LOCUS       NM_021859               1670 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus megakaryocyte-associated tyrosine kinase (Matk),
            mRNA.
ACCESSION   NM_021859
VERSION     NM_021859.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Gunn,N.J., Gorman,M.A., Dobson,R.C., Parker,M.W. and Mulhern,T.D.
  TITLE     Purification, crystallization, small-angle X-ray scattering and
            preliminary X-ray diffraction analysis of the SH2 domain of the
            Csk-homologous kinase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 3), 336-339
            (2011)
   PUBMED   21393838
  REMARK    GeneRIF: The CHK SH2 was expressed in Escherichia coli and the
            purified protein was characterized as monomeric by synchrotron
            small-angle X-ray scattering in-line with size-exclusion
            chromatography.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Kuo,S.S., Moran,P., Gripp,J., Armanini,M., Phillips,H.S.,
            Goddard,A. and Caras,I.W.
  TITLE     Identification and characterization of Batk, a predominantly
            brain-specific non-receptor protein tyrosine kinase related to Csk
  JOURNAL   J Neurosci Res 38 (6), 705-715 (1994)
   PUBMED   7807586
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087726.1.
            
            On Dec 26, 2004 this sequence version replaced NM_021859.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1670
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /note="megakaryocyte-associated tyrosine kinase"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
     exon            1..51
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            52..111
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1506
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /EC_number="2.7.10.2"
                     /note="protein kinase BATK; tyrosine-protein kinase CTK;
                     megakaryocyte-associated tyrosine kinase (non-receptor
                     protein tyrosine kinase); non-receptor protein kinase
                     protein"
                     /codon_start=1
                     /product="megakaryocyte-associated tyrosine-protein
                     kinase"
                     /protein_id="NP_068631.1"
                     /db_xref="GeneID:60450"
                     /db_xref="RGD:69058"
                     /translation="MPTQRWAPGTQCMTKCENSRPKPGELAFRKGDMVTILEACEDKS
                     WYRAKHHSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGL
                     FLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVCFCNLMDMVEHYTRDKG
                     AICTKLVKPKRKQGAKSAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQKV
                     AVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLR
                     TRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK
                     AELRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKE
                     VSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKIVEKLGRELRSVGVAAP
                     AGGQEAEGSAPTRSQDP"
     exon            112..225
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            226..341
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            342..561
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            562..655
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            656..721
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            722..821
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            822..906
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            907..980
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1179
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1266
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1631
                     /gene="Matk"
                     /gene_synonym="Batk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagccaggg acccaggcag ccacagtcct gcggtgccgc actgggatgg ggtgaaccct
       61 caattctaag gagcttggca ccccacgcct gctgcagcta agatgccaac gcaacgctgg
      121 gcccctggga ctcaatgtat gaccaagtgc gagaactcac gccccaagcc cggtgagcta
      181 gcctttcgaa agggtgacat ggtgaccatc ttggaggcct gtgaggacaa gagctggtac
      241 cgagccaagc accacagcag tgggcaggaa gggctgctgg cggctgctgc tctgcgacag
      301 agggaggccc tttccacaga ccccaagctc agcctcatgc catggttcca tggcaagatt
      361 tccggtcagg aagccataca gcagctgcag ccacccgagg atgggctgtt cctcgtgagg
      421 gaatcggccc gtcaccctgg tgactatgtc ctgtgtgtca gtttcggccg tgatgtcatc
      481 cactaccgtg tcttgcatcg agatgggcac ctcaccattg atgaggccgt gtgtttctgt
      541 aatctgatgg acatggtaga gcactacacc agggacaagg gcgccatctg caccaagctg
      601 gtgaagccca agaggaaaca gggcgcaaag tccgcagagg aagagctcgc caaggctggc
      661 tggctgctag acctgcagca tctgactctg ggagcacaga ttggagaggg agagtttgga
      721 gccgtcctgc agggcgagta cttgggacag aaggtggccg tgaagaatat aaagtgtgat
      781 gtgacagccc aggccttcct ggatgagacg gctgtgatga caaagctgca gcacaggaac
      841 ctagtgcgac tcctgggtgt gatcctgcac cacggcctgt acattgtcat ggaacacgtg
      901 agcaagggca acctggtgaa cttcctgcgc acgcggggcc gtgcgcttgt gagcacctct
      961 cagctcctgc agtttgctct tcacgttgct gaaggcatgg agtacctgga gagcaagaag
     1021 ctggtacaca gggacctggc tgctcgaaac atcctggtct ctgaggactt agtggccaag
     1081 gtcagtgact ttggcctagc aaaggcagag cttaggaagg ggctggactc aagtcggctg
     1141 ccagtcaagt ggacagcacc cgaggctctc aaaaatggga ggttctccag caagtcggat
     1201 gtctggagtt ttggggtgct actgtgggaa gtcttctcat atggaagagc cccatacccc
     1261 aagatgtcgc taaaggaggt ttcagaggct gtggagaagg gttaccgcat ggagcccccc
     1321 gacagctgcc caggccctgt gcataccctc atgggcagct gctgggaggc tgagccctcg
     1381 cgcagaccac cgttccgcaa aatagtggag aagctgggtc gtgagctccg cagtgtgggc
     1441 gtcgcagccc ccgccggggg acaggaggct gagggctcag ctcccacacg gagccaggac
     1501 ccctgacccc tgaactggaa agcaagagga cacagatgta gggtcacagg gccagggtga
     1561 gccagtgcac aggctccgga gcccctggga tccccgttac tgggacaccc cataaagagt
     1621 gattggaagg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
