcaggtct cctgtcacct
      721 aagtcccaac ccactttcct cctggttttg ggaaaaatct cttttccact gtcacatttg
      781 accccaaatg caagtcacca gctagcagac actgaccttt gaaggagaca gagggttact
      841 tagagggagt ggagggtgga aagtgggcag gtgagcatcg gaagtctcca gctgcttagc
      901 ttccccctga cccacctggt ttcaataaaa catcctgcaa ctcctcaaaa aaaaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
