LOCUS       NM_001006979            1970 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus matrilin 1 (Matn1), mRNA.
ACCESSION   NM_001006979 XM_216351
VERSION     NM_001006979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   van der Weyden,L., Wei,L., Luo,J., Yang,X., Birk,D.E., Adams,D.J.,
            Bradley,A. and Chen,Q.
  TITLE     Functional knockout of the matrilin-3 gene causes premature
            chondrocyte maturation to hypertrophy and increases bone mineral
            density and osteoarthritis
  JOURNAL   Am J Pathol 169 (2), 515-527 (2006)
   PUBMED   16877353
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Segat,D., Frie,C., Nitsche,P.D., Klatt,A.R., Piecha,D., Korpos,E.,
            Deak,F., Wagener,R., Paulsson,M. and Smyth,N.
  TITLE     Expression of matrilin-1, -2 and -3 in developing mouse limbs and
            heart
  JOURNAL   Matrix Biol 19 (7), 649-655 (2000)
   PUBMED   11102754
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Huang,X., Birk,D.E. and Goetinck,P.F.
  TITLE     Mice lacking matrilin-1 (cartilage matrix protein) have alterations
            in type II collagen fibrillogenesis and fibril organization
  JOURNAL   Dev Dyn 216 (4-5), 434-441 (1999)
   PUBMED   10633862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 2, 2020 this sequence version replaced NM_001006979.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083869.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000005.1  148401620-148401743
            125-471             JAXUCZ010000005.1  148402999-148403345
            472-694             JAXUCZ010000005.1  148405302-148405524
            695-817             JAXUCZ010000005.1  148406837-148406959
            818-1234            JAXUCZ010000005.1  148407412-148407828
            1235-1387           JAXUCZ010000005.1  148408399-148408551
            1388-1471           JAXUCZ010000005.1  148410189-148410272
            1472-1970           JAXUCZ010000005.1  148410758-148411256
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1970
                     /gene="Matn1"
                     /note="matrilin 1"
                     /db_xref="GeneID:297894"
                     /db_xref="RGD:1359410"
     exon            1..124
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1521
                     /gene="Matn1"
                     /note="cartilage matrix protein; matrilin 1, cartilage
                     matrix protein"
                     /codon_start=1
                     /product="cartilage matrix protein precursor"
                     /protein_id="NP_001006980.1"
                     /db_xref="GeneID:297894"
                     /db_xref="RGD:1359410"
                     /translation="MKVTSGPAFGLCSLMLLLLLQVPGSLGLASQPRGHLCRTRPTDL
                     VFVVDSSRSVRPVEFEKVKVFLSQVIKSLDVGPNATRVGLVNYASTVKPEFPLRAHTS
                     KASLLQAVHRIQPLSTGTMTGLALQFAITKALSDAEGGRSRSSDISKVVIVVTDGRPQ
                     DSVRDVSERARASGIELFAIGVGRVDKATLRQIASEPQDEHVDYVESYNVIEKLAKKF
                     QEAFCVSDLCATGDHYCEQVCVSSPGSYTCACHEGFTLNSDGKTCNVCRGGGNGSATD
                     LVFLIDGSKSVRPENFELVKKFINQIVDTLDVSDRLAQVGLVQYSSSIRQEFPLGRFH
                     TKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDY
                     INDAARKAKDLGFKMFAVGVGNAVEEELREIASEPVADHYFYTADFKTINQIGKKLQK
                     KICVEEEDPCACESIVRFEAKVEGLLQDLTRKLEAVSKRLAVLENRVI"
     exon            125..471
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..694
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..817
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1234
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1387
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1471
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1970
                     /gene="Matn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctgtcc ttgttgctgc agccatgaag gtcacctctg gtccagcctt tggactctgt
       61 agcctgatgc tcctgctgct gctacaggtc cctggtagcc tcggtcttgc ctcccagccc
      121 agaggtcacc tctgccggac acgacccacg gacctggtct tcgttgttga tagttctcgc
      181 agtgtgagac ccgtggagtt tgagaaggtg aaggtgttcc tgtcccaggt cattaagtca
      241 ctggatgtgg ggcccaatgc cacgagggtg ggcttggtca actacgccag cactgtcaag
      301 ccggagttcc cacttcgggc ccacacctcc aaggcgtcgc tgctacaggc tgtgcaccgc
      361 atccagccgc tgtccacggg caccatgact ggcctggcgc tgcaattcgc catcaccaag
      421 gccttgagtg acgctgaggg ggggcgctcc agatcttccg acatcagcaa ggttgtcatc
      481 gtcgtgactg atgggaggcc tcaggacagt gtgcgggacg tgtctgagcg cgcgcgagcc
      541 agtggcatcg agctgttcgc catcggcgtg ggccgcgtgg acaaggctac actgagacag
      601 atcgctagcg agccgcagga tgagcacgtg gattacgtgg agagctacaa tgtcatcgag
      661 aagctggcca agaagttcca agaggccttt tgcgtgtcag acctgtgtgc cacaggggac
      721 cactattgtg agcaggtgtg cgtcagctct ccaggctcct acacctgtgc ctgccatgag
      781 ggcttcaccc tgaacagcga tggaaagacc tgcaatgtct gccgaggcgg tggaaacggc
      841 tcagccactg acctggtctt cctcattgac ggatccaaga gtgtgcggcc tgagaacttt
      901 gagctggtga agaagttcat caaccagatt gtggatactc tagatgtgtc cgacaggctg
      961 gcccaggtcg ggctggtaca gtactcaagc tctatacgcc aggagttccc gcttggtcgc
     1021 ttccacacca agaaggacat taaggccgct gtgaggaaca tgtcctacat ggagaagggc
     1081 accatgacag gcgccgccct gaagtatctc atagacaatt ccttcactgt gtccagcggg
     1141 gcaaggcccg gagcccagaa ggtgggcatc gtcttcactg atggccggag ccaggactac
     1201 attaatgacg ctgccaggaa ggccaaggac cttggcttta agatgtttgc cgtgggtgtg
     1261 ggcaatgctg tggaagagga gctgagggaa attgcctcag agccagtggc cgaccactac
     1321 ttttacacag ccgacttcaa gaccatcaac cagattggca agaagttgca gaaaaaaatc
     1381 tgtgtggagg aagaagaccc gtgtgcctgt gagtccatag tgaggtttga ggccaaggtg
     1441 gagggtctgt tgcaggacct gaccaggaag ctggaagctg tgagcaaacg gctggctgtc
     1501 ctggagaaca gagtcatcta aggactcttg tgacctggcc acctcccaca gagtcctgga
     1561 aatgtcccct gtagctagag ttagtctggc tgtgctactt tagcaaggga gcctgcagag
     1621 gatggctgta ggtcttccct gctgccctag ggctgagcag gaggggacac gtgcttgtga
     1681 ctgctgggag tgtgggacga tgactagtgt tgagtgtacg tgtgtctgat tgtgctcatg
     1741 tatgtttggg agcagggatg tgtgcagagg tgaaagcgca gagaaggggc gtgtgagcga
     1801 ctgcgtgcat gatttttccc accgaaagct taatatattc ctgttttctt tttcctccag
     1861 ttaattcttt acccagtcaa ttcttgactc tgagtgattt ctttcttttt tctttttttt
     1921 cttttttttt tttgttcctt gagaaaaaaa attaaatgcg gttcattgta
//
