LOCUS       NM_022210               1936 bp    mRNA    linear   ROD 14-OCT-2024
DEFINITION  Rattus norvegicus MYC associated factor X (Max), transcript variant
            1, mRNA.
ACCESSION   NM_022210
VERSION     NM_022210.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Lani-Louzada,R., Marra,C., Dias,M.S., de Araujo,V.G., Abreu,C.A.,
            Ribas,V.T., Adesse,D., Allodi,S., Chiodo,V., Hauswirth,W.,
            Petrs-Silva,H. and Linden,R.
  TITLE     Neuroprotective Gene Therapy by Overexpression of the Transcription
            Factor MAX in Rat Models of Glaucomatous Neurodegeneration
  JOURNAL   Invest Ophthalmol Vis Sci 63 (2), 5 (2022)
   PUBMED   35103748
  REMARK    GeneRIF: Neuroprotective Gene Therapy by Overexpression of the
            Transcription Factor MAX in Rat Models of Glaucomatous
            Neurodegeneration.
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Comino-Mendez,I., Leandro-Garcia,L.J., Montoya,G.,
            Inglada-Perez,L., de Cubas,A.A., Curras-Freixes,M., Tysoe,C.,
            Izatt,L., Leton,R., Gomez-Grana,A., Mancikova,V.,
            Apellaniz-Ruiz,M., Mannelli,M., Schiavi,F., Favier,J.,
            Gimenez-Roqueplo,A.P., Timmers,H.J., Roncador,G., Garcia,J.F.,
            Rodriguez-Antona,C., Robledo,M. and Cascon,A.
  TITLE     Functional and in silico assessment of MAX variants of unknown
            significance
  JOURNAL   J Mol Med (Berl) 93 (11), 1247-1255 (2015)
   PUBMED   26070438
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Romero,O.A., Torres-Diz,M., Pros,E., Savola,S., Gomez,A., Moran,S.,
            Saez,C., Iwakawa,R., Villanueva,A., Montuenga,L.M., Kohno,T.,
            Yokota,J. and Sanchez-Cespedes,M.
  TITLE     MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF
            programs and is synthetic lethal with BRG1
  JOURNAL   Cancer Discov 4 (3), 292-303 (2014)
   PUBMED   24362264
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Qin,J., Whyte,W.A., Anderssen,E., Apostolou,E., Chen,H.H.,
            Akbarian,S., Bronson,R.T., Hochedlinger,K., Ramaswamy,S.,
            Young,R.A. and Hock,H.
  TITLE     The polycomb group protein L3mbtl2 assembles an atypical
            PRC1-family complex that is essential in pluripotent stem cells and
            early development
  JOURNAL   Cell Stem Cell 11 (3), 319-332 (2012)
   PUBMED   22770845
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Yang,L., Tan,X., Yang,Z., Li,Q. and Miao,X.
  TITLE     [Expression of RAD51 and MAX in pancreatic cancer rats]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 35 (2), 146-151 (2010)
   PUBMED   20197614
  REMARK    GeneRIF: The positive rate of Max expression was significantly
            lower in ductal adenocarcinoma in the control group.
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Wang,Y., Toury,R., Hauchecorne,M. and Balmain,N.
  TITLE     Expression and subcellular localization of the Myc superfamily
            proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate
            cartilage chondrocytes of growing rats
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 43 (2), 175-188 (1997)
   PUBMED   9130602
REFERENCE   7  (bases 1 to 1936)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   8  (bases 1 to 1936)
  AUTHORS   Hopewell,R. and Ziff,E.B.
  TITLE     The nerve growth factor-responsive PC12 cell line does not express
            the Myc dimerization partner Max
  JOURNAL   Mol Cell Biol 15 (7), 3470-3478 (1995)
   PUBMED   7791753
REFERENCE   9  (bases 1 to 1936)
  AUTHORS   Izawa,M.
  TITLE     Molecular cloning and sequencing of rat Max cDNA:
            castration-induced expression of the 2 kb transcript in male
            accessory sex organs of rats
  JOURNAL   Biochim Biophys Acta 1216 (3), 492-494 (1993)
   PUBMED   8268234
REFERENCE   10 (bases 1 to 1936)
  AUTHORS   Zervos,A.S., Gyuris,J. and Brent,R.
  TITLE     Mxi1, a protein that specifically interacts with Max to bind
            Myc-Max recognition sites
  JOURNAL   Cell 72 (2), 223-232 (1993)
   PUBMED   8425219
  REMARK    Erratum:[Cell. 1994 Oct 21;79(2):following 388.. PMID: 7954804]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 13, 2022 this sequence version replaced NM_022210.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399492.470641.1,
                                           SRR26643293.35849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               JAXUCZ010000006.1  101395060-101395290 c
            232-258             JAXUCZ010000006.1  101394357-101394383 c
            259-366             JAXUCZ010000006.1  101386534-101386641 c
            367-490             JAXUCZ010000006.1  101372653-101372776 c
            491-1936            JAXUCZ010000006.1  101369989-101371434 c
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1936
                     /gene="Max"
                     /note="MYC associated factor X"
                     /db_xref="GeneID:60661"
                     /db_xref="RGD:621101"
     exon            1..231
                     /gene="Max"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..678
                     /gene="Max"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein max; myc-associated factor X"
                     /codon_start=1
                     /product="protein max isoform 1"
                     /protein_id="NP_071546.1"
                     /db_xref="GeneID:60661"
                     /db_xref="RGD:621101"
                     /translation="MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFH
                     SLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRAL
                     EKARSSAQLQTNYPSSDNSLYTNAKGGTISAFDGGSDSSSESEPEEPQNRKKLRMEAS
                     "
     exon            232..258
                     /gene="Max"
                     /inference="alignment:Splign:2.1.0"
     exon            259..366
                     /gene="Max"
                     /inference="alignment:Splign:2.1.0"
     exon            367..490
                     /gene="Max"
                     /inference="alignment:Splign:2.1.0"
     exon            491..1936
                     /gene="Max"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgttgatc cggtgctaca gtgaggtggt tgtcgcccgt gttgtgtgtg tgtgagtgtg
       61 tgagtgagtg agcgagtgag tgagtgagtg tgtgcgtggg ggcactcggc ttgttgttgt
      121 cggtgacttc ccccttccct ccacccctcc cctccccggc cgccgctgca gtggccgctc
      181 cctgggccgt aggaaatgag cgataacgat gacatcgagg tggagagcga cgaagagcaa
      241 ccgaggtttc aatctgcggc tgacaaacgg gctcaccata atgcactgga acgaaaacgt
      301 agggaccaca tcaaagacag ctttcacagt ttgcgggact cagtcccatc actccaagga
      361 gagaaggcat cccgggccca aatcctagac aaagcaacag agtatatcca gtatatgcga
      421 aggaaaaacc atacgcacca gcaagacatt gatgacctca agcggcagaa tgctcttctg
      481 gagcaacaag tccgtgcact ggagaaggca agatcaagtg cccaactgca gaccaactac
      541 ccctcctcag acaacagcct ctacaccaac gccaagggcg gcaccatctc tgccttcgat
      601 gggggttcag actccagctc agagtccgag cctgaggagc cccagaacag gaagaaactg
      661 cggatggagg ccagctaagc catgcggggc aggccagcga gaaactgtct gctcacccgt
      721 tgcagcctcc ttcagttcat cactagaacc ctcagaacca ttgagaagac tcttttcctt
      781 ttctctctat taattgttat tttgcataga agctcttgga caacagctct caccccctgc
      841 cctgtgtcca ctatttttaa acgtatgccc ttcaggggtt cctgtcccca ccagaaattt
      901 taaaccaaaa caccctaact tggcagctct ttctgtggag gacagacggc cggccagacc
      961 tctgagtaca tggtgtcctg cccaccctac cagctcctcc agccctcaga gcatgtgcct
     1021 ggaggacgcc tgctctgcta ggctctcctc ccagccccct cacctctgtt tggtggactt
     1081 tgtgaatctc tgaactgctc tactttgaca agatgaccag attggagtaa tcagaatgaa
     1141 ccccctctcc tttgtaagga ttatttttgg aaaagcggtc tctcctgttg aaagaccaga
     1201 ttcttgaaga agtttgtgtg gtagagaagg aaagcggcga cagctttgca gcaccttggc
     1261 acagtcactc ttcagctgtt taagcctgcc cagccagcct tccagaaggc cacgcgacgc
     1321 tggtatgtat aggagacagc agcagtgaaa cggctcccag gagtggggtg gctactgtgg
     1381 gtgggctggg agggagttgt aggtggggta gaggttttgt attaagggcc agtgatgatg
     1441 ttttgatatt tatttcctgc tactgaaatt tgaatctgaa tgaaatgccc ctatttctga
     1501 tgatgtcgat attgtaaagc gacagattca taaagtaatg atcaaatctt cacttctgtg
     1561 tgtatttcta agaaacagag ccaactcttt tatatgtaaa caccaagagc gacttacctg
     1621 gtactaaacc cacagcccag ccctccttcc ttcctcctgt cctggaattg tcgccactgt
     1681 gtgatccggc cctggctctg actgtggtca gcagatccca gtgaagggtt tctcgtcttt
     1741 aggcttcatt tctttgtctt tttcctactc tgttgccagc atttgctgat ttctagtgta
     1801 tactttgtag tctcagtcgg tgttgattcc attccgtgga aataaaagta tgttgtacat
     1861 actgcccaag aatctccctg caagttaagg ctcccccttt actataagaa tataaataaa
     1921 gacttatttt atcctt
//
