LOCUS       NM_001005556            2965 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus mitochondrial antiviral signaling protein (Mavs),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001005556 XM_230537
VERSION     NM_001005556.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   Song,N., Qi,Q., Cao,R., Qin,B., Wang,B., Wang,Y., Zhao,L., Li,W.,
            Du,X., Liu,F., Yan,Y., Yi,W., Jiang,H., Li,T., Zhou,T., Li,H.Y.,
            Xia,Q., Zhang,X.M., Zhong,W., Li,A.L. and Duan,X.
  TITLE     MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity
            against Lethal RNA Viruses
  JOURNAL   Cell Rep 28 (9), 2386-2396 (2019)
   PUBMED   31461653
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Ding,S., Zhu,S., Ren,L., Feng,N., Song,Y., Ge,X., Li,B.,
            Flavell,R.A. and Greenberg,H.B.
  TITLE     Rotavirus VP3 targets MAVS for degradation to inhibit type III
            interferon expression in intestinal epithelial cells
  JOURNAL   Elife 7, e39494 (2018)
   PUBMED   30460894
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Da Costa,A., Garza,E., Graham,J.B., Swarts,J.L., Soerens,A.G.,
            Gale,M. and Lund,J.M.
  TITLE     Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3
            expression following acute flavivirus infection
  JOURNAL   Sci Rep 7, 40720 (2017)
   PUBMED   28094802
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   Kandasamy,M., Suryawanshi,A., Tundup,S., Perez,J.T., Schmolke,M.,
            Manicassamy,S. and Manicassamy,B.
  TITLE     RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell
            Responses during Influenza Virus Infection
  JOURNAL   PLoS Pathog 12 (7), e1005754 (2016)
   PUBMED   27438481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2965)
  AUTHORS   Gupta,S., Termini,J.M., Issac,B., Guirado,E. and Stone,G.W.
  TITLE     Constitutively Active MAVS Inhibits HIV-1 Replication via Type I
            Interferon Secretion and Induction of HIV-1 Restriction Factors
  JOURNAL   PLoS One 11 (2), e0148929 (2016)
   PUBMED   26849062
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2965)
  AUTHORS   Wang,D., Fang,L., Li,T., Luo,R., Xie,L., Jiang,Y., Chen,H. and
            Xiao,S.
  TITLE     Molecular cloning and functional characterization of porcine
            IFN-beta promoter stimulator 1 (IPS-1)
  JOURNAL   Vet Immunol Immunopathol 125 (3-4), 344-353 (2008)
   PUBMED   18586328
REFERENCE   7  (bases 1 to 2965)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   8  (bases 1 to 2965)
  AUTHORS   Kawai,T., Takahashi,K., Sato,S., Coban,C., Kumar,H., Kato,H.,
            Ishii,K.J., Takeuchi,O. and Akira,S.
  TITLE     IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I
            interferon induction
  JOURNAL   Nat Immunol 6 (10), 981-988 (2005)
   PUBMED   16127453
REFERENCE   9  (bases 1 to 2965)
  AUTHORS   Xu,L.G., Wang,Y.Y., Han,K.J., Li,L.Y., Zhai,Z. and Shu,H.B.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
REFERENCE   10 (bases 1 to 2965)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081869.1.
            
            On Oct 8, 2004 this sequence version replaced XM_230537.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2965
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /note="mitochondrial antiviral signaling protein"
                     /db_xref="GeneID:311430"
                     /db_xref="RGD:1359371"
     exon            1..227
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            228..406
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1813
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /note="IPS-1; virus-induced-signaling adapter; interferon
                     beta promoter stimulator protein 1; virus-induced
                     signaling adaptor"
                     /codon_start=1
                     /product="mitochondrial antiviral-signaling protein"
                     /protein_id="NP_001005556.1"
                     /db_xref="GeneID:311430"
                     /db_xref="RGD:1359371"
                     /translation="MTFAEEKTYKYIRYNHSKFCCVDVLEILPYLSCLTTSDQDRLRA
                     SYKQLGNQGTLWELFNTLQRRPGWVEVFIRALRICELPGLAEQVTRVYQSYLPPGASL
                     HSLDPLQSPRIPTTVSEPSAFAAGHTIPDSGFQDKPGYPKPVQDTQPPKSPVENSEEP
                     PQANFGAIPRMSGDSLISSPNPPALSPQPSREHPEQEPELGGPSTANVDSVPIATYGP
                     VSPTVSFQPLPRIAPRTNLSPGVTVSALSAKTTLSSSSTGSAFAKGAGDQAKAATCVS
                     TKEGVPTNSVTTSSVPSIKPVPVNTMSSKLPISTKSTAATPSTVPTNIAPSKLPINSV
                     YTGIVPSKVTASVAKASASTMPPERNNKQAKETLEAPATVVTTGSSLTRPDISSRSLH
                     SGPELSKPGVLVSQVDNEPFSACSMDLAISPSTSLGSEPNHGPEENEYSSFRIQVDKS
                     PSVDLLGSPEPLATQQSPEEEEPCASSVSWAKWLGATSALLAAFLAVMLYRSRHLAQ"
     exon            407..584
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            585..754
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            755..908
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1384
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..2942
                     /gene="Mavs"
                     /gene_synonym="Visa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgcagcctg ggtgtgggtc ctcagtgctc tgtgctcact gaggttgttc agggagggga
       61 ccttggtcag agccgagtgc tcctaggatt tcgcaggagc gccccgggcc tgggcgctcg
      121 gtgccagaga agatcctgaa ccggattagg ggagaatgcg gtctgcccca tacggattcg
      181 cgaccccggc agttccttga accgcatcca gcacctttag caagcagtcc atctctctca
      241 gtccatccca cccacccagg gttggagtcc ctccagaagc tgagcagcca tgacatttgc
      301 tgaggaaaag acctataagt atatccgcta caaccacagc aagttttgct gtgttgatgt
      361 tctggagatc ctgccttacc tgtcctgcct cacaaccagt gaccaggatc gattacgggc
      421 ttcctacaag caactaggaa accagggcac actctgggaa ctcttcaata cgctccagcg
      481 tcggcctggc tgggtagagg tcttcatccg ggcactgagg atctgtgagc tgcctgggct
      541 ggctgagcaa gtgactcgag tttatcagag ctacctgcct cctggggcct cactccactc
      601 cctagaccca ttgcagtcac caagaattcc taccacggtt tccgaacctt ctgcatttgc
      661 agcaggccac accatccctg acagtggctt ccaagataaa ccaggttacc ctaagcctgt
      721 ccaggacacc cagccaccaa agtccccagt agagaattcg gaggaacccc cacaggccaa
      781 ctttggggcc attccaagga tgtcgggtga ctctttgata tcctcaccta acccaccggc
      841 cctcagccct cagccctcca gagagcatcc cgagcaagaa cccgaactgg ggggcccctc
      901 cacagcaaat gttgactctg ttcccatagc aacctatgga cctgtgtctc caactgtttc
      961 cttccagccc cttccacgta ttgccccgag gacaaacctc tcgcctgggg tcacagtatc
     1021 agctctatct gccaagacca ctttgtcctc ctcttctact ggatcagctt ttgcaaaggg
     1081 agcaggtgac caggccaagg ctgccacctg tgtcagcact aaagagggag tacctaccaa
     1141 ttctgtgact accagctcag tgccttccat caaaccagta ccagtaaata ccatgtcttc
     1201 caagttgccc atcagtacaa agtccactgc tgcaacgccc tctactgtgc ccactaatat
     1261 agcgccatca aaattaccca tcaactcagt atatactggc atagtgccat ccaaagtgac
     1321 tgctagtgtg gccaaagcaa gtgccagcac aatgccacct gagaggaaca acaagcaagc
     1381 caaggagacc ctggaggctc cagcaaccgt agtcaccact ggaagcagcc tgaccagacc
     1441 agatatcagt tccaggagct tgcactctgg gccagagtta agcaagccag gggtgctggt
     1501 gtcccaggtg gacaacgagc cattctcagc ctgctctatg gaccttgcca tcagccctag
     1561 cacctccttg ggctcagaac ccaaccatgg tccagaggag aatgagtatt catcctttcg
     1621 aatccaggtg gataaaagtc ccagtgttga tctgttagga agccctgagc cactagccac
     1681 ccagcagtcc ccagaagagg aagagccttg tgccagttca gtgtcctggg ctaagtggct
     1741 gggggccacc agtgcactct tggctgcatt cctggcagtg atgctctacc gtagcaggca
     1801 cctggcccag tgaagcctca gctgtatgcc acactcactt gctcagtcct gccaagcatg
     1861 ccctctaggc ttggggtggt agatatggcg aggtccactg agttatccag gtacaggtgc
     1921 tacctgtact gaggcgccat cactatgtgg tgggggaaga gacactgctt ctatcctggt
     1981 tcatgtcatc ttctggtctt cagcttttgg gggccctgta tcccttccat tgcttctgac
     2041 ctgcccacag ggcagggtaa gattgcatgc tatgtgctcc taaggaggta tccccaccag
     2101 actcatccct attggcccaa gcctgaagat gaggaggcat tgcactgttg acagtgcccc
     2161 tcctctcacc caggtctcct gaaacacaag cgtagaatag tgatgagtgg tcccgtagca
     2221 tccaatgcct tccaccagca gcctggctga ggcctcggca gagtgcctgg gagcagcaga
     2281 gcagctggtc tcttgggagc tttgggtgct ctgccccttt ggtccctctc cccagccaga
     2341 cagccctaag ggtgggcctg gaggttctct gtggactcca agaaagccag aagcagctcc
     2401 caggcctgag aaagcccctg ggagccttgc tccagcctcc ttatcccagc tcttcacttc
     2461 tcccctcctg gtctccattc tctttgacct cctacactgg atgatgagat acctagtggg
     2521 cagagctcag gctgggcttg gatcagttcc accctttctc tgcctttagc agatgtttag
     2581 cttctctagt cttcctccca gtgtggacag tgggtagcac ttccttttac tgggctcctc
     2641 tgagtttgaa ggatagagat atttgcctag tgcctatccc cgagggtgtg agcacaagtt
     2701 cttgccgtcc tgcccaggct ggtagagcta aggtgagagc atgagagaca gagtgcacag
     2761 tggtaatagc acagtctttg agagagcagc cttcgcctcc atcgtgcttt tgtctcctcc
     2821 ctggtcaggt gtagacctta cctctgtgcc tcacttttct cacctgtgag atggggtgaa
     2881 tatgcatata tatgctaata tattctagtt ttattgggat taattaaaag agtttatctg
     2941 taaaaaaaaa aaaaaaaaaa aaaaa
//
