LOCUS       NM_001134796            5371 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus microtubule associated serine/threonine kinase 3
            (Mast3), mRNA.
ACCESSION   NM_001134796 XM_001064901
VERSION     NM_001134796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5371)
  AUTHORS   Xu,Q., Yin,S., Yao,Y., Li,X., Song,B., Yang,Y., Liu,Y., Chen,R.,
            Li,J., Ma,T., Meng,X., Huang,C. and Li,J.
  TITLE     MAST3 modulates the inflammatory response and proliferation of
            fibroblast-like synoviocytes in rheumatoid arthritis
  JOURNAL   Int Immunopharmacol 77, 105900 (2019)
   PUBMED   31644963
  REMARK    GeneRIF: In an experimental arthritis model, we successfully
            explored the effect of MAST3 on inflammatory response and
            proliferation of fibroblast-like synovial cells(FLSs) in vitro. In
            synovial tissues of inflamed joints as well as in FLSs, we explored
            that the expression of MAST3 was significantly increased. Silencing
            or overexpressing of MAST3 was involved in the process of
            proliferation and inflammatory response of FLSs.
REFERENCE   2  (bases 1 to 5371)
  AUTHORS   Garland,P., Quraishe,S., French,P. and O'Connor,V.
  TITLE     Expression of the MAST family of serine/threonine kinases
  JOURNAL   Brain Res 1195, 12-19 (2008)
   PUBMED   18206861
  REMARK    GeneRIF: MAST3 shows selective expression in the striatum and
            cerebral cortex of rats.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 6, 2008 this sequence version replaced XM_001064901.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.55343.1,
                                           SRR26643298.70920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000016.1  18683642-18683851
            211-299             JAXUCZ010000016.1  18686098-18686186
            300-372             JAXUCZ010000016.1  18686265-18686337
            373-451             JAXUCZ010000016.1  18686866-18686944
            452-609             JAXUCZ010000016.1  18687125-18687282
            610-685             JAXUCZ010000016.1  18687359-18687434
            686-895             JAXUCZ010000016.1  18687792-18688001
            896-997             JAXUCZ010000016.1  18688161-18688262
            998-1130            JAXUCZ010000016.1  18688330-18688462
            1131-1189           JAXUCZ010000016.1  18688765-18688823
            1190-1275           JAXUCZ010000016.1  18689164-18689249
            1276-1484           JAXUCZ010000016.1  18689327-18689535
            1485-1623           JAXUCZ010000016.1  18689814-18689952
            1624-1756           JAXUCZ010000016.1  18690897-18691029
            1757-1922           JAXUCZ010000016.1  18691126-18691291
            1923-2024           JAXUCZ010000016.1  18691407-18691508
            2025-2147           JAXUCZ010000016.1  18691750-18691872
            2148-2257           JAXUCZ010000016.1  18692179-18692288
            2258-2394           JAXUCZ010000016.1  18692440-18692576
            2395-2633           JAXUCZ010000016.1  18693637-18693875
            2634-2846           JAXUCZ010000016.1  18694048-18694260
            2847-3073           JAXUCZ010000016.1  18694398-18694624
            3074-3196           JAXUCZ010000016.1  18694795-18694917
            3197-3333           JAXUCZ010000016.1  18695112-18695248
            3334-3515           JAXUCZ010000016.1  18695325-18695506
            3516-5371           JAXUCZ010000016.1  18695977-18697832
FEATURES             Location/Qualifiers
     source          1..5371
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..5371
                     /gene="Mast3"
                     /note="microtubule associated serine/threonine kinase 3"
                     /db_xref="GeneID:688540"
                     /db_xref="RGD:1587639"
     exon            1..210
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..4039
                     /gene="Mast3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 3"
                     /protein_id="NP_001128268.1"
                     /db_xref="GeneID:688540"
                     /db_xref="RGD:1587639"
                     /translation="MSDPSYWTAVAAPGHRSRLAKGALLQRSKSCRSGNRKSLVVGTP
                     SPTLSRPLSPLSVPTAGNSPLDSPRNFSAAAAINFPFARRADGRRWSLASLPSSGYGT
                     NTPSSTVSSSSSSRERLHQLPFQPTADELRFLSKHFRSSESVVDEDGGRSPRLRPRSR
                     SLSPGRTSGTFDNEIVMMNHVYRERFPKATAQMEGRLQDFLAAFAPGDRLALADGVLG
                     FIHHQIVELARDCLAKSGEALVTSRYFLEMQDKLERLLQDAHERSDSAEVGFIVQLVR
                     KLLIIISRPARLLECLEFDPEEFYHLLEAAEGQAREDQGVKTDLPRYIIRQLGLAKDP
                     LEEIQPLNDLDEGQPPAPGSPESRGLGGPSRRQPCESDFETIKLISNGAYGAVYLVRH
                     RDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVGMFCSFETRRHLCMVM
                     EYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSLG
                     HIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEYIAPEVIFRQGYGKP
                     VDWWAMGVILYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPPDAQDLITRLL
                     RQSPMDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYR
                     HLGSEGDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPNPTFAERSFSEDREEG
                     WEQSGEGDGGRRLSTDLRLRSWTPASSCQPSSCQSDRGPSPSLLSTISLDMPKFAFSS
                     EDEGAGSGPADTRKPVFILGEPDPPPPTTPVTPKPCNLSADTAVLSHARLRSNSTGAR
                     HSTPRPLDAGRGRRLGSSRDPGPEKPRASPGGSGGRVPKSASVSALSLIITADDGSGG
                     PLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMG
                     DSDVYTVHHVVWSVEEGSPAQEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKI
                     SLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKRISKPSSVLHT
                     SRSFSSGLQHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPTDTASPPSVSPSSSSP
                     ASPATGHTRPSSLHGLAAKLGPPRHKSGRRKSTSSIPPSPLACPPVPTPPPRSPSPLP
                     GHIPIPARSPRLRRGQSADKLGLGTSERLDGDGGRRGRGAETELVVMRRLHLSERRDS
                     FKKQEAVQEVSFDEEPGPTGAVPKIAVQGAEATPGSPGPARED"
     exon            211..299
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            300..372
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..451
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..609
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..685
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..895
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..997
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1130
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1189
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1275
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1484
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1623
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1756
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1922
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2024
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2147
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2257
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2394
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2633
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2846
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3073
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3196
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3333
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3515
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..5371
                     /gene="Mast3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgggctt cctccttgct acccgcgcgc tcttgtagcc cgcggcccct gggccgctcc
       61 accgggctca ggccgaatcc ggccgatctg gccgtggccg ggccaggcgg agggccacag
      121 catgtcggac cccagctact ggaccgcggt ggcggccccc ggacaccgca gccgcctggc
      181 caagggtgcg ctgctacaac gttccaaaag ctgccgcagt ggcaaccgta agagcctagt
      241 cgtggggacg ccttcaccca ctctctccag acctttgtca ccactctctg tcccaactgc
      301 aggtaacagc cccttggaca gtcctcggaa cttctctgcc gcagcggcca tcaatttccc
      361 ctttgcccgg agggctgacg gcagaagatg gtcacttgct tccctcccgt catcaggcta
      421 tgggaccaac actcccagct ccactgtgtc gtcaagctca tcctcccggg agcgtctaca
      481 ccagctccct ttccaaccca ctgcggacga actgcgcttc ctgtccaagc acttccgcag
      541 ctcagagagt gtggtggatg aggatggagg ccgttctccg cgcctgcgcc cacgctcacg
      601 aagcctcagc cctggacgaa catcaggaac cttcgacaac gagatagtga tgatgaatca
      661 tgtataccgg gagcgcttcc ccaaggccac agcgcagatg gagggccggc tgcaggactt
      721 cctggcagca tttgctcctg gagaccgcct ggcactggca gacggtgtcc tgggcttcat
      781 ccaccaccag atcgtggagt tggcgaggga ctgcctggcc aagtcgggcg aggctctagt
      841 cacctcccgc tatttcctgg agatgcaaga caagctggag cgactactgc aggatgctca
      901 tgagaggtca gatagcgccg aagtgggctt catcgtgcag ttggtccgca agctgctcat
      961 catcatctcc aggccagcgc ggctgctcga gtgcttggag ttcgaccccg aagaattcta
     1021 ccatctgctg gaggctgcag agggccaggc ccgcgaggac cagggcgtga agactgatct
     1081 gccccgctac atcatccgcc agctgggcct tgccaaggac cctctagaag agattcagcc
     1141 cctgaatgac cttgatgaag gccagccacc agctcctgga tcccctgaga gccgaggcct
     1201 gggcggtccg tctcggaggc agccatgtga gagcgacttt gagaccatca agcttattag
     1261 caatggagcc tatggggctg tctacctggt gcgccacagg gacacacgac agcgcttcgc
     1321 catcaagaag atcaacaagc agaatttgat tctgcgcaac cagatccaac aggtgtttgt
     1381 ggagcgagac atcctcacct tcgccgagaa cccctttgtg gtcggcatgt tctgctcttt
     1441 tgaaacccgt cgccacctct gcatggtgat ggagtatgtg gaagggggtg actgcgccac
     1501 gctgctgaaa aacatgggcc cactgcctgt ggacatggcc cgcatgtact tcgcggagac
     1561 ggtactggct ctggagtatc tgcacaacta tggcatcgtg caccgagacc tcaaacctga
     1621 caacctgctc atcacctccc tcggccacat caagctgacg gacttcggcc tgtccaagat
     1681 cggcctcatg agcatggcca ccaacctgta tgaaggtcac atcgagaagg atgctcgaga
     1741 gtttgtggac aagcaggtgt gcgggacgcc tgaatacatc gcgccagagg tgatcttccg
     1801 ccagggctat gggaagccag tagactggtg ggccatgggc gtcatcctgt atgagttcct
     1861 ggtgggctgc gtgcctttct ttggggacac acctgaggag ctgttcggac aggttgtcag
     1921 tgatgagatc atgtggccag agggagatga ggcccttccc cccgacgccc aggatctcat
     1981 tactaggctt ctgcgtcaga gcccaatgga caggctgggg actggaggca cccacgaggt
     2041 gaaacagcac cccttcttcc tggccctgga ctgggcaggg ctcctgagac acaaggcaga
     2101 gtttgtccca cagcttgaag ctgaggacga caccagctac tttgacactc gctctgagcg
     2161 gtaccgccac ttgggctccg agggtgacga gacgaatgac gaggaatcct ccacagagat
     2221 cccccagttc tcttcctgtt cccaccgctt cagcaaggtc tacagcagtt ccgagttcct
     2281 ggctgtccag cccaacccca cctttgctga aagaagcttc agtgaggacc gagaggaagg
     2341 ttgggagcaa agcggtgaag gggacggtgg ccgccggctg agcactgacc tccggctgag
     2401 gtcctggaca cctgcttcct cctgtcagcc gtcttcctgt cagagcgacc ggggtcccag
     2461 cccgtctctc ctaagcacca tcagcttgga catgcctaaa tttgccttct cctctgaaga
     2521 tgagggagca ggctcagggc ctgctgacac cagaaagccc gtcttcatct tgggggagcc
     2581 tgacccccca cccccgacca ccccagtgac acctaagccc tgcaaccttt ctgccgacac
     2641 agctgttctc agccatgccc gccttcgaag taacagtaca ggcgcccggc actcaactcc
     2701 tcggcccctg gatgccggca gaggccgccg cctaggaagc tcaagagacc ccggcccaga
     2761 gaagcccagg gcctcccctg gtggcagcgg gggtcgagtg cccaagtcag cctctgtgtc
     2821 tgccctgtcc ctcatcatca cggcagacga cggcagtggg ggccccctca tgagtccctt
     2881 gtcgccccgc tcgctgtcct ccaacccctc ctcccgagac tcctcaccta gccgggaccc
     2941 atcaccagtg tgtggtagcc tgcggccccc catcgtcatc cacagctcgg gcaagaagta
     3001 cggcttcagc cttcgcgcca ttcgtgtcta catgggagac agcgacgtgt acacggtgca
     3061 ccatgtggtc tggagcgtgg aggaggggag ccctgcgcag gaggcgggac tgcgtgctgg
     3121 ggacctcatc acacacatca acggggaatc tgtcctgggc ctggtgcaca tggatgtggt
     3181 ggagctgctg ctgaagagtg gcaacaagat ctccctgcgc accacggccc tggagaacac
     3241 ctccatcaag gtggggcctg cccggaagaa cgtggccaag ggccgcatgg cccgaagaag
     3301 caagcgcagc cgccggcgcg agacccagga ccggcggaag tccttgttta agaggatctc
     3361 gaagccatct tctgtgctcc acaccagccg tagtttctcc tcgggcctcc agcactctct
     3421 gtcctccagc gagagcctcc ctggatcacc cactcacagc ctgtccccta gccccaccac
     3481 gccctgccgc agccctgccc ccgacgtccc cacagacaca gcatccccac ccagtgtatc
     3541 cccaagttcc agcagtcccg cttctccagc aactggccac acccgtccca gctcacttca
     3601 tggcctggca gccaagctcg ggccacctcg acacaagagc ggccgccgca agtccacaag
     3661 cagtatccct ccgtcaccac tggcttgccc gccagtgccc acacccccac cacgctcgcc
     3721 gtctcccctt cctgggcaca ttcccatacc agcacggtcc cctaggctgc gtaggggcca
     3781 gtctgccgat aagctgggcc taggcaccag tgagaggctg gatggggacg gaggccggcg
     3841 tggcagaggg gccgagactg agctggtcgt catgaggagg ctgcatctgt cagagcgccg
     3901 ggactccttc aagaagcagg aggccgtgca ggaagtgagc ttcgatgagg agcctgggcc
     3961 gactggtgcg gtgccgaaga tcgctgtgca gggtgcagag gccacgcctg gaagcccagg
     4021 accagccagg gaagactgag ccccgtctct ggccacttcc tcacggagct ctcatcttta
     4081 ccaagtcaca cctagatggg gtgcagccat cggcttggga cttggctgga gggtgccccc
     4141 tcccaggaag ggctggggtg gggtgccagt gacttgtaaa tagcaagccc tcgcgactaa
     4201 tttattactt tttataagca atagccaggc tgatccccct ggtggactta gctgtctgtc
     4261 ttgtcctcgg ccccggaatg cagcctacag accctattct ctgggccaag gcgaagcact
     4321 ttgggcaact tctgtgtttc ctagtttgtc ccatgtcctt tccaagtgta tgtgtgctgt
     4381 gtgtgtgttt gtccatccca ttcccaaccc aagacccacc tcaaggcaca caaaagctgg
     4441 tccctgctaa gtttggacag gatttggaag ctgtgccctg aagcaggagg atcaccagtt
     4501 cagtggtggg ctgcaccctg aagactacct tctgtgtctg aatagctctc ttcagactgt
     4561 ctttactcca ctctgcctgt gatcctgcat gtttcagttt aggggaagtg tgggaacacg
     4621 gggcttgggg gataaggaat gctctggttt aaggcagaat agcccataca ccttgcagga
     4681 agtaactgac aaacctaagg gccatcaagg tagggaaggt atccactgca gggataggac
     4741 aaagacttgt ctagccaagt gaggaccatg cctgaccacc aacccccaca ctacaaaatc
     4801 aatgcacacg tgcagagtcc catgtgtgtg aggcccagca tggtgagcct gggaccataa
     4861 tgtgatctcc cttgagtgct agaggaccga gtggacccca gctatgctgt gtaattctgg
     4921 aggcgtgtct ttcccattct gtgcctgtgt tgctgtgttt acaggactaa ccccagtgac
     4981 ttgcacactt catgtgcact gagcacgcct gaagtccccc agctttgtgt gatccaagca
     5041 gctgaggtcc cccaaggcca gaggcttgtc ccacaatgcc ccagtaagat tcctggctca
     5101 ggacaggatc tcccggccct actgtgagca tggccatggg ggagcccagg ctgtccccat
     5161 aatgctgtgt gatccagcag ccatctagaa ggttgtcagt gatggcggct ctccacactt
     5221 catgagggga atttgcaggc actcaaaccc tctctgcacc ctccctgacg cccagccagt
     5281 atcgtctgct ggaagagacc aaggctgtgc atgagtagcc ctccactcat cttggagctg
     5341 gcatcaaata aagtcccatg acgacatctg a
//
