LOCUS       NM_001107369            2989 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus microtubule associated serine/threonine
            kinase-like (Mastl), mRNA.
ACCESSION   NM_001107369 XM_001053405 XM_225629
VERSION     NM_001107369.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Adhikari D, Diril MK, Busayavalasa K, Risal S, Nakagawa S,
            Lindkvist R, Shen Y, Coppola V, Tessarollo L, Kudo NR, Kaldis P and
            Liu K.
  TITLE     Mastl is required for timely activation of APC/C in meiosis I and
            Cdk1 reactivation in meiosis II
  JOURNAL   J Cell Biol 206 (7), 843-853 (2014)
   PUBMED   25246615
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Li YH, Kang H, Xu YN, Heo YT, Cui XS, Kim NH and Oh JS.
  TITLE     Greatwall kinase is required for meiotic maturation in porcine
            oocytes
  JOURNAL   Biol Reprod 89 (3), 53 (2013)
   PUBMED   23843240
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Voets E and Wolthuis RM.
  TITLE     MASTL is the human orthologue of Greatwall kinase that facilitates
            mitotic entry, anaphase and cytokinesis
  JOURNAL   Cell Cycle 9 (17), 3591-3601 (2010)
   PUBMED   20818157
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Burgess A, Vigneron S, Brioudes E, Labbe JC, Lorca T and Castro A.
  TITLE     Loss of human Greatwall results in G2 arrest and multiple mitotic
            defects due to deregulation of the cyclin B-Cdc2/PP2A balance
  JOURNAL   Proc Natl Acad Sci U S A 107 (28), 12564-12569 (2010)
   PUBMED   20538976
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Navarro-Lerida I, Martinez Moreno M, Roncal F, Gavilanes F, Albar
            JP and Rodriguez-Crespo I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Gandhi MJ, Cummings CL and Drachman JG.
  TITLE     FLJ14813 missense mutation: a candidate for autosomal dominant
            thrombocytopenia on human chromosome 10
  JOURNAL   Hum Hered 55 (1), 66-70 (2003)
   PUBMED   12890928
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474100.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_225629.4, XM_001053405.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..2989
                     /gene="Mastl"
                     /note="microtubule associated serine/threonine
                     kinase-like"
                     /db_xref="GeneID:307169"
                     /db_xref="RGD:1309186"
     exon            1..242
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2660
                     /gene="Mastl"
                     /EC_number="2.7.11.1"
                     /note="microtubule-associated serine/threonine-protein
                     kinase-like; serine/threonine-protein kinase
                     greatwall-like"
                     /codon_start=1
                     /product="serine/threonine-protein kinase greatwall"
                     /protein_id="NP_001100839.1"
                     /db_xref="GeneID:307169"
                     /db_xref="RGD:1309186"
                     /translation="MESASGSEENEEGAATEKCVNRIPVPRPPSIEEFTIVKPISRGA
                     FGKVYLGQKGSKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSA
                     SNVYLIMEYLIGGDVKSLLHIYGYFDEEMAIKYTSEVALALDYLHRHGIIHRDLKPDN
                     MLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMSKPKQDYSRTPGQVLSLISSLG
                     FFTPVGEKDQDSANVFSAPKSEAQLSQGSICPMSIDQKEPISYSSKLLKSCFETLASN
                     PEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFVSSVESECHSSPKWEKDCQSAKPSSTM
                     MSWSAGEMPYAKSVSAIETKTDLELALSPIHDSSNIPPTGRNYMTLPRKCFSREISWE
                     AREPDINNETMTIDEVSFCQSNHWAVNSSATSEEHLCKRNCKRNFHLVDSSPCQEIIQ
                     SKKNCIEYEANKEKTGCCANQATGLTAQVQNLKLSVCKSQQHDYANKENTVTYLTDRR
                     TPEELHIPTIAKNLMSELDEDCELSSKKDCLHSNSVCSDEDRAPKTVCVDSDSSFPGV
                     SMMESSLEIQALEPDKSIRDYSFEEPNTEDLLMLPKCQENSLPKDDWHASIQDSNQML
                     APPSKAPKTFASKTNVVAFRSFSSHINASSNSEPSKVSTTSLDTMDISCDYSGSCPMA
                     VTPTEKGRACVSHQTPSQVKLGTSYRTPKSVRRGPPPVDDGRILGTPDYLAPELLLGA
                     AHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDKSQSA
                     MDMLLTIDDTKRAGMKELKHHPLFSEVDWENLQHQTMPFVPQPDNETDTSYFEARNNA
                     QHLTISGFSL"
     exon            243..380
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            381..520
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            521..609
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            610..716
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            717..864
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1037
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..2147
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2286
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2400
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2502
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2989
                     /gene="Mastl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgaaagca tttgaatcta cttggcggga gttagtactg tagtgcgaac tgttcagcta
       61 tggagtccgc ctcgggaagt gaggagaatg aagaaggtgc ggcgacagag aaatgcgtga
      121 ataggatccc agtaccaaga ccaccctcca ttgaagaatt cactatagtg aagcccatta
      181 gccgtggcgc attcgggaaa gtgtacctgg gacagaaagg cagcaagttg tacgcggtga
      241 aggttgtcaa aaaagcagac atgatcaata aaaatatgac tcatcaggta caggctgaga
      301 gagatgccct ggcactgagc aaaagccctt ttgttgtgca tctgtattac tcactacagt
      361 cagcaagcaa cgtctacttg ataatggaat atcttattgg tggagatgtc aagtctctcc
      421 tacatatata tggttatttt gatgaagaga tggctataaa atatacttct gaagtagcat
      481 tggctttaga ctacctgcac agacatggca tcatccacag ggatttgaaa ccggacaata
      541 tgcttatttc caatgagggt catattaagc tgacagattt tggcctttcc aaagttactc
      601 tgaatagaga catcaatatg atggatattc tcacgacacc atcaatgtct aaacctaagc
      661 aagattattc gagaacccca ggacaagtct tatctctcat cagttctttg ggatttttca
      721 caccagttgg agaaaaagat caagactctg caaatgtgtt ttcagcacct aagtctgaag
      781 cacaactttc tcaaggatca atttgtccta tgtccataga tcagaaggag ccaatttctt
      841 attctagcaa actactaaaa tcatgttttg aaacacttgc atccaatcca gaaatacctg
      901 tgaaatgtct gacttctaat ctactccagt gtaggaaaag actgggtacc tcaagtacta
      961 gtagccagtc tcataccttc gtatccagtg tggagtcaga atgtcacagc agtcccaaat
     1021 gggagaaaga ctgccagagt gccaagccat caagtacaat gatgagctgg agtgccggtg
     1081 aaatgccgta tgcaaaatct gtaagtgcca tcgagacaaa aacggatttg gaattagcac
     1141 tttctcccat tcatgacagc agtaacattc ctcccactgg aagaaactac atgaccctcc
     1201 ctagaaagtg cttctccagg gaaatctctt gggaggcaag agaaccggat ataaataatg
     1261 agaccatgac cattgacgag gtcagtttct gtcagtccaa tcattgggct gtaaattcta
     1321 gtgctacatc tgaagaacac ctctgtaaaa gaaactgtaa aagaaatttc cacttggttg
     1381 actccagtcc ttgtcaggaa attatacaaa gtaaaaaaaa ctgtatagaa tatgaagcca
     1441 ataaggaaaa gacaggctgt tgtgcaaatc aagctacagg cttgacagcc caagtccaga
     1501 acctgaagct atcagtgtgc aaaagtcagc aacatgacta tgctaataag gagaacactg
     1561 tcacctattt aactgacaga cgaaccccag aagaactgca tataccaaca atagcaaaga
     1621 acctcatgtc tgagctcgat gaagactgtg agctgagcag taaaaaagac tgcctccatt
     1681 ctaattccgt atgttctgat gaggatagag ctcctaaaac tgtctgtgta gactctgatt
     1741 catcttttcc tggagtgtct atgatggaaa gttcactgga aattcaggcc ttagagccag
     1801 ataaaagcat cagagactac tcttttgaag aaccaaatac tgaagatcta cttatgttac
     1861 caaaatgcca agaaaattcc ttgccaaaag atgactggca tgcttctatc caagacagta
     1921 accaaatgtt agctcctcct tcaaaggcgc caaaaacatt cgcctctaaa accaatgtcg
     1981 tggcttttcg aagttttagc agtcacatta atgcatccag taattcagaa ccatccaaag
     2041 tgagcacaac ttctttagac actatggaca tttcctgtga ctacagtggt tcgtgtccca
     2101 tggctgtgac ccctactgag aaagggaggg cctgtgtgtc acatcagact ccgagtcagg
     2161 tcaagttggg aacatcatac agaactccaa agagtgtgag aagagggcca cccccagtag
     2221 atgatggacg gattctagga accccggatt acctggcacc tgagctccta ctgggagccg
     2281 cccatggtcc tgcagtagac tggtgggcac ttggagtctg cttgtttgaa tttctaacag
     2341 gaatcccccc tttcaatgat gaaacaccac agcaagtatt ccagaatatt ctaaaaagag
     2401 atatcccgtg gccagaaggt gaagaaaagc tatctgataa gtctcaaagt gcgatggata
     2461 tgctgttaac cattgatgac acaaagagag ctgggatgaa agaactgaaa catcatcctc
     2521 tcttcagtga agtggactgg gagaatctgc agcatcagac tatgcctttc gtgccccaac
     2581 cagacaacga aacagataca tcctactttg aagccaggaa caatgctcag catctgacca
     2641 tatctgggtt cagtctgtag cacatgcatg ccatttctat ctaacttgtg atatagaatt
     2701 ttaacactag attcatctac acggaataag tcattattgt accgaggcta aacagtttta
     2761 atgagtacaa cagcttttac agagttaaaa tactgtaaaa aatataaaca gtaatctcta
     2821 ccttagaact gtacataagg catcatggct tttttcatct tatttattca ctgcacttta
     2881 tgaagagcaa tgtctcaata aactaaaaca gcactaccac tctaaacaga ggggatgaac
     2941 cataagcttg tatgtatctg ttgatgttag ttctgttcac tttggtgtt
//
