LOCUS       NM_001127659            2783 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus methionyl-tRNA synthetase 1 (Mars1), mRNA.
ACCESSION   NM_001127659
VERSION     NM_001127659.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Han,J.M., Jeong,S.J., Park,M.C., Kim,G., Kwon,N.H., Kim,H.K.,
            Ha,S.H., Ryu,S.H. and Kim,S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   Yannay-Cohen,N., Carmi-Levy,I., Kay,G., Yang,C.M., Han,J.M.,
            Kemeny,D.M., Kim,S., Nechushtan,H. and Razin,E.
  TITLE     LysRS serves as a key signaling molecule in the immune response by
            regulating gene expression
  JOURNAL   Mol Cell 34 (5), 603-611 (2009)
   PUBMED   19524539
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Le Marechal,P.,
            Negrutskii,B. and Mirande,M.
  TITLE     Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the
            Cytoplasm of Human Cells
  JOURNAL   J Biol Chem 284 (20), 13746-13754 (2009)
   PUBMED   19289464
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Kaminska,M., Havrylenko,S., Decottignies,P., Gillet,S., Le
            Marechal,P., Negrutskii,B. and Mirande,M.
  TITLE     Dissection of the structural organization of the aminoacyl-tRNA
            synthetase complex
  JOURNAL   J Biol Chem 284 (10), 6053-6060 (2009)
   PUBMED   19131329
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Kim,J.Y., Kang,Y.S., Lee,J.W., Kim,H.J., Ahn,Y.H., Park,H., Ko,Y.G.
            and Kim,S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Kaminska,M., Shalak,V. and Mirande,M.
  TITLE     The appended C-domain of human methionyl-tRNA synthetase has a
            tRNA-sequestering function
  JOURNAL   Biochemistry 40 (47), 14309-14316 (2001)
   PUBMED   11714285
REFERENCE   10 (bases 1 to 2783)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1149184.1,
                                           SRR22399481.2966676.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000007.1  65023635-65023753   c
            120-210             JAXUCZ010000007.1  65022692-65022782   c
            211-289             JAXUCZ010000007.1  65022492-65022570   c
            290-424             JAXUCZ010000007.1  65022276-65022410   c
            425-500             JAXUCZ010000007.1  65021416-65021491   c
            501-679             JAXUCZ010000007.1  65021024-65021202   c
            680-786             JAXUCZ010000007.1  65020770-65020876   c
            787-903             JAXUCZ010000007.1  65016903-65017019   c
            904-1107            JAXUCZ010000007.1  65016594-65016797   c
            1108-1309           JAXUCZ010000007.1  65015402-65015603   c
            1310-1384           JAXUCZ010000007.1  65013964-65014038   c
            1385-1555           JAXUCZ010000007.1  65010402-65010572   c
            1556-1651           JAXUCZ010000007.1  65010172-65010267   c
            1652-1769           JAXUCZ010000007.1  65009934-65010051   c
            1770-1983           JAXUCZ010000007.1  65009474-65009687   c
            1984-2115           JAXUCZ010000007.1  65008168-65008299   c
            2116-2220           JAXUCZ010000007.1  65007981-65008085   c
            2221-2407           JAXUCZ010000007.1  65007698-65007884   c
            2408-2479           JAXUCZ010000007.1  65007125-65007196   c
            2480-2572           JAXUCZ010000007.1  65006789-65006881   c
            2573-2783           JAXUCZ010000007.1  65006456-65006666   c
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2783
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /note="methionyl-tRNA synthetase 1"
                     /db_xref="GeneID:299851"
                     /db_xref="RGD:1305321"
     exon            1..119
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2719
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /EC_number="6.1.1.10"
                     /note="methionine-tRNA synthetase"
                     /codon_start=1
                     /product="methionine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_001121131.1"
                     /db_xref="GeneID:299851"
                     /db_xref="RGD:1305321"
                     /translation="MRLFVSEGSPGSLPVLAAAARARGRAELLISTVGPEECVVPFLT
                     RPKVPVLQLDSGNYLFSASAICRYFFLLCGWEQDDLTNQWLEWEATELQPVLSAALYC
                     LVVQGKKGEDVLGPLRRVLTHIDHSLSRQNCPFLAGDTESLADIVLWGALYPLLQDPA
                     YLPEELGALQSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPQPLPPEGRAV
                     SNEPEEEELATLSEEDIIAAVAAWEKGLENLPPLQPQQHPVLPVPGERNVLITSALPY
                     VNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKAMEEGLTPQEI
                     CDKYHAIHVDIYRWFNISFDTFGRTTTPLQTKITQDIFQRLLTRGFVLQDTVEQLRCE
                     QCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAIELKRPQCKVCRSHPVVKSSK
                     HLFLDLPKLEKRLEDWLGKTMPGSDWTPNARFIIRSWLRDGLKPRCITRDLKWGTPVP
                     LEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHGLVF
                     PCSALGAEDNYTLVKNLIATEYLNYEDGKFSKSRGIGVFGDMAQDTGIPADIWRFYLL
                     YIRPEGQDSAFSWTDLLIKNNSELLNNLGNFINRAGMFVSKFFGGCVPEMVLTHDDRR
                     LVAHVSWELQRYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGDEMDRQRA
                     GTVTGMAVNIAALLSVMLQPYMPTVSSTIQTQLQLPEAACRILATSFICTLPAGHRIG
                     TVSPLFQKLENDQIENLRQRFGGGQAKGSPKPAVVEAVTTAGSQDIQVLVDEVTKQGN
                     IVRELKAQKADKNQVAAEVAKLLDLKKQLALAEGKPIETPKGKKKK"
     exon            120..210
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            211..289
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            290..424
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            425..500
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            501..679
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            680..786
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            787..903
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1107
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1309
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1384
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1555
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1651
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1769
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1983
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2115
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2220
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2407
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2479
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2572
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2783
                     /gene="Mars1"
                     /gene_synonym="Mars"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagacacg atgaggctgt tcgtgagcga aggctccccg ggtagcctgc cggtgctggc
       61 tgcggccgcg agggcccggg gccgggcgga gctgctcatc agcaccgtag gccccgaaga
      121 gtgtgtggta ccatttctta cccggcctaa ggtccctgtc ttgcagctgg atagcggcaa
      181 ctacctcttc tctgctagtg caatctgccg atattttttt ctgttatgcg gctgggaaca
      241 agatgatctt accaaccaat ggctggaatg ggaagcaaca gaactgcagc cggttctgtc
      301 tgctgcccta tactgtctag tggttcaagg caaaaaaggg gaagatgtac ttggcccact
      361 tcggagagtc ctgactcaca ttgatcacag cttgagtcgg caaaactgtc ctttcttggc
      421 aggggacaca gaatctctag ctgacattgt tttgtgggga gcactatatc ctttactgca
      481 agacccagct tacctccctg aggagttggg tgccctacaa agctggttcc agacactaag
      541 tacccaggag ccatgtcagc gagctgcaga gactgtgctg aaacagcagg gtgtcctggc
      601 actgcgtccc tacctccaaa aacagcccca gccccagccc ctacctcctg aggggagagc
      661 tgtcagcaat gaacctgagg aggaagagct ggctaccctg tctgaggagg acatcattgc
      721 tgctgttgct gcttgggaga agggtctgga aaacttacct ccactacagc cccagcagca
      781 tccagtgttg cctgtgcctg gagaaaggaa tgtgctcatc acgagtgccc tcccttatgt
      841 caacaatgtc ccccaccttg gaaacatcat tggctgtgtg ctcagtgctg atgtctttgc
      901 aaggtactct cgccttcgcc agtggaacac cctctatctg tgtggcacag atgagtatgg
      961 tactgcgaca gagaccaagg ccatggaaga gggtctaacc ccacaagaaa tctgtgacaa
     1021 ataccacgcc atacatgttg acatctaccg ctggttcaat atatcgtttg atacgttcgg
     1081 tcgcacaacc actcctctgc agaccaaaat cacacaggac atcttccaga ggttgctgac
     1141 acggggtttt gtgctgcaag atactgtaga gcagcttcgc tgtgagcagt gtgcacgttt
     1201 cttggctgac cgctttgtgg agggagtgtg tcccttttgt ggctatgaag aggcccgggg
     1261 tgaccagtgt gacaagtgtg gcaagctcat caatgccatt gagctcaaga gacctcagtg
     1321 caaagtctgc cgctcccacc ctgtggtgaa gtcctcaaag cacctgtttc tagacttgcc
     1381 taagttagag aagcgcctgg aggactggct ggggaagacg atgcctggca gtgactggac
     1441 acccaatgcc aggttcatta ttcgatcctg gcttcgagat ggactcaagc cacgatgcat
     1501 caccagagac ctcaaatggg gaactcctgt gcccttggaa ggttttgagg acaaggtatt
     1561 ttatgtctgg tttgatgcta ctattggcta tctgtccatc acagccaact acacagacca
     1621 gtgggagaga tggtggaaga atccagaaca agtggacctt taccagttca tggccaaaga
     1681 caatgttccc ttccatggct tggtctttcc ttgttcagcc ctaggagctg aggataacta
     1741 caccttagtc aagaacctca tcgctacaga atacctgaac tacgaggacg ggaagttctc
     1801 taagagccgg gggataggag tgtttggaga catggcccaa gatacaggga tccctgctga
     1861 catctggcga ttctatctgc tatacattcg gcctgagggc caggacagtg ccttctcctg
     1921 gacagacttg ctgattaaaa acaattctga gctgcttaac aacctgggca acttcatcaa
     1981 tagagctggc atgttcgtgt ctaagttttt tgggggttgt gtgcctgaga tggtgctgac
     2041 ccacgatgac agacgcctgg tggcacatgt ctcctgggaa ctccagcgct atcaccagct
     2101 gttggaaaag gttcggatcc gggatgcctt gcgcagtatc cttaccatat ctcggcatgg
     2161 caaccaatat attcaagtga atgagccctg gaaacggatt aaaggcgatg agatggacag
     2221 gcagcgggca ggcacggtga caggaatggc agtgaacata gctgccttgc tgtctgtcat
     2281 gctccagccg tacatgccca cagtcagctc caccattcag acccagctcc agctcccaga
     2341 ggcagcctgc cgcatccttg ccacaagctt catttgtacc ttaccagcag gccaccgaat
     2401 tggcacagtc agtcctttgt tccagaaatt ggaaaatgac cagattgaaa atttgaggca
     2461 gcgctttgga gggggccagg ctaaagggtc ccccaagcca gcagttgttg aggcagttac
     2521 tacagcaggg tcgcaggaca tacaagtgct ggtggatgag gtaaccaaac agggaaacat
     2581 agttcgggaa ctgaaagcac agaaggcaga caagaaccag gttgctgcag aagtggctaa
     2641 actcttggat ctaaagaaac agttggcttt ggctgagggg aagcccattg aaactccgaa
     2701 aggcaagaag aaaaagtgag agaatgttca cacaaagtca ctttactggg tatggacagt
     2761 aataaagaat gtacagtgta caa
//
