LOCUS       NM_012757               2042 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus MAS1 proto-oncogene, G protein-coupled receptor
            (Mas1), mRNA.
ACCESSION   NM_012757
VERSION     NM_012757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Zhou,G., Fan,L., Li,Z., Li,J., Kou,X., Xiao,M., Gao,M. and Qu,X.
  TITLE     G protein-coupled receptor MAS1 induces an inhibitory effect on
            myocardial infarction-induced myocardial injury
  JOURNAL   Int J Biol Macromol 207, 72-80 (2022)
   PUBMED   35247425
  REMARK    GeneRIF: G protein-coupled receptor MAS1 induces an inhibitory
            effect on myocardial infarction-induced myocardial injury.
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Chen,Y., Li,S., Xu,Z., Zhang,Y., Zhang,H. and Shi,L.
  TITLE     Aerobic training-mediated DNA hypermethylation of Agtr1a and Mas1
            genes ameliorate mesenteric arterial function in spontaneously
            hypertensive rats
  JOURNAL   Mol Biol Rep 48 (12), 8033-8044 (2021)
   PUBMED   34743271
  REMARK    GeneRIF: Aerobic training-mediated DNA hypermethylation of Agtr1a
            and Mas1 genes ameliorate mesenteric arterial function in
            spontaneously hypertensive rats.
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Pereira,V.M., Reis,F.M., Casalechi,M. and Reis,A.M.
  TITLE     Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor
            in Rat Polycystic Ovaries
  JOURNAL   Protein Pept Lett 28 (3), 249-254 (2021)
   PUBMED   32851948
  REMARK    GeneRIF: Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas
            Receptor in Rat Polycystic Ovaries.
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Savoia,C., Arrabito,E., Parente,R., Nicoletti,C., Madaro,L.,
            Battistoni,A., Filippini,A., Steckelings,U.M., Touyz,R.M. and
            Volpe,M.
  TITLE     Mas Receptor Activation Contributes to the Improvement of Nitric
            Oxide Bioavailability and Vascular Remodeling During Chronic AT1R
            (Angiotensin Type-1 Receptor) Blockade in Experimental Hypertension
  JOURNAL   Hypertension 76 (6), 1753-1761 (2020)
   PUBMED   33070664
  REMARK    GeneRIF: Mas Receptor Activation Contributes to the Improvement of
            Nitric Oxide Bioavailability and Vascular Remodeling During Chronic
            AT1R (Angiotensin Type-1 Receptor) Blockade in Experimental
            Hypertension.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Brito,V.G.B., Patrocinio,M.S., de Sousa,M.C.L., Barreto,A.E.A.,
            Frasnelli,S.C.T., Lara,V.S., Santos,C.F. and Oliveira,S.H.P.
  TITLE     Telmisartan Prevents Alveolar Bone Loss by Decreasing the
            Expression of Osteoclasts Markers in Hypertensive Rats With
            Periodontal Disease
  JOURNAL   Front Pharmacol 11, 579926 (2020)
   PUBMED   33364953
  REMARK    Erratum:[Front Pharmacol. 2021 Feb 19;11:635927. doi:
            10.3389/fphar.2020.635927.. PMID: 33679393]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Walther,T., Balschun,D., Voigt,J.P., Fink,H., Zuschratter,W.,
            Birchmeier,C., Ganten,D. and Bader,M.
  TITLE     Sustained long term potentiation and anxiety in mice lacking the
            Mas protooncogene
  JOURNAL   J Biol Chem 273 (19), 11867-11873 (1998)
   PUBMED   9565612
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Metzger,R., Bader,M., Ludwig,T., Berberich,C., Bunnemann,B. and
            Ganten,D.
  TITLE     Expression of the mouse and rat mas proto-oncogene in the brain and
            peripheral tissues
  JOURNAL   FEBS Lett 357 (1), 27-32 (1995)
   PUBMED   8001672
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Wolf,G. and Neilson,E.G.
  TITLE     Effects of angiotensin II on proximal tubular cells stably
            transfected with the c-mas oncogene
  JOURNAL   Am J Physiol 263 (5 Pt 2), F931-F938 (1992)
   PUBMED   1332507
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Martin,K.A., Grant,S.G. and Hockfield,S.
  TITLE     The mas proto-oncogene is developmentally regulated in the rat
            central nervous system
  JOURNAL   Brain Res Dev Brain Res 68 (1), 75-82 (1992)
   PUBMED   1521325
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Young,D., O'Neill,K., Jessell,T. and Wigler,M.
  TITLE     Characterization of the rat mas oncogene and its high-level
            expression in the hippocampus and cerebral cortex of rat brain
  JOURNAL   Proc Natl Acad Sci U S A 85 (14), 5339-5342 (1988)
   PUBMED   2455902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078884.1.
            
            On Aug 23, 2004 this sequence version replaced NM_012757.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078884.1, CK599058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..2042
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /note="MAS1 proto-oncogene, G protein-coupled receptor"
                     /db_xref="GeneID:25153"
                     /db_xref="RGD:3049"
     exon            1..40
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            41..167
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            168..478
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /inference="alignment:Splign:2.1.0"
     exon            479..1998
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..1489
                     /gene="Mas1"
                     /gene_synonym="c-mas; Mgra"
                     /note="MAS proto-oncogene; angiotensin-(1-7) receptor;
                     Mas-related G protein-coupled receptor a; MAS1 oncogene"
                     /codon_start=1
                     /product="proto-oncogene Mas"
                     /protein_id="NP_036889.1"
                     /db_xref="GeneID:25153"
                     /db_xref="RGD:3049"
                     /translation="MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPL
                     GFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYY
                     TIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSC
                     LVTTMEYVMCIDSGEESHSQSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTW
                     ASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANP
                     FIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV"
ORIGIN      
        1 ggaggaaggc tgcctgcata ctgggaagac cagcccacag ttaccagttc ttccggcttt
       61 ctggattctc aaagtcagaa ggggaaccct gggctttggt gaagcactcg aggctctctt
      121 cctgtgatcg acaatcaaca tctaggactg ggtagagttg gttccaggag atgcttccat
      181 gagaaacagg aagggaatga aattccccga tgctgcccat gttactgact gatgatacca
      241 ccagctgccc caggcctcca gccctctgtc ctcagctgag cttcccacca ctgtgctctc
      301 caccaagacc tgctaggatg agctgtcctt ctgctcggac tgtcaccgcc agccaggtaa
      361 acatgcagtc tgcaactaca gttactctgt aacgagatgg gcgtctggac aaagagtctg
      421 ctgtcccaga gctgggttta cctggagacg tccccagacc agtcatcctg ccagagagaa
      481 aatggcctga agtggtccag cacaagaact cctcatggac caatcaaata tgacatcctt
      541 tgctgaggag aaagccatga atacctccag cagaaatgcc tccctgggga cttcacaccc
      601 acccattccc atagtgcact gggtcatcat gagcatctct cctctcggct ttgtggagaa
      661 cgggatcctc ctctggttcc tttgcttccg gatgaggaga aatcccttca cggtctatat
      721 cacccacttg tccattgctg acatctccct cctgttctgt atttttattc tgtccatcga
      781 ctatgcttta gactatgaac tctcttctgg ccattactac acaatcgtga cgttatcggt
      841 gacttttcta tttggctaca acacaggcct ctatctgctg acagccatca gtgtggagag
      901 atgcctttca gtcctctacc ccatctggta cagatgtcac cgccccaagc accagtcggc
      961 attcgtctgt gccctcctgt gggcactttc atgcttggtg accaccatgg agtacgtcat
     1021 gtgtattgac agcggagaag agagtcactc tcagagtgac tgtcgggcgg tcatcatctt
     1081 catagccatc ctcagcttct tggtcttcac tccgctcatg ttagtgtcca gcaccatctt
     1141 ggtggtgaag atacggaaga acacatgggc ctcccattct tcgaagctgt acatcgtcat
     1201 catggtcacc attatcatat tcctcatctt tgccatgccc atgcgggtcc tctacctgtt
     1261 gtattacgag tactggtcaa cctttgggaa cctgcataac atctccttgc ttttctccac
     1321 catcaatagc agcgccaacc ctttcatcta cttttttgtg ggcagcagta agaagaagcg
     1381 cttcagggag tccttaaaag tggtcctgac cagagctttc aaagacgaga tgcaacctag
     1441 gcgtcaggag ggcaatggca acactgtatc cattgagact gtggtctgag gaccgcaggg
     1501 ggagtcttag acagaaacag ctgaatgtgg gtggctttcg atttgtgctt ggaatgcaat
     1561 ttaagtccat ttaaatctcc taaatctgat aagaaggaag cattctacat gcatgggggt
     1621 ctaatcgatg atgagcttgt gttgctactt agtatcttct ggaaatgctt ccatatgtga
     1681 cgggactctg tcttttctat cattatcaaa gactcattct tctcttagct gtccagtagt
     1741 gttcaacagt taactataaa aactgcccta gcaggaacta tctgaattgt gactcagaga
     1801 acctggggag gctgtgtgat gactgctgtg tgctcctagg tgacctcagg caagtggctt
     1861 gggagagcct gatttcccct cttagtggaa atagtgacag tctgtactgc ttaggttagt
     1921 gtccagtatg atgaggtagg caaagcaccc agctcactgt caaagttcaa taaatatccg
     1981 tctctccttg tcctttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aa
//
