LOCUS       NM_134351               1337 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus methionine adenosyltransferase 2A (Mat2a), mRNA.
ACCESSION   NM_134351
VERSION     NM_134351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Guo,H.X., Zheng,Y., Zhao,G.K., Wang,H.Q., Yu,S., Gao,F.,
            Zhang,J.B., Zhang,Y.H. and Yuan,B.
  TITLE     Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the
            miR-125a-5p/MAT2A Axis
  JOURNAL   Int J Mol Sci 23 (24), 15477 (2022)
   PUBMED   36555116
  REMARK    GeneRIF: Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating
            the miR-125a-5p/MAT2A Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Liu,Z., Wang,B. and Guo,Q.
  TITLE     MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain
            injury during subarachnoid hemorrhage via MAT2A-mediated the p38
            MAPK/STAT3 signaling pathway
  JOURNAL   Brain Res Bull 175, 107-115 (2021)
   PUBMED   34284075
  REMARK    GeneRIF: MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate
            early brain injury during subarachnoid hemorrhage via
            MAT2A-mediated the p38 MAPK/STAT3 signaling pathway.
REFERENCE   3  (bases 1 to 1337)
  AUTHORS   Chen,Y.W., Du,Q.R., He,Y.J., Chen,W.S., Jiang,W.Y., Gui,Q.,
            Xu,C.C., Wang,W. and Cheng,H.Y.
  TITLE     Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung
            Cancer Development
  JOURNAL   J Immunol Res 2021, 5510869 (2021)
   PUBMED   34258296
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1337)
  AUTHORS   Cai,S., Ye,Q., Zeng,X., Yang,G., Ye,C., Chen,M., Yu,H., Wang,Y.,
            Wang,G., Huang,S., Quan,S., Zeng,X. and Qiao,S.
  TITLE     CBS and MAT2A improve methionine-mediated DNA synthesis through
            SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation
  JOURNAL   Cell Prolif 54 (1), e12950 (2021)
   PUBMED   33179842
  REMARK    GeneRIF: CBS and MAT2A improve methionine-mediated DNA synthesis
            through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.
REFERENCE   5  (bases 1 to 1337)
  AUTHORS   Ngai,Y.F., Sulistyoningrum,D.C., O'Neill,R., Innis,S.M.,
            Weinberg,J. and Devlin,A.M.
  TITLE     Prenatal alcohol exposure alters methyl metabolism and programs
            serotonin transporter and glucocorticoid receptor expression in
            brain
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 309 (5), R613-R622 (2015)
   PUBMED   26180184
REFERENCE   6  (bases 1 to 1337)
  AUTHORS   Lu,S.C., Huang,Z.Z., Yang,H., Mato,J.M., Avila,M.A. and
            Tsukamoto,H.
  TITLE     Changes in methionine adenosyltransferase and S-adenosylmethionine
            homeostasis in alcoholic rat liver
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 279 (1), G178-G185 (2000)
   PUBMED   10898761
REFERENCE   7  (bases 1 to 1337)
  AUTHORS   LeGros,H.L. Jr., Halim,A.B., Geller,A.M. and Kotb,M.
  TITLE     Cloning, expression, and functional characterization of the beta
            regulatory subunit of human methionine adenosyltransferase (MAT II)
  JOURNAL   J Biol Chem 275 (4), 2359-2366 (2000)
   PUBMED   10644686
REFERENCE   8  (bases 1 to 1337)
  AUTHORS   Hiroki,T., Horikawa,S. and Tsukada,K.
  TITLE     Structure of the rat methionine adenosyltransferase 2A gene and its
            promoter
  JOURNAL   Eur J Biochem 250 (3), 653-660 (1997)
   PUBMED   9461287
REFERENCE   9  (bases 1 to 1337)
  AUTHORS   De La Rosa,J., Ostrowski,J., Hryniewicz,M.M., Kredich,N.M.,
            Kotb,M., LeGros,H.L. Jr., Valentine,M. and Geller,A.M.
  TITLE     Chromosomal localization and catalytic properties of the
            recombinant alpha subunit of human lymphocyte methionine
            adenosyltransferase
  JOURNAL   J Biol Chem 270 (37), 21860-21868 (1995)
   PUBMED   7665609
REFERENCE   10 (bases 1 to 1337)
  AUTHORS   Horikawa,S., Sasuga,J., Shimizu,K., Ozasa,H. and Tsukada,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNA encoding the rat
            kidney S-adenosylmethionine synthetase
  JOURNAL   J Biol Chem 265 (23), 13683-13686 (1990)
   PUBMED   1696256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05571.1, SRR8487227.9350.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1337
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /note="methionine adenosyltransferase 2A"
                     /db_xref="GeneID:171347"
                     /db_xref="RGD:619985"
     exon            1..168
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1265
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /EC_number="2.5.1.6"
                     /note="non-hepatic-type S-adenosylmethionine synthetase;
                     methionine adenosyltransferase 2; MAT 2; MAT-II; adoMet
                     synthetase 2; adoMet synthase 2; methionine
                     adenosyltransferase II, alpha"
                     /codon_start=1
                     /product="S-adenosylmethionine synthase isoform type-2"
                     /protein_id="NP_599178.1"
                     /db_xref="GeneID:171347"
                     /db_xref="RGD:619985"
                     /translation="MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDA
                     HLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYK
                     TCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKL
                     NAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEM
                     RDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGA
                     HGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFH
                     YGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKK
                     LKY"
     exon            169..246
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..369
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..482
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..626
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..845
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1028
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1162
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1337
                     /gene="Mat2a"
                     /gene_synonym="Sams2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatctgcgc cctccgcagt cctctgcctc gttgccgctc cgtctcccca gagtcgcctt
       61 ctctcatcgc tgcagccatg aacgggcagc tcaacggctt ccatgaggcg ttcatcgagg
      121 aggggacatt ccttttcact tcagagtctg taggggaagg tcatccagat aagatttgtg
      181 accaaatcaa tgatgctgtc cttgatgcac accttcagca ggaccctgat gctaaagtgg
      241 cttgtgaaac tgttgctaaa actggaatga tccttcttgc tggggaaatt acatctagag
      301 ctgccattga ttaccagaaa gtggttcgtg aagccataaa gcacattggc tatgatgatt
      361 cttccaaagg gtttgactac aagacttgta atgtgttggt tgccttggaa caacagtcac
      421 cagatatcgc ccaaggtgtt catcttgacc ggaatgagga agacattggt gcaggagatc
      481 agggtttgat gtttggttat gccactgatg aaactgaaga gtgtatgcct ttaactattg
      541 tcttagcaca caagctaaat gctaaactgg ctgagctacg ccgcaatggc acattgcctt
      601 ggttacgccc agattctaaa actcaagtga ctgtgcagta tatgcaagat cgaggtgctg
      661 tgattcccat cagagtccat acaattgtta tatctgttca gcatgatgaa gaagtttgtc
      721 ttgatgaaat gagggatgct ctgaaggaga aattgatcaa agctgttgta cctgcaaagt
      781 accttgatga ggatacaatt taccacctac agccaagtgg cagattcgtt attggtgggc
      841 ctcagggtga tgctggtttg actggccgaa aaatcattgt ggatacttat ggcggttggg
      901 gagctcatgg aggaggggcc ttttcaggaa aggattatac caaagtggac cgttcagctg
      961 cttatgctgc tcgttgggtg gcaaaatccc ttgttaaagg aggtctgtgc aggagggttc
     1021 ttgttcaggt ctcttatgct attggagttt ctcatccatt gtcgatctcc attttccatt
     1081 atggtacttc tcagaagagt gagagagagc tattagaaat tgtgaagaat aattttgatc
     1141 ttcgccctgg ggtcattgtc agggatctgg atctgaagaa gccaatttat cagaggactg
     1201 cagcctatgg ccactttggt agggacagct tcccctggga agtgcccaaa aagcttaaat
     1261 attgaaagtg ttagcctttt ttccccagac ttgttggcgt aggttacaga gaagccttca
     1321 agctctgagg gaaaggg
//
