LOCUS       NM_001108005            5686 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus microtubule associated serine/threonine kinase 2
            (Mast2), mRNA.
ACCESSION   NM_001108005 XM_001070900 XM_233782
VERSION     NM_001108005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5686)
  AUTHORS   Garland,P., Quraishe,S., French,P. and O'Connor,V.
  TITLE     Expression of the MAST family of serine/threonine kinases
  JOURNAL   Brain Res 1195, 12-19 (2008)
   PUBMED   18206861
  REMARK    GeneRIF: MAST2 expression patterns are evident in the hippocampus,
            cerebellum, 3rd ventricle and cerebral cortex of rats.
REFERENCE   2  (bases 1 to 5686)
  AUTHORS   Zhou,H., Xiong,H., Li,H., Plevy,S.E., Walden,P.D., Sassaroli,M.,
            Prestwich,G.D. and Unkeless,J.C.
  TITLE     Microtubule-associated serine/threonine kinase-205 kDa and Fc gamma
            receptor control IL-12 p40 synthesis and NF-kappa B activation
  JOURNAL   J Immunol 172 (4), 2559-2568 (2004)
   PUBMED   14764729
REFERENCE   3  (bases 1 to 5686)
  AUTHORS   Adey,N.B., Huang,L., Ormonde,P.A., Baumgard,M.L., Pero,R.,
            Byreddy,D.V., Tavtigian,S.V. and Bartel,P.L.
  TITLE     Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both
            inhibits and stimulates PDZ binding
  JOURNAL   Cancer Res 60 (1), 35-37 (2000)
   PUBMED   10646847
REFERENCE   4  (bases 1 to 5686)
  AUTHORS   Walden,P.D. and Millette,C.F.
  TITLE     Increased activity associated with the MAST205 protein kinase
            complex during mammalian spermiogenesis
  JOURNAL   Biol Reprod 55 (5), 1039-1044 (1996)
   PUBMED   8902215
REFERENCE   5  (bases 1 to 5686)
  AUTHORS   Walden,P.D. and Cowan,N.J.
  TITLE     A novel 205-kilodalton testis-specific serine/threonine protein
            kinase associated with microtubules of the spermatid manchette
  JOURNAL   Mol Cell Biol 13 (12), 7625-7635 (1993)
   PUBMED   8246979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 12, 2022 this sequence version replaced NM_001108005.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14142.1,
                                           SRR26643293.29316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               JAXUCZ010000005.1  135151719-135152161 c
            444-591             JAXUCZ010000005.1  135128909-135129056 c
            592-734             JAXUCZ010000005.1  135120307-135120449 c
            735-766             JAXUCZ010000005.1  135097732-135097763 c
            767-858             JAXUCZ010000005.1  135058235-135058326 c
            859-934             JAXUCZ010000005.1  135043948-135044023 c
            935-1013            JAXUCZ010000005.1  135037189-135037267 c
            1014-1168           JAXUCZ010000005.1  135034079-135034233 c
            1169-1244           JAXUCZ010000005.1  135032470-135032545 c
            1245-1454           JAXUCZ010000005.1  135029635-135029844 c
            1455-1556           JAXUCZ010000005.1  135027369-135027470 c
            1557-1689           JAXUCZ010000005.1  135024225-135024357 c
            1690-1751           JAXUCZ010000005.1  135023441-135023502 c
            1752-1837           JAXUCZ010000005.1  135022916-135023001 c
            1838-2046           JAXUCZ010000005.1  135022276-135022484 c
            2047-2185           JAXUCZ010000005.1  135021339-135021477 c
            2186-2318           JAXUCZ010000005.1  135020071-135020203 c
            2319-2484           JAXUCZ010000005.1  135019191-135019356 c
            2485-2586           JAXUCZ010000005.1  135018637-135018738 c
            2587-2709           JAXUCZ010000005.1  135018277-135018399 c
            2710-2819           JAXUCZ010000005.1  135018035-135018144 c
            2820-2974           JAXUCZ010000005.1  135017570-135017724 c
            2975-3246           JAXUCZ010000005.1  135017080-135017351 c
            3247-3441           JAXUCZ010000005.1  135016789-135016983 c
            3442-3668           JAXUCZ010000005.1  135016007-135016233 c
            3669-3791           JAXUCZ010000005.1  135015691-135015813 c
            3792-3928           JAXUCZ010000005.1  135015135-135015271 c
            3929-4122           JAXUCZ010000005.1  135014857-135015050 c
            4123-5686           JAXUCZ010000005.1  135013006-135014569 c
FEATURES             Location/Qualifiers
     source          1..5686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..5686
                     /gene="Mast2"
                     /note="microtubule associated serine/threonine kinase 2"
                     /db_xref="GeneID:313819"
                     /db_xref="RGD:1304573"
     exon            1..443
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..5633
                     /gene="Mast2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="microtubule-associated serine/threonine-protein
                     kinase 2"
                     /protein_id="NP_001101475.2"
                     /db_xref="GeneID:313819"
                     /db_xref="RGD:1304573"
                     /translation="MKRSRCRERPQPPPARREDAAPRAAELPQPQSLPPRRRAPPGRQ
                     LLEERSGPMGHDSREQDMVSGLSPLLFRKLSNPDIFSPTGKAKLQRQLSQDDCKLRRG
                     SLASSLSGKQLLPLSSSVHSSVGQVTWQSTGEASNLVRMRNQSLGQSAPSLTAGLKEL
                     SLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFS
                     FVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTADELHFLTK
                     HFSTENVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFPKATAQMEE
                     RLAEFISCNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSHYFYELQENLE
                     KLLQDAHERSESSDVAFVIQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAK
                     EGHGIKCDIPRYIVSQLGLTRDPLEEMVQLSSYDSPDTPETDDSVEGRGASQPSKKTP
                     SEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILT
                     FAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLAL
                     EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFL
                     DKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS
                     DEIVWPEGDDALPPDAQDLTSKLLHQNPLERLGTSSAYEVKQHPFFMGLDWTGLLRQK
                     AEFIPQLESEDDTSYFDTRSERYHHVDSEDEEEVSEDGCLEIRQFSSCSPRFSKVYSS
                     MERLSLLEGHRTPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSES
                     SHTESDSSPPMTVRHRSGLPDVPRCAEETSSTPRKQQQEGIWVLTPPSGEGSSRPVPE
                     RPLERQLKLDEEPPGQSSRSCPAMETRGRGTPQLAEEATAKAISDLAVRRARHRLLSG
                     DSIEKRTTRPVNKVIKSASATALSLLIPSEHHACSPLASPMSPHSQSSNPSSRDSSPS
                     RDFLPALGSLRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPASEA
                     GLRQGDLITHVNGEPVHGLVHTEVVELVLKSGNKVSISTTPLENTSIKVGPARKGSSK
                     AKMARRSKRSRGKDGQESRKRNSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPCSP
                     THSHSLSPRSPPQGYRVAPDTVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLA
                     PKLQRQYRSPRRKSAGSIPLSPLAHTPSPPAAAASPQRSPSPLSGHGSQSFPTKLHLS
                     PPLGRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAAAEKKLAPSRKHSLDLPHGELKK
                     ELTPREANPLEVVGTRSVLSGKGPLPGKGVLQPAPSRALGTLRQDRAERRESLQKQEA
                     IREVDSSEDDTDEEPENSQATQEPRLSPHPEASQNLLPKGSGEGREEDTFLHRDLKNR
                     GPVLSGLLTGNRIEVPGLSQRKLWRPQAFEEATNSLQAPSLSRSGPTSPTPSEGCWEA
                     RQLHTQALATLHPSSSELTPTSCSAATSTSGKPGTWSWKFLIEGPDRASTNKKITRTG
                     EPANSQDLETTVPTQVPKNLSPEEEKPQPPSVRGLTHPLLEVPSQNWLWESGCEQMEK
                     EDPSLSITEVPGSSGNRRQDIPCRAHHLSPETRPSLLWRSQELGGQQEHQDLALTSDE
                     LLKQT"
     exon            444..591
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            592..734
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..766
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..858
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..934
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1013
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1168
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1244
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1454
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1556
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1689
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1751
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1837
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2046
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2185
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2318
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2484
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2586
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2709
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2819
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2974
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            2975..3246
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3441
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3668
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3791
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            3792..3928
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..4122
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..5686
                     /gene="Mast2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcgggt ggccggccga gcgtgtgccg ggcggcggag ggcgcggtgg ctgctatgct
       61 gcctccgtga ggctcgccgg gacggtctcg gcgcctcagc ccacaggaag tgcggggaca
      121 ccgcgggccg ggtgcgggtg gcttccagtg cccgccgggc catgttggcc gcggaccggg
      181 cttgccgcgg cagcgctgcg gcccggggcc gagccaggcc ggcgcagtcg cggtgctaac
      241 gcccgcgggg cccagacgcg gagatgaagc ggagccgctg ccgcgagcgg ccgcagccgc
      301 cacccgcccg ccgggaggat gcggctccgc gggcggccga gttgccccag ccgcagtctt
      361 tgcccccgcg ccggcgagcg ccgcccggga ggcagctact ggaggagcgg agcgggccta
      421 tggggcacga cagcagggag caggatatgg tttctggact tagtcccctg ctcttcagaa
      481 agcttagtaa tcctgacata ttttcaccta ctggaaaagc taaactccag cgacaactta
      541 gtcaggatga ctgtaagtta cggagaggaa gcctggccag ttctctgtca ggtaagcagc
      601 tgctcccttt gtccagcagt gtacacagca gtgtgggaca ggtaacttgg cagtctacag
      661 gagaagcatc aaacttggtt cgaatgagaa accaatctct tggacagtct gcaccttccc
      721 ttactgctgg cttgaaggaa ttgagccttc cgaggagagg cagcttctgt cggacgagta
      781 accgcaagag cttgattgta acctctagca catcacccac actaccaagg ccacactcgc
      841 cactccatgg ccacacgggt aacagtccct tggacagccc tcggaatttc tctccaaatg
      901 ctcctgctca cttttccttt gttcctgccc gtaggactga tggacggcgc tggtctttgg
      961 cctcattgcc ttcttcaggc tatggaacca acactcctag ctctacagtc tcttcatcgt
     1021 gttcctcaca agaaaagctt catcagttac ctttccagcc gacagctgat gaactacact
     1081 ttctgacgaa gcattttagc acagagaatg taccagatga ggagggacgt cagtccccag
     1141 ccatgcggcc ccgttcccgc agcctcagtc ctggacggtc cccagtttcc tttgacagtg
     1201 aaataataat gatgaatcat gtgtacaaag aaagattccc caaggccact gcacaaatgg
     1261 aagagcgact agctgagttc atttcctgta acaccccaga tagtgtgctg cccttggcag
     1321 atggagcact aagttttatt catcatcaag taattgagat ggcccgagac tgcctggata
     1381 aatctcggag tggcctcatt acatcgcact atttctatga acttcaagag aatttggaaa
     1441 agcttctaca agatgctcat gaacgctcag aaagctcaga cgtagccttt gtgattcagc
     1501 tggtgaaaaa gctgatgatc atcattgccc gcccagctcg tctcctggaa tgcctggagt
     1561 ttgaccctga agaattttac cacctcttag aagcagctga gggtcatgcc aaagagggac
     1621 atggaattaa atgtgacatt ccccgctaca tcgttagcca gctgggcctc acacgggatc
     1681 ccctagagga aatggtccag ttgagcagct atgacagccc tgatactccg gagacagacg
     1741 attcagttga ggggcgtggg gcatctcagc catctaaaaa gaccccctct gaagaggact
     1801 ttgagaccat taagctcatc agcaatggcg cctatggggc tgtctttctg gtgcggcaca
     1861 agtccactcg gcagcgcttt gctatgaaga agattaataa gcaaaaccta atcctacgga
     1921 accagatcca gcaggcattt gtggaacgcg acatactgac ttttgctgaa aacccctttg
     1981 tagtcagcat gttctgctcc tttgagacca agcgtcactt atgcatggtg atggaatacg
     2041 ttgaaggggg agactgtgcc actctgctca agaacatcgg ggccctacct gtggacatgg
     2101 ttcgtctgta cttcgcggaa acggtgctgg ccttggaata cttacacaac tacggcatcg
     2161 tacaccgtga cctcaagcct gacaaccttc taattacatc catggggcac atcaaactca
     2221 ctgactttgg actttctaaa attggcctca tgagtttgac aaccaacttg tatgagggcc
     2281 atattgaaaa ggatgcccgg gagttcctag acaagcaggt atgcgggacc ccggaataca
     2341 tagcacctga ggtgatcctg cgtcagggat atgggaagcc agtggactgg tgggccatgg
     2401 gcataatcct gtatgagttc ctggtgggtt gcgtcccttt ctttggagac actccggagg
     2461 agctctttgg gcaagtgatc agcgatgaga ttgtgtggcc tgagggtgat gatgcacttc
     2521 ccccagatgc ccaagacctc acttccaaac tgcttcacca gaacccacta gaaagactgg
     2581 gcacaagtag tgcctatgaa gtgaagcagc acccgttctt catgggtctg gactggacag
     2641 gacttcttcg ccagaaggct gaattcatac ctcaactgga gtcagaggat gataccagct
     2701 actttgatac ccgttcagaa cgataccacc atgtggactc cgaggatgag gaggaagtga
     2761 gtgaggatgg ctgccttgag atccgccagt tttcttcctg ctctccaagg ttcagcaagg
     2821 tttacagtag catggagagg ctttccctgc ttgagggaca ccggacacca cccccaacca
     2881 agcgcagcct gagtgaggag aaggaagatc actcagatgg cttggcagga ctgaagggcc
     2941 gagaccgcag ctgggtgatt gggtcccctg agatattgcg gaagcggtta tctgtgtctg
     3001 agtcatccca cacagagagt gattccagcc ctccaatgac agtgcggcac cgctcaggcc
     3061 tcccagatgt gcctcgttgt gctgaggaga ccagtagcac ccctcggaag caacaacagg
     3121 aaggtatttg ggtcctcacg cccccatctg gagaggggtc atctaggcct gttcctgaac
     3181 gaccactgga gaggcagctg aagctggacg aggagcctcc tggccaaagc agtcggtctt
     3241 gtccagccat ggagacacga ggccgtggga ccccacaatt agctgaggaa gctacagcca
     3301 aagccatcag tgacctagct gtgcgcaggg cccggcaccg gctgctctct ggggactcta
     3361 tagagaagcg caccactcgc cctgtcaaca aagtgattaa gtcagcctca gccacagccc
     3421 tgtccctcct cattccttca gaacaccatg cctgttcacc attggccagc cccatgtccc
     3481 cacattctca gtcatccaac ccatcatcca gggactcttc tccaagcagg gacttcttgc
     3541 ctgccctcgg cagcctgagg cctcccatca tcatccaccg agctggcaag aagtatggct
     3601 tcaccctgcg ggccattcgt gtctacatgg gtgactcaga tgtctacact gtacaccata
     3661 tggtgtggca tgtggaggac ggtggtccag ccagtgaagc ggggcttcgt cagggtgacc
     3721 tcatcaccca cgtcaatggt gagcccgtgc acgggctggt ccatacagaa gtggtagagc
     3781 tggttctgaa gagtggaaac aaggtatcaa tttcaacaac tcccttggag aacacatcca
     3841 tcaaagtggg gccggctagg aaaggcagct ctaaggccaa gatggcccga aggagcaaaa
     3901 ggagccgggg caaggacggg caggaaagcc gaaaaagaaa ctccctattc cggaaaatca
     3961 caaagcaggc ctccttgcta cacaccagcc gcagcctttc ttcccttaac cgctctttgt
     4021 catcggggga gagtgggccc tgctctccca cacacagcca cagcctctct ccccgatctc
     4081 ctcctcaggg ctaccgggta gccccagata ctgtgcactc agtaggaggg aattcatcac
     4141 agagcagctc tcccagctcc agtgtgccca gctctcctgc tggctccgga catacacggc
     4201 ccagctccct tcatggattg gcacccaagc tccaacgcca gtaccgctcg ccaaggcgca
     4261 agtcagcagg cagcatccca ctgtcaccat tggcccatac cccttctcca ccagcagcag
     4321 cagcttcccc tcagcgttcc ccatcaccct tgtctggcca tgggtctcag tcctttccta
     4381 ccaagcttca cttgtctcct ccactaggta ggcagctctc acggcccaag agtgcagagc
     4441 caccccgctc tccgctactt aagagggtgc agtctgctga gaagcttgcg gctgcactgg
     4501 cagctgctga gaagaagtta gcgccttccc gaaagcatag tcttgacctg ccccacggag
     4561 agctgaagaa ggaactgaca cccagggaag ccaaccctct ggaggtagtt ggaaccagaa
     4621 gtgtgctttc tgggaaagga ccacttccag gaaagggggt gctgcagcct gctccttcac
     4681 gggcccttgg gaccctacgg caggaccgag ctgaacgccg agagtcattg caaaaacaag
     4741 aagctatccg ggaagtagac tcctcagaag atgacactga tgaggagccc gagaacagcc
     4801 aggccaccca ggagccaaga ttgtcccccc acccagaagc aagccagaat ctactcccta
     4861 aaggttcggg agagggtagg gaagaggaca ctttcttgca tagggatcta aagaaccggg
     4921 gtcctgtact ctcgggcctg ttgacaggga atagaataga agttcctggg ctctcccaga
     4981 ggaagctttg gaggccacaa gcctttgagg aagctaccaa ctccttacag gcccctagcc
     5041 tgagcaggtc tggacccaca agccccaccc cctctgaagg ctgctgggag gcgcggcagc
     5101 tccacacaca ggcactagct acacttcatc ccagctcttc agaactcacc cctaccagtt
     5161 gttctgctgc cacctccacc tctggaaagc cagggacatg gtcctggaaa ttccttattg
     5221 agggtccaga ccgagcatcc acaaacaaga agataacaag gacaggtgaa ccagctaact
     5281 cccaagattt ggaaaccaca gttccaactc aggttcctaa gaacctgtct cctgaggaag
     5341 agaagccaca gccaccaagt gtccgtgggc tgacccatcc gcttcttgag gtccccagcc
     5401 agaactggtt atgggagtct ggatgtgagc aaatggagaa agaggaccca tccctgagca
     5461 tcaccgaagt gcctggttcc tcaggcaaca ggaggcagga cattccatgc agagcccacc
     5521 atctgagccc agaaacccgg cccagtctgc tctggagaag ccaagaactt gggggccagc
     5581 aagagcatca ggacttagca ctgacatcag atgagctttt aaagcaaaca tagcagttgt
     5641 ttgctctcct tgcactcacc tgtgtaatac accctcctgg aaacca
//
