LOCUS       NM_012860               3056 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus methionine adenosyltransferase 1A (Mat1a), mRNA.
ACCESSION   NM_012860 XM_346484
VERSION     NM_012860.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3056)
  AUTHORS   Sanchez-Perez,G.F. and Pajares,M.A.
  TITLE     Polar Interactions at the Dimer-Dimer Interface of Methionine
            Adenosyltransferase MAT I Control Tetramerization
  JOURNAL   Int J Mol Sci 22 (24), 13206 (2021)
   PUBMED   34948004
  REMARK    GeneRIF: Polar Interactions at the Dimer-Dimer Interface of
            Methionine Adenosyltransferase MAT I Control Tetramerization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3056)
  AUTHORS   Perez,C., Perez-Zuniga,F.J., Garrido,F., Reytor,E., Portillo,F. and
            Pajares,M.A.
  TITLE     The Oncogene PDRG1 Is an Interaction Target of Methionine
            Adenosyltransferases
  JOURNAL   PLoS One 11 (8), e0161672 (2016)
   PUBMED   27548429
  REMARK    GeneRIF: The oncogene PDRG1 is an interaction target of methionine
            adenosyltransferases.
            Erratum:[PLoS One. 2016 Sep 22;11(9):e0163761. doi:
            10.1371/journal.pone.0163761.. PMID: 27658062]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3056)
  AUTHORS   Shafqat,N., Muniz,J.R., Pilka,E.S., Papagrigoriou,E., von Delft,F.,
            Oppermann,U. and Yue,W.W.
  TITLE     Insight into S-adenosylmethionine biosynthesis from the crystal
            structures of the human methionine adenosyltransferase catalytic
            and regulatory subunits
  JOURNAL   Biochem J 452 (1), 27-36 (2013)
   PUBMED   23425511
REFERENCE   4  (bases 1 to 3056)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   5  (bases 1 to 3056)
  AUTHORS   Frau,M., Tomasi,M.L., Simile,M.M., Demartis,M.I., Salis,F.,
            Latte,G., Calvisi,D.F., Seddaiu,M.A., Daino,L., Feo,C.F.,
            Brozzetti,S., Solinas,G., Yamashita,S., Ushijima,T., Feo,F. and
            Pascale,R.M.
  TITLE     Role of transcriptional and posttranscriptional regulation of
            methionine adenosyltransferases in liver cancer progression
  JOURNAL   Hepatology 56 (1), 165-175 (2012)
   PUBMED   22318685
  REMARK    GeneRIF: we found for the first time a post-transcriptional
            regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 3056)
  AUTHORS   Mingorance,J., Alvarez,L., Pajares,M.A. and Mato,J.M.
  TITLE     Recombinant rat liver S-adenosyl-L-methionine synthetase tetramers
            and dimers are in equilibrium
  JOURNAL   Int J Biochem Cell Biol 29 (3), 485-491 (1997)
   PUBMED   9202427
REFERENCE   7  (bases 1 to 3056)
  AUTHORS   Chamberlin,M.E., Ubagai,T., Mudd,S.H., Levy,H.L. and Chou,J.Y.
  TITLE     Dominant inheritance of isolated hypermethioninemia is associated
            with a mutation in the human methionine adenosyltransferase 1A gene
  JOURNAL   Am J Hum Genet 60 (3), 540-546 (1997)
   PUBMED   9042912
REFERENCE   8  (bases 1 to 3056)
  AUTHORS   Alvarez,L., Asuncion,M., Corrales,F., Pajares,M.A. and Mato,J.M.
  TITLE     Analysis of the 5' non-coding region of rat liver
            S-adenosylmethionine synthetase mRNA and comparison of the Mr
            deduced from the cDNA sequence and the purified enzyme
  JOURNAL   FEBS Lett 290 (1-2), 142-146 (1991)
   PUBMED   1915866
REFERENCE   9  (bases 1 to 3056)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
REFERENCE   10 (bases 1 to 3056)
  AUTHORS   Horikawa,S., Ishikawa,M., Ozasa,H. and Tsukada,K.
  TITLE     Isolation of a cDNA encoding the rat liver S-adenosylmethionine
            synthetase
  JOURNAL   Eur J Biochem 184 (3), 497-501 (1989)
   PUBMED   2806235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089770.1.
            
            On Oct 6, 2005 this sequence version replaced NM_012860.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089770.1, X60822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132280, SAMD00132296
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3056              BC089770.1         1-3056
FEATURES             Location/Qualifiers
     source          1..3056
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3056
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /note="methionine adenosyltransferase 1A"
                     /db_xref="GeneID:25331"
                     /db_xref="RGD:3050"
     exon            1..259
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1356
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /EC_number="2.5.1.6"
                     /note="MAT 1; MAT-I/III; adoMet synthetase 1; methionine
                     adenosyltransferase 1; methionine adenosyltransferase
                     I/III; adoMet synthase 1; S - adenosylmethionine
                     synthetase; methionine adenosyltransferase I, alpha"
                     /codon_start=1
                     /product="S-adenosylmethionine synthase isoform type-1"
                     /protein_id="NP_036992.2"
                     /db_xref="GeneID:25331"
                     /db_xref="RGD:3050"
                     /translation="MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLD
                     AHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDF
                     KTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHK
                     LNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEA
                     MREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWG
                     AHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIF
                     TYGTSKKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPK
                     KLVF"
     exon            260..337
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            338..460
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            461..573
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            574..717
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            718..936
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1119
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1253
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..3028
                     /gene="Mat1a"
                     /gene_synonym="AdoMet; SADE; SAS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttaggcaga agtcatctcc ttgtgattct gcccaagatc tgcccgttgg gtttgtaggg
       61 ggaggaagaa aaaaaaaaag agagagacag agaaaagaaa ctacaggcaa actttcagct
      121 ttgaagttgt caccttggag aagtgaagtc gagaagtgtg acaccatgaa tggacctgtg
      181 gatggcttgt gtgaccattc tctaagtgaa gagggagcct tcatgttcac atctgaatcg
      241 gtaggagaag ggcatccaga taagatctgt gaccagatta gtgatgcagt gctggatgcc
      301 catctcaagc aagaccccaa tgccaaggtg gcctgtgaga cagtgtgcaa gacagggatg
      361 gtgctcctgt gtggagagat cacctcaatg gccatgattg actaccagcg ggtggtgaga
      421 gacaccatta agcacattgg ctacgatgac tctgccaagg gcttcgactt caagacctgc
      481 aatgtgctcg tggctctgga gcaacagtcc ccagacattg cccaatgtgt ccatctagac
      541 agaaatgagg aggacgttgg tgcaggagat cagggtctga tgttcggcta tgccactgac
      601 gagacagagg agtgcatgcc gctcaccatt gttcttgctc acaaactcaa cacccggatg
      661 gcagatctga ggcgctctgg tgtccttccc tggctgagac ctgattctaa gactcaggta
      721 acagttcagt acgtgcagga taatggtgct gtcatccctg ttcgcgtcca caccatcgtc
      781 atctctgtgc aacacaacga agacataaca ctggaggcca tgcgagaggc cctgaaggag
      841 caggtgatca aagctgtggt gccagccaag tacctggatg aagacaccat ctaccacctg
      901 cagccaagtg ggcggtttgt catcggaggt ccccaggggg atgcaggtgt cacaggccgc
      961 aagattattg tggacacata cggaggctgg ggtgcccatg gtggtggtgc cttctctgga
     1021 aaggactaca ccaaggtgga ccgctcagca gcttatgccg cccgctgggt ggccaagtct
     1081 ctggtgaagg ctgggctctg ccggagagtc cttgttcagg tgtcctatgc cattggtgtg
     1141 gcagaacctc tgtccatttc cattttcacc tacggaactt ccaagaagac cgagcgagag
     1201 ctactagagg ttgtgaacaa gaactttgat ctccggccgg gtgttattgt cagggacttg
     1261 gatctgaaga agcccatcta ccagaagact gcatgctatg gtcatttcgg aagaagcgag
     1321 tttccctggg aggtccccaa gaagcttgtg ttttagagct gccgggaagc ttagctctgt
     1381 cctatactca acctcctcaa gatctcaact ccctggtctc agagagccct ccctgcttcc
     1441 caccctcatg gcaaagccag cttcctctga ttttccccct acccggcaat ctgcaaacat
     1501 cttattagtg gcaaggcagg tggtttctgg tgctaggtca tcaggtctcc ttgcaaggat
     1561 agtcagtgtt ccctccctgt ctctcagatg acagcaatgt taattttgtg taaaagttgc
     1621 tcctatcatc ccctcccgta gtctgaagct aaccaggcca tctcttcctc cgtcctggac
     1681 atgtgcccag acgaatgttt tgtcccatat ctctggcttc ccctttacat tggcagccag
     1741 aggtcctgag ccggggcttc ctcagggtcc ctctgagact gggcatctgc tccctaggat
     1801 atggtcagtg tcccctgaac atctgcattc tgtgagggac tgagctgtgt gttcttcatc
     1861 ccaacacaat aaggtggtat cgtcattatc cacagtgaca gatggggaaa ctgaggctcg
     1921 gagagttatg gagctctgac aggttcctat agctgcgtgc accagagtca agaaacagat
     1981 cttgactcta ggaattttga ctctaaccct cacacctgca tcccaaacaa gatgttgacc
     2041 agagtgatga cacatggatt gacaagaggt tatgacctct tatttaaggc ctgggtttca
     2101 ggagaattag atgaacctaa tggctcttgg tgagccctgg acagtgttcc cacaaaatca
     2161 agatggaaac atgtaagtgt ctcatttgtt ctggaagagg gcttaaggaa agctgagcat
     2221 cttggtctat aaagctggac tggggtctgt aattaagagg aagcttcatg gtcctagcgc
     2281 ccaacactca aagacaggtg tgtgaattct ttgagcatgg gatctaatca tggacagccc
     2341 catgtgcttg cttcctcaca gaggagaggc agttcgttgt tccagcacag acaaccagcc
     2401 tctatagggg acccttcaag gctttcttgt gccctggacc ctcacactta tgcagtctga
     2461 atgctgctag ggaagtgggt gatccaggtg aggagccagc gtccaagcag ttgacaagtt
     2521 gcccaagatc tcacaagaac tgacttttac caggtagcct gggtgtgtct gtctagcaga
     2581 gtcctgagaa catgtctcta ggtgtcccat catgatcagc atcacacacc cagcctgtcc
     2641 ctcgttgggg cttccccaca gcatactgcc ctcatagctc tcaaacacgt ggcttcagga
     2701 acggacctgg ctcatatcga tggttctggc ttaggagaag gactgagcag cttcatcaag
     2761 gagcagacac cttgcatctg ccttaactgg acagagaccc cagctttccc cattccacca
     2821 gggcgaggaa acagcagaga gaaaagcccc aggagccaac agatcctgaa gctgtatgtg
     2881 atgtagaagc ttgggtcttt ccatggggtc agggctgcct gggagccaag ttcctcacag
     2941 cagagggaag gatgggtatg cagaaggctg aattcctgta acttaagctt tatctaaata
     3001 aaaatccaga attgtatact tgttctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
