LOCUS       NM_001108936            2072 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus MARVEL domain containing 2 (Marveld2), mRNA.
ACCESSION   NM_001108936 XM_001062343 XM_345145
VERSION     NM_001108936.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2072)
  AUTHORS   Hofling,C., Rossner,S., Flachmeyer,B., Krueger,M., Hartig,W. and
            Michalski,D.
  TITLE     Tricellulin, alpha-Catenin and Microfibrillar-Associated Protein 5
            Exhibit Concomitantly Altered Immunosignals along with Vascular,
            Extracellular and Cytoskeletal Elements after Experimental Focal
            Cerebral Ischemia
  JOURNAL   Int J Mol Sci 24 (15), 11893 (2023)
   PUBMED   37569268
  REMARK    GeneRIF: Tricellulin, alpha-Catenin and Microfibrillar-Associated
            Protein 5 Exhibit Concomitantly Altered Immunosignals along with
            Vascular, Extracellular and Cytoskeletal Elements after
            Experimental Focal Cerebral Ischemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2072)
  AUTHORS   Schuetz,A., Radusheva,V., Krug,S.M. and Heinemann,U.
  TITLE     Crystal structure of the tricellulin C-terminal coiled-coil domain
            reveals a unique mode of dimerization
  JOURNAL   Ann N Y Acad Sci 1405 (1), 147-159 (2017)
   PUBMED   28661558
REFERENCE   3  (bases 1 to 2072)
  AUTHORS   Su,P., Zhao,F., Cao,Z., Zhang,J., Aschner,M. and Luo,W.
  TITLE     Mir-203-mediated tricellulin mediates lead-induced in vitro loss of
            blood-cerebrospinal fluid barrier (BCB) function
  JOURNAL   Toxicol In Vitro 29 (5), 1185-1194 (2015)
   PUBMED   25975750
  REMARK    GeneRIF: Our study is the first to show the expression and
            localization of TRIC in the choroid plexus in vitro
REFERENCE   4  (bases 1 to 2072)
  AUTHORS   Nakatsu,D., Kano,F., Taguchi,Y., Sugawara,T., Nishizono,T.,
            Nishikawa,K., Oda,Y., Furuse,M. and Murata,M.
  TITLE     JNK1/2-dependent phosphorylation of angulin-1/LSR is required for
            the exclusive localization of angulin-1/LSR and tricellulin at
            tricellular contacts in EpH4 epithelial sheet
  JOURNAL   Genes Cells 19 (7), 565-581 (2014)
   PUBMED   24889144
REFERENCE   5  (bases 1 to 2072)
  AUTHORS   Nayak,G., Lee,S.I., Yousaf,R., Edelmann,S.E., Trincot,C., Van
            Itallie,C.M., Sinha,G.P., Rafeeq,M., Jones,S.M., Belyantseva,I.A.,
            Anderson,J.M., Forge,A., Frolenkov,G.I. and Riazuddin,S.
  TITLE     Tricellulin deficiency affects tight junction architecture and
            cochlear hair cells
  JOURNAL   J Clin Invest 123 (9), 4036-4049 (2013)
   PUBMED   23979167
REFERENCE   6  (bases 1 to 2072)
  AUTHORS   Masuda,S., Oda,Y., Sasaki,H., Ikenouchi,J., Higashi,T., Akashi,M.,
            Nishi,E. and Furuse,M.
  TITLE     LSR defines cell corners for tricellular tight junction formation
            in epithelial cells
  JOURNAL   J Cell Sci 124 (Pt 4), 548-555 (2011)
   PUBMED   21245199
REFERENCE   7  (bases 1 to 2072)
  AUTHORS   Kikuchi,S., Ninomiya,T., Tatsumi,H., Sawada,N. and Kojima,T.
  TITLE     Tricellulin is expressed in autotypic tight junctions of peripheral
            myelinating Schwann cells
  JOURNAL   J Histochem Cytochem 58 (12), 1067-1073 (2010)
   PUBMED   21097846
REFERENCE   8  (bases 1 to 2072)
  AUTHORS   Raleigh,D.R., Marchiando,A.M., Zhang,Y., Shen,L., Sasaki,H.,
            Wang,Y., Long,M. and Turner,J.R.
  TITLE     Tight junction-associated MARVEL proteins marveld3, tricellulin,
            and occludin have distinct but overlapping functions
  JOURNAL   Mol Biol Cell 21 (7), 1200-1213 (2010)
   PUBMED   20164257
REFERENCE   9  (bases 1 to 2072)
  AUTHORS   Riazuddin,S., Ahmed,Z.M., Fanning,A.S., Lagziel,A., Kitajiri,S.,
            Ramzan,K., Khan,S.N., Chattaraj,P., Friedman,P.L., Anderson,J.M.,
            Belyantseva,I.A., Forge,A., Riazuddin,S. and Friedman,T.B.
  TITLE     Tricellulin is a tight-junction protein necessary for hearing
  JOURNAL   Am J Hum Genet 79 (6), 1040-1051 (2006)
   PUBMED   17186462
REFERENCE   10 (bases 1 to 2072)
  AUTHORS   Ikenouchi,J., Furuse,M., Furuse,K., Sasaki,H., Tsukita,S. and
            Tsukita,S.
  TITLE     Tricellulin constitutes a novel barrier at tricellular contacts of
            epithelial cells
  JOURNAL   J Cell Biol 171 (6), 939-945 (2005)
   PUBMED   16365161
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_345145.3, XM_001062343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..2072
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /note="MARVEL domain containing 2"
                     /db_xref="GeneID:365657"
                     /db_xref="RGD:1306909"
     exon            1..133
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..1294
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1825
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /note="MARVEL (membrane-associating) domain containing 2"
                     /codon_start=1
                     /product="MARVEL domain-containing protein 2"
                     /protein_id="NP_001102406.1"
                     /db_xref="GeneID:365657"
                     /db_xref="RGD:1306909"
                     /translation="MSSSDGRSRIRDRDYSEVPRDSPCPDGIVRTLQSLHSSELAVSA
                     DPLPPPPLPLQPPFGPSFYSGDTEEPAVAPDLKPVRRFVPDSWKNFFRGKKKDPEWDK
                     PVSDIRYISDGVECSPPASPARPNHHPPNSYKDPSGGSQGTFDSQQEADAMFPHDPYA
                     SLDRRTQTARTYSEKVEEYNLRYSYMKSWAGLLRILGVVELLLGAGVFACVTAYIHKD
                     NEWYNLFGYTQSYGMGGLGSLGNTYGGYYYTGPKTPFVLVVAGLAWIATIIILVLGMS
                     MYYRTILLDSSWWPLTEFGVNVALFVLYMAAAIVYVNDTNRGGLCYYPLFNTPMNALF
                     CRVEGGQIAAMIFLFVNMIVYLVSALVCLKLWRHEAARKHREFMEQQEINDPSLSSKR
                     RMCEVATSDRQKDQEVNFKELRTTTKMAPELLSGHIPPGHIPKPIVMPDYVAKYPVIQ
                     TDDDRERYKAVFQDQFSEYKELSAEVQATLRKFDELDTVMSRLPHHSENRQEHERISR
                     IHEEFRKKKNDPSFLEKKERCEYLKNKLSHIKQRIQEYDKVMNWDTQGYP"
     exon            1295..1330
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1479
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1651
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1702
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..2072
                     /gene="Marveld2"
                     /gene_synonym="Mrvldc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcttgctt cctggccaga gctccgcagc ccgccgggct ggcgggcggg gcgctgggac
       61 cgggtcacgc cccaggagct cgatcccagt ttcggtgccc gcgggaacgc gtgctcttcc
      121 ggcggccgcg caggtgtgaa agtcacaaat gtcgtcgagt gatggaaggt ccaggattcg
      181 ggacagggac tatagtgagg tgccgaggga ctcgccttgt ccagatggta tcgtaagaac
      241 cctccagtct cttcacagca gtgagctggc tgtgagcgca gatcctctgc ctcctccccc
      301 tctcccgtta cagccaccat tcggccccag cttctactca ggtgacacag aggaaccagc
      361 ggtggcacca gatctcaagc cggtgagacg ctttgttccc gactcctgga agaacttctt
      421 cagagggaag aaaaaggacc cagaatggga taagccagtg tcagatatca gatacatctc
      481 cgacggtgtg gagtgttccc ctccagcctc tccagcaaga ccaaaccacc acccacccaa
      541 ctcttacaaa gatccttccg gagggtccca aggcaccttc gattcccagc aagaggcgga
      601 cgccatgttt ccccacgacc cctatgcttc cttagaccgg cgcacacaga cggcgcggac
      661 gtacagtgag aaggtagagg aatacaatct gcggtactcc tacatgaagt cgtgggcagg
      721 cctgctgaga attctgggcg tggtggagct gcttctggga gctggcgtct tcgcgtgtgt
      781 cacagcttac atccacaagg acaacgagtg gtacaacctg tttggctata cacagtccta
      841 tggcatggga ggtcttggca gcctgggcaa tacatacggg ggttattact acactggccc
      901 caagacccct tttgtactcg tggtggctgg attggcttgg atcgcgacga ttattatcct
      961 ggtgcttggc atgtccatgt attaccgcac catccttttg gattctagct ggtggcccct
     1021 gaccgagttt ggagttaacg ttgccttgtt tgttttgtac atggctgcag ccatagtcta
     1081 tgtgaatgat accaaccgag gtggactctg ctactacccg ttatttaata cgccaatgaa
     1141 cgcgctgttc tgccgggtag aaggaggtca gatagccgca atgatcttcc tgtttgtcaa
     1201 catgatagtt tatcttgtca gcgccctcgt ctgcctgaag ctgtggaggc atgaagcagc
     1261 ccggaaacat agggaattca tggagcagca ggagataaat gacccatcgt tgtcgtcaaa
     1321 aaggagaatg tgtgaagtgg ccaccagtga ccgacagaag gaccaagaag tcaatttcaa
     1381 agagttaaga acaacaacga aaatggctcc tgaacttctg agtggacaca tccctcctgg
     1441 ccacattcct aagcccatcg taatgcctga ctatgtggca aaataccctg tgattcagac
     1501 ggatgacgat cgggaacgct ataaggctgt gttccaagac cagttttcag agtacaagga
     1561 gctgtctgcg gaagtgcagg ccaccctgag gaagtttgac gagctggaca cggtgatgag
     1621 caggctgcca catcattctg aaaaccgcca ggaacacgag agaatttcaa gaattcatga
     1681 agagtttagg aagaaaaaga atgacccttc gtttctggaa aaaaaggagc gttgtgagta
     1741 cctcaagaac aaactctctc acataaagca aagaatccag gaatacgata aagtgatgaa
     1801 ttgggatact cagggttatc cctagatgct gtctgaaacg gtttatagcc aactgttcat
     1861 tcactgcctt tgcatgttgg tctcctgggt gagaagcagg cacttccggg tcatcttctg
     1921 cttggtctaa agacatccta ggtaaaaacc gtgtgatttt actcaaacat ttcaaaacag
     1981 ttctcaaacc cacaagggcc tttcctgaga tgggagaggc agcgtgttca gctgtgtgca
     2041 gtttctcatt aacaaggatc ttgggcgagt tg
//
