LOCUS       NM_001395570            2424 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus matrilin 3 (Matn3), mRNA.
ACCESSION   NM_001395570 XM_039112187
VERSION     NM_001395570.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Chen,H., Guo,S., Li,R., Yang,L., Wang,R., Jiang,Y. and Hao,Y.
  TITLE     YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic
            transformation in ischemic stroke via the PI3K/AKT pathway
  JOURNAL   J Neuropathol Exp Neurol 83 (3), 194-204 (2024)
   PUBMED   38230623
  REMARK    GeneRIF: YTHDF2-regulated matrilin-3 mitigates post-reperfusion
            hemorrhagic transformation in ischemic stroke via the PI3K/AKT
            pathway.
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Bell,P.A., Wagener,R., Zaucke,F., Koch,M., Selley,J., Warwood,S.,
            Knight,D., Boot-Handford,R.P., Thornton,D.J. and Briggs,M.D.
  TITLE     Analysis of the cartilage proteome from three different mouse
            models of genetic skeletal diseases reveals common and discrete
            disease signatures
  JOURNAL   Biol Open 2 (8), 802-811 (2013)
   PUBMED   23951406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Borochowitz,Z.U., Scheffer,D., Adir,V., Dagoneau,N., Munnich,A. and
            Cormier-Daire,V.
  TITLE     Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type:
            homozygote matrilin 3 mutation in a novel form of SEMD
  JOURNAL   J Med Genet 41 (5), 366-372 (2004)
   PUBMED   15121775
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Chapman,K.L., Mortier,G.R., Chapman,K., Loughlin,J., Grant,M.E. and
            Briggs,M.D.
  TITLE     Mutations in the region encoding the von Willebrand factor A domain
            of matrilin-3 are associated with multiple epiphyseal dysplasia
  JOURNAL   Nat Genet 28 (4), 393-396 (2001)
   PUBMED   11479597
REFERENCE   5  (bases 1 to 2424)
  AUTHORS   Segat,D., Frie,C., Nitsche,P.D., Klatt,A.R., Piecha,D., Korpos,E.,
            Deak,F., Wagener,R., Paulsson,M. and Smyth,N.
  TITLE     Expression of matrilin-1, -2 and -3 in developing mouse limbs and
            heart
  JOURNAL   Matrix Biol 19 (7), 649-655 (2000)
   PUBMED   11102754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039112187.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN12840108, SAMN17050755
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000006.1  37467729-37468006
            279-845             JAXUCZ010000006.1  37472320-37472886
            846-971             JAXUCZ010000006.1  37475718-37475843
            972-1097            JAXUCZ010000006.1  37478753-37478878
            1098-1223           JAXUCZ010000006.1  37480610-37480735
            1224-1349           JAXUCZ010000006.1  37482833-37482958
            1350-1460           JAXUCZ010000006.1  37484986-37485096
            1461-2424           JAXUCZ010000006.1  37486813-37487776
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2424
                     /gene="Matn3"
                     /note="matrilin 3"
                     /db_xref="GeneID:313954"
                     /db_xref="RGD:1305085"
     exon            1..278
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1516
                     /gene="Matn3"
                     /codon_start=1
                     /product="matrilin-3 precursor"
                     /protein_id="NP_001382499.1"
                     /db_xref="GeneID:313954"
                     /db_xref="RGD:1305085"
                     /translation="MLFSALLRNLPGLLLLLWPLLLLPPPAAPGRLTRASVRRLGTRV
                     PGGSPGHFSARATSTRAPYSGVRGSGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVS
                     RIIDTLDIGATDTRVAVVNYASTVKIEFQLNTYSNKQALKQAVARITPLSTGTMSGLA
                     IQTAMEEAFTVEAGARGPTSNIPKVAIIVTDGRPQDQVNEVAARARASGIELYAVGVD
                     RADMESLKMMASKPLEDHVFYVETYGVIEKLSARFQETFCALDQCMLGTHQCQHVCVS
                     DGDGRHHCECSQGYTLNADGKTCSAIDKCALNTHGCEQICVNDRNGSYHCECYEGYTL
                     NADRKTCAAQDKCALGTHGCQHICVNDGAGSHHCECFEGYTLNADKKTCSVRDKCALG
                     THGCQHICVSDGAVSYHCDCFPGYTLNDDKKTCSDIEEVRSLISIEDACSCGATLAFQ
                     EKVSSHLQKLNTKLDNILKKLQVTEYGQLHR"
     exon            279..845
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..971
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1097
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1223
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1349
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1460
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..2424
                     /gene="Matn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcgacc gacccttagt actctagtca cctcgtggct cacagacccc ggcaggtcgt
       61 caagcccatc atgttgttct cagccctctt acgcaacctc ccgggacttc tgctgctgct
      121 ctggccgctg ttactcctgc cgcccccggc tgctcctgga cgtttgaccc gcgcgagtgt
      181 ccgccgactg gggacaagag tccccggggg cagccctggg catttctctg ctcgggctac
      241 ttccacccgc gcgccatatt ccggggtccg tggctcaggt gtttgcaaga gcaggccttt
      301 ggacttggtc tttatcatcg acagttctcg tagcgtccgg cctctggaat tcaccaaggt
      361 gaagaccttt gtctcccgca tcattgacac tctggacatc ggggccacag acacgagggt
      421 ggctgtggtg aactatgcca gcaccgtgaa gatagagttc cagctcaaca cctattcaaa
      481 taagcaggcc ctgaaacagg ctgtggcacg gatcacaccc ttgtcaaccg gcaccatgtc
      541 agggctagct atccagacag caatggaaga agccttcacc gtggaggctg gagctcgggg
      601 gcccacatct aacatcccaa aggtagctat tatcgtgaca gatgggaggc cccaggacca
      661 ggtgaatgag gtggctgccc gagcccgggc atctggcatt gagctgtacg ctgtgggtgt
      721 ggaccgggca gatatggagt ccctcaagat gatggctagc aagcccctgg aagatcacgt
      781 cttctatgtg gagacctatg gggtcattga gaagctctcg gctagattcc aggaaacctt
      841 ttgtgctctg gaccagtgca tgcttggcac acaccagtgt cagcacgtgt gcgtcagcga
      901 tggtgatggc aggcatcact gcgaatgtag ccaagggtat accttgaacg ctgatgggaa
      961 aacgtgttca gccattgata agtgtgccct caacactcat ggatgtgaac agatctgtgt
     1021 caacgacaga aatggttctt accactgcga gtgctatgaa gggtacacat tgaatgcaga
     1081 caggaaaaca tgtgcagctc aggacaaatg cgccttgggt acacacggtt gccagcacat
     1141 ctgtgtgaat gacggagccg ggtcccatca ctgtgaatgc tttgaaggct acactctgaa
     1201 tgcagataag aagacatgtt cagtccgaga caagtgtgct ctggggactc atggctgcca
     1261 gcacatctgt gtgagcgatg gagcagtgtc ctaccactgt gactgtttcc ctggctatac
     1321 cttgaatgat gacaagaaga catgttcaga cattgaagaa gtccgaagcc tcatttctat
     1381 agaagatgcc tgcagctgtg gggccacact ggcattccag gagaaggtca gctcccatct
     1441 ccagaagctg aacactaaac ttgacaacat tttgaagaag ttgcaagtaa ctgaatatgg
     1501 acaactacat cgttaaactg tgcaaaattc tcgcctggaa ggtggagtgc ttgacacgca
     1561 cgattctcat tctcttgtat acattatctg atgctcctgc taataatttg ccattataaa
     1621 tgcttgacat tatttggtca atataagggt tttctggaga actagtatca tttcctaagg
     1681 agataaatgt gcagaccctt actgaaaagc aagctttaat gtctcatagt tatgactgtg
     1741 aaatcattaa taagatgaaa agtgaaaagt ttaatgtttt cttatctact cattgagcca
     1801 tctaagtttt aattgtttat attagtgaga taatcttatt cataaaactt taggtctatt
     1861 ttctctttta taatatgaac cagccttatt atcaagagtg caaattttat gaaaaattca
     1921 cacatacgaa gataaaataa ttaaacagag aatttagaat tgtttaaatt cttttgttgg
     1981 aatattatta aagctacaat caaggaatta taacacatgt acctaaaaat aatttacaca
     2041 gactaagtgg atgttacgtg atacttttaa ttcatcaacg acatagaaac aaacaactaa
     2101 agagtactgg ctatgaactt atggtgctaa gatttttgcc aatggaaaaa aaatttgaat
     2161 tctatcattt tgttttagca tgtaatgtaa ttggtgaaat tacataatta taaaattagt
     2221 acaagcaaca aggtataata ttatctttta aagaatgtct gtaataagac taattttttc
     2281 actcaaaata taatgaatac atgtattttt taagtgcagc tgagaacttt tggaatggaa
     2341 caattcttta aattttgtgc tacttgatct gtgtatgttt gtattgtttt taacataata
     2401 aaagttccta tctttctaca ttaa
//
